E-cadherin transfection down-regulates the epidermal growth factor receptor and reverses the invasive phenotype of human papilloma virus-transfected keratinocytes.

abstract：:Rats were immunized with cultured cells from chemically induced transitional cell carcinomas of the mouse urinary bladder, and their spleen cells were hybridized with NS-1 mouse myeloma cells. Following initial screening of antibodies made by hybridoma clones, the tissue distribution of antigens defined by the antibod...

journal_title：Cancer research

authors： Hellström I,Hellström KE,Rollins N,Lee VK,Hudkins KL,Nepom GT

更新日期：1985-05-01 00:00:00

abstract：:Multicellular spheroids composed of transformed cells are known to mimic the growth characteristics of tumors and to develop gradients in proliferation with increasing size. This progressive accumulation of quiescent cells is presumably an active process that occurs in response to the microenvironmental stresses that ...

journal_title：Cancer research

authors： LaRue KE,Khalil M,Freyer JP

更新日期：2004-03-01 00:00:00

abstract：:Serine/arginine (SR) protein-specific kinase (SRPK), a family of cell cycle-regulated protein kinases, phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing. However, the physiologic roles of this event in cell cycle are incompletely understood. Here, we show that SRPK2 bind...

journal_title：Cancer research

authors： Jang SW,Yang SJ,Ehlén A,Dong S,Khoury H,Chen J,Persson JL,Ye K

更新日期：2008-06-15 00:00:00

abstract：:Human lymphoblastoid cell lines from normal individuals and from patients with ataxia telangiectasia were either proficient or deficient in their ability to repair the mutagenic DNA adduct O6-methylguanine that is induced by methylating carcinogens. There was no relationship between the capacity to repair O6-methylgua...

journal_title：Cancer research

authors： Shiloh Y,Becker Y

更新日期：1981-12-01 00:00:00

abstract：:Deletion of the chromosome 5q [del(5q)] is one of the most common cytogenetic abnormalities observed in patients with de novo myelodysplastic syndromes (MDS) and therapy-related MDS or acute myeloid leukemia (t-MDS/tAML). Emerging evidence indicates that activation of the Wnt/β-catenin pathway contributes to the devel...

journal_title：Cancer research

authors： Li L,Sheng Y,Li W,Hu C,Mittal N,Tohyama K,Seba A,Zhao YY,Ozer H,Zhu T,Qian Z

更新日期：2017-08-01 00:00:00

abstract：:Myc oncoproteins exert tumorigenic effects by regulating expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes...

journal_title：Cancer research

authors： Wong M,Tee AEL,Milazzo G,Bell JL,Poulos RC,Atmadibrata B,Sun Y,Jing D,Ho N,Ling D,Liu PY,Zhang XD,Hüttelmaier S,Wong JWH,Wang J,Polly P,Perini G,Scarlett CJ,Liu T

更新日期：2017-05-01 00:00:00

abstract：:Neuroblastoma cells accumulate ascorbic acid and iron. It was hypothesized that these features could be exploited for sensitizing neuroblastoma cells for therapy in combination with reactive oxygen intermediates. In the present study the effects of 6-hydroxydopamine (6-OHDA) and H2O2 on metabolic parameters critical f...

journal_title：Cancer research

authors： Bruchelt G,Schraufstätter IU,Niethammer D,Cochrane CG

更新日期：1991-11-15 00:00:00

abstract：:The calcium channel blocker verapamil has been shown to reverse multidrug resistance (T. Tsuruo et al., Cancer Res. 41: 1967-1972, 1981), but the mechanism of action of this agent has not been fully elucidated. A radioactive photoactive analogue of verapamil, N-[benzoyl-3,5-3H-(+/-)-5-[(3,4-dimethoxyphenetyl)methylami...

journal_title：Cancer research

authors： Yusa K,Tsuruo T

更新日期：1989-09-15 00:00:00

abstract：:Most carcinomas spread to distant sites through lymphatic vessels. Several preclinical and clinical studies have shown a positive correlation between the incidence of lymph node metastasis and secretion of the lymphatic growth factor vascular endothelial growth factor-C (VEGF-C) by tumor cells, suggesting tumor lympha...

journal_title：Cancer research

authors： Issa A,Le TX,Shoushtari AN,Shields JD,Swartz MA

更新日期：2009-01-01 00:00:00

abstract：:Anti-inflammatory drugs and antibiotics alter the risk of breast cancer in women, but roles for bacteria and inflammation in breast malignancies are poorly understood. A recent study in mice suggests that intestinal bacteria can trigger mammary carcinoma. The mechanisms involved in this effect suggest that dysregulate...

journal_title：Cancer research

authors： Rao VP,Poutahidis T,Fox JG,Erdman SE

更新日期：2007-02-01 00:00:00

abstract：:A model for cell detachment which may influence metastasis in vivo is described involving the transfer of hamster melanoma cells from aggregates of those tumor cells to hamster fibroblast aggregates. The aggregates were made by the spontaneous association of cultured cells. Tumor and fibroblast aggregates were then in...

journal_title：Cancer research

authors： Umbreit JN,Erbe RW

更新日期：1979-06-01 00:00:00

abstract：:Deregulation of translation initiation factors contributes to many pathogenic conditions, including cancer. Here, we report the definition of a novel regulatory pathway for translational initiation with possible therapeutic import in cancer. Specifically, we found that casein kinase 1ε (CK1ε) is highly expressed in br...

journal_title：Cancer research

authors： Shin S,Wolgamott L,Roux PP,Yoon SO

更新日期：2014-01-01 00:00:00

abstract：:A single cancer cell contains large numbers of genetic alterations that in combination create the malignant phenotype. However, whether amplified and mutated genes form functional and physical interaction networks that could explain the selection for cells with combined alterations is unknown. To investigate this issu...

journal_title：Cancer research

authors： Nikolsky Y,Sviridov E,Yao J,Dosymbekov D,Ustyansky V,Kaznacheev V,Dezso Z,Mulvey L,Macconaill LE,Winckler W,Serebryiskaya T,Nikolskaya T,Polyak K

更新日期：2008-11-15 00:00:00

abstract：:IFNγ is conventionally recognized as an inflammatory cytokine that plays a central role in antitumor immunity. Although it has been used clinically to treat a variety of malignancies, low levels of IFNγ in the tumor microenvironment (TME) increase the risk of tumor metastasis during immunotherapy. Accumulating evidenc...

journal_title：Cancer research

authors： Song M,Ping Y,Zhang K,Yang L,Li F,Zhang C,Cheng S,Yue D,Maimela NR,Qu J,Liu S,Sun T,Li Z,Xia J,Zhang B,Wang L,Zhang Y

更新日期：2019-07-15 00:00:00

abstract：:DR-nm23 cDNA was cloned recently by differential screening of a cDNA library derived from chronic myelogenous leukemia-blast crisis primary cells. It is highly homologous to the putative metastasis suppressor nm23-H1 gene and the closely related nm23-H2 gene. When overexpressed in the myeloid precursor 32Dcl3 cell lin...

journal_title：Cancer research

authors： Martinez R,Venturelli D,Perrotti D,Veronese ML,Kastury K,Druck T,Huebner K,Calabretta B

更新日期：1997-03-15 00:00:00

abstract：:The chemotherapeutic agent 6-mercaptopurine was previously shown to inhibit the binding of 7r,8t-dihydroxy-9,10t-oxy-7,8,9,10-tetrahydro-benzo(a) pyrene (BPDE-I) to DNA in Chinese hamster ovary cells. Two compounds related to 6-mercaptopurine, 2,6-dithiopurine (DTP) and thiopurinol (TP), have been tested for inhibitio...

journal_title：Cancer research

authors： MacLeod MC,Mann KL,Thai G,Conti CJ,Reiners JJ Jr

更新日期：1991-09-15 00:00:00

abstract：:BALB/cJ X C57BL/10Sn F1 (hereafter called B10F1) hybrids resist challenge with the BALB/c plasmacytoma, MPC-11, by a radiation-sensitive, silica-insensitive mechanism, whereas BALB/cJ X BALB.B F1 (hereafter called BALB.BF1) hybrids are as susceptible to MPC-11 as are homozygous BALB/c mice themselves. To investigate t...

journal_title：Cancer research

authors： Marsili MA,Walker MC,Phillips-Quagliata JM

更新日期：1986-01-01 00:00:00

abstract：:Heat shock protein 70 (HSP70) inhibits apoptosis and thereby increases the survival of cells exposed to a wide range of lethal stimuli. HSP70 has also been shown to increase the tumorigenicity of cancer cells in rodent models. The protective function of this chaperone involves interaction and neutralization of the cas...

journal_title：Cancer research

authors： Schmitt E,Parcellier A,Gurbuxani S,Cande C,Hammann A,Morales MC,Hunt CR,Dix DJ,Kroemer RT,Giordanetto F,Jäättelä M,Penninger JM,Pance A,Kroemer G,Garrido C

更新日期：2003-12-01 00:00:00

abstract：:The oncogenic protein Ski associates with Smad proteins and counteracts their activation of gene expression and growth inhibition in response to transforming growth factor beta (TGF-beta). Here we show that Ski protein levels are increased in all 44 human melanoma tumor tissues analyzed in vivo. In addition, Ski subce...

journal_title：Cancer research

authors： Reed JA,Bales E,Xu W,Okan NA,Bandyopadhyay D,Medrano EE

更新日期：2001-11-15 00:00:00

abstract：:We recently reported the isolation of the K-sam complementary DNA (cDNA), which was amplified preferentially in poorly differentiated types of stomach cancer and codes for one of the heparin-binding growth factor or fibroblast growth factor (FGF) receptor families. The K-sam-related gene, N-sam (NCC-IT-cell-derived sa...

journal_title：Cancer research

authors： Hattori Y,Odagiri H,Katoh O,Sakamoto H,Morita T,Shimotohno K,Tobinai K,Sugimura T,Terada M

更新日期：1992-06-15 00:00:00

abstract：:Among the many proteases associated with human cancer, seprase or fibroblast activation protein alpha, a type II transmembrane glycoprotein, has two types of EDTA-resistant protease activities: dipeptidyl peptidase and a 170-kDa gelatinase activity. To test if activation of gelatinases associated with seprase could be...

journal_title：Cancer research

authors： Chen D,Kennedy A,Wang JY,Zeng W,Zhao Q,Pearl M,Zhang M,Suo Z,Nesland JM,Qiao Y,Ng AK,Hirashima N,Yamane T,Mori Y,Mitsumata M,Ghersi G,Chen WT

更新日期：2006-10-15 00:00:00

abstract：:Glioblastoma (GBM) is often treated with the cytotoxic drug temozolomide, but the disease inevitably recurs in a drug-resistant form after initial treatment. Here, we report that in GBM cells, even a modest decrease in the mismatch repair (MMR) components MSH2 and MSH6 have profound effects on temozolomide sensitivity...

journal_title：Cancer research

authors： McFaline-Figueroa JL,Braun CJ,Stanciu M,Nagel ZD,Mazzucato P,Sangaraju D,Cerniauskas E,Barford K,Vargas A,Chen Y,Tretyakova N,Lees JA,Hemann MT,White FM,Samson LD

更新日期：2015-08-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy is an emerging immunotherapy against several malignancies including glioblastoma, the most common and most aggressive malignant primary brain tumor in adults. The challenges in solid tumor immunotherapy comprise heterogenously expressed tumor target antigens and restricte...

journal_title：Cancer research

authors： Weiss T,Weller M,Guckenberger M,Sentman CL,Roth P

更新日期：2018-02-15 00:00:00

abstract：:Homogeneously staining regions (HSRs) were found in hypodiploid cells (40%) of a subline of the human melanoma cell line, MeWo, (MeWo-C) but were absent from the hypotetraploid cells (60%). Another subline (MeWo-B) was also shown to contain two populations of cells, 70% hypodiploid and 30% hypotetraploid. None of the ...

journal_title：Cancer research

authors： Shtromas I,White BN,Holden JJ,Reimer DL,Roder JC

更新日期：1985-02-01 00:00:00

abstract：:The present study was designed to determine whether alterations in host metabolism associated with progressive tumor growth were a result of the anorexia frequently observed with cancer or could be attributed to other direct tumor effects. Rates of tyrosine flux, oxidation, and incorporation into protein, as well as f...

journal_title：Cancer research

authors： Kawamura I,Moldawer LL,Keenan RA,Batist G,Bothe A Jr,Bistrian BR,Blackburn GL

更新日期：1982-03-01 00:00:00

abstract：:Multimodal therapy is generally more effective than single-agent treatment for cancer. rRp450 is an engineered herpes simplex viral mutant that replicates in and kills tumor cells in a relatively selective fashion. It also expresses, in infected cells, the cyclophosphamide (CPA)-sensitive rat cytochrome P450 2B1 (CYP2...

journal_title：Cancer research

authors： Aghi M,Chou TC,Suling K,Breakefield XO,Chiocca EA

更新日期：1999-08-15 00:00:00

abstract：:Cellular retinoic acid-binding protein (cRABP) was detected in the cytosol of virus-induced papilloma (Shope) of rabbit skin. The Shope papilloma cRABP showed the same ligand specificity and sedimentation value (2S) as was found in other animal species. The level of cRABP in the papillomatous tissue was significantly ...

journal_title：Cancer research

authors： Rattanapanone V,Tashiro S,Tokuda H,Rattanapanone N,Ito Y

更新日期：1981-04-01 00:00:00

abstract：:Renal cell carcinoma is frequently infiltrated by cells of the immune system. This makes it important to understand interactions between cancer cells and immune cells so they can be manipulated to bring clinical benefit. Here, we analyze subsets and functions of T lymphocytes infiltrating renal cell tumors directly ex...

journal_title：Cancer research

authors： Attig S,Hennenlotter J,Pawelec G,Klein G,Koch SD,Pircher H,Feyerabend S,Wernet D,Stenzl A,Rammensee HG,Gouttefangeas C

更新日期：2009-11-01 00:00:00

abstract：:Modulation of surface transferrin receptor activity has been associated with leukemia cell differentiation and proliferation. To examine the mechanisms involved in regulating this event, receptor protein and mRNA levels were measured in HL-60 promyelocytic leukemia cells induced to differentiate along the myelocytic a...

journal_title：Cancer research

authors： Ho PT,Ishiguro K,Sartorelli AC

更新日期：1989-04-15 00:00:00

abstract：:Aclacinomycin A (aclarubicin) is an anthracycline anticancer agent with demonstrated activity against both leukemias and solid tumors. Previous results suggested that a major activity of aclacinomycin A is the inhibition of topoisomerase II catalytic activity. We have applied a yeast system to test whether aclacinomyc...

journal_title：Cancer research

authors： Nitiss JL,Pourquier P,Pommier Y

更新日期：1997-10-15 00:00:00