Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

abstract：:Strategies for the prevention of cancer include those aimed at reducing the incidence of cancer (primary prevention) and cancer mortality through early detection of tumors (secondary prevention). The efficacy of prevention interventions is evaluated by clinical trials. The conduct of clinical trials is aided by the us...

journal_title：Cancer research

authors： Helzlsouer KJ

更新日期：1994-04-01 00:00:00

abstract：:In an attempt to approach the mechanism by which estrogen and antiestrogen regulate the growth of estrogen receptor-positive breast cancer, we have studied the effects of the antiestrogens tamoxifen (TAM) and 4-hydroxytamoxifen (OH-TAM) on the induction of two estrogen-specific proteins in a variant of MCF7 cells term...

journal_title：Cancer research

authors： Vignon F,Lippman ME,Nawata H,Derocq D,Rochefort H

更新日期：1984-05-01 00:00:00

abstract：:We tried to purify carcinoembryonic antigen (CEA)-related antigens in normal human feces and found that, besides nonspecific cross-reacting antigen (fecal NCA), there are three other molecular species of CEA-related antigens which have been inclusively called normal fecal antigen (NFA). These were designated normal fe...

journal_title：Cancer research

authors： Kuroki M,Koga Y,Matsuoka Y

更新日期：1981-02-01 00:00:00

abstract：:Accumulating evidence suggests important roles for the receptor tyrosine kinase Axl in cancer progression, invasion, metastasis, drug resistance, and patient mortality, highlighting Axl as an attractive target for therapeutic development. We have generated and characterized a potent and selective small-molecule inhibi...

journal_title：Cancer research

authors： Holland SJ,Pan A,Franci C,Hu Y,Chang B,Li W,Duan M,Torneros A,Yu J,Heckrodt TJ,Zhang J,Ding P,Apatira A,Chua J,Brandt R,Pine P,Goff D,Singh R,Payan DG,Hitoshi Y

更新日期：2010-02-15 00:00:00

abstract：:Several studies have shown that neuroblastoma and retinoblastoma tumor cells often have elevated N-myc mRNA levels compared to normal adult neuronal or retinal tissues, and it has been suggested that increased expression of this protooncogene may play an important role in tumorigenesis or malignant progression in cell...

journal_title：Cancer research

authors： Amy CM,Bartholomew JC

更新日期：1987-12-01 00:00:00

abstract：:Male Sprague-Dawley rats were given weekly s.c. injections of 1,2-dimethylhydrazine (21 mg/kg) for 20 weeks. The injections were then discontinued, and, after an interval of 2 to 8 weeks, experimental animals were given i.p. injections of 5,6-dihydroxytryptamine (5,6DHT) at a dose of 40 mg/kg and sacrificed at interva...

journal_title：Cancer research

authors： Tutton PJ,Barkla DH

更新日期：1977-04-01 00:00:00

abstract：:IgG monoclonal antibodies have made significant contributions to cancer therapy, but suffer from several limitations that restrict their effectiveness in unleashing host immune system components against tumors. The development of monoclonal antibodies of an alternative class, namely IgE, may offer enhanced immune surv...

journal_title：Cancer research

authors： Karagiannis SN,Josephs DH,Bax HJ,Spicer JF

更新日期：2017-06-01 00:00:00

abstract：:Carcinomas of the exocrine pancreas are poorly understood and have a poor prognosis because of their highly malignant nature. Using two human pancreatic cancer cell lines, AsPc-1 and Capan-2, we have investigated avenues that might be useful in targeting the delivery of antineoplastic agents to such cancers. Qualitati...

journal_title：Cancer research

authors： Gonzalez DE,Covitz KM,Sadée W,Mrsny RJ

更新日期：1998-02-01 00:00:00

abstract：:Chinese hamster ovary cells were exposed to the sulfhydryl compound cysteamine at different temperatures (5 degrees C, 37 degrees C, 44 degrees C) at concentrations known to generate activated oxygen species. At 37 degrees C, the cellular glutathione (GSH) content increased linearly over the time of drug exposure (2 h...

journal_title：Cancer research

authors： Issels RD,Bourier S,Biaglow JE,Gerweck LE,Wilmanns W

更新日期：1985-12-01 00:00:00

abstract：:The interaction of hypoxia-inducible factor 1alpha and the CH1 domain of the transcriptional coactivator p300/CBP is necessary for the expression of hypoxia responsive genes and tumor angiogenesis. The transcription factor CITED2 binds p300/CBP at the CH1 domain and functions as a negative regulator of hypoxia signali...

journal_title：Cancer research

authors： Fox SB,Bragança J,Turley H,Campo L,Han C,Gatter KC,Bhattacharya S,Harris AL

更新日期：2004-09-01 00:00:00

abstract：:Prostate cancer is the most commonly diagnosed noncutaneous neoplasm and second most common cause of cancer-related mortality in western men. To investigate the mechanisms of prostate cancer development and progression, we did expression profiling of human prostate cancer and benign tissues. We show that the SOX4 is o...

journal_title：Cancer research

authors： Liu P,Ramachandran S,Ali Seyed M,Scharer CD,Laycock N,Dalton WB,Williams H,Karanam S,Datta MW,Jaye DL,Moreno CS

更新日期：2006-04-15 00:00:00

abstract：:The ability of the bovine C-type leukemia virus to induce syncytia formation in monolayer cell cultures has been used to develop a specific and simple infectivity assay for the virus. Using bovine embryonic spleen cells or human diploid embryonic lung cells as indicator cells, the results of the assay can be evaluated...

journal_title：Cancer research

authors： Ferrer JF,Diglio CA

更新日期：1976-03-01 00:00:00

abstract：:The effect of hydrocortisone on blood-borne tumor metastasis was studied in an i.v. inoculation experiment with Ehrlich hypotetraploid clone 1, Ehrlich hypotetraploid stock, and Ehrlich hyperdiploid stock tumors. The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced me...

journal_title：Cancer research

authors： Kodama M,Kodama T

更新日期：1975-04-01 00:00:00

abstract：:Systemic chemotherapy generally has been considered immunosuppressive, but it has become evident that certain chemotherapeutic drugs elicit immunogenic danger signals in dying cancer cells that can incite protective antitumor immunity. In this study, we investigated whether locoregionally applied therapies, such as me...

journal_title：Cancer research

authors： Dudek-Perić AM,Ferreira GB,Muchowicz A,Wouters J,Prada N,Martin S,Kiviluoto S,Winiarska M,Boon L,Mathieu C,van den Oord J,Stas M,Gougeon ML,Golab J,Garg AD,Agostinis P

更新日期：2015-04-15 00:00:00

abstract：:Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes. In this study, we showed frequent overexpression of OATP1B3 in colorectal adenocarcinomas. Quantitative reverse transcription-PCR analysis of 17 colon tumors indicated tumoral overexpression of OATP1B3 by approximately ...

journal_title：Cancer research

authors： Lee W,Belkhiri A,Lockhart AC,Merchant N,Glaeser H,Harris EI,Washington MK,Brunt EM,Zaika A,Kim RB,El-Rifai W

更新日期：2008-12-15 00:00:00

abstract：:Thyroid-stimulating hormone (TSH) has long been recognized as the major proliferative and functional stimulus for thyroid follicular cells. TSH receptor (TSHR) engagement stimulates the production of cyclic AMP and the subsequent activation of downstream effector molecules, including protein kinase A, S6K1, and Rap1, ...

journal_title：Cancer research

authors： Brewer C,Yeager N,Di Cristofano A

更新日期：2007-09-01 00:00:00

abstract：:The presence of a valine (V) versus a phenylanaline (F) at position 158 of Fc gamma RIIIa/CD16a improves the affinity for IgG and is associated with higher therapeutic response to rituximab. Increased CD16 expression on natural killer (NK) cells from donors with the VV or VF versus FF genotype has recently been report...

journal_title：Cancer research

authors： Congy-Jolivet N,Bolzec A,Ternant D,Ohresser M,Watier H,Thibault G

更新日期：2008-02-15 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA) is highly expressed by both normal and malignant prostate epithelial cells and by the neovasculature of many tumor types; however, it is not expressed by normal endothelial cells or other normal tissues. PSMA, therefore, represents an attractive candidate for selectively targe...

journal_title：Cancer research

authors： Aggarwal S,Singh P,Topaloglu O,Isaacs JT,Denmeade SR

更新日期：2006-09-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers largely due to disseminated disease at the time of presentation. Here, we investigated the role and mechanism of action of the metastasis-associated protein anterior gradient 2 (AGR2) in the pathogenesis of pancreatic cancer. AGR2 was induc...

journal_title：Cancer research

authors： Dumartin L,Whiteman HJ,Weeks ME,Hariharan D,Dmitrovic B,Iacobuzio-Donahue CA,Brentnall TA,Bronner MP,Feakins RM,Timms JF,Brennan C,Lemoine NR,Crnogorac-Jurcevic T

更新日期：2011-11-15 00:00:00

abstract：:Myc transcriptional activity is frequently deregulated in human cancers, but a Myc-driven gene signature with prognostic ability across multiple tumor types remains lacking. Here, we selected 18 Myc-regulated genes from published studies of Myc family targets in epithelial ovarian cancer (EOC) and neuroblastoma. A Myc...

journal_title：Cancer research

authors： Jung M,Russell AJ,Liu B,George J,Liu PY,Liu T,DeFazio A,Bowtell DD,Oberthuer A,London WB,Fletcher JI,Haber M,Norris MD,Henderson MJ

更新日期：2017-02-15 00:00:00

abstract：:Immunostimulatory CpG oligodeoxynucleotides (ODNs) can enhance the therapeutic effect of monoclonal antibodies (mAbs) by enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Distinct classes of CpG ODNs have been found recently to stimulate different effector cell populations. We used murine cancer models t...

journal_title：Cancer research

authors： van Ojik HH,Bevaart L,Dahle CE,Bakker A,Jansen MJ,van Vugt MJ,van de Winkel JG,Weiner GJ

更新日期：2003-09-01 00:00:00

abstract：:Previous studies from our laboratory have shown that the activation of G(2)-M checkpoint after exposure of MCF-7 breast cancer cells to gamma-irradiation (IR) is dependent on the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. Studies presented in this report indicate that IR exposure of MC...

journal_title：Cancer research

authors： Yan Y,Black CP,Cao PT,Haferbier JL,Kolb RH,Spieker RS,Ristow AM,Cowan KH

更新日期：2008-07-01 00:00:00

abstract：:Interleukin 4 (IL-4) receptors were detected by a monoclonal antibody on tumor cells of 10 of 29 squamous cell carcinomas and 6 of 17 adenocarcinomas of the lung. None of the small cell carcinomas or carcinoid tumors stained. Parallel sections stained for epidermal growth factor receptors showed that all but 2 of the ...

journal_title：Cancer research

authors： Tungekar MF,Turley H,Dunnill MS,Gatter KC,Ritter MA,Harris AL

更新日期：1991-01-01 00:00:00

abstract：:The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B have emerged as key mutation drivers in cancer. Here, we show that APOBEC3A and APOBEC3B activities impose a unique type of replication stress by inducing abasic sites at replication forks. In contrast to cells under other types ...

journal_title：Cancer research

authors： Buisson R,Lawrence MS,Benes CH,Zou L

更新日期：2017-09-01 00:00:00

abstract：:Iodine-131-labeled anti-CD45 antibody has been added to conventional hematopoietic stem cell transplant preparative regimens to deliver targeted radiation to hematopoietic tissues, with the goal of decreasing relapse rates without increasing toxicity. However, higher radiation doses could be delivered to leukemia cell...

journal_title：Cancer research

authors： Ruffner KL,Martin PJ,Hussell S,Nourigat C,Fisher DR,Bernstein ID,Matthews DC

更新日期：2001-07-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is characterized by a pathogenic vasculature that drives aggressive local invasion. Recent work suggests that GBM cells recruit bone marrow-derived progenitor cells (BMDC) to facilitate recurrence after radiotherapy, but how this may be achieved is unclear. In this study, we established t...

journal_title：Cancer research

authors： Burrell K,Singh S,Jalali S,Hill RP,Zadeh G

更新日期：2014-07-15 00:00:00

abstract：:Members of the INK4 family of cyclin-dependent kinase (CDK) inhibitors specifically bind and inhibit the G1-specific CDK molecules CDK4 and CDK6. One of the INK4 molecules, p16, is also known as multiple tumor suppressor and has been found to be mutated or deleted in various tumors and cell lines. We have previously i...

journal_title：Cancer research

authors： Noh SJ,Li Y,Xiong Y,Guan KL

更新日期：1999-02-01 00:00:00

abstract：:The zinc finger gene MZF-1 is preferentially expressed in primitive hematopoietic cells and plays an important role in regulating myelopoiesis. Regulators of development are potential targets for neoplastic transformation. This study investigated whether unregulated expression of MZF-1 could function as an oncogene. R...

journal_title：Cancer research

authors： Hromas R,Morris J,Cornetta K,Berebitsky D,Davidson A,Sha M,Sledge G,Rauscher F 3rd

更新日期：1995-08-15 00:00:00

abstract：:Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took advantage of the ability of the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside to increase the intracellular levels of AICA ribotide, an ...

journal_title：Cancer research

authors： Swinnen JV,Beckers A,Brusselmans K,Organe S,Segers J,Timmermans L,Vanderhoydonc F,Deboel L,Derua R,Waelkens E,De Schrijver E,Van de Sande T,Noël A,Foufelle F,Verhoeven G

更新日期：2005-03-15 00:00:00

abstract：:Dog and rat animal models have been developed for repeated intravascular administrations to the liver. However, mice have generally been considered too small to use for these models. This study describes the development of mouse models that permit the establishment of liver metastases that can be subsequently treated ...

journal_title：Cancer research

authors： Kasuya H,Kuruppu DK,Donahue JM,Choi EW,Kawasaki H,Tanabe KK

更新日期：2005-05-01 00:00:00