Abstract：
:Evaluation of a large panel of radiation-induced rat skin tumors of diverse size and histological type revealed a correlation between c-myc copy number and tumor size. Both the frequency and degree of c-myc gene amplification were increased in large compared to small carcinomas, but none of the sarcomas examined showed c-myc amplification. Serial biopsies of individual tumors exhibited similar trends of increasing c-myc copy number in later biopsies. In one regressing tumor, the c-myc gene copy number paralleled the growth rate of the tumor during growth and regression. The average time required from tumor appearance to significant gene amplification was close to the average period between tumor appearance and the onset of rapid growth. The data suggest that, rather than being a target gene for the direct early effects of ionizing radiation, c-myc functions as a late-stage progression-related oncogene in this model system.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Garte SJ,Burns FJ,Ashkenazi-Kimmel T,Felber M,Sawey MJsubject
Has Abstractpub_date
1990-05-15 00:00:00pages
3073-7issue
10eissn
0008-5472issn
1538-7445journal_volume
50pub_type
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