Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer.

abstract：:The ability of the vitamin E (RRR-alpha-tocopherol) derivatives alpha-tocopheryl succinate (alpha-TOS) and alpha-tocopheryloxyacetic acid (alpha-TEA) to suppress tumor growth in preclinical animal models has recently led to increased interest in their potential use for treating human cancer. To make the use of these v...

journal_title：Cancer research

authors： Hahn T,Szabo L,Gold M,Ramanathapuram L,Hurley LH,Akporiaye ET

更新日期：2006-10-01 00:00:00

abstract：:A historical cohort of 68 female breast cancer patients from one institution who were enrolled in a multicenter randomized controlled trial between 1971 and 1973 were followed up to the beginning of 1986. Weight and height at the time of mastectomy were transformed into two indices of body size, namely the Quetelet In...

journal_title：Cancer research

authors： Suissa S,Pollak M,Spitzer WO,Margolese R

更新日期：1989-06-01 00:00:00

abstract：:Clonal proliferation of human T-lymphotropic virus type I (HTLV-I)-infected cells has been detected by Southern blot analysis and inverse PCR in patients with adult T-cell leukemia, patients with HTLV-I-associated diseases, and even in asymptomatic carriers. Combining inverse PCR with long PCR, we amplified the genomi...

journal_title：Cancer research

authors： Etoh K,Tamiya S,Yamaguchi K,Okayama A,Tsubouchi H,Ideta T,Mueller N,Takatsuki K,Matsuoka M

更新日期：1997-11-01 00:00:00

abstract：:A common feature of mammalian cell lines selected for multiple drug resistance is the overexpression of a high-molecular-weight surface membrane glycoprotein(s). While its amount has been shown to be related to the degree of resistance of such cells, its function in this phenomenon remains obscure. Because there are s...

journal_title：Cancer research

authors： Beck WT,Cirtain MC,Ashmun RA,Mirro J

更新日期：1986-09-01 00:00:00

abstract：:The formation of a microvascular endothelium plays a critical role in the growth and metastasis of established tumors. The ability of a fragment from the first type III repeat of fibronectin (III(1C)), anastellin, to suppress tumor growth and metastasis in vivo has been reported to be related to its antiangiogenic pro...

journal_title：Cancer research

authors： Ambesi A,Klein RM,Pumiglia KM,McKeown-Longo PJ

更新日期：2005-01-01 00:00:00

abstract：:Virtually all patients with chronic myelogenous leukemia (CML) express an aberrant protein (p210 Bcr-Abl) that contains NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl. In a yeast two-hybrid screen, we have identified TSG101 as a binding partner for Bcr. Because TSG101 is a subunit of the mam...

journal_title：Cancer research

authors： Olabisi OO,Mahon GM,Kostenko EV,Liu Z,Ozer HL,Whitehead IP

更新日期：2006-06-15 00:00:00

abstract：:The use of rat testicular seminiferous tubular basement membrane (STBM) segments as a model substratum for the in vitro maintenance of tumor cells dissociated from a transplantable pancreatic acinar rat carcinoma (J. K. Reddy and M. S. Rao, Science (Wash. DC), 198: 78-80, 1977) is described. Ultrastructurally pure, ho...

journal_title：Cancer research

authors： Watanabe TK,Hansen LJ,Reddy NK,Kanwar YS,Reddy JK

更新日期：1984-11-01 00:00:00

abstract：:Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (...

journal_title：Cancer research

authors： Hecht SS,el-Bayoumy K,Rivenson A,Amin S

更新日期：1994-01-01 00:00:00

abstract：:Prior investigations on the beneficial effect of dietary processed tomato products and lycopene on prostate cancer risk suggested that lycopene may require the presence of other constituents to exert its chemopreventive potential. We investigated whether ketosamines, a group of carbohydrate derivatives present in dehy...

journal_title：Cancer research

authors： Mossine VV,Chopra P,Mawhinney TP

更新日期：2008-06-01 00:00:00

abstract：:In an effort to achieve high concentrations of 5-fluorouracil (5-FUra) in the hepatic circulation while minimizing systemic exposure, several routes of intrahepatic administration were compared in the canine model. To ascertain these data, 5-FUra (30 mg/kg) was given as a bolus into either a systemic vein (femoral vei...

journal_title：Cancer research

authors： Didolkar MS,Covell DG,Jackson AJ,Walker AP,Kalidindi SR

更新日期：1984-11-01 00:00:00

abstract：:Human epithelial tumor progression and metastasis involve cellular invasion, dissemination in the vasculature, and regrowth at metastatic sites. Notch signaling has been implicated in metastatic progression but its roles have yet to be fully understood. Here we report the important role of Notch signaling in maintaini...

journal_title：Cancer research

authors： Bajaj J,Maliekal TT,Vivien E,Pattabiraman C,Srivastava S,Krishnamurthy H,Giri V,Subramanyam D,Krishna S

更新日期：2011-07-15 00:00:00

abstract：:Two lines of human colonic carcinoma cells have different sensitivities to 5-fluorouracil and 1-(2-chlorethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU). The growth of the BE line is 50% inhibited by 330 microM 5-fluorouracil and 15 microM methyl-CCNU, and the HT-29 line is 50% inhibited by 85 and 140 microM,...

journal_title：Cancer research

authors： Sutton JE,Roos IA,Hillcoat BL

更新日期：1982-12-01 00:00:00

abstract：:Estradiol and triphenylethylene antiestrogen actions have been studied extensively in breast cancer cell lines. However, their effects are still poorly understood on normal human breast cells. We have developed a culture system of normal human breast epithelial (HBE) cells. It has been shown previously that cultured H...

journal_title：Cancer research

authors： Malet C,Gompel A,Spritzer P,Bricout N,Yaneva H,Mowszowicz I,Kuttenn F,Mauvais-Jarvis P

更新日期：1988-12-15 00:00:00

abstract：:It has recently been reported that the human myeloma cell line U266 proceeds to undergo apoptosis after cultivation with the antiestrogen tamoxifen, thus raising the possibility that antiestrogens may be candidates for use in myeloma therapy. To obtain basic information on the effects of antiestrogens on myeloma cells...

journal_title：Cancer research

authors： Otsuki T,Yamada O,Kurebayashi J,Moriya T,Sakaguchi H,Kunisue H,Yata K,Uno M,Yawata Y,Ueki A

更新日期：2000-03-01 00:00:00

abstract：:Cancer stem cells (CSC) play a central role in cancer metastasis and development of drug resistance. miRNA are important in regulating CSC properties and are considered potential therapeutic targets. Here we report that miR-328-3p (miR-328) is significantly upregulated in ovarian CSC. High expression of miR-328 mainta...

journal_title：Cancer research

authors： Srivastava AK,Banerjee A,Cui T,Han C,Cai S,Liu L,Wu D,Cui R,Li Z,Zhang X,Xie G,Selvendiran K,Patnaik S,Karpf AR,Liu J,Cohn DE,Wang QE

更新日期：2019-05-01 00:00:00

abstract：:The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain we...

journal_title：Cancer research

authors： Lin EY,Pollard JW

更新日期：2007-06-01 00:00:00

abstract：:Degradation and invasion of basement membrane by tumor cells involves the cooperative hydrolysis of proteoglycans, collagens, and glycoproteins mediated by a number of enzymes including proteases, collagenases, and glycosidases. In order to study these processes in vitro, a tissue culture system was developed in which...

journal_title：Cancer research

authors： Woynarowska B,Wikiel H,Bernacki RJ

更新日期：1989-10-15 00:00:00

abstract：:The N-myc gene is transiently expressed during normal embryonic development and abnormally expressed in several tumors of neuroendocrine origin. Little is known of the function of the N-myc gene product in either normal or neoplastic tissue. We utilized synthetic antisense oligodeoxynucleotides to specifically inhibit...

journal_title：Cancer research

authors： Rosolen A,Whitesell L,Ikegaki N,Kennett RH,Neckers LM

更新日期：1990-10-01 00:00:00

abstract：:The product of the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene, menin, is an integral component of MLL1/MLL2 histone methyltransferase complexes specific for Lys4 of histone H3 (H3K4). We show that menin is a transcriptional coactivator of the nuclear receptors for estrogen and vitamin D. Activati...

journal_title：Cancer research

authors： Dreijerink KM,Mulder KW,Winkler GS,Höppener JW,Lips CJ,Timmers HT

更新日期：2006-05-01 00:00:00

abstract：:Murine sarcoma virus (Moloney strain) (MSV-M)-induced tumors are unusual in that they regularly appear less than 2 weeks after virus inoculation, progress for 1 to 2 weeks, and are rejected by normal adult BALB/c mice. Rejectio leaves the animals immune to tumor induction. In the present study, presensitization of nor...

journal_title：Cancer research

authors： Wood GW

更新日期：1976-12-01 00:00:00

abstract：:In this study, we show that rodent albumin is expressed by and cell surface localized on at least some murine tumor cells. We have been able to purify this tumor-expressed albumin from in vivo grown tumor masses. The tumor-expressed albumin, unlike normal serum albumin purified from blood, is capable of inhibiting T-c...

journal_title：Cancer research

authors： Graner MW,Likhacheva A,Davis J,Raymond A,Brandenberger J,Romanoski A,Thompson S,Akporiaye E,Katsanis E

更新日期：2004-11-01 00:00:00

abstract：:We have screened 57 cases of primary, nonfunctional, pituitary adenomas for loss of heterozygosity of markers on chromosome 9p. Using a panel of 11 microsatellite markers, we found hemizygous deletion with at least one of the markers in 18 tumors (31.5%). The frequency of loss was similar in both noninvasive (8 of 26;...

journal_title：Cancer research

authors： Farrell WE,Simpson DJ,Bicknell JE,Talbot AJ,Bates AS,Clayton RN

更新日期：1997-07-01 00:00:00

abstract：:Glutamine supplementation has been advocated for patients requiring parenteral nutritional support. However, the direct effect of glutamine on neoplastic cells is poorly understood. We therefore investigated the effects of glutamine on the proliferation, differentiation, and cell-matrix interactions of two human colon...

journal_title：Cancer research

authors： Turowski GA,Rashid Z,Hong F,Madri JA,Basson MD

更新日期：1994-11-15 00:00:00

abstract：:The pharmacodynamic parameters of 1-beta-D-arabinofuranosylcytosine (ara-C) in patient plasma and its active anabolite 1-beta-D-arabinofuranosylcytosine-5-triphosphate (ara-CTP) in circulating and bone marrow blast cells were studied in 20 pediatric patients with acute leukemia. ara-C (3 g/m2) was administered as a sh...

journal_title：Cancer research

authors： Avramis VI,Biener R,Krailo M,Finklestein J,Ettinger L,Willoughby M,Siegel SE,Holcenberg JS

更新日期：1987-12-15 00:00:00

abstract：:The effect of pretreatment with L-asparaginase on the cytotoxicity of methotrexate (MTX) was studied in L5178Y murine leukemic cells and L-929 cells grown in vitro. The results were correlated with the effects of L-asparaginase on DNA synthesis. At low concentrations of the enzyme, pretreatment of cells enhanced the e...

journal_title：Cancer research

authors： Chlopkiewicz B,Koziorowska J

更新日期：1975-06-01 00:00:00

abstract：:The proto-oncogene, c-src, has been implicated in the tumorigenesis in breast cancer. However, the relationship of c-src with distant metastasis is unclear. Moreover, the role of c-src in organ-preferential metastasis of breast cancer is unknown. Because breast cancer has a strong predilection for metastasizing to bon...

journal_title：Cancer research

authors： Myoui A,Nishimura R,Williams PJ,Hiraga T,Tamura D,Michigami T,Mundy GR,Yoneda T

更新日期：2003-08-15 00:00:00

abstract：:Non-small cell lung cancer patients carrying oncogenic EGFR mutations initially respond to EGFR-targeted therapy, but later elicit minimal response due to dose-limiting toxicities and acquired resistance. EGF816 is a novel, irreversible mutant-selective EGFR inhibitor that specifically targets EGFR-activating mutation...

journal_title：Cancer research

authors： Jia Y,Juarez J,Li J,Manuia M,Niederst MJ,Tompkins C,Timple N,Vaillancourt MT,Pferdekamper AC,Lockerman EL,Li C,Anderson J,Costa C,Liao D,Murphy E,DiDonato M,Bursulaya B,Lelais G,Barretina J,McNeill M,Epple R,Mar

更新日期：2016-03-15 00:00:00

abstract：:The lethal and bone marrow toxicity and antitumor activity of the cis- and trans-2-hydroxylated metabolites of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) have been correlated with their relative in vitro alkylating and carbamoylating activities. Both the isomers have considerably greater alkylating activity a...

journal_title：Cancer research

authors： Heal JM,Fox PA,Doukas D,Schein PS

更新日期：1978-04-01 00:00:00

abstract：:Of 20,000 plant extracts submitted to the National Cancer Institute antitumor screens from 1960 to 1980, over 95% exhibited inadequate tumor-inhibiting activity or promoted tumor growth. Of these, 50 extracts representing 42 species showed significant levels of tumor growth enhancement compared to controls on the basi...

journal_title：Cancer research

authors： Caldwell ME,Brewer WR

更新日期：1983-12-01 00:00:00

abstract：:The occurrence of spontaneous skin papillomas in Japanese newts (Cynops pyrrhogaster) from Niigata prefecture in Northern Japan was monitored over four seasons covering a period of 2 years. Of 13,613 newts, 249 were found to possess papillomas. The percentage of newts with papillomas was highest in autumn, ranging fro...

journal_title：Cancer research

authors： Asashima M,Komazaki S,Satou C,Oinuma T

更新日期：1982-09-01 00:00:00