Genomic and Epigenomic Signatures in Ovarian Cancer Associated with Resensitization to Platinum Drugs.

abstract：:Previous studies have shown that among populations with a high rate of consanguinity, there is a significant increase in the prevalence of cancer. Single nucleotide polymorphism (SNP) array data (Affymetrix, 50K XbaI) analysis revealed long regions of homozygosity in genomic DNAs taken from tumor and matched normal ti...

journal_title：Cancer research

authors： Bacolod MD,Schemmann GS,Wang S,Shattock R,Giardina SF,Zeng Z,Shia J,Stengel RF,Gerry N,Hoh J,Kirchhoff T,Gold B,Christman MF,Offit K,Gerald WL,Notterman DA,Ott J,Paty PB,Barany F

更新日期：2008-04-15 00:00:00

abstract：:The rate of tumor growth in vivo in adult rats (250- to 350-g total body weight) is stimulated during an acute fast. No tumor growth stimulation is observed in fasted immature rats (less than about 200-g total body weight). The different tumor growth responses in rats of these two age groups appear to depend on the in...

journal_title：Cancer research

authors： Sauer LA,Dauchy RT

更新日期：1987-02-15 00:00:00

abstract：:A novel putative tumor suppressor gene and member of the NF2/ERM/ 4.1 superfamily was isolated using Differential Display PCR (DDPCR) on primary lung tumors. When reintroduced into nonexpressing non-small cell lung carcinoma cell lines, this gene, named DAL-1 (for Differentially expressed in Adenocarcinoma of the Lung...

journal_title：Cancer research

authors： Tran YK,Bögler O,Gorse KM,Wieland I,Green MR,Newsham IF

更新日期：1999-01-01 00:00:00

abstract：:Two newly synthesized nitrosoureido sugars have been evaluated for their antitumor activity and diabetogenic potential in a number of in vitro and in vivo preclinical tumor model systems. 2-Amino-2-deoxy-N'-methyl-N'-nitrosoureido-1,3,4,6-tetra-O-acetyl-alpha- D- mannopyranose (MAZ), a lipophilic mannosamine derivativ...

journal_title：Cancer research

authors： Bernacki RJ,Wilson GL,Mossman BT,Angelino N,Kanter PM,Korytnyk W

更新日期：1985-02-01 00:00:00

abstract：:p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate a G1 checkpoint, which allows time for DNA repair before S phase entry. By inhibiting cell cycle progression, p21(Cip1) potentially suppresses tumorigenesis, an...

journal_title：Cancer research

authors： Jackson RJ,Engelman RW,Coppola D,Cantor AB,Wharton W,Pledger WJ

更新日期：2003-06-15 00:00:00

abstract：:Telomerase is a ribonucleoprotein that synthesizes telomeric DNA on chromosomal ends. Telomerase activation has been seen in many immortal cell lines and cancers. Telomerase activity was analyzed in prostate carcinoma; in coexistent prostatic intraepithelial neoplasia (PIN), benign prostatic hyperplasia (BPH), atrophy...

journal_title：Cancer research

authors： Zhang W,Kapusta LR,Slingerland JM,Klotz LH

更新日期：1998-02-15 00:00:00

abstract：:We have found that the synthetic compound CC-5079 potently inhibits cancer cell growth in vitro and in vivo by a novel combination of molecular mechanisms. CC-5079 inhibits proliferation of cancer cell lines from various organs and tissues at nanomolar concentrations. Its IC(50) value ranges from 4.1 to 50 nmol/L. The...

journal_title：Cancer research

authors： Zhang LH,Wu L,Raymon HK,Chen RS,Corral L,Shirley MA,Narla RK,Gamez J,Muller GW,Stirling DI,Bartlett JB,Schafer PH,Payvandi F

更新日期：2006-01-15 00:00:00

abstract：:We investigated the effect of iododeoxyuridine (IdUrd) exposure on cis-diamminedichloroplatinum (CDDP) cytotoxicity in the human bladder cancer cell line 647V. Following a 48-h incubation with 2-20 microM IdUrd, a 1-h exposure to 0-120 microM CDDP produced a dose-dependent increase in CDDP cytotoxicity as measured by ...

journal_title：Cancer research

authors： Chi KH,Kunugi KA,Kinsella TJ

更新日期：1994-05-15 00:00:00

abstract：:We have studied the sensitivities of four hematopoietic stem cell types to heat stress as well as their abilities to develop thermotolerance. Granulocyte-macrophage colony forming units were the most heat resistant bone marrow progenitors tested. Of the erythroid progenitors tested, erythrocyte colony forming units we...

journal_title：Cancer research

authors： Mivechi NF,Li GC

更新日期：1986-01-01 00:00:00

abstract：:The difficulty to dissect a complex phenotype of established malignant cells to several critical transcriptional programs greatly impedes our understanding of the malignant transformation. The genetic elements required to transform some primary human cells to a tumorigenic state were described in several recent studie...

journal_title：Cancer research

authors： Milyavsky M,Tabach Y,Shats I,Erez N,Cohen Y,Tang X,Kalis M,Kogan I,Buganim Y,Goldfinger N,Ginsberg D,Harris CC,Domany E,Rotter V

更新日期：2005-06-01 00:00:00

abstract：:Fusion proteins consisting of the extracellular region of murine B7.1 or B7.2 and the Fc portion of murine IgG2a (B7-IgG) were evaluated for their ability to promote antitumor responses. Therapeutic administration of soluble B7-IgG in mice with established tumors induced complete regression of the tumor and increased ...

journal_title：Cancer research

authors： Sturmhoefel K,Lee K,Gray GS,Thomas J,Zollner R,O'Toole M,Swiniarski H,Dorner A,Wolf SF

更新日期：1999-10-01 00:00:00

abstract：:Recent studies indicate that ovarian cancer may be highly responsive to antivascular therapeutics. We have developed an antivascular tumor therapeutic using the F3 peptide to target cisplatin-loaded nanoparticles (F3-Cis-Np) to tumor vessels. We show that although F3-Cis-Np bind with high specificity to both human ova...

journal_title：Cancer research

authors： Winer I,Wang S,Lee YE,Fan W,Gong Y,Burgos-Ojeda D,Spahlinger G,Kopelman R,Buckanovich RJ

更新日期：2010-11-01 00:00:00

abstract：:Normal human cells can be transformed to anchorage-independent growth by transfection with DNA from MOLT-4 lymphoblasts, derived from a patient with acute lymphocytic leukemia. Cells were treated with polyethylene glycol 6000, and DNA was administered as a calcium phosphate coprecipitate . The transforming activity of...

journal_title：Cancer research

authors： Sutherland BM,Bennett PV

更新日期：1984-07-01 00:00:00

abstract：:Estrogen-related receptor alpha (ERRalpha) was identified as a gene related to estrogen receptor alpha (ERalpha) and belongs to a class of nuclear orphan receptors. ERRalpha binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significa...

journal_title：Cancer research

authors： Suzuki T,Miki Y,Moriya T,Shimada N,Ishida T,Hirakawa H,Ohuchi N,Sasano H

更新日期：2004-07-01 00:00:00

abstract：:Elevated expression of Bmi-1 is associated with many cancers, including breast cancer. Here, we examined the oncogenic potential of Bmi-1 in MCF10A cells, a spontaneously immortalized, nontransformed strain of human mammary epithelial cells (HMEC). Bmi-1 overexpression alone in MCF10A cells did not result in oncogenic...

journal_title：Cancer research

authors： Datta S,Hoenerhoff MJ,Bommi P,Sainger R,Guo WJ,Dimri M,Band H,Band V,Green JE,Dimri GP

更新日期：2007-11-01 00:00:00

abstract：:Estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to inactive estrogen sulfates, whereas steroid sulfatase (STS) hydrolyzes estrone sulfate to estrone. Both EST and STS have been suggested to play important roles in regulating the in situ production of estrogens in human breast carcinoma tissu...

journal_title：Cancer research

authors： Suzuki T,Nakata T,Miki Y,Kaneko C,Moriya T,Ishida T,Akinaga S,Hirakawa H,Kimura M,Sasano H

更新日期：2003-06-01 00:00:00

abstract：:Noscapine, a benzylisoquinoline alkaloid derived from opium, was recently reported to exhibit activity against a variety of cancers through a poorly understood mechanism. Because the transcription factor NF-kappaB has been linked with inflammation, survival, proliferation, invasion, and angiogenesis in tumors, we hypo...

journal_title：Cancer research

authors： Sung B,Ahn KS,Aggarwal BB

更新日期：2010-04-15 00:00:00

abstract：:In the present study, we examined the presence of deacetylases capable of producing free hexosamines, which we have shown earlier to be immunosuppressive against human natural killer (NK) cell-mediated cytotoxicity, from N-acetylhexosamines in human tumor cells. When human NK-resistant colon cancer cells (Colo-320DM) ...

journal_title：Cancer research

authors： Yagita M,Seppo A,Renkonen O,Saksela E

更新日期：1993-12-01 00:00:00

abstract：:hsa-mir-483 is located within intron 2 of the IGF2 locus. We found that the mature microRNA (miRNA) miR-483-3p is overexpressed in 100% of Wilms' tumors. In addition, colon, breast, and liver cancers exhibit high or even extremely high levels of miR-483-3p in approximately 30% of the cases. A coregulation with IGF2 mR...

journal_title：Cancer research

authors： Veronese A,Lupini L,Consiglio J,Visone R,Ferracin M,Fornari F,Zanesi N,Alder H,D'Elia G,Gramantieri L,Bolondi L,Lanza G,Querzoli P,Angioni A,Croce CM,Negrini M

更新日期：2010-04-15 00:00:00

abstract：:A two site enzyme immunoassay which quantitatively identifies types I, II, and III of protein kinase C isozymes has been designed. The soluble protein kinase C isozymes were selectively immobilized by type-specific monoclonal antibodies, MC-1a, -2a, and -3a (H. Hidaka et al., J Biol. Chem., 263: 4523-4526, 1988) which...

journal_title：Cancer research

authors： Hagiwara M,Hachiya T,Watanabe M,Usuda N,Iida F,Tamai K,Hidaka H

更新日期：1990-09-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis of transformed and cancer cells but not of most normal cells. Recent studies have revealed an unforeseen toxicity of TRAIL toward normal human hepatocytes, thereby bringing into question the safety of systemic administrati...

journal_title：Cancer research

authors： Ozoren N,Kim K,Burns TF,Dicker DT,Moscioni AD,El-Deiry WS

更新日期：2000-11-15 00:00:00

abstract：:Despite the apparent similarity of the dexamethasone-receptor concentration in the rat liver and Novikoff hepatoma cytoplasms, the in vitro translocation of the dexamethasone-receptor complex into liver or hepatoma nuclei was three times greater from liver as compared to hepatoma cytosol; both cytosols showed an appar...

journal_title：Cancer research

authors： Liu SL,Webb TE

更新日期：1977-06-01 00:00:00

abstract：:We have applied Raman spectroscopy to analyze the chemical composition of microcalcifications occurring in benign and malignant lesions in the human breast. Microcalcifications were initially separated into two categories based on their Raman spectrum: type I, calcium oxalate dihydrate, and type II, calcium hydroxyapa...

journal_title：Cancer research

authors： Haka AS,Shafer-Peltier KE,Fitzmaurice M,Crowe J,Dasari RR,Feld MS

更新日期：2002-09-15 00:00:00

abstract：:Previous studies from our laboratories have shown that carcinogenic peroxisome proliferators significantly increase the mRNA levels of peroxisomal beta-oxidation genes in the rat liver by enhancing the transcriptional activity. Because of a good correlation between the inducibility of peroxisome proliferation and carc...

journal_title：Cancer research

authors： Nemali MR,Usuda N,Reddy MK,Oyasu K,Hashimoto T,Osumi T,Rao MS,Reddy JK

更新日期：1988-09-15 00:00:00

abstract：:Busulfan, a bifunctional alkylating agent, is a mainstay of myeloablative preparative regimens before hematopoietic stem cell transplantation. The apparent oral clearance of busulfan expressed relative to body surface area is 2-3-fold higher in children 1-4 years old than it is in adults. The first step in busulfan el...

journal_title：Cancer research

authors： Gibbs JP,Murray G,Risler L,Chien JY,Dev R,Slattery JT

更新日期：1997-12-15 00:00:00

abstract：:A metastatic renal cell carcinoma (RCC) tumor model xenograft that expresses the targetable, membrane-bound tumor-associated antigen carbonic anhydrase type 9 (CA IX) is described. The xenograft, established from a high-grade type-2 chromophil RCC (cRCC), has been serially transplanted in immune compromised mice, in w...

journal_title：Cancer research

authors： Zisman A,Pantuck AJ,Bui MH,Said JW,Caliliw RR,Rao N,Shintaku P,Berger F,Gambhir SS,Belldegrun AS

更新日期：2003-08-15 00:00:00

abstract：:9-beta-D-Arabinofuranosyladenine (ara-A) is an inhibitor of DNA replication with antitumor and antiviral activity. The molecular basis for this inhibitory effect has remained unclear. The present work has examined the effects of 9-beta-D-arabinofuranosyladenine-triphosphate on DNA polymerase-beta. These studies were p...

journal_title：Cancer research

authors： Ohno Y,Spriggs D,Matsukage A,Ohno T,Kufe D

更新日期：1989-04-15 00:00:00

abstract：:Deletion of endoplasmic reticulum resident chaperone Grp78 results in activation of the unfolded protein response and causes rapid depletion of the entire intestinal epithelium. Whether modest reduction of Grp78 may affect stem cell fate without compromising intestinal integrity remains unknown. Here, we employ a mode...

journal_title：Cancer research

authors： van Lidth de Jeude JF,Spaan CN,Meijer BJ,Smit WL,Soeratram TTD,Wielenga MCB,Westendorp BF,Lee AS,Meisner S,Vermeulen JLM,Wildenberg ME,van den Brink GR,Muncan V,Heijmans J

更新日期：2018-11-01 00:00:00

abstract：:Ataxia-telangiectasia (A-T) is a human disease characterized by high cancer risk, immune defects, radiation sensitivity, and genetic instability. Although A-T homozygotes are rare, the A-T gene may play a role in sporadic breast cancer and other common cancers. Abnormalities of DNA repair, genetic recombination, chrom...

journal_title：Cancer research

authors： Meyn MS

更新日期：1995-12-15 00:00:00

abstract：:Mutations in the p53 gene were identified in five of eight non-melanoma skin tumors in the sun-exposed areas of xeroderma pigmentosum patients by the polymerase chain reaction and single strand conformation polymorphism analysis followed by sequencing of the DNA. All mutations occurred at the dipyrimidine sites, indic...

journal_title：Cancer research

authors： Sato M,Nishigori C,Zghal M,Yagi T,Takebe H

更新日期：1993-07-01 00:00:00