Who is the boss in the retinoblastoma family? The point of view of Rb2/p130, the little brother.

Abstract:

:This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107. After a brief analysis of the established structural and functional similarities among the three genes, the main purpose is to critically analyze present evidence whether Rb2/p130 shares the role of a tumor suppressor. Taking into account the well-proven growth suppressive properties of Rb2/p130 and p107, we discuss the analysis of mutated or deleted forms of Rb2/p130 found in a number of human cancers. Finally, we take into consideration the data provided by the targeted disruption of each RB family gene, alone or in combination, in the mouse model.

journal_name

Cancer Res

journal_title

Cancer research

authors

Paggi MG,Giordano A

subject

Has Abstract

pub_date

2001-06-15 00:00:00

pages

4651-4

issue

12

eissn

0008-5472

issn

1538-7445

journal_volume

61

pub_type

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