Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer.

abstract：:The expression of epidermal growth factor receptor and transglutaminase type I, polyamine (putrescine, spermidine, and spermine) levels, ornithine decarboxylase activity, and micronuclei occurrence were assessed in the 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch model to elucidate the role and t...

journal_title：Cancer research

authors： Shin DM,Gimenez IB,Lee JS,Nishioka K,Wargovich MJ,Thacher S,Lotan R,Slaga TJ,Hong WK

更新日期：1990-04-15 00:00:00

abstract：:Culture of human peripheral blood leukocytes with interleukin 2 (IL-2) stimulates their differentiation into lymphokine-activated killer (LAK) cells, with a broad range of cytotoxicity against fresh tumor cells and tumor cell lines (Grimm et al., J. Exp. Med., 155: 1823-1841, 1982). We chose to utilize a molecular app...

journal_title：Cancer research

authors： Kovacs EJ,Beckner SK,Longo DL,Varesio L,Young HA

更新日期：1989-02-15 00:00:00

abstract：:A variety of heterologous mammalian cells were inoculated into nude mice and scored for tumorigenicity. The cells tested were from primary cell cultures, established cell lines of neoplastic origin, established cell lines of nontumor origin, and primary cell cultures transformed by oncogenic viruses. Regardless of the...

journal_title：Cancer research

authors： Stiles CD,Desmond W,Chuman LM,Sato G,Saier MH

更新日期：1976-04-01 00:00:00

abstract：:Driver tyrosine kinase mutations are rare in sarcomas, and patterns of tyrosine phosphorylation are poorly understood. To better understand the signaling pathways active in sarcoma, we examined global tyrosine phosphorylation in sarcoma cell lines and human tumor samples. Anti-phosphotyrosine antibodies were used to p...

journal_title：Cancer research

authors： Bai Y,Li J,Fang B,Edwards A,Zhang G,Bui M,Eschrich S,Altiok S,Koomen J,Haura EB

更新日期：2012-05-15 00:00:00

abstract：:We have shown previously that the transduction of a number of human tumor cell lines with an adenovirus (AV1Y28) expressing a single-chain antibody fragment (scFv) directed against Ras proteins results in radiosensitization. Because Ras is involved in the regulation of a number of transcription factors, we have determ...

journal_title：Cancer research

authors： Russell JS,Raju U,Gumin GJ,Lang FF,Wilson DR,Huet T,Tofilon PJ

更新日期：2002-04-15 00:00:00

abstract：:The formation of a microvascular endothelium plays a critical role in the growth and metastasis of established tumors. The ability of a fragment from the first type III repeat of fibronectin (III(1C)), anastellin, to suppress tumor growth and metastasis in vivo has been reported to be related to its antiangiogenic pro...

journal_title：Cancer research

authors： Ambesi A,Klein RM,Pumiglia KM,McKeown-Longo PJ

更新日期：2005-01-01 00:00:00

abstract：:The estimated growth rates for five lines of human fibroblasts (Human Genetic Mutant Cell Repository designations 0011, 2936B , 0038A , 2912A , and 3529), during the first few population doublings after establishment of the lines, were within the expected range, i.e., equivalent to doubling times from 16 to 28 hr, wit...

journal_title：Cancer research

authors： Tamm I,Kikuchi T,Wang E,Pfeffer LM

更新日期：1984-06-01 00:00:00

abstract：:Lectin binding [concanavalin A, biotinylated ricinus communis agglutinin, and biotinylated succinylated wheat germ agglutinin (B-SWGA)] was used to detect the glycosylated proteins associated with a residual protein fraction [insoluble in 4% sodium dodecyl sulfate and termed the nuclear residual fraction (NRF)] or wit...

journal_title：Cancer research

authors： Burrus GR,Schmidt WN,Briggs JA,Hnilica LS,Briggs RC

更新日期：1988-02-01 00:00:00

abstract：:A subset of aggressive colorectal cancers exhibit BRAF mutation, MLH1 methylation, and a CpG island methylator phenotype (CIMP), but precursors are poorly established. In this study, we determined the status of these markers in colorectal polyps and evaluated associated risk factors. The study included 771 polyp cases...

journal_title：Cancer research

authors： Burnett-Hartman AN,Newcomb PA,Potter JD,Passarelli MN,Phipps AI,Wurscher MA,Grady WM,Zhu LC,Upton MP,Makar KW

更新日期：2013-05-01 00:00:00

abstract：:Despite studies that show the antitumor activity of Hsp90 inhibitors, such as geldanamycin (GA) and its derivative 17-allylamino-demethoxygeldanamycin (17-AAG), recent reports indicate that these inhibitors lack significant single-agent clinical activity. Resistance to Hsp90 inhibitors has been previously linked to ex...

journal_title：Cancer research

authors： McCollum AK,TenEyck CJ,Stensgard B,Morlan BW,Ballman KV,Jenkins RB,Toft DO,Erlichman C

更新日期：2008-09-15 00:00:00

abstract：:Ovarian and testicular tumors were induced in the offspring (F1 generation) of MRC rats that received single or multiple doses of N-nitrosobis(2-oxopropyl)amine on the 14th, 18th, and/or 20th days of pregnancy. The ovarian tumor incidence was significantly higher (46%) in the F1 generation exposed to the carcinogen a ...

journal_title：Cancer research

authors： Pour PM

更新日期：1986-08-01 00:00:00

abstract：:beta-Catenin is an ubiquitously expressed cytoplasmic protein that has a crucial role in both cadherin-mediated cell-cell adhesion and as a downstream signaling molecule in the wingless/Wnt pathway. Activating mutations in exon 3 of the beta-catenin gene, at the phosphorylation sites for ubiquitination and degradation...

journal_title：Cancer research

authors： Rashid A,Gao YT,Bhakta S,Shen MC,Wang BS,Deng J,Fraumeni JF Jr,Hsing AW

更新日期：2001-04-15 00:00:00

abstract：:Breast cancer-initiating cells have been recently identified in breast carcinoma as CD44+/CD24(-/low) cells, which exclusively retain tumorigenic activity and display stem cell-like properties. However, at present, direct evidence that breast cancer-initiating cells can be propagated in vitro is still lacking. We repo...

journal_title：Cancer research

authors： Ponti D,Costa A,Zaffaroni N,Pratesi G,Petrangolini G,Coradini D,Pilotti S,Pierotti MA,Daidone MG

更新日期：2005-07-01 00:00:00

abstract：:Androgens via their receptor (AR) may play a role in prostate cancer etiology. This study focuses on the inhibitory effects of resveratrol on androgen action in the LNCaP prostate cancer cell line. We found that resveratrol represses different classes of androgen up-regulated genes at the protein or mRNA level includi...

journal_title：Cancer research

authors： Mitchell SH,Zhu W,Young CY

更新日期：1999-12-01 00:00:00

abstract：:A major challenge in treating cancer is the difficulty of bringing therapy to poorly perfused areas of solid tumors, which are often most resistant to chemotherapy and radiation. GRP94 is a chaperone protein localized in the endoplasmic reticulum with antiapoptotic properties. We report here that in vitro the proximal...

journal_title：Cancer research

authors： Reddy RK,Dubeau L,Kleiner H,Parr T,Nichols P,Ko B,Dong D,Ko H,Mao C,DiGiovanni J,Lee AS

更新日期：2002-12-15 00:00:00

abstract：:Inherited mutations of the human BRCA2 gene confer increased risks for developing breast, ovarian, and several other cancers. Unlike previously described Brca2 knockout mice that display predominantly embryonic lethal phenotypes, we developed mice with a homozygous germ-line deletion of Brca2 exon 27 that exhibit a mo...

journal_title：Cancer research

authors： McAllister KA,Bennett LM,Houle CD,Ward T,Malphurs J,Collins NK,Cachafeiro C,Haseman J,Goulding EH,Bunch D,Eddy EM,Davis BJ,Wiseman RW

更新日期：2002-02-15 00:00:00

abstract：:In vitro responsiveness of endometrial adenocarcinoma to progestins was evaluated histologically by incubation of tissue fragments in medium containing 10(-6) M medroxyprogesterone acetate. In a series of 19 experiments, formation of sub- and supranuclear vacuoles, which reflects accumulation of glycogen in response t...

journal_title：Cancer research

authors： Holinka CF,Deligdisch L,Gurpide E

更新日期：1984-01-01 00:00:00

abstract：:We have studied glycosyltransferase activities in human lymphocytes stimulated with the plant mitogens E-phytohemagglutinin or concanavalin A (Con A) and have compared the results with activities found in resting lymphocytes. Compared to resting lymphocytes, Con A-stimulated lymphocytes possess an enhanced capacity to...

journal_title：Cancer research

authors： Speckart SF,Boldt DH,Ryerson KL

更新日期：1978-12-01 00:00:00

abstract：:Previous cytogenetic analysis has revealed frequent losses of chromosome 1p21-22 in human malignant mesothelioma, suggesting that the loss or inactivation of a tumor suppressor gene's) residing at this site may contribute to the tumorigenic conversion of mesothelial cells. To more precisely define the location of the ...

journal_title：Cancer research

authors： Lee WC,Balsara B,Liu Z,Jhanwar SC,Testa JR

更新日期：1996-10-01 00:00:00

abstract：:The expression of osteopontin (OPN), CD44 variants, and integrins has been correlated with tumorigenesis and metastasis. Here we show that these proteins cooperate to enhance cell motility. First, we demonstrate that several different CD44 variants bind to OPN in an arginine-glycineaspartic acid-independent manner, bu...

journal_title：Cancer research

authors： Katagiri YU,Sleeman J,Fujii H,Herrlich P,Hotta H,Tanaka K,Chikuma S,Yagita H,Okumura K,Murakami M,Saiki I,Chambers AF,Uede T

更新日期：1999-01-01 00:00:00

abstract：:Aberrant epidermal growth factor receptor (EGFR) signaling is a major cause of tumor progression and metastasis; the underlying mechanisms, however, are not well understood. In particular, it remains elusive whether deregulated EGFR pathway is involved in epithelial-mesenchymal transition (EMT), an early event that oc...

journal_title：Cancer research

authors： Lo HW,Hsu SC,Xia W,Cao X,Shih JY,Wei Y,Abbruzzese JL,Hortobagyi GN,Hung MC

更新日期：2007-10-01 00:00:00

abstract：:The pancreatic carcinogen N-nitrosobis(2-oxopropyl)-amine was administered to Syrian golden hamsters after cholecystoduodenostomy and choledochostomy to investigate a possible bile reflux mechanism as a factor in pancreatic carcinogenesis. The induced lesions were similar in morphology, multiplicity, and distribution ...

journal_title：Cancer research

authors： Pour P,Donnelly T

更新日期：1978-07-01 00:00:00

abstract：:The anticarcinogenic activities of retinoic acid (RA) are believed to be mediated by the nuclear RA receptor (RAR) and by the RA-binding protein cellular RA-binding protein-II (CRABP-II). In MCF-7 mammary carcinoma cells, growth inhibition by RA entails an early cell cycle arrest followed by induction of apoptosis. He...

journal_title：Cancer research

authors： Donato LJ,Suh JH,Noy N

更新日期：2007-01-15 00:00:00

abstract：:Tumor-associated mutants of the p53 tumor suppressor protein exert biological activities compatible with an oncogenic gain of function. To explore the underlying molecular mechanism, we performed microarray analysis, comparing p53-null cells to mutant p53-expressing cells. One of the genes up-regulated in the presence...

journal_title：Cancer research

authors： Weisz L,Zalcenstein A,Stambolsky P,Cohen Y,Goldfinger N,Oren M,Rotter V

更新日期：2004-11-15 00:00:00

abstract：:The effect of "antiangiogenesis" therapy using cortisone acetate (CA) with or without heparin on tumor growth as well as in combination with chemotherapy was investigated. C3H mice were implanted intradermally with N-[4-(5-nitro-2-furyl)-thiazolyl]formamide induced undifferentiated transitional cell carcinoma, MBT-2, ...

journal_title：Cancer research

authors： Lee K,Erturk E,Mayer R,Cockett AT

更新日期：1987-10-01 00:00:00

abstract：:Cancer chemotherapy may be improved by increasing antineoplastic drug specificity for tumor cells. We have synthesized a glucuronide prodrug that can be enzymatically converted to an antineoplastic agent at tumor cells that are able to bind beta-glucuronidase-monoclonal antibody conjugates. The glucuronide prodrug BHA...

journal_title：Cancer research

authors： Wang SM,Chern JW,Yeh MY,Ng JC,Tung E,Roffler SR

更新日期：1992-08-15 00:00:00

abstract：:Pancreatic neuroendocrine tumors (PanNET) were classified into grades (G) 1 to 3 by the World Health Organization in 2017, but the precise mechanisms of PanNET initiation and progression have remained unclear. In this study, we used a genetically engineered mouse model to investigate the mechanisms of PanNET formation...

journal_title：Cancer research

authors： Yamauchi Y,Kodama Y,Shiokawa M,Kakiuchi N,Marui S,Kuwada T,Sogabe Y,Tomono T,Mima A,Morita T,Matsumori T,Ueda T,Tsuda M,Nishikawa Y,Kuriyama K,Sakuma Y,Ota Y,Maruno T,Uza N,Masuda A,Tatsuoka H,Yabe D,Minamiguc

更新日期：2020-09-01 00:00:00

abstract：:The transcription factor activating transcription factor 2 (ATF2) has been shown to be associated with melanocytic oncogenesis and melanoma tumor proliferation in preclinical models. The clinical significance of ATF2 expression is unknown. To determine the prognostic value of ATF2 in melanoma, we evaluated the pattern...

journal_title：Cancer research

authors： Berger AJ,Kluger HM,Li N,Kielhorn E,Halaban R,Ronai Z,Rimm DL

更新日期：2003-12-01 00:00:00

abstract：:Parathyroid tumors may occur in a sporadic fashion or, more rarely, as part of a familial syndrome (such as familial multiple endocrine neoplasia type I). The MENI gene has been mapped by linkage analysis to chromosome 11 at band q11-q13, and presumably acts as a tumor suppressor gene. In the present study, which is a...

journal_title：Cancer research

authors： Friedman E,De Marco L,Gejman PV,Norton JA,Bale AE,Aurbach GD,Spiegel AM,Marx SJ

更新日期：1992-12-15 00:00:00

abstract：:C19ORF5 is a sequence homologue of microtubule-associated proteins MAP1A/MAP1B of unknown function, except for its association with mitochondria-associated proteins and the paclitaxel-like microtubule stabilizer and candidate tumor suppressor RASSF1A. Here, we show that when overexpressed in mammalian cells the recomb...

journal_title：Cancer research

authors： Liu L,Vo A,Liu G,McKeehan WL

更新日期：2005-05-15 00:00:00