Abstract：
:The p53 gene has been implicated as a tumor suppressor gene involved in the pathogenesis of lung cancer. Our previous study revealed that the p53 gene is frequently mutated with a distinct nucleotide substitution pattern in small cell lung cancer specimens in Japanese patients. In this study, we examined 30 primary, resected non-small cell lung cancer samples in Japanese patients using complementary DNA-polymerase chain reaction and sequencing. Mutations changing the p53 coding sequence were found in 14 of 30 tumor samples (47%), while G:C to T:A transversions which are uncommon in other cancers such as colon cancer were the most frequently observed mutations, in agreement with an earlier report on non-small cell lung cancer in American patients. Furthermore, the present study shows for the first time that in univariate and multivariate analyses, the presence of p53 mutations is closely associated with lifetime cigarette consumption.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Suzuki H,Takahashi T,Kuroishi T,Suyama M,Ariyoshi Y,Takahashi T,Ueda Rsubject
Has Abstractpub_date
1992-02-01 00:00:00pages
734-6issue
3eissn
0008-5472issn
1538-7445journal_volume
52pub_type
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