Shark cartilage, cancer and the growing threat of pseudoscience.

abstract：:Membrane-bound complement inhibitors protect host cells from inadvertent complement attack, and complement inhibitors are often up-regulated on tumors, possibly representing a selective adaptation by tumors to escape elimination by a host antitumor immune response. Relevant in vivo studies using rodent models of human...

journal_title：Cancer research

authors： Caragine TA,Okada N,Frey AB,Tomlinson S

更新日期：2002-02-15 00:00:00

abstract：:Drug sensitivity assays were performed using a variation of a colorimetric [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)] assay on V79, CHO-AuxB1, CHRC5, NCI-H460, and NCI-H249 cell lines following optimization of experimental conditions for each cell line. Results from this assay were compared w...

journal_title：Cancer research

authors： Carmichael J,DeGraff WG,Gazdar AF,Minna JD,Mitchell JB

更新日期：1987-02-15 00:00:00

abstract：:Preincubation of murine colon 26 colon adenocarcinoma cells with gamma-interferon (IFN-gamma), but not alpha-interferon, produced a significant increase in experimental pulmonary metastases in syngeneic BALB/c and T-cell-deficient BALB/c nude mice. The enhancement was seen after as little as 1 h of exposure to 1 unit/...

journal_title：Cancer research

authors： Kelly SA,Gschmeissner S,East N,Balkwill FR

更新日期：1991-08-01 00:00:00

abstract：:Previous studies with Adriamycin-sensitive and -resistant (ADRR) MCF-7 human breast tumor cell lines indicated that Adriamycin formed significantly less hydroxyl radical (.OH) as the result of enhanced detoxification of reactive oxygen intermediates in the ADRR cell line. In order to further define the sites of drug a...

journal_title：Cancer research

authors： Sinha BK,Mimnaugh EG,Rajagopalan S,Myers CE

更新日期：1989-07-15 00:00:00

abstract：:Virtually all patients with chronic myelogenous leukemia (CML) express an aberrant protein (p210 Bcr-Abl) that contains NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl. In a yeast two-hybrid screen, we have identified TSG101 as a binding partner for Bcr. Because TSG101 is a subunit of the mam...

journal_title：Cancer research

authors： Olabisi OO,Mahon GM,Kostenko EV,Liu Z,Ozer HL,Whitehead IP

更新日期：2006-06-15 00:00:00

abstract：:We have previously presented evidence that a transient block to DNA replication induces an aberrant form of DNA synthesis. The most feasible explanation for this data is that the block to DNA replication results in some segments of the chromosomal DNA being replicated more than once in a single cell cycle. This form o...

journal_title：Cancer research

authors： Woodcock DM,Adams JK,Cooper IA

更新日期：1982-11-01 00:00:00

abstract：:The effects of taxol on antitubulin immunofluorescent staining patterns, cellular DNA content, and labeling with [3H]thymidine were measured for the taxol-sensitive HL60 and taxol-resistant K562 cell lines after exposures for 0, 4, 12, and 24 h. Taxol caused a relative increase in the fraction of 4C interphase and met...

journal_title：Cancer research

authors： Roberts JR,Allison DC,Donehower RC,Rowinsky EK

更新日期：1990-02-01 00:00:00

abstract：:Micromolar concentrations of fecapentaene-12, a mutagen found in human feces, decrease survival measured as colony-forming efficiency and membrane integrity of cultured human fibroblasts. Fecapentaene-12 also decreases the content of cellular free low-molecular-weight thiols including glutathione. Fecapentaene-12 reac...

journal_title：Cancer research

authors： Dypbukt JM,Edman CC,Sundqvist K,Kakefuda T,Plummer SM,Harris CC,Grafström RC

更新日期：1989-11-01 00:00:00

abstract：:Neuroblastoma, one of the most common pediatric solid tumors, is characterized by two extreme disease courses, spontaneous regression and life-threatening progression. Here, we conducted a genome-wide search for differences in DNA methylation that distinguish between neuroblastomas of the two types. Three CpG islands ...

journal_title：Cancer research

authors： Abe M,Ohira M,Kaneda A,Yagi Y,Yamamoto S,Kitano Y,Takato T,Nakagawara A,Ushijima T

更新日期：2005-02-01 00:00:00

abstract：:Detecting the presence and diversity of low-level mutations in human tumors undergoing genomic instability is desirable due to their potential prognostic value and their putative influence on the ability of tumors to resist drug treatment and/or metastasize. However, direct measurement of these genetic alterations in ...

journal_title：Cancer research

authors： Liu WH,Kaur M,Wang G,Zhu P,Zhang Y,Makrigiorgos GM

更新日期：2004-04-01 00:00:00

abstract：:We demonstrate here that paclitaxel exposure to RPMI-1788 B lymphoblasts caused a dose- and time-dependent increase in nuclear factor activator protein 1 (AP-1) DNA binding activity. The basal DNA binding activities of nuclear factors NF-kappaB and Ets were not affected by paclitaxel. Consistent with these biochemical...

journal_title：Cancer research

authors： Amato SF,Swart JM,Berg M,Wanebo HJ,Mehta SR,Chiles TC

更新日期：1998-01-15 00:00:00

abstract：:Sodium saccharin and sodium ascorbate are known to promote urinary bladder carcinogenesis in rats following initiation with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or N-butyl-N-(4-hydroxybutyl) nitrosamine. Sodium salts of other organic acids have also been shown to be bladder tumor promoters. In addition...

journal_title：Cancer research

authors： Cohen SM,Ellwein LB,Okamura T,Masui T,Johansson SL,Smith RA,Wehner JM,Khachab M,Chappel CI,Schoenig GP

更新日期：1991-04-01 00:00:00

abstract：:Immunotherapy based on adoptive transfer of tumor antigen-specific CD8(+) T cell (TC) is generally limited by poor in vivo expansion and tumor infiltration. In this study, we report that activated STAT5 transcription factors (STAT5CA) confer high efficiency on CD8(+) effector T cells (eTC) for host colonization after ...

journal_title：Cancer research

authors： Grange M,Buferne M,Verdeil G,Leserman L,Schmitt-Verhulst AM,Auphan-Anezin N

更新日期：2012-01-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) functions primarily as an inhibitory neurotransmitter in the mature central nervous system, and GABA/GABA receptors are also present in nonneural tissues, including cancer, but their precise function in nonneuronal or cancerous cells has thus far been poorly defined. Through the genome-w...

journal_title：Cancer research

authors： Takehara A,Hosokawa M,Eguchi H,Ohigashi H,Ishikawa O,Nakamura Y,Nakagawa H

更新日期：2007-10-15 00:00:00

abstract：:Expression and function of the Fas apoptotic pathway was investigated in normal and malignant human breast epithelial cells. Nontransformed mammary epithelial cell lines all expressed high levels of Fas mRNA and protein, but only one of seven breast cancer cell lines (T47D) expressed high levels of Fas. Apoptosis was ...

journal_title：Cancer research

authors： Keane MM,Ettenberg SA,Lowrey GA,Russell EK,Lipkowitz S

更新日期：1996-10-15 00:00:00

abstract：:Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations. Hereby, we clarify how these COOH-terminal alteration...

journal_title：Cancer research

authors： Bolli N,Nicoletti I,De Marco MF,Bigerna B,Pucciarini A,Mannucci R,Martelli MP,Liso A,Mecucci C,Fabbiano F,Martelli MF,Henderson BR,Falini B

更新日期：2007-07-01 00:00:00

abstract：:Because of its relatively indolent clinical course, chronic lymphocytic leukemia (CLL) offers a versatile model for testing novel therapeutic regimens and drug combinations. Nicotinamide is the main NAD(+) precursor and a direct inhibitor of four classes of enzymes, including the sirtuins. SIRT1, the main member of th...

journal_title：Cancer research

authors： Audrito V,Vaisitti T,Rossi D,Gottardi D,D'Arena G,Laurenti L,Gaidano G,Malavasi F,Deaglio S

更新日期：2011-07-01 00:00:00

abstract：:Systemic delivery of anticancer agents is accompanied by many unwanted side effects that can be mitigated by encapsulation of antineoplastic agents. However, encapsulation necessitates a technique for controlled delivery to the cancerous tissue. We have developed a novel drug delivery system that releases drug from st...

journal_title：Cancer research

authors： Nelson JL,Roeder BL,Carmen JC,Roloff F,Pitt WG

更新日期：2002-12-15 00:00:00

abstract：:The expression of the major glycoprotein, gp71, of murine leukemia virus was studied on the surfaces of a variety of normal murine cell lines with a monospecific rabbit antiserum raised against purified Friend murine leukemia virus gp71. Using viable cell membrane immunofluorescence, most established and early passage...

journal_title：Cancer research

authors： Cloyd MW,Bolognesi DP,Bigner DD

更新日期：1977-03-01 00:00:00

abstract：:The human uterine cervix offers a unique opportunity to study the early lesions of squamous cell carcinoma, i.e., carcinoma in situ and dysplasia [combined as cervical intraepithelial neoplasia (CIN)]. In vivo, the patients with CIN have the epidemiological common denominators or "markers" of early onset of coitus, mu...

journal_title：Cancer research

authors： Wilbanks GD

更新日期：1976-07-01 00:00:00

abstract：:Multiple myeloma (MM) is a treatable, but incurable, malignancy of plasma cells (PC) in the bone marrow (BM). It represents the final stage in a continuum of PC dyscrasias and is consistently preceded by a premalignant phase termed monoclonal gammopathy of undetermined significance (MGUS). The existence of this well-d...

journal_title：Cancer research

authors： van Nieuwenhuijzen N,Spaan I,Raymakers R,Peperzak V

更新日期：2018-05-15 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients with AML and that ROS production promotes proliferation of AML cells...

journal_title：Cancer research

authors： Robinson AJ,Hopkins GL,Rastogi N,Hodges M,Doyle M,Davies S,Hole PS,Omidvar N,Darley RL,Tonks A

更新日期：2020-03-01 00:00:00

abstract：:Loss of expression of the E-cadherin cell-cell adhesion molecule is important in carcinoma development and progression. Because previous data suggest that loss of E-cadherin expression in breast carcinoma may result from a dominant transcriptional repression pathway acting on the E-cadherin proximal promoter, we pursu...

journal_title：Cancer research

authors： Hajra KM,Chen DY,Fearon ER

更新日期：2002-03-15 00:00:00

abstract：:We are developing a noninvasive approach for targeting imaging and therapeutic radionuclides to prostate cancer. Our method, Enzyme-Mediated Cancer Imaging and Therapy (EMCIT), aims to use enzyme-dependent, site-specific, in vivo precipitation of a radioactive molecule within the extracellular space of solid tumors. A...

journal_title：Cancer research

authors： Pospisil P,Wang K,Al Aowad AF,Iyer LK,Adelstein SJ,Kassis AI

更新日期：2007-03-01 00:00:00

abstract：:The interactions of tumorigenic cells with the extracellular matrix play a critical role in the establishment of metastases. Thrombospondin (TSP) is prominent at sites of tissue injury and promotes the attachment, spreading, and motility of several cell types. We have investigated the relationship between human carcin...

journal_title：Cancer research

authors： Yabkowitz R,Mansfield PJ,Dixit VM,Suchard SJ

更新日期：1993-01-15 00:00:00

abstract：:A correlation exists between the ability of tumor cells to aggregate platelets and their tendency to metastasize. Tumor cell-induced platelet aggregation (TCIPA) facilitates the embolization of the vasculature with tumor cells and the formation of metastatic foci. It is well documented that matrix metalloproteinases (...

journal_title：Cancer research

authors： Jurasz P,Sawicki G,Duszyk M,Sawicka J,Miranda C,Mayers I,Radomski MW

更新日期：2001-01-01 00:00:00

abstract：:Proliferating mammalian stem and cancer cells express telomerase [telomerase reverse transcriptase (TERT)] in an effort to extend chromosomal G-overhangs and maintain telomere ends. Telomerase-expressing cells also have higher levels of the single-stranded DNA-binding protein SSB1, which has a critical role in DNA dou...

journal_title：Cancer research

authors： Pandita RK,Chow TT,Udayakumar D,Bain AL,Cubeddu L,Hunt CR,Shi W,Horikoshi N,Zhao Y,Wright WE,Khanna KK,Shay JW,Pandita TK

更新日期：2015-03-01 00:00:00

abstract：:Retinoids have chemopreventive activity for epithelial tumors in a variety of systems, including the two-stage tumorigenesis system of mouse skin in which only the promotion stage is inhibited. We asked whether dietary vitamin A deficiency could affect the skin tumorigenic response, prior to major changes in body weig...

journal_title：Cancer research

authors： De Luca LM,Shores RL,Spangler EF,Wenk ML

更新日期：1989-10-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) produce angiogenic factors and in breast cancer are associated with high vascular grade and poor survival. TAMs preferentially migrate to hypoxic areas within tumors and strongly express hypoxia-inducible factor (HIF)-2 alpha. This study examined whether HIF-2 alpha was involved in ...

journal_title：Cancer research

authors： Leek RD,Talks KL,Pezzella F,Turley H,Campo L,Brown NS,Bicknell R,Taylor M,Gatter KC,Harris AL

更新日期：2002-03-01 00:00:00

abstract：:Progression of prostate cancer is believed to be dependent on angiogenesis induced by tumor cells. 3,3'-Diindolylmethane (DIM) has been shown to repress neovascularization in a Matrigel plug assay and inhibit cell proliferation, migration, invasion, and capillary tube formation of cultured human umbilical vein endothe...

journal_title：Cancer research

authors： Kong D,Li Y,Wang Z,Banerjee S,Sarkar FH

更新日期：2007-04-01 00:00:00