Relationship between aberrant DNA replication and loss of cell viability in Chinese hamster ovary CHO-K1 cells.

abstract：:Microdialysis is a technique that enables measurement of extracellular concentrations of unbound analytes. A small probe with a semipermeable membrane is implanted in tissue and constantly perfused. Small analytes in the interstitial fluid diffuse into the perfusate and are collected. Often, microdialysate concentrati...

journal_title：Cancer research

authors： Ettinger SN,Poellmann CC,Wisniewski NA,Gaskin AA,Shoemaker JS,Poulson JM,Dewhirst MW,Klitzman B

更新日期：2001-11-01 00:00:00

abstract：:Although chemoresistance remains a primary challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), exploiting oxidative stress might offer novel therapeutic clues. Here we explored the potential of targeting cystine/glutamate exchanger (SLC7A11/xCT), which contributes to the maintenance of intracellular...

journal_title：Cancer research

authors： Daher B,Parks SK,Durivault J,Cormerais Y,Baidarjad H,Tambutte E,Pouysségur J,Vučetić M

更新日期：2019-08-01 00:00:00

abstract：:Tasidotin (ILX-651), an orally active synthetic microtubule-targeted derivative of the marine depsipeptide dolastatin-15, is currently undergoing clinical evaluation for cancer treatment. Tasidotin inhibited proliferation of MCF7/GFP breast cancer cells with an IC(50) of 63 nmol/L and inhibited mitosis with an IC(50) ...

journal_title：Cancer research

authors： Ray A,Okouneva T,Manna T,Miller HP,Schmid S,Arthaud L,Luduena R,Jordan MA,Wilson L

更新日期：2007-04-15 00:00:00

abstract：:RAF kinase inhibitor protein (RKIP) is a seminal regulator of intracellular signaling and exhibits both antimetastatic and antitumorigenic properties. Decreased expression of RKIP has been described in several human malignancies, including acute myelogenous leukemia (AML). As the mechanisms leading to RKIP loss in AML...

journal_title：Cancer research

authors： Hatzl S,Geiger O,Kuepper MK,Caraffini V,Seime T,Furlan T,Nussbaumer E,Wieser R,Pichler M,Scheideler M,Nowek K,Jongen-Lavrencic M,Quehenberger F,Wölfler A,Troppmair J,Sill H,Zebisch A

更新日期：2016-06-15 00:00:00

abstract：:Anti-VEGF therapy prolongs recurrence-free survival in patients with glioblastoma but does not improve overall survival. To address this discrepancy, we investigated immunologic resistance mechanisms to anti-VEGF therapy in glioma models. A screening of immune-associated alterations in tumors after anti-VEGF treatment...

journal_title：Cancer research

authors： Long Y,Tao H,Karachi A,Grippin AJ,Jin L,Chang YE,Zhang W,Dyson KA,Hou AY,Na M,Deleyrolle LP,Sayour EJ,Rahman M,Mitchell DA,Lin Z,Huang J

更新日期：2020-02-01 00:00:00

abstract：:Multiple transcriptional events take place when normal urothelium is transformed into tumor tissue. These can now be monitored simultaneously by the use of oligonucleotide arrays, and expression patterns of superficial and invasive tumors can be established. Single-cell suspensions were prepared from bladder biopsies ...

journal_title：Cancer research

authors： Thykjaer T,Workman C,Kruhøffer M,Demtröder K,Wolf H,Andersen LD,Frederiksen CM,Knudsen S,Orntoft TF

更新日期：2001-03-15 00:00:00

abstract：:Receptor protein-tyrosine kinases (RPTKs) are tightly regulated during normal cellular processes including cell growth, differentiation, and metabolism. Recently, a RPTK-like molecule named novel oncogene with kinase-domain (NOK) has been cloned and characterized. Overexpression of NOK caused severe cellular transform...

journal_title：Cancer research

authors： Chen Y,Li YH,Chen XP,Gong LM,Zhang SP,Chang ZJ,Zhang XF,Fu XY,Liu L

更新日期：2005-12-01 00:00:00

abstract：:Normal, viral transformed and tumor-derived cells grown in tissue culture and representing different species were tested for their ability to produce an extracellular tumor angiogenesis factor (TAF). TAF was assayed by measuring the host-mediated vascular response of the chorioallantoic membrane to TAF preparations. A...

journal_title：Cancer research

authors： Klagsbrun M,Knighton D,Folkman J

更新日期：1976-01-01 00:00:00

abstract：:The role of the immune system in tumor elimination has been shown to be increasingly ambiguous, as many tumors not only escape recognition by the adaptive immune response but also even prime the immune cells to promote tumor growth. This effect is achieved through a number of mechanisms, which include both direct inte...

journal_title：Cancer research

authors： Kareva I,Hahnfeldt P

更新日期：2013-05-01 00:00:00

abstract：:Nude mice bearing xenografts of HT-29 human colon cancer cell line were treated for 4 weeks with a [D-Trp6] agonist of luteinizing hormone releasing hormone (LH-RH), somatostatin analogue (RC-160), and bombesin/gastrin releasing peptide antagonist (RC-3095). Some inhibitory effect of [D-Trp6] LH-RH microcapsules relea...

journal_title：Cancer research

authors： Radulovic S,Miller G,Schally AV

更新日期：1991-11-01 00:00:00

abstract：:Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors, hypoxia is associated with aggressive disease course and poor clinical outcomes. Furthermore, many aggressive tumors have been shown to display gene expression signatures characteristic of human embryonic stem cells (hESC). We now...

journal_title：Cancer research

authors： Mathieu J,Zhang Z,Zhou W,Wang AJ,Heddleston JM,Pinna CM,Hubaud A,Stadler B,Choi M,Bar M,Tewari M,Liu A,Vessella R,Rostomily R,Born D,Horwitz M,Ware C,Blau CA,Cleary MA,Rich JN,Ruohola-Baker H

更新日期：2011-07-01 00:00:00

abstract：:The expression of different components of the plasminogen activator (PA)/plasmin system was explored in a series of colorectal neoplasia. We have found that urokinase (uPA) and urokinase receptor (uPA-R) gene expression is upregulated in adenomas and carcinomas, and that uPA/uPA-R production is confined to stromal cel...

journal_title：Cancer research

authors： Delbaldo C,Cunningham M,Vassalli JD,Sappino AP

更新日期：1995-10-15 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors are known to exert antimetastatic and antiangiogenic activity in vitro and in vivo. RECK is a membrane-anchored glycoprotein that negatively regulates matrix metalloproteinases (MMPs) and inhibits tumor metastasis and angiogenesis. In this study, we test the possibility that HDAC ...

journal_title：Cancer research

authors： Liu LT,Chang HC,Chiang LC,Hung WC

更新日期：2003-06-15 00:00:00

abstract：:A simple technique is described for fixing colony-containing layers of soft agar and drying them onto microscopic slides. The method is extrapolated from techniques used in immunology for permanent preservation of immunodiffusion or immunoelectrophoresis plates. Slides prepared in this fashion are eminently suitable f...

journal_title：Cancer research

authors： Salmon SE,Buick RN

更新日期：1979-03-01 00:00:00

abstract：:A hormone-dependent subline of the transplantable rat mammary tumor MTW9 contains binding sites for both prolactin and estrogen. Prolactin binding is saturable (K-d similar to 2 times 10-9 M), hormone specific, and destroyed by proteases. By contrast, an autonomous subline derived from the same parent tumor has lost m...

journal_title：Cancer research

authors： Costlow ME,Buschow RA,Richert NJ,McGuire WL

更新日期：1975-04-01 00:00:00

abstract：:O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein which plays an important role in chemotherapy, mutagenesis, and carcinogenesis. The specific activity of MGMT in female rat liver can be induced by approximately 20-fold by treatment of the rats with gamma-irradiation. Maximum response occurred 48 h...

journal_title：Cancer research

authors： Chan CL,Wu Z,Eastman A,Bresnick E

更新日期：1992-04-01 00:00:00

abstract：:CD99 is a Mr 32,000 transmembrane molecule that shows a high level of expression on cells of the hemopoietic system as well as on Ewing tumor cells. Within the hematopoietic system, CD99 has been implicated in cell adhesion and cell death, participating in this way in the differentiation of T-cell precursors. In this ...

journal_title：Cancer research

authors： Scotlandi K,Baldini N,Cerisano V,Manara MC,Benini S,Serra M,Lollini PL,Nanni P,Nicoletti G,Bernard G,Bernard A,Picci P

更新日期：2000-09-15 00:00:00

abstract：:Enhancement of specific transplantation resistance to a syngeneic tumor (KMT-17) was observed in WKA rats by treatment with the antileukemia drug busulfan (BU) (15 mg/kg) 5 days before and 5 days after immunization with X-irradiated KMT-17 tumor cells. Rats immunized with X-irradiated KMT-17 cells and then treated wit...

journal_title：Cancer research

authors： Mizushima Y,Sendo F,Takeichi N,Hosohawa M,Kobayashi H

更新日期：1981-07-01 00:00:00

abstract：:To identify genetic alterations underlying rectal carcinogenesis, we used global gene expression profiling of a series of 17 locally advanced rectal adenocarcinomas and 20 normal rectal mucosa biopsies on oligonucleotide arrays. A total of 351 genes were differentially expressed (P < 1.0e-7) between normal rectal muco...

journal_title：Cancer research

authors： Grade M,Ghadimi BM,Varma S,Simon R,Wangsa D,Barenboim-Stapleton L,Liersch T,Becker H,Ried T,Difilippantonio MJ

更新日期：2006-01-01 00:00:00

abstract：:The nucleoside analogue 1-beta-D-arabinofuranosylcytosine (ara-C) is incorporated into herpes simplex virus type 1 (HSV-1) DNA, and this correlates with inhibition of virus replication. The technique of Weigle-type reactivation (WR) was used to compare the ability of induced cellular DNA repair pathways to recognize o...

journal_title：Cancer research

authors： Bubley GJ,Crumpacker CS,Schnipper LE

更新日期：1984-05-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 p...

journal_title：Cancer research

authors： El Ayachi I,Fatima I,Wend P,Alva-Ornelas JA,Runke S,Kuenzinger WL,Silva J,Silva W,Gray JK,Lehr S,Barch HC,Krutilina RI,White AC,Cardiff R,Yee LD,Yang L,O'Regan RM,Lowry WE,Seagroves TN,Seewaldt V,Krum SA,Miranda

更新日期：2019-03-01 00:00:00

abstract：:There is little information on early molecular events in the development of N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis and of the effects of chemopreventive agents on these events. In this study, we identified genes in rat esophagus that were differentially expressed in response to short-te...

journal_title：Cancer research

authors： Reen RK,Dombkowski AA,Kresty LA,Cukovic D,Mele JM,Salagrama S,Nines R,Stoner GD

更新日期：2007-07-01 00:00:00

abstract：:Patterns of gene expression in normal and neoplastic rat mammary tissues were compared by cell-free translation of their total polyadenylated RNAs and by dot blot hybridization of the RNA to cloned complementary DNA probes for six of the major milk proteins, including: Mr 42,000 and 25,000 caseins, X-casein, whey phos...

journal_title：Cancer research

authors： Horn TM,Sodroski J,Qasba PK

更新日期：1983-04-01 00:00:00

abstract：:Ovarian cancer is mainly confined in peritoneal cavity and its metastasis is often associated with the formation of malignant ascites. As lysophosphatidic acid (LPA) is present at high levels in ascites of ovarian cancer patients and potently stimulates cell migration, we reason that LPA-stimulated cell migration may ...

journal_title：Cancer research

authors： Chen H,Wu X,Pan ZK,Huang S

更新日期：2010-12-01 00:00:00

abstract：:Mutations in the NH(2)-terminal regulatory domain of the beta-catenin gene lead to aberrant stabilization and accumulation of the protein and increased TCF/LEF-dependent transcription. Although these mutations are common in some cancers, they are infrequent in prostate and breast cancer. We have found that metastatic ...

journal_title：Cancer research

authors： Rios-Doria J,Kuefer R,Ethier SP,Day ML

更新日期：2004-10-15 00:00:00

abstract：:Inactivation of p53 signaling by mutation of p53 itself or abrogation of its normal function by other transfactors, such as MDM2, is a key event in the development of most human cancers. To identify novel regulators of p53, we have used a phenotype-based selection in which a total cDNA library in a retroviral vector h...

journal_title：Cancer research

authors： Agarwal MK,Ruhul Amin AR,Agarwal ML

更新日期：2007-01-01 00:00:00

abstract：:Epidermal growth factor receptor vIII (EGFRvIII) is a tumor-specific, ligand-independent, constitutively active variant of the EGFR. Its expression has been detected in gliomas and various other human malignancies. To more fully characterize the function and potential biological role of EGFRvIII in regulating cell pro...

journal_title：Cancer research

authors： Tang CK,Gong XQ,Moscatello DK,Wong AJ,Lippman ME

更新日期：2000-06-01 00:00:00

abstract：:Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways that drive disease aggressiveness in tumors with high MIF expression, we analyzed the expression of coding and noncoding genes in high and low MIF-expressing tumor...

journal_title：Cancer research

authors： Yang S,He P,Wang J,Schetter A,Tang W,Funamizu N,Yanaga K,Uwagawa T,Satoskar AR,Gaedcke J,Bernhardt M,Ghadimi BM,Gaida MM,Bergmann F,Werner J,Ried T,Hanna N,Alexander HR,Hussain SP

更新日期：2016-07-01 00:00:00

abstract：:Angiogenesis is a hallmark of cancer that promotes tumor progression and metastasis. However, antiangiogenic agents have limited efficacy in cancer therapy due to the development of resistance. In clear cell renal cell carcinoma (ccRCC), AXL expression is associated with antiangiogenic resistance and poor survival. He...

journal_title：Cancer research

authors： Xiao Y,Zhao H,Tian L,Nolley R,Diep AN,Ernst A,Fuh KC,Miao YR,von Eyben R,Leppert JT,Brooks JD,Peehl DM,Giaccia AJ,Rankin EB

更新日期：2019-11-15 00:00:00

abstract：:Activity increase of the cytosolic isozyme of thymidine kinase (TK) in resected specimens of lung tumor patients would be a useful marker for tumor malignancy and prognosis. In 24 resected cases of malignant lung tumors, the whole enzyme extracts of the tumorous part of the specimens showed that the activities of TK, ...

journal_title：Cancer research

authors： Yusa T,Yamaguchi Y,Ohwada H,Hayashi Y,Kuroiwa N,Morita T,Asanagi M,Moriyama Y,Fujimura S

更新日期：1988-09-01 00:00:00