Inhibition of growth of HT-29 human colon cancer xenografts in nude mice by treatment with bombesin/gastrin releasing peptide antagonist (RC-3095).

abstract：:Functional studies using freshly isolated tumor-infiltrating B lymphocytes(TIB) are difficult to perform and interpret. Here we document a novel function of TIB using fresh human lung cancer tissues engrafted in SCID mice; they are at activated state and produce tumor-specific antibodies in tumor microenvironment: (a)...

journal_title：Cancer research

authors： Yasuda M,Takenoyama M,Obata Y,Sugaya M,So T,Hanagiri T,Sugio K,Yasumoto K

更新日期：2002-03-15 00:00:00

abstract：:We have developed a defined serum-free medium for the in vitro growth of normal and neoplastic urothelium. Growth of epithelial cells in this medium was stimulated while proliferation of fibroblasts was inhibited. The medium allowed for the isolation of a new line from a high grade human bladder carcinoma. Several str...

journal_title：Cancer research

authors： Dubeau L,Jones PA

更新日期：1987-04-15 00:00:00

abstract：:1 alpha,25-Dihydroxyvitamin D3 [1 alpha,25(OH)2D3], a hormonally active form of vitamin D3, was shown previously to enhance chemically induced transformation of BALB 3T3 cells and Syrian hamster embryo cells. This report demonstrates that 1 alpha,25(OH)2D3, like phorbol ester tumor promoters, induces anchorage-indepen...

journal_title：Cancer research

authors： Hosoi J,Abe E,Suda T,Colburn NH,Kuroki T

更新日期：1986-11-01 00:00:00

abstract：:Whole-slide histology images contain information that is valuable for clinical and basic science investigations of cancer, but extracting quantitative measurements from these images is challenging for researchers who are not image analysis specialists. In this paper, we describe HistomicsML2, a software tool for learn...

journal_title：Cancer research

authors： Lee S,Amgad M,Mobadersany P,McCormick M,Pollack BP,Elfandy H,Hussein H,Gutman DA,Cooper LA

更新日期：2020-12-21 00:00:00

abstract：:Correlation was greater than 90% between feline leukemia virus (FeLV), group-specific antigen (GSA) in leukocytes, and viral infectivity (VI) in serum or plasma from 132 cats infected with either the Rickard strain of FeLV, the Snyder-Theilen strain of feline sarcoma virus, or field strains of FeLV. Detection of GSA i...

journal_title：Cancer research

authors： Hoover EA,Olsen RG,Mathes LE,Schaller JP

更新日期：1977-10-01 00:00:00

abstract：:Emerging evidence indicates the presence of tumor-initiating cells (TIC) or cancer stem cells in osteosarcoma. However, no study has shown specific markers to identify osteosarcoma TICs with in vivo tumor formation ability. Additionally, there has been a lack of investigations gauging the contribution of osteosarcoma ...

journal_title：Cancer research

authors： Adhikari AS,Agarwal N,Wood BM,Porretta C,Ruiz B,Pochampally RR,Iwakuma T

更新日期：2010-06-01 00:00:00

abstract：:While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic T lymphocytes (CTL). Because CD4(+) T cells improve CTL respon...

journal_title：Cancer research

authors： Ahrends T,Bąbała N,Xiao Y,Yagita H,van Eenennaam H,Borst J

更新日期：2016-05-15 00:00:00

abstract：:Several in vitro cell systems were exposed to hematoporphyrin derivative (HPD): established lines of rat kangaroo epithelial kidney; normal mouse embryonic fibroblasts; and differentiated neonatal rat myocardial cells. The uptake of HPD (25 to 100 micrograms/ml) by individual cells occurred rapidly over a 2-hr period ...

journal_title：Cancer research

authors： Berns MW,Dahlman A,Johnson FM,Burns R,Sperling D,Guiltinan M,Siemens A,Walter R,Wright W,Hammer-Wilson M,Wile A

更新日期：1982-06-01 00:00:00

abstract：:Abnormal cleavage of amyloid precursor protein (APP) in the central nervous system has been linked to the development of Alzheimer's disease. Recent work has identified additional roles for APP in peripheral tissue, such as cellular proliferation and motility. APP undergoes proteolytic processing to release a soluble ...

journal_title：Cancer research

authors： Hansel DE,Rahman A,Wehner S,Herzog V,Yeo CJ,Maitra A

更新日期：2003-11-01 00:00:00

abstract：:In summary, analysis of the P01 program indicates that differences exist in scores and funding requirements between purely basic and translational P01s; P01 funding has been stable and the P01 policies consistent; growth in average costs for P01s has lagged compared to R01s; P01 grantees have a higher success rate tha...

journal_title：Cancer research

authors： Broder S,Cushing M

更新日期：1993-02-01 00:00:00

abstract：:Defects in cell cycle control and increased genomic instability, including gene amplification, often occur during cancer development. Cyclin D1 plays a pivotal role in G1, and this gene is frequently amplified and overexpressed in several types of human cancer. This study demonstrates that ectopic overexpression of cy...

journal_title：Cancer research

authors： Zhou P,Jiang W,Weghorst CM,Weinstein IB

更新日期：1996-01-01 00:00:00

abstract：:A new tumor model is described that is suitable for the evaluation of antibody-directed drug-delivery protocols and a modification in the procedure for covalently coupling antibody to the surface of drug-containing liposomes is presented. These immunospecific liposomes containing cytosine arabinonucleoside (Ara-C) hav...

journal_title：Cancer research

authors： Bankert RB,Yokota S,Ghosh SK,Mayhew E,Jou YH

更新日期：1989-01-15 00:00:00

abstract：:The aim of this study was to evaluate to what extent tumor necrosis factor alpha (TNF-alpha) and interleukin 1 may explain the development of experimental cancer cachexia. For this purpose, C57BL/6J mice bearing a transplantable low differentiated rapidly growing tumor were passively immunized every other day with rab...

journal_title：Cancer research

authors： Gelin J,Moldawer LL,Lönnroth C,Sherry B,Chizzonite R,Lundholm K

更新日期：1991-01-01 00:00:00

abstract：:Tumors are complex tissues composed of transformed epithelial cells as well as cancer-activated fibroblasts (CAF) that facilitate epithelial tumor cell invasion. We show here that CAFs and other mesenchymal cells rely much more on glutamine than epithelial tumor cells; consequently, they are more sensitive to inhibiti...

journal_title：Cancer research

authors： Mestre-Farrera A,Bruch-Oms M,Peña R,Rodríguez-Morató J,Alba-Castellón L,Comerma L,Quintela-Fandino M,Duñach M,Baulida J,Pozo ÓJ,García de Herreros A

更新日期：2021-01-15 00:00:00

abstract：:The interleukin (IL)-13 receptor alpha2 (IL-13Ralpha2) chain is a primary binding and internalization subunit for a Th2-derived immune regulatory cytokine, IL-13. Although extremely high levels of IL-13Ralpha2 chain are expressed on a variety of human tumor cells and specimens, its precise role in tumor immunology has...

journal_title：Cancer research

authors： Kawakami K,Terabe M,Kawakami M,Berzofsky JA,Puri RK

更新日期：2006-04-15 00:00:00

abstract：:Gli signaling is critical for central nervous system development and is implicated in tumorigenesis. To monitor Gli signaling in gliomas in vivo, we created platelet-derived growth factor-induced gliomas in a Gli-luciferase reporter mouse. We find that Gli activation is found in gliomas and correlates with grade. In a...

journal_title：Cancer research

authors： Becher OJ,Hambardzumyan D,Fomchenko EI,Momota H,Mainwaring L,Bleau AM,Katz AM,Edgar M,Kenney AM,Cordon-Cardo C,Blasberg RG,Holland EC

更新日期：2008-04-01 00:00:00

abstract：:A nationwide study of all 3183 female patients with breast cancer in Israel diagnosed over a 7-year period (1960 to 1966) was conducted. Monthly series analysis showed a clear seasonal pattern in the symptomatology of the disease most pronounced in patients younger than 55 years, in all ethnic groups, mainly confined ...

journal_title：Cancer research

authors： Cohen P,Wax Y,Modan B

更新日期：1983-02-01 00:00:00

abstract：:Certain human tumors are extensively infiltrated by eosinophils and contain extracellular deposits of eosinophil peroxidase, which uses hydrogen peroxide as a substrate to produce highly toxic hypohalous acids. We hypothesized that J558L HI, an interleukin 5-transfected murine plasmacytoma that is infiltrated by numer...

journal_title：Cancer research

authors： Samoszuk MK,Wimley WC,Nguyen V

更新日期：1996-01-01 00:00:00

abstract：:The retinoblastoma (Rb) family consists of the tumor suppressor pRb and related proteins p107 and pRb2/p130. Ectopic expression of pRb and p107 results in a growth arrest of sensitive cells in the G1 phase of the cell cycle. We demonstrated here that the growth-suppressive properties of pRb2/p130 were also specific fo...

journal_title：Cancer research

authors： Claudio PP,De Luca A,Howard CM,Baldi A,Firpo EJ,Koff A,Paggi MG,Giordano A

更新日期：1996-05-01 00:00:00

abstract：:In spite of preclinical efficacy and recent randomized, controlled studies with adenoviral vectors expressing herpes simplex virus-1 thymidine kinase (HSV1-TK) showing statistically significant increases in survival, most clinical trials using single therapies have failed to provide major therapeutic breakthroughs. Be...

journal_title：Cancer research

authors： Ali S,King GD,Curtin JF,Candolfi M,Xiong W,Liu C,Puntel M,Cheng Q,Prieto J,Ribas A,Kupiec-Weglinski J,van Rooijen N,Lassmann H,Lowenstein PR,Castro MG

更新日期：2005-08-15 00:00:00

abstract：:The content of cholesterol and cholesterol ester as well as the levels of acyl coenzyme A:cholesterol acyltransferase activity were determined in the microsomes from Morris hepatomas 7777, 5123D, and 7787. The free cholesterol content, expressed per mg microsomal protein, was significantly increased only in the micros...

journal_title：Cancer research

authors： van Heusden GP,van der Krift TP,Hostetler KY,Wirtz KW

更新日期：1983-09-01 00:00:00

abstract：:To study the relationships between different DNA repair pathways, we established a set of clones in which one specific DNA repair gene was silenced using long-term RNA interference in HeLa cell line. We focus here on genes involved in either nucleotide excision repair (XPA and XPC) or nonhomologous end joining (NHEJ; ...

journal_title：Cancer research

authors： Despras E,Pfeiffer P,Salles B,Calsou P,Kuhfittig-Kulle S,Angulo JF,Biard DS

更新日期：2007-03-15 00:00:00

abstract：:Lymphomas are rarely, if ever, found to be in excess following exposure to ionizing radiation. Hodgkin's disease has never been linked to radiation, and the evidence for non-Hodgkin's lymphoma (NHL) is very weak. Low doses of radiation from diagnostic X-ray procedures or from occupational exposures do not appear to ca...

journal_title：Cancer research

authors： Boice JD Jr

更新日期：1992-10-01 00:00:00

abstract：:Activation of apoptosis is believed to be critical for the role of p53 as a tumor suppressor. Here, we report a new mouse strain carrying a human p53 transgene in the mouse p53-null background. Expression of human p53 in these mice was comparable with wild-type murine p53; however, transactivation, induction of apopto...

journal_title：Cancer research

authors： Dudgeon C,Kek C,Demidov ON,Saito S,Fernandes K,Diot A,Bourdon JC,Lane DP,Appella E,Fornace AJ Jr,Bulavin DV

更新日期：2006-03-15 00:00:00

abstract：:Human cancer cell lines are commonly used in basic cancer research to understand the behavior of primary tumors. Aberrations in the DNA methylation patterns are nowadays recognized as a hallmark of the cancer cell. However, no comprehensive study defines the DNA methylation environment present in the established cance...

journal_title：Cancer research

authors： Paz MF,Fraga MF,Avila S,Guo M,Pollan M,Herman JG,Esteller M

更新日期：2003-03-01 00:00:00

abstract：:The endoplasmic reticulum (ER) has been posited as a potential anticancer target. The synthetic antitumor alkyl-lysophospholipid analogue edelfosine accumulates in the ER of solid tumor cells. This ER accumulation of the drug leads to the inhibition of phosphatidylcholine and protein synthesis, G(2)-M arrest, depletio...

journal_title：Cancer research

authors： Nieto-Miguel T,Fonteriz RI,Vay L,Gajate C,López-Hernández S,Mollinedo F

更新日期：2007-11-01 00:00:00

abstract：:Tissue phytosterol and cholesterol levels in 10 benign and 8 malignant breast tumors were quantitated to reexamine the hypothesis that malignant tumors had distinctive phytosterol content. Phytosterols were present in 9 of 10 benign and 7 of 8 malignant breast tumors. Mean (+/- S.E.) cholesterol, campesterol, stigmast...

journal_title：Cancer research

authors： Mellies MJ,Ishikawa TT,Glueck CJ,Crissman JD

更新日期：1977-09-01 00:00:00

abstract：:The specific binding of labeled porcine insulin, human prolactin, and human growth hormone was studied in 63 human breast tumors and 15 nonmalignant breast tissues. Most (90%) of the tumors demonstrated significant binding of insulin, as did 80% of nonmalignant tissues. Autoradiographic studies indicated that insulin ...

journal_title：Cancer research

authors： Holdaway IM,Friesen HG

更新日期：1977-07-01 00:00:00

abstract：:Tumor necrosis factor (TNF) acts via a cell surface receptor to induce a variety of cellular events including cytolysis, differentiation, and mitogenesis. The mechanisms underlying the cell specific actions of TNF are not known. In the present study, postreceptor events associated with the autoinduction of TNF express...

journal_title：Cancer research

authors： Spriggs DR,Sherman ML,Imamura K,Mohri M,Rodriguez C,Robbins G,Kufe DW

更新日期：1990-11-15 00:00:00

abstract：:Carcinoma in situ (CIS) is the common precursor of histologically heterogeneous testicular germ cell tumors (TGCTs), which in recent decades have markedly increased and now are the most common malignancy of young men. Using genome-wide gene expression profiling, we identified >200 genes highly expressed in testicular ...

journal_title：Cancer research

authors： Almstrup K,Hoei-Hansen CE,Wirkner U,Blake J,Schwager C,Ansorge W,Nielsen JE,Skakkebaek NE,Rajpert-De Meyts E,Leffers H

更新日期：2004-07-15 00:00:00