Abstract：
:Renal cell carcinoma is frequently infiltrated by cells of the immune system. This makes it important to understand interactions between cancer cells and immune cells so they can be manipulated to bring clinical benefit. Here, we analyze subsets and functions of T lymphocytes infiltrating renal cell tumors directly ex vivo following mechanical disaggregation and without any culture step. Subpopulations of memory and effector CD4(+) Th1, Th2, and Th17 and CD8(+) Tc1 cells were identified based on surface phenotype, activation potential, and multicytokine production. Compared with the same patient's peripheral blood, T lymphocytes present inside tumors were found to be enriched in functional CD4(+) cells of the Th1 lineage and in effector memory CD8(+) cells. Additionally, several populations of CD4(+) and CD8(+) regulatory T cells were identified that may synergize to locally dampen antitumor T-cell responses.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Attig S,Hennenlotter J,Pawelec G,Klein G,Koch SD,Pircher H,Feyerabend S,Wernet D,Stenzl A,Rammensee HG,Gouttefangeas Cdoi
10.1158/0008-5472.CAN-09-0852subject
Has Abstractpub_date
2009-11-01 00:00:00pages
8412-9issue
21eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-09-0852journal_volume
69pub_type
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