Identification of melanoma inhibitory activity and other differentially expressed messenger RNAs in human melanoma cell lines with different metastatic capacity by messenger RNA differential display.

abstract：:Glycerol and D2O can provide a protective effect to Chinese hamster V79 cells receiving heat treatment. The mechanism for this effect is assumed to be the ability of these agents to stabilize proteins which implies that one of the possible heat-killing mechanisms is the inactivation of a heat-sensitive molecule (prote...

journal_title：Cancer research

authors： Lin PS,Hefter K,Ho KC

更新日期：1984-12-01 00:00:00

abstract：:Coho salmon (Oncorhynchus kisutch) and chinook salmon (Oncorhynchus tshawytscha) from Lakes Ontario, Michigan, Erie, or Huron were found to suffer epizootics of thyroid hyperplasia and goiters which appeared to have an environmental etiology. There were 13-fold differences in goiter prevalence within the Great Lakes, ...

journal_title：Cancer research

authors： Moccia RD,Leatherland JF,Sonstegard RA

更新日期：1981-06-01 00:00:00

abstract：:Amphoterin has been suggested to regulate invasive process extension and cell migration in tumor cells and embryonic neurons through binding to receptor for advanced glycation end products (RAGE), a multiligand transmembrane receptor belonging to the immunoglobulin superfamily. In this study, we identify a COOH-termin...

journal_title：Cancer research

authors： Huttunen HJ,Fages C,Kuja-Panula J,Ridley AJ,Rauvala H

更新日期：2002-08-15 00:00:00

abstract：:Amplification and overexpression of erbB2 (Her-2/neu) proto-oncogene has been linked to human malignancies including tumors of the breast, ovary, and stomach. It has been implicated in tumor growth, sensitivity to standard chemotherapy, prognosis of patients, and disease-free survival. Although the clinical use of tra...

journal_title：Cancer research

authors： Jani JP,Finn RS,Campbell M,Coleman KG,Connell RD,Currier N,Emerson EO,Floyd E,Harriman S,Kath JC,Morris J,Moyer JD,Pustilnik LR,Rafidi K,Ralston S,Rossi AM,Steyn SJ,Wagner L,Winter SM,Bhattacharya SK

更新日期：2007-10-15 00:00:00

abstract：:Interleukin-2-based regimens of biological therapy have shown some clinical promise for the treatment of kidney cancer in humans, although the mechanisms responsible for tumor regression occurring in these patients remain unclear. Preclinical insight into these mechanisms is limited by a paucity of orthotopic animal m...

journal_title：Cancer research

authors： Gruys ME,Back TC,Subleski J,Wiltrout TA,Lee JK,Schmidt L,Watanabe M,Stanyon R,Ward JM,Wigginton JM,Wiltrout RH

更新日期：2001-08-15 00:00:00

abstract：:The increasing availability and maturity of DNA microarray technology has led to an explosion of cancer profiling studies. To extract maximum value from the accumulating mass of publicly available cancer gene expression data, methods are needed to evaluate, integrate, and intervalidate multiple datasets. Here we demon...

journal_title：Cancer research

authors： Rhodes DR,Barrette TR,Rubin MA,Ghosh D,Chinnaiyan AM

更新日期：2002-08-01 00:00:00

abstract：:Most cancer-associated single-nucleotide polymorphisms (SNP) identified using genome-wide association studies are located outside of protein-coding regions, and their significance and mode of action have been a source of continuing debate. One proposed mechanism of action of the SNPs is that they would affect the acti...

journal_title：Cancer research

authors： Sur I,Tuupanen S,Whitington T,Aaltonen LA,Taipale J

更新日期：2013-07-15 00:00:00

abstract：:The association between nonleukemic death and various features recorded at presentation in patients with refractory anemia (RA), RA with ring sideroblasts, and RA with excess of blasts was analyzed in 251 patients using the proportional hazards model. Features associated with higher nonleukemic death rates were: 1% or...

journal_title：Cancer research

authors： Oguma S,Yoshida Y,Uchino H,Maekawa T

更新日期：1987-07-01 00:00:00

abstract：:microRNAs (miRNA) are small noncoding RNAs that participate in diverse biological processes by suppressing target gene expression. Altered expression of miR-21 has been reported in cancer. To gain insights into its potential role in tumorigenesis, we generated miR-21 knockout colon cancer cells through gene targeting....

journal_title：Cancer research

authors： Wang P,Zou F,Zhang X,Li H,Dulak A,Tomko RJ Jr,Lazo JS,Wang Z,Zhang L,Yu J

更新日期：2009-10-15 00:00:00

abstract：:The human papillomavirus type 16 (HPV-16), the type most often associated with cervical cancer, immortalizes primary keratinocytes and inhibits serum/calcium-stimulated differentiation in culture. In this study, we have used a model of keratinocyte immortalization based upon HPV-16 to analyze perturbation of function ...

journal_title：Cancer research

authors： Wilding J,Vousden KH,Soutter WP,McCrea PD,Del Buono R,Pignatelli M

更新日期：1996-11-15 00:00:00

abstract：:The immunobiology of Friend erythroleukemia virus (FLV) has been the focal point of much research into immunological control of leukemia. We have been studying a murine model in which a rapidly fatal FLV infection of DBA/2 mice is suppressed to a dormant state by treatment with statolon, a double stranded RNA extract ...

journal_title：Cancer research

authors： DiCicco LM,Truitt GA,Wheelock EF

更新日期：1986-01-01 00:00:00

abstract：:In contrast to methotrexate (MTX) and aminopterin (AMT), the 8-deaza analogues of these antifolates are not substrates for rabbit liver aldehyde oxidase. Since they are not converted to 7-hydroxy derivatives, they have been investigated with regard to their cytotoxicity for CCRF-CEM cells, transport into these cells, ...

journal_title：Cancer research

authors： Kuehl M,Brixner DI,Broom AD,Avery TL,Blakley RL

更新日期：1988-03-15 00:00:00

abstract：:A phenolic amine compound, 4-S-cysteaminylphenol (4-S-CAP), is a potent depigmenting agent. To develop more efficacious antimelanoma agents, we synthesized four homologues of 4-S-CAP: N-acetyl-4-S-CAP (N-Ac-4-S-CAP), alpha-methyl-4-S-CAP, 4-S-homo-CAP, and N,N'-dimethyl-4-S-CAP. We tested these five compounds in mice ...

journal_title：Cancer research

authors： Alena F,Jimbow K,Ito S

更新日期：1990-06-15 00:00:00

abstract：:Primary solid tumors were mechanically and/or enzymatically disassociated, and the resulting suspensions of single cells and small clumps of cells were seeded onto three different substrates, i.e., tissue culture plastic, rat smooth muscle cells (SMCs), and SMC-derived extracellular matrix. Tests of the relative effec...

journal_title：Cancer research

authors： Bogenmann E,Mark C,Isaacs H,Neustein HB,De Clerck YA,Laug WE,Jones PA

更新日期：1983-03-01 00:00:00

abstract：:The semisynthetic vitamin E derivative alpha-tocopheryloxyacetic acid (α-TEA) induces tumor cell apoptosis and may offer a simple adjuvant supplement for cancer therapy if its mechanisms can be better understood. Here we report that α-TEA also triggers tumor cell autophagy and that it improves cross-presentation of tu...

journal_title：Cancer research

authors： Li Y,Hahn T,Garrison K,Cui ZH,Thorburn A,Thorburn J,Hu HM,Akporiaye ET

更新日期：2012-07-15 00:00:00

abstract：:Previous data on the effects of a single dose of hydroxyurea on C3H mouse duodenum and mammary tumors from a fast growing line (S102F) were used to predict times that may be optimal (i.e., minimize killing of the duodenal S-phase cells while enhancing the killing of tumor S-phase cells) for the administration of subse...

journal_title：Cancer research

authors： Dethlefsen LA,Sorensen SP,Riley RM

更新日期：1975-03-01 00:00:00

abstract：:Our recent study found that activation of signal transducer and activator of transcription 3 (Stat3) is up-regulated in human brain metastatic cells and contributes to brain metastasis of melanoma. However, the molecular mechanisms underlying this increased Stat3 activation and effect on brain metastasis are unknown. ...

journal_title：Cancer research

authors： Huang FJ,Steeg PS,Price JE,Chiu WT,Chou PC,Xie K,Sawaya R,Huang S

更新日期：2008-12-01 00:00:00

abstract：:Activities of the adenine purine nucleotide cycle enzymes, i.e., adenylosuccinate (SAMP) synthetase, SAMP lyase, and adenosine 5'-monophosphate deaminse, were determined in hepatic tissue of rats fed and/or given injections of 3'-methyl-4-dimethylaminoazobenzene, 4'-methyl-4-dimethylaminoazobenzene, thioacetamide, eth...

journal_title：Cancer research

authors： Smith LD,Emerson RL,Nixon LK

更新日期：1979-06-01 00:00:00

abstract：:Mortality surveys and death certificate studies have suggested an association between leukemia and farming. To investigate whether exposure to carcinogens in an agricultural setting is related to risk of leukemia, the authors conducted a population-based case-control interview study of 578 white men with leukemia and ...

journal_title：Cancer research

authors： Brown LM,Blair A,Gibson R,Everett GD,Cantor KP,Schuman LM,Burmeister LF,Van Lier SF,Dick F

更新日期：1990-10-15 00:00:00

abstract：:Reactive oxygen species play a critical role in the onset of apoptosis induced by various extracellular stimuli, including ionizing radiation. Therefore active regulation of reactive oxygen species-metabolizing enzymes may be one response to an apoptotic stimulus. In this regard, HP100 cells, H(2)O(2)-resistant varian...

journal_title：Cancer research

authors： Nenoi M,Ichimura S,Mita K,Yukawa O,Cartwright IL

更新日期：2001-08-01 00:00:00

abstract：:Angiogenesis, the sprouting of new blood vessels from existing vessels, occurs in many physiological and pathological processes, including embryonic development, wound healing, and tumor growth. It is required for tumor growth because new blood vessel formation is necessary for tumors to expand beyond a minimum volume...

journal_title：Cancer research

authors： Millauer B,Longhi MP,Plate KH,Shawver LK,Risau W,Ullrich A,Strawn LM

更新日期：1996-04-01 00:00:00

abstract：:One set of genes sufficient for transformation of primary human cells uses the combination of Ha-Ras-V12, the telomerase catalytic subunit hTERT, SV40 large tumor antigen (LT), and SV40 small tumor antigen (ST). Whereas SV40 LT inactivates the retinoblastoma protein and p53, the contribution of ST is poorly understood...

journal_title：Cancer research

authors： Moreno CS,Ramachandran S,Ashby DG,Laycock N,Plattner CA,Chen W,Hahn WC,Pallas DC

更新日期：2004-10-01 00:00:00

abstract：:Elucidating the mechanisms of prostate cancer (CaP) survival and metastasis are critical to the discovery of novel therapeutic targets. The monomeric G protein Rap1 has been implicated in cancer tumorigenesis. Rap1 signals to pathways involved in cell adhesion, migration, and survival, suggesting Rap1 may promote seve...

journal_title：Cancer research

authors： Bailey CL,Kelly P,Casey PJ

更新日期：2009-06-15 00:00:00

abstract：:Eosinophilia in tissues and/or circulating blood is known to be associated with a wide variety of malignancies but the role of the eosinophil in neoplastic conditions is not known. Using the cheek pouch of the Syrian hamster as an experimental model for oral carcinogenesis, it has recently been shown that eosinophils ...

journal_title：Cancer research

authors： Ghiabi M,Gallagher GT,Wong DT

更新日期：1992-01-15 00:00:00

abstract：:Acinetobacter glutaminase-asparaginase (AGA) and Escherichia coli asparaginase were compared for their effects on plasma and tissue levels of amino acids, ammonia, and glutamyl transferase activity in the mouse. Free asparagine was depleted similarly in plasma and tissues by both enzymes. AGA treatment produced partia...

journal_title：Cancer research

authors： Holcenberg JS,Tang E,Dolowy WC

更新日期：1975-05-01 00:00:00

abstract：:Both Src kinase and membrane type 1 matrix metalloproteinase (MT1-MMP) play critical roles in cancer invasion and metastasis. It is not clear, however, how the spatiotemporal activation of these two critical enzymes is coordinated in response to an oncogenic epithelial growth factor (EGF) stimulation. Here, we have vi...

journal_title：Cancer research

authors： Ouyang M,Huang H,Shaner NC,Remacle AG,Shiryaev SA,Strongin AY,Tsien RY,Wang Y

更新日期：2010-03-15 00:00:00

abstract：:A major challenge in treating cancer is the difficulty of bringing therapy to poorly perfused areas of solid tumors, which are often most resistant to chemotherapy and radiation. GRP94 is a chaperone protein localized in the endoplasmic reticulum with antiapoptotic properties. We report here that in vitro the proximal...

journal_title：Cancer research

authors： Reddy RK,Dubeau L,Kleiner H,Parr T,Nichols P,Ko B,Dong D,Ko H,Mao C,DiGiovanni J,Lee AS

更新日期：2002-12-15 00:00:00

abstract：:Loss of heterozygosity (LOH) and replication error (RER) are important phenomena in tumor development, with diagnostic and prognostic relevance. Therefore, screening for LOH and RER is a desirable first step in the molecular analysis of tumors. We used semiautomated procedures based on multicolor fluorescently labeled...

journal_title：Cancer research

authors： Canzian F,Salovaara R,Hemminki A,Kristo P,Chadwick RB,Aaltonen LA,de la Chapelle A

更新日期：1996-07-15 00:00:00

abstract：:The mechanisms by which cells accurately distinguish between DNA double-strand break (DSB) ends and telomeric DNA ends remain poorly defined. Recent investigations have revealed intriguing interactions between DNA repair and telomeres. We were the first to report a requirement for the nonhomologous end-joining (NHEJ) ...

journal_title：Cancer research

authors： Williams ES,Klingler R,Ponnaiya B,Hardt T,Schrock E,Lees-Miller SP,Meek K,Ullrich RL,Bailey SM

更新日期：2009-03-01 00:00:00

abstract：:Normal bone marrow progenitors and some leukemic cells develop only a limited amount of thermotolerance. Further, once developed, thermotolerance decays at a faster rate than that normally observed in cells of nonhemopoietic origin. Thermotolerance induction and maintenance correlates with reduced levels of expression...

journal_title：Cancer research

authors： Mivechi NF,Ouyang H,Hahn GM

更新日期：1992-12-15 00:00:00