Differentiation of pancreatic acinar carcinoma cells cultured on rat testicular seminiferous tubular basement membranes.

abstract：:In order to study whether cell fusion would modify the DNA copy number of an amplified oncogene, somatic cell hybrids were made between the human neuroepithelioma cell line MCIXC and HeLaCOT human adenocarcinoma cells. MCIXC contains approximately 21 copies of the c-myc oncogene and HeLaCOT contains approximately 5 co...

journal_title：Cancer research

authors： Iman DS,Shay JW

更新日期：1989-08-15 00:00:00

abstract：:It has recently been reported that the human myeloma cell line U266 proceeds to undergo apoptosis after cultivation with the antiestrogen tamoxifen, thus raising the possibility that antiestrogens may be candidates for use in myeloma therapy. To obtain basic information on the effects of antiestrogens on myeloma cells...

journal_title：Cancer research

authors： Otsuki T,Yamada O,Kurebayashi J,Moriya T,Sakaguchi H,Kunisue H,Yata K,Uno M,Yawata Y,Ueki A

更新日期：2000-03-01 00:00:00

abstract：:Pharmacokinetic studies of 5-fluorouracil (5-FUra) were performed on 18 patients divided into three groups: seven patients were given 5-FUra i.v. by rapid injection; five patients received the drug p.o.; and six patients were treated by continuous i.v. infusion for 96 hr. The results showed rapid i.v. injection to be ...

journal_title：Cancer research

authors： Fraile RJ,Baker LH,Buroker TR,Horwitz J,Vaitkevicius VK

更新日期：1980-07-01 00:00:00

abstract：:Flow cytometry was used to determine the daunomycin content of rat bone marrow cells after incubation in vitro. The spontaneous fluorescence of daunomycin was measured upon excitation with laser light at 488 nm. Forward and perpendicular light scatters of the cells were simultaneously measured to allow identification ...

journal_title：Cancer research

authors： Nooter K,van den Engh G,Sonneveld P

更新日期：1983-11-01 00:00:00

abstract：:A common single nucleotide polymorphism (SNP), rs6983267, at 8q24.21 has recently been shown to associate with colorectal cancer (CRC). Three independent SNP association studies showed that rs6983267 contributes to CRC with odds ratios (OR) of 1.17 to 1.22. Here, we genotyped a population-based series of 1,042 patient...

journal_title：Cancer research

authors： Tuupanen S,Niittymäki I,Nousiainen K,Vanharanta S,Mecklin JP,Nuorva K,Järvinen H,Hautaniemi S,Karhu A,Aaltonen LA

更新日期：2008-01-01 00:00:00

abstract：:The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tumorigenesis. Using ...

journal_title：Cancer research

authors： Ohm JE,Mali P,Van Neste L,Berman DM,Liang L,Pandiyan K,Briggs KJ,Zhang W,Argani P,Simons B,Yu W,Matsui W,Van Criekinge W,Rassool FV,Zambidis E,Schuebel KE,Cope L,Yen J,Mohammad HP,Cheng L,Baylin SB

更新日期：2010-10-01 00:00:00

abstract：:17beta-Hydroxysteroid dehydrogenase type 12 (17beta-HSD12) has been shown to be involved in elongation of very long chain fatty acid (VLCFA) as well as in biosynthesis of estradiol (E2). 17beta-HSD12 expression was also reported in breast carcinomas but its functions have remained unknown. In this study, we examined t...

journal_title：Cancer research

authors： Nagasaki S,Suzuki T,Miki Y,Akahira J,Kitada K,Ishida T,Handa H,Ohuchi N,Sasano H

更新日期：2009-02-15 00:00:00

abstract：:BALB/c mice were hyperimmunized against a membrane preparation derived from a pool of transurethral resection specimens which included three benign prostatic hyperplasia and one prostate adenocarcinoma tissue samples. The activated lymphocytes were fused with the NS-1 mouse myeloma cell line, and supernatants from imm...

journal_title：Cancer research

authors： Starling JJ,Sieg SM,Beckett ML,Wirth PR,Wahab Z,Schellhammer PF,Ladaga LE,Poleskic S,Wright GL Jr

更新日期：1986-01-01 00:00:00

abstract：:The possible mutagenic potential of exposure to 1.5 GHz electromagnetic near field (EMF) was investigated using brain tissues of Big Blue mice (BBM). Male BBM were locally exposed to EMF in the head region at 2.0, 0.67, and 0 W/kg specific absorption rate for 90 min/day, 5 days/week, for 4 weeks. No gliosis or degener...

journal_title：Cancer research

authors： Takahashi S,Inaguma S,Cho YM,Imaida K,Wang J,Fujiwara O,Shirai T

更新日期：2002-04-01 00:00:00

abstract：:Copper plays an essential role in promoting angiogenesis. Tumors that become angiogenic acquire the ability to enter a phase of rapid growth and exhibit increased metastatic potential, the major cause of morbidity in cancer patients. We report that copper deficiency induced by tetrathiomolybdate (TM) significantly imp...

journal_title：Cancer research

authors： Pan Q,Kleer CG,van Golen KL,Irani J,Bottema KM,Bias C,De Carvalho M,Mesri EA,Robins DM,Dick RD,Brewer GJ,Merajver SD

更新日期：2002-09-01 00:00:00

abstract：:Transglutaminase activity was determined in normal and transformed paired cell systems. Reduced enzyme activity was found in virus-transformed human and hamster cells and in chemically transformed mouse cells relative to normal counterparts. Most of the enzyme activity was localized in the particulate fraction sedimen...

journal_title：Cancer research

authors： Birckbichler PJ,Orr GR,Conway E,Patterson MK Jr

更新日期：1977-05-01 00:00:00

abstract：:The rabbit uterine protein, blastokinin, is detectable as an antigen in both male and female genital tract tissues, in preimplantation embryos, and in lungs from late fetal stages, immatures, and adults. Thus, it serves as an example of how an antigen of normal tissue exists in a developmental progression from one gen...

journal_title：Cancer research

authors： Daniel JC Jr,Milazzo JT

更新日期：1976-09-01 00:00:00

abstract：:CD44 is an integral membrane glycoprotein that functions as a receptor for the extracellular matrix glycan, hyaluronan. Here we report that CD44 is a novel biomarker for non-small cell lung tumors, squamous metaplasia of the lung, and activated type II pneumocytes. We have examined the expression of CD44 in 12 human l...

journal_title：Cancer research

authors： Penno MB,August JT,Baylin SB,Mabry M,Linnoila RI,Lee VS,Croteau D,Yang XL,Rosada C

更新日期：1994-03-01 00:00:00

abstract：:The implementation of a number of chemical carcinogen screening programs has been accompanied by the observation that some screens might have high false-positive error rates. With designs presently used at the National Cancer Institute and historical spontaneous tumor rates based upon control animals in previous exper...

journal_title：Cancer research

authors： Fears TR,Tarone RE,Chu KC

更新日期：1977-07-01 00:00:00

abstract：:Multicellular spheroids composed of transformed cells are known to mimic the growth characteristics of tumors and to develop gradients in proliferation with increasing size. This progressive accumulation of quiescent cells is presumably an active process that occurs in response to the microenvironmental stresses that ...

journal_title：Cancer research

authors： LaRue KE,Khalil M,Freyer JP

更新日期：2004-03-01 00:00:00

abstract：:The antitumor activity of IFN-alpha is well established. However, the role of the plasmacytoid dendritic cell (PDC), the major producer of IFN-alpha upon viral infection, in tumor biology is unknown. We sought to study the presence and function of PDC in a human solid tumor. Here, we demonstrate that PDCs infiltrate t...

journal_title：Cancer research

authors： Hartmann E,Wollenberg B,Rothenfusser S,Wagner M,Wellisch D,Mack B,Giese T,Gires O,Endres S,Hartmann G

更新日期：2003-10-01 00:00:00

abstract：:Studies demonstrate that some colon cancers possess receptors for various gastrointestinal hormones or neurotransmitters, the occupation of which can affect growth. These results are limited because frequently only a small number of tumors are studied, only 1 or 2 receptors are sought, and the effect on cell function ...

journal_title：Cancer research

authors： Frucht H,Gazdar AF,Park JA,Oie H,Jensen RT

更新日期：1992-03-01 00:00:00

abstract：:The signaling pathways that mediate the development of pancreatic ductal adenocarcinoma (PDAC) downstream of mutant Kras remain incompletely understood. Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer. Phosphorylation of rpS6 was increased in pancreatic acinar cells ...

journal_title：Cancer research

authors： Khalaileh A,Dreazen A,Khatib A,Apel R,Swisa A,Kidess-Bassir N,Maitra A,Meyuhas O,Dor Y,Zamir G

更新日期：2013-03-15 00:00:00

abstract：:Glucuronidation is an important pathway in the metabolism of nicotine, with previous studies suggesting that ∼22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine gl...

journal_title：Cancer research

authors： Chen G,Giambrone NE Jr,Dluzen DF,Muscat JE,Berg A,Gallagher CJ,Lazarus P

更新日期：2010-10-01 00:00:00

abstract：:LIGHT, a ligand for the lymphotoxin-beta receptor, establishes lymphoid-like tissues inside tumor sites and recruits naïve T cells into the tumor. However, whether these infiltrating T cells are specific for tumor antigens is not known. We hypothesized that therapy with LIGHT can expand functional tumor-specific CD8(+...

journal_title：Cancer research

authors： Kanodia S,Da Silva DM,Karamanukyan T,Bogaert L,Fu YX,Kast WM

更新日期：2010-05-15 00:00:00

abstract：:A consecutive series of 99 untreated patients undergoing radical surgical resection for stage I-IV laryngeal carcinomas has been studied prospectively. Our purpose was to analyze the predictive relevance of proliferative variables studied [proliferating cell nuclear antigen (PCNA) expression, volume-corrected mitotic ...

journal_title：Cancer research

authors： Tomasino RM,Daniele E,Bazan V,Morello V,Tralongo V,Nuara R,Nagar C,Salvato M,Ingria F,Restivo S

更新日期：1995-12-15 00:00:00

abstract：:Melanomas harboring BRAF mutations can be treated with BRAF inhibitors (BRAFi), but responses are varied and tumor recurrence is inevitable. Here we used an integrative approach of experimentation and mathematical flux balance analyses in BRAF-mutated melanoma cells to discover that elevated antioxidant capacity is li...

journal_title：Cancer research

authors： Paudel BB,Lewis JE,Hardeman KN,Hayford CE,Robbins CJ,Stauffer PE,Codreanu SG,Sherrod SD,McLean JA,Kemp ML,Quaranta V

更新日期：2020-10-15 00:00:00

abstract：:Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy. T...

journal_title：Cancer research

authors： Tsai YT,Chuang MJ,Tang SH,Wu ST,Chen YC,Sun GH,Hsiao PW,Huang SM,Lee HJ,Yu CP,Ho JY,Lin HK,Chen MR,Lin CC,Chang SY,Lin VC,Yu DS,Cha TL

更新日期：2015-09-01 00:00:00

abstract：:Hematogenous carcinoma metastasis is supported by aggregated platelets and leukocytes, forming tumor cell emboli. Early tumor cell-platelet interactions can be mediated by P-selectin binding to tumor cell surface ligands and this process is blocked by heparin. We previously showed that L-selectin deficiency also atten...

journal_title：Cancer research

authors： Läubli H,Stevenson JL,Varki A,Varki NM,Borsig L

更新日期：2006-02-01 00:00:00

abstract：:Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. We previously reported the discovery of ABT-737, a potent, small-molecule Bcl-2 family protein inhibitor. A major limitation of ABT-737 is that it is not or...

journal_title：Cancer research

authors： Tse C,Shoemaker AR,Adickes J,Anderson MG,Chen J,Jin S,Johnson EF,Marsh KC,Mitten MJ,Nimmer P,Roberts L,Tahir SK,Xiao Y,Yang X,Zhang H,Fesik S,Rosenberg SH,Elmore SW

更新日期：2008-05-01 00:00:00

abstract：:Neuroblastoma is a neural crest-derived embryonal malignancy, which accounts for 13% of all pediatric cancer mortality, primarily due to tumor recurrence. Therapy-resistant cancer stem cells are implicated in tumor relapse, but definitive phenotypic evidence of the existence of these cells has been lacking. In this st...

journal_title：Cancer research

authors： Hsu DM,Agarwal S,Benham A,Coarfa C,Trahan DN,Chen Z,Stowers PN,Courtney AN,Lakoma A,Barbieri E,Metelitsa LS,Gunaratne P,Kim ES,Shohet JM

更新日期：2013-07-01 00:00:00

abstract：:A molecular target associated with the progression of gastric cancer has not yet been uncovered. FBXW7 is a tumor suppressor gene transcriptionally controlled by p53 that plays a role in the regulation of cell cycle exit and reentry via c-Myc degradation. Few studies have addressed the clinical significance of FBXW7 e...

journal_title：Cancer research

authors： Yokobori T,Mimori K,Iwatsuki M,Ishii H,Onoyama I,Fukagawa T,Kuwano H,Nakayama KI,Mori M

更新日期：2009-05-01 00:00:00

abstract：:Cellular motility is a critical function in embryonic development, tissue repair, and tumor invasion. We used assays of scattering (epithelial colony dispersion), cell migration, and cell invasion to study cytokine-regulated motility in epithelial and carcinoma cell lines. Tumor necrosis factor (TNF) stimulated motili...

journal_title：Cancer research

authors： Rosen EM,Goldberg ID,Liu D,Setter E,Donovan MA,Bhargava M,Reiss M,Kacinski BM

更新日期：1991-10-01 00:00:00

abstract：:We investigated the prognostic value of p53 mutation type for 145 soft tissue sarcoma patients. In a PCR-SSCP-sequencing analysis, 15 mutations were identified: 10 non-frameshift (non-fs) and 5 frameshift (fs) mutations. Patients possessing non-fs mutations had a significantly poorer prognosis than patients without p5...

journal_title：Cancer research

authors： Taubert H,Meye A,Würl P

更新日期：1996-09-15 00:00:00

abstract：:The conditions for growing preneoplastic mammary epithelial cells in primary cell cultures with serum-free factor-defined medium were established in a series of experiments. The cells, grown in Dulbecco's modified Eagle's medium with 0.6 mM Ca2+, epidermal growth factor, transferrin, insulin, and Na2SeO3, were fibrobl...

journal_title：Cancer research

authors： Medina D,Oborn CJ

更新日期：1980-11-01 00:00:00