Characterization of a novel human tumor antigen interleukin-13 receptor alpha2 chain.

abstract：:Progression of the eukaryotic cell division cycle is regulated by a series of structurally related serine/threonine protein kinases known as cyclin-dependent kinases (CDKs). The D-type cyclin-dependent kinases, CDK4 and CDK6, have been strongly implicated in the control of G1 progression and the phosphorylation of the...

journal_title：Cancer research

authors： Li Y,Nichols MA,Shay JW,Xiong Y

更新日期：1994-12-01 00:00:00

abstract：:Autotaxin (ATX) is an exoenzyme that potently induces tumor cell motility, and enhances experimental metastasis and angiogenesis. ATX was shown recently to be identical to serum lysophospholipase D activity, producing lysophosphatidic acid (LPA) from lyso-glycerophospholipids. LPA, itself a strong chemoattractant for ...

journal_title：Cancer research

authors： Clair T,Aoki J,Koh E,Bandle RW,Nam SW,Ptaszynska MM,Mills GB,Schiffmann E,Liotta LA,Stracke ML

更新日期：2003-09-01 00:00:00

abstract：:A stable phenol, gamma-L-glutaminyl-4-hydroxybenzene (GHB), is oxidized by tyrosinase in the gill tissues of the mushroom Agaricus bisporus to a quinone and a second oxidation product which together suppress mitochondrial energy production and the synthesis of proteins and nucleic acids in the zygote, thus establishin...

journal_title：Cancer research

authors： Vogel FS,Kemper LA,Jeffs PW,Cass MW,Graham DG

更新日期：1977-04-01 00:00:00

abstract：:Natural killer (NK) cells safeguard against early tumor formation by destroying transformed target cells in a process referred to as NK immune surveillance. However, the immune escape mechanisms used by malignant brain tumors to subvert this innate type of immune surveillance remain unclear. Here we show that malignan...

journal_title：Cancer research

authors： Baker GJ,Chockley P,Yadav VN,Doherty R,Ritt M,Sivaramakrishnan S,Castro MG,Lowenstein PR

更新日期：2014-09-15 00:00:00

abstract：:Most carcinomas spread to distant sites through lymphatic vessels. Several preclinical and clinical studies have shown a positive correlation between the incidence of lymph node metastasis and secretion of the lymphatic growth factor vascular endothelial growth factor-C (VEGF-C) by tumor cells, suggesting tumor lympha...

journal_title：Cancer research

authors： Issa A,Le TX,Shoushtari AN,Shields JD,Swartz MA

更新日期：2009-01-01 00:00:00

abstract：:TEL-AML1 gene fusion derived by chromosomal translocation is a common acquired genetic lesion in pediatric cancer that is present in approximately 25% of B-cell precursor acute lymphoblastic leukemias, and recent evidence suggests that this recombination event may initiate leukemogenesis prenatally during fetal hemopo...

journal_title：Cancer research

authors： Wiemels JL,Greaves M

更新日期：1999-08-15 00:00:00

abstract：:MdmX and Mdm2 regulate p53 tumor suppressor functions by controlling p53 transcriptional activity and/or stability in cells exposed to DNA damage. Accumulating evidence indicates that ATM-mediated phosphorylation and degradation of Mdm2 and MdmX may be the initial driving force that induces p53 activity during the ear...

journal_title：Cancer research

authors： Zhang X,Lin L,Guo H,Yang J,Jones SN,Jochemsen A,Lu X

更新日期：2009-10-15 00:00:00

abstract：:Methylglyoxal-bis(guanylhydrazone) (MGBG) is a polycationic drug which is useful in the chemotherapy of lymphoid and myeloid proliferative disorders. The drug has recently been shown to produce selective ultrastructural damage to the mitochondria of proliferating cell populations. It is important to understand the mol...

journal_title：Cancer research

authors： Feuerstein B,Porter CW,Dave C

更新日期：1979-10-01 00:00:00

abstract：:Human polynucleotide phosphorylase (hPNPase(old-35)) is a type I IFN-inducible 3',5' exoribonuclease that mediates mRNA degradation. In melanoma cells, slow and sustained overexpression of hPNPase(old-35) induces G(1) cell cycle arrest ultimately culminating in apoptosis, whereas rapid overexpression of hPNPase(old-35...

journal_title：Cancer research

authors： Sarkar D,Park ES,Barber GN,Fisher PB

更新日期：2007-09-01 00:00:00

abstract：:We present a light scattering study using angle-resolved low coherence interferometry (a/LCI) to assess nuclear morphology and subcellular structure within MCF-7 cells at several time points after treatment with chemotherapeutic agents. Although the nuclear diameter and eccentricity are not observed to change, the lig...

journal_title：Cancer research

authors： Chalut KJ,Ostrander JH,Giacomelli MG,Wax A

更新日期：2009-02-01 00:00:00

abstract：:Butyrate, at concentrations greater than 0.75 mM, induces hemoglobin accumulation in murine erythroleukemia cells (MELC). At concentrations below 0.75 mM, butyrate inhibits hemoglobin accumulation induced by hexamethylene bisacetamide (HMBA) as well as HMBA induced commitment to terminal cell division. The blocking of...

journal_title：Cancer research

authors： Corin RE,Haspel HC,Peretz AM,Sonenberg M,Rifkind RA

更新日期：1986-03-01 00:00:00

abstract：:Ursodeoxycholic acid (UDCA) protects cells from the apoptotic effects of hydrophobic bile acids and some other cytotoxic agents. We observed the opposite result when assessing the effects of UDCA on the apoptotic response to mitochondrial photodamage induced by photodynamic therapy (PDT). Two photosensitizers with pre...

journal_title：Cancer research

authors： Kessel D,Caruso JA,Reiners JJ Jr

更新日期：2000-12-15 00:00:00

abstract：:Chloroethylnitrosoureas induce reactive O6-guanine adducts in DNA that can form either interstrand cross-links or a covalent complex with the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). To test our hypothesis that these end-products are formed from the common precursor, 1-O6-ethanoguanine, we com...

journal_title：Cancer research

authors： Gonzaga PE,Potter PM,Niu TQ,Yu D,Ludlum DB,Rafferty JA,Margison GP,Brent TP

更新日期：1992-11-01 00:00:00

abstract：:The gastrin gene is expressed widely in pancreatic adenocarcinomas and the study aimed to assess its role in both the resistance of cancer cells to apoptosis and the sensitivity of cells to chemotherapeutic agents. Two human pancreatic cell lines, PAN1 and BXPC3, expressed gastrin at both the RNA and protein levels an...

journal_title：Cancer research

authors： Harris JC,Gilliam AD,McKenzie AJ,Evans SA,Grabowska AM,Clarke PA,McWilliams DF,Watson SA

更新日期：2004-08-15 00:00:00

abstract：:Type 2 diabetes, which is mainly linked to obesity, is associated with increased incidence of liver cancer. We have previously found that in various models of obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cyclin D1, suggesting a plausible mechanism linking diabetes and liver cancer prog...

journal_title：Cancer research

authors： Luo C,Liang J,Sharabi K,Hatting M,Perry EA,Tavares CDJ,Goyal L,Srivastava A,Bilodeau M,Zhu AX,Sicinski P,Puigserver P

更新日期：2020-08-15 00:00:00

abstract：:The differential display technique was used to identify mRNAs differentially expressed in human melanoma cell lines with different metastatic capacity. We report the isolation of nine different clones, of which four were uniquely expressed in the highly metastatic human melanoma cell line MV3, whereas the other five c...

journal_title：Cancer research

authors： van Groningen JJ,Bloemers HP,Swart GW

更新日期：1995-12-15 00:00:00

abstract：:Methylation associated inactivation of RASSF1, a putative tumor suppressor identified at 3p21.3, has been frequently observed in several human malignancies, including lung and breast cancers. To explore the penetrance of RASSF1 in gastric carcinogenesis, we performed expression and mutation analyses of 3 isotypes of R...

journal_title：Cancer research

authors： Byun DS,Lee MG,Chae KS,Ryu BG,Chi SG

更新日期：2001-10-01 00:00:00

abstract：:Ovarian cancer is resistant to the antiproliferative effects of transforming growth factor-beta (TGF-beta); however, the mechanism of this resistance remains unclear. We used oligonucleotide arrays to profile 37 undissected, 68 microdissected advanced-stage, and 14 microdissected early-stage papillary serous cancers t...

journal_title：Cancer research

authors： Sunde JS,Donninger H,Wu K,Johnson ME,Pestell RG,Rose GS,Mok SC,Brady J,Bonome T,Birrer MJ

更新日期：2006-09-01 00:00:00

abstract：:A role of the epidermal growth factor receptor (EGFR) family has been suggested in colon cancer etiology, progression, and/or severity. Our recently identified pan-erbB inhibitor EGFR-related protein (ERRP) targets EGFRs by attenuating their activation and subsequent signaling leading to cellular growth inhibition. In...

journal_title：Cancer research

authors： Schmelz EM,Xu H,Sengupta R,Du J,Banerjee S,Sarkar FH,Rishi AK,Majumdar AP

更新日期：2007-06-01 00:00:00

abstract：:Using the principle of functional polarization of dendritic cells (DCs), we have developed a novel protocol to generate human DCs combining the three features critical for the induction of type-1 immunity: (a) fully mature status; (b) responsiveness to secondary lymphoid organ chemokines; and (c) high interleukin-12p7...

journal_title：Cancer research

authors： Mailliard RB,Wankowicz-Kalinska A,Cai Q,Wesa A,Hilkens CM,Kapsenberg ML,Kirkwood JM,Storkus WJ,Kalinski P

更新日期：2004-09-01 00:00:00

abstract：:Cancer research has long been hampered by the limitations of the current model systems. Both cultured cells and mouse xenografts grow in an environment highly dissimilar to that of their originating tumor, frequently resulting in promising treatments that are ultimately clinically ineffective. The development of highl...

journal_title：Cancer research

authors： Morton JJ,Bird G,Refaeli Y,Jimeno A

更新日期：2016-11-01 00:00:00

abstract：:The rate of repopulation of surviving cells increases during fractionated radiotherapy and limits the ability to control tumors. Repopulation is likely to be more important during the longer intervals between courses of chemotherapy and is a potential cause of clinical resistance to chemotherapy. To evaluate the rate ...

journal_title：Cancer research

authors： Wu L,Tannock IF

更新日期：2003-05-01 00:00:00

abstract：:Sera from 91 adult acute nonlymphocytic leukemia patients were tested for circulating immune complexes by the C1q binding test. In 42 patients tested prior to the initiation of therapy, C1q binding activity was inversely correlated with leukemic infiltrate of the bone marrow (rs = -0.34, p less than 0.02), but it was ...

journal_title：Cancer research

authors： Crane MM,Rossen RD,McCredie KB,Trujillo JM

更新日期：1984-07-01 00:00:00

abstract：:The DNA intercalator, 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) and the nonintercalator, etoposide (VP-16) produce topoisomerase II-mediated protein-linked DNA strand breaks. This function of topoisomerase II was investigated in relation to cell proliferation and cell cycle. Mouse fibroblasts NIH 3T3 and...

journal_title：Cancer research

authors： Markovits J,Pommier Y,Kerrigan D,Covey JM,Tilchen EJ,Kohn KW

更新日期：1987-04-15 00:00:00

abstract：:The incidence, distribution, size, and histopathology of colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed a chemically defined fiber-free diet or nutritionally and calorically equivalent diets containing either 4.5 or 9.0% purified cellulose or pectin. This double-...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1980-08-01 00:00:00

abstract：:Membrane-bound complement inhibitors protect host cells from inadvertent complement attack, and complement inhibitors are often up-regulated on tumors, possibly representing a selective adaptation by tumors to escape elimination by a host antitumor immune response. Relevant in vivo studies using rodent models of human...

journal_title：Cancer research

authors： Caragine TA,Okada N,Frey AB,Tomlinson S

更新日期：2002-02-15 00:00:00

abstract：:CPT-11 [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin ] is a prodrug that is converted to the active metabolite SN-38 by carboxylesterases. In its active form, the drug inhibits topoisomerase I, causes DNA damage, and induces apoptosis. Data in this study show metabolism of CPT-11 to SN-38 (7-ethyl...

journal_title：Cancer research

authors： Danks MK,Morton CL,Pawlik CA,Potter PM

更新日期：1998-01-01 00:00:00

abstract：:Tumor-derived cell lines are used as in vitro cancer models, but their ability to accurately reflect the phenotype and genotype of the parental histology remains questionable, given the prevalence of documented cell line-specific cytogenetic changes. We have addressed the issue of whether copy number alterations seen ...

journal_title：Cancer research

authors： Greshock J,Nathanson K,Martin AM,Zhang L,Coukos G,Weber BL,Zaks TZ

更新日期：2007-04-15 00:00:00

abstract：:Liblomycin (LBM), a novel bleomycin analogue, and bleomycin A2 (BLM A2) were compared with respect to their relative potential to inhibit growth in a human head and neck squamous carcinoma cell line and to produce DNA damage within cellular DNA and nuclei DNA and against isolated naked DNA. Against the BLM-sensitive c...

journal_title：Cancer research

authors： Wassermann K,Zwelling LA,Lown JW,Hartley JA,Nishikawa K,Lin JR,Newman RA

更新日期：1990-03-15 00:00:00

abstract：:The synthesis of a protein of Mr 32,000 (p32) is enhanced by various tumor promoters, chemical carcinogens, metal salts, and heat shock in BALB/c 3T3 cells. We have isolated a complementary DNA (cDNA) clone for p32 from a lambda gt10 library of BALB/c 3T3 cells. The library was constructed from mRNA extracted from the...

journal_title：Cancer research

authors： Kageyama H,Hiwasa T,Tokunaga K,Sakiyama S

更新日期：1988-09-01 00:00:00