Abstract：
:The N-myc gene is transiently expressed during normal embryonic development and abnormally expressed in several tumors of neuroendocrine origin. Little is known of the function of the N-myc gene product in either normal or neoplastic tissue. We utilized synthetic antisense oligodeoxynucleotides to specifically inhibit N-myc gene expression in the neuroepithelioma cell line CHP100. These cells contain single copy N-myc alleles but overexpress c-myc. N-myc antisense oligomer treatment was found to be growth inhibitory without affecting levels of c-myc protein. N-myc antisense oligomer-treated cells also lost the characteristic cellular heterogeneity displayed by CHP100 in vitro.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Rosolen A,Whitesell L,Ikegaki N,Kennett RH,Neckers LMsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
6316-22issue
19eissn
0008-5472issn
1538-7445journal_volume
50pub_type
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