Ganglioside GM3 can induce megakaryocytoid differentiation of human leukemia cell line K562 cells.

abstract：:The majority of BRCA1-associated breast cancers are basal cell-like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53-mutated tumors. At 0.5 mg/k...

journal_title：Cancer research

authors： Shafee N,Smith CR,Wei S,Kim Y,Mills GB,Hortobagyi GN,Stanbridge EJ,Lee EY

更新日期：2008-05-01 00:00:00

abstract：:Abnormal cleavage of amyloid precursor protein (APP) in the central nervous system has been linked to the development of Alzheimer's disease. Recent work has identified additional roles for APP in peripheral tissue, such as cellular proliferation and motility. APP undergoes proteolytic processing to release a soluble ...

journal_title：Cancer research

authors： Hansel DE,Rahman A,Wehner S,Herzog V,Yeo CJ,Maitra A

更新日期：2003-11-01 00:00:00

abstract：:That ferritin, an iron storage protein, can be produced by neuroblastoma cells raises the possibility that iron may have some role in promoting tumor cell growth. To explore this possibility, we studied the effects of desferoxamine, a compound which chelates iron, on viability of CHP 126 and CHP 100, two human neurobl...

journal_title：Cancer research

authors： Blatt J,Stitely S

更新日期：1987-04-01 00:00:00

abstract：:Activated ras oncogene transfection into suitable recipient cells has been shown to induce the metastatic phenotype (Thorgeirsson, et al., Mol. Cell. Biol., 5: 259-262, 1985). We have used this model system to study the correlation of basement membrane collagenolysis with metastatic propensity. The c-Ha-ras oncogene a...

journal_title：Cancer research

authors： Garbisa S,Pozzatti R,Muschel RJ,Saffiotti U,Ballin M,Goldfarb RH,Khoury G,Liotta LA

更新日期：1987-03-15 00:00:00

abstract：:Two murine monoclonal antibodies, 2H6G5 (IgM) and 4A9E10 (IgG3), were obtained by using either cultured human hepatocellular carcinoma cells (PLC/PRF/5) or the acidic glycolipid mixture prepared from the same cells as immunogens. The antigen in PLC/PRF/5 cell membranes recognized by both antibodies was identified as a...

journal_title：Cancer research

authors： Hiraiwa N,Iida N,Ishizuka I,Itai S,Shigeta K,Kannagi R,Fukuda Y,Imura H

更新日期：1988-12-01 00:00:00

abstract：:A crucial ingredient of any hyperthermia procedure is the accurate measurement of achieved temperature. In this paper, we present some accuracy and resolution suggestions and address the problem of temperature measurements when electromagnetic energy is used as the mode of heating. In such cases, conventional metallic...

journal_title：Cancer research

authors： Christensen DA

更新日期：1979-06-01 00:00:00

abstract：:Cancer chemotherapy may be improved by increasing antineoplastic drug specificity for tumor cells. We have synthesized a glucuronide prodrug that can be enzymatically converted to an antineoplastic agent at tumor cells that are able to bind beta-glucuronidase-monoclonal antibody conjugates. The glucuronide prodrug BHA...

journal_title：Cancer research

authors： Wang SM,Chern JW,Yeh MY,Ng JC,Tung E,Roffler SR

更新日期：1992-08-15 00:00:00

abstract：:Two monoclonal antibodies, OC 125 and OC 133, bind to distinct determinants on the surface of human epithelial ovarian carcinoma cell lines. OC 125 and OC 133 recognize determinants on molecules with molecular weights greater than 200,000 and 80,000, respectively. When binding to four different cell lines was compared...

journal_title：Cancer research

authors： Masuho Y,Zalutsky M,Knapp RC,Bast RC Jr

更新日期：1984-07-01 00:00:00

abstract：:An inbred-strain (C57BL/6) transgenic (Tyr-SV40E) mouse model of ultraviolet radiation (UVR)-induced metastatic cutaneous melanoma was produced without the use of chemical carcinogens and without resulting in other skin malignancies. Expression of this transgene occurs specifically in melanocytic-lineage cells. In unt...

journal_title：Cancer research

authors： Kelsall SR,Mintz B

更新日期：1998-09-15 00:00:00

abstract：:In spite of preclinical efficacy and recent randomized, controlled studies with adenoviral vectors expressing herpes simplex virus-1 thymidine kinase (HSV1-TK) showing statistically significant increases in survival, most clinical trials using single therapies have failed to provide major therapeutic breakthroughs. Be...

journal_title：Cancer research

authors： Ali S,King GD,Curtin JF,Candolfi M,Xiong W,Liu C,Puntel M,Cheng Q,Prieto J,Ribas A,Kupiec-Weglinski J,van Rooijen N,Lassmann H,Lowenstein PR,Castro MG

更新日期：2005-08-15 00:00:00

abstract：:miRNAs (miR) are a critical class of small (21-25 nucleotides) noncoding endogenous RNAs implicated in gene expression regulation. We identified miR-23b and miR-27b as miRNAs that are highly upregulated in human breast cancer. We found that engineered knockdown of miR-23b and miR-27b substantially repressed breast can...

journal_title：Cancer research

authors： Jin L,Wessely O,Marcusson EG,Ivan C,Calin GA,Alahari SK

更新日期：2013-05-01 00:00:00

abstract：:Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular and clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2, 12, and 31, we stratified 77 primary CRC...

journal_title：Cancer research

authors： Whitehall VL,Wynter CV,Walsh MD,Simms LA,Purdie D,Pandeya N,Young J,Meltzer SJ,Leggett BA,Jass JR

更新日期：2002-11-01 00:00:00

abstract：:B7-H4 (VTCN1, B7x, B7s) is a ligand for inhibitory coreceptors on T cells implicated in antigenic tolerization. B7-H4 is expressed by tumor cells and tumor-associated macrophages (TAM), but its potential contributions to tumoral immune escape and therapeutic targeting have been less studied. To interrogate B7-H4 expre...

journal_title：Cancer research

authors： Dangaj D,Lanitis E,Zhao A,Joshi S,Cheng Y,Sandaltzopoulos R,Ra HJ,Danet-Desnoyers G,Powell DJ Jr,Scholler N

更新日期：2013-08-01 00:00:00

abstract：:Copy number alterations are crucial for the development of colorectal cancer. Our whole-genome analysis identified tocopherol alpha transfer protein-like (TTPAL) as preferentially amplified in colorectal cancer. Here we demonstrate that frequent copy number gain of TTPAL leads to gene overexpression in colorectal canc...

journal_title：Cancer research

authors： Gou H,Liang JQ,Zhang L,Chen H,Zhang Y,Li R,Wang X,Ji J,Tong JH,To KF,Sung JJY,Chan FKL,Fang JY,Yu J

更新日期：2019-07-01 00:00:00

abstract：:Isozymes of carbamyl phosphate synthetase (CPS), CPS I, a mitochondrial enzyme found exclusively in liver and involved in urea synthesis, and of CPS II, a soluble cytoplasmic enzyme widely distributed in animal tissues, were assayed in rat liver and in a series of rat liver neoplasms ranging widely in growth rate and ...

journal_title：Cancer research

authors： Lawson D,Paik WK,Morris HP,Weinhouse S

更新日期：1975-01-01 00:00:00

abstract：:This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107. After a brief analysis of the established structural and functional similarities among the three genes, the main purp...

journal_title：Cancer research

authors： Paggi MG,Giordano A

更新日期：2001-06-15 00:00:00

abstract：:Motility related protein-1 (MRP-1) is a transmembrane glycoprotein that is identical to the CD9 antigen. In previous studies, we showed that various types of cultured tumor cells transfected with MRP-1/CD9 cDNA have low motility and diminished metastatic potential to the lung. More recently we used immunohistochemical...

journal_title：Cancer research

authors： Higashiyama M,Taki T,Ieki Y,Adachi M,Huang CL,Koh T,Kodama K,Doi O,Miyake M

更新日期：1995-12-15 00:00:00

abstract：:Metabolic reprogramming of cancer cells and the tumor microenvironment are emerging as key factors governing tumor growth, metastasis, and response to therapies including immune checkpoint inhibitors. It has been recognized that rapidly proliferating cancer cells, tumor-infiltrating lymphocytes, and vascular endotheli...

journal_title：Cancer research

authors： Ngwa VM,Edwards DN,Philip M,Chen J

更新日期：2019-08-15 00:00:00

abstract：:Two newly synthesized nitrosoureido sugars have been evaluated for their antitumor activity and diabetogenic potential in a number of in vitro and in vivo preclinical tumor model systems. 2-Amino-2-deoxy-N'-methyl-N'-nitrosoureido-1,3,4,6-tetra-O-acetyl-alpha- D- mannopyranose (MAZ), a lipophilic mannosamine derivativ...

journal_title：Cancer research

authors： Bernacki RJ,Wilson GL,Mossman BT,Angelino N,Kanter PM,Korytnyk W

更新日期：1985-02-01 00:00:00

abstract：:The pool sizes of purine nucleotides, nucleosides, and nucleobases were measured in the host tissues liver, skeletal muscle, and blood of Ehrlich ascites tumor-bearing mice during the different periods of tumor growth. There were large differences of tissue concentrations of these metabolites between control animals, ...

journal_title：Cancer research

authors： Siems WG,Grune T,Schmidt H,Tikhonov YV,Pimenov AM

更新日期：1993-11-01 00:00:00

abstract：:The formation of 7-(2-hydroxyethyl)guanine (7-HEG) in DNA of target and nontarget tissues was investigated in male B6C3F1 mice (20/group) and F344 rats (10/group) exposed to 0, 3, 10, 33, 100, or 300 (rats only) ppm ethylene oxide (ETO) by inhalation for 6 h/day for 4 weeks (5 days/week) and mice exposed to 100 ppm ET...

journal_title：Cancer research

authors： Walker VE,Fennell TR,Upton PB,Skopek TR,Prevost V,Shuker DE,Swenberg JA

更新日期：1992-08-15 00:00:00

abstract：:Berberine, a natural product derived from a plant used in Chinese herbal medicine, is reported to exhibit anticancer effects; however, its mechanism of action is not clearly defined. Herein, we demonstrate that berberine induces apoptosis in acute lymphoblastic leukemia (ALL) cells by downregulating the MDM2 oncoprote...

journal_title：Cancer research

authors： Zhang X,Gu L,Li J,Shah N,He J,Yang L,Hu Q,Zhou M

更新日期：2010-12-01 00:00:00

abstract：:N'-[2-chloroethyl]-N[2-(methylsulfonyl) ethyl]-N'-nitrosourea (cystemustine),a chloroethylnitrosourea antineoplastic drug, provokes cellular proliferation inhibition and redifferentiation, but there was no cell death in B16 melanoma tumors. Because the phospholipid (Plp) metabolism is tightly involved in tumor growth ...

journal_title：Cancer research

authors： Morvan D,Demidem A,Papon J,De Latour M,Madelmont JC

更新日期：2002-03-15 00:00:00

abstract：:We know that the Yin Yang 1 protein (YY1) overexpression is positively and strongly correlated with the degree of malignancy of bone tumors. Therefore, we questioned whether we could influence cell invasiveness by deleting YY1 in human osteosarcoma cells (SaOs-2), as tested in Matrigel-coated filters and metastasis im...

journal_title：Cancer research

authors： de Nigris F,Rossiello R,Schiano C,Arra C,Williams-Ignarro S,Barbieri A,Lanza A,Balestrieri A,Giuliano MT,Ignarro LJ,Napoli C

更新日期：2008-03-15 00:00:00

abstract：:Delivery of therapeutic agents to the brain and its neoplasms depends on the presence of membrane transport proteins in the blood-brain barrier and in the target cells. The cellular and subcellular localization of these membrane transporters determines the drug accessibility to the brain and its tumors. We therefore a...

journal_title：Cancer research

authors： Bronger H,König J,Kopplow K,Steiner HH,Ahmadi R,Herold-Mende C,Keppler D,Nies AT

更新日期：2005-12-15 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) receptor agonists are extensively used in the treatment of sex hormone-dependent cancers via the desensitization of pituitary gonadotropes and consequent decrease in steroid sex hormone secretion. However, evidence now points to a direct inhibitory effect of GnRH analogs on cancer...

journal_title：Cancer research

authors： Maudsley S,Davidson L,Pawson AJ,Chan R,López de Maturana R,Millar RP

更新日期：2004-10-15 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) kinase 4 (MKK4) is a component of a stress and cytokine-induced signal transduction pathway involving MAPK proteins. The MKK4 protein has been implicated in activation of JNK1 and p38 MAPK on phosphorylation by conserved kinase pathways. A recent report on the deletion and mutat...

journal_title：Cancer research

authors： Su GH,Hilgers W,Shekher MC,Tang DJ,Yeo CJ,Hruban RH,Kern SE

更新日期：1998-06-01 00:00:00

abstract：:To assess whether CYP3A4 and CYP3A7 have a similar capacity to activate carcinogenic mycotoxins, we established cell lines stably expressing human CYP3A4 and CYP3A7, which are adult- and fetal-specific forms of cytochrome P450 in human livers, respectively. Each cDNA was introduced into CR-119 cells which had been est...

journal_title：Cancer research

authors： Hashimoto H,Nakagawa T,Yokoi T,Sawada M,Itoh S,Kamataki T

更新日期：1995-02-15 00:00:00

abstract：:CXCL16 is a new member of the chemokine superfamily, which exists in a transmembrane as well as a soluble form. Its receptor CXCR6 is detected on CD4(+) T cells, CD8(+) T cells, and natural killer T cells. Here, we report a significant correlation of CXCL16 expression by tumor cells with the infiltration of T cells an...

journal_title：Cancer research

authors： Hojo S,Koizumi K,Tsuneyama K,Arita Y,Cui Z,Shinohara K,Minami T,Hashimoto I,Nakayama T,Sakurai H,Takano Y,Yoshie O,Tsukada K,Saiki I

更新日期：2007-05-15 00:00:00

abstract：:There is an unmet need for pharmacodynamic and predictive biomarkers for antiangiogenic agents. Recent studies have shown that soluble vascular endothelial growth factor receptor 2 (sVEGFR2), VEGF, and several other soluble factors may be modulated by VEGF pathway inhibitors. We conducted a broad profiling of cytokine...

journal_title：Cancer research

authors： Nikolinakos PG,Altorki N,Yankelevitz D,Tran HT,Yan S,Rajagopalan D,Bordogna W,Ottesen LH,Heymach JV

更新日期：2010-03-15 00:00:00