Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT.

abstract：:Neuroblastomas are extremely aggressive, although heterogeneous, cancers with a poor prognosis upon metastasis. Some evidence has suggested a correlative silencing of caspase-8 with MYCN amplification in neuroblastoma. A prognostic effect of this silencing, however, has been disputed. We report here hitherto undescrib...

journal_title：Cancer research

authors： Finlay D,Vuori K

更新日期：2007-12-15 00:00:00

abstract：:In an attempt to identify phytochemicals contributing to the well-documented preventive effect of plant-based diets on cancer incidence and mortality, we have previously shown that certain flavonoids inhibit in vitro angiogenesis. Here, we show that the flavonoid luteolin inhibited tumor growth and angiogenesis in a m...

journal_title：Cancer research

authors： Bagli E,Stefaniotou M,Morbidelli L,Ziche M,Psillas K,Murphy C,Fotsis T

更新日期：2004-11-01 00:00:00

abstract：:The Siah (seven in absentia homolog) family of RING-domain proteins are components of ubiquitin ligase complexes, targeting proteins for proteasomal degradation. Siah family members have been reported to function in Ras, estrogen, DNA-damage, and hypoxia response pathways. Although earlier reports implicated Siah prot...

journal_title：Cancer research

authors： House CM,Möller A,Bowtell DD

更新日期：2009-12-01 00:00:00

abstract：:The importance of bystander effects is becoming more appreciated, as studies show they may affect the course of cancer and other chronic diseases. The term "bystander effects" refers to changes in naïve cells sharing the same milieu with cells that have been damaged. Bystander cells may be in contact with, or distant ...

journal_title：Cancer research

authors： Martin OA,Redon CE,Nakamura AJ,Dickey JS,Georgakilas AG,Bonner WM

更新日期：2011-05-15 00:00:00

abstract：:Aberrant methylation of promoter CpG islands (CGI) is involved in silencing of tumor suppressor genes and is also a potential cancer biomarker. Here, to identify CGIs aberrantly methylated in human melanomas, we did a genome-wide search using methylation-sensitive representational difference analysis. CGIs in putative...

journal_title：Cancer research

authors： Furuta J,Nobeyama Y,Umebayashi Y,Otsuka F,Kikuchi K,Ushijima T

更新日期：2006-06-15 00:00:00

abstract：:Noninvasive, nonmetastatic BW5147 T-lymphoma cells were transfected with the activated human c-Ha-ras oncogene and were examined subsequently for the acquisition of invasive properties in vitro and of metastatic potential in vivo. It was found that several transfectants harboring the ras gene had become invasive in vi...

journal_title：Cancer research

authors： Collard JG,Schijven JF,Roos E

更新日期：1987-02-01 00:00:00

abstract：:The chemotherapeutic effect of B859-35, the (-)-enantiomer of dihydropyrine 3-methyl-5-3-(4,4-diphenyl-1-piperidinyl)-propyl-1,4-dihydro-2,6-dimethy l-4- (3-nitrophenyl)-pyridine-3,5-dicarboxylate-hydrochloride (niguldipine), was tested on tumors induced in Syrian golden hamsters by N-nitrosodiethylamine (DEN). Periph...

journal_title：Cancer research

authors： Schuller HM,Correa E,Orloff M,Reznik GK

更新日期：1990-03-01 00:00:00

abstract：:A widely held tenet of present day oncology is that tumor cells treated with anticancer agents die from apoptosis, and that cells resistant to apoptosis are resistant to cancer treatment. We suggest, in this review, that this tenet may need to be reexamined for human tumors of nonhematological origin, for two principa...

journal_title：Cancer research

authors： Brown JM,Wouters BG

更新日期：1999-04-01 00:00:00

abstract：:Patients with longstanding extensive ulcerative colitis have an increased risk of developing colorectal cancer (CRC). There are significant differences in the early pathogenesis of colitis-associated tumors compared with common CRC, whereas the frequency, degree, and significance of microsatellite instability (MSI) as...

journal_title：Cancer research

authors： Kohonen-Corish MR,Daniel JJ,te Riele H,Buffinton GD,Dahlstrom JE

更新日期：2002-04-01 00:00:00

abstract：:Cholangiocarcinoma is a strongly aggressive malignancy with a very poor prognosis. Effective therapeutic strategies are lacking because molecular mechanisms regulating cholangiocarcinoma cell growth are unknown. Furthermore, experimental in vivo animal models useful to study the pathophysiologic mechanisms of malignan...

journal_title：Cancer research

authors： Fava G,Alpini G,Rychlicki C,Saccomanno S,DeMorrow S,Trozzi L,Candelaresi C,Venter J,Di Sario A,Marzioni M,Bearzi I,Glaser S,Alvaro D,Marucci L,Francis H,Svegliati-Baroni G,Benedetti A

更新日期：2008-08-15 00:00:00

abstract：:TGF-β has limited effects on ovarian cancer cells, but its contributions to ovarian tumor growth might be mediated through elements of the tumor microenvironment. In the present study, we tested the hypothesis that TGF modulates ovarian cancer progression by modulating the contribution of cancer-associated fibroblasts...

journal_title：Cancer research

authors： Yeung TL,Leung CS,Wong KK,Samimi G,Thompson MS,Liu J,Zaid TM,Ghosh S,Birrer MJ,Mok SC

更新日期：2013-08-15 00:00:00

abstract：:Isolated mitochondria from highly glycolytic Ehrlich and AS30-D tumor cells have a 12.4- and a 2.3-fold higher cholesterol level, respectively, than that of rat liver mitochondria. The passive proton permeability of Ehrlich and AS30-D tumor inner membrane mitochondria is, respectively, 4- and 1.4-fold lower than that ...

journal_title：Cancer research

authors： Baggetto LG,Clottes E,Vial C

更新日期：1992-09-15 00:00:00

abstract：:An assay using a bimane derivative has been developed to detect free glutathione (GSH) in individual viable cells by flow cytometry. Monochlorobimane [syn-(ClCH2CH3)-1,5-diazabicycla[3.30]acta-3,6-diene-2,8-dio ne], itself nonfluorescent, reacts with GSH to form a highly fluorescent derivative. High pressure liquid ch...

journal_title：Cancer research

authors： Rice GC,Bump EA,Shrieve DC,Lee W,Kovacs M

更新日期：1986-12-01 00:00:00

abstract：:The epidermal growth factor (EGF) receptor in two colon carcinoma lines and in one vulval carcinoma line tested contains carbohydrate determinants that are recognized by monoclonal antibodies to tumor-associated antigens. These antibodies are directed to sialylated Lea and to difucosylated structures of the Y type. Ce...

journal_title：Cancer research

authors： Basu A,Murthy U,Rodeck U,Herlyn M,Mattes L,Das M

更新日期：1987-05-15 00:00:00

abstract：:We show here that PRL-3 protein is expressed in fetal heart, developing blood vessels, and pre-erythrocytes but not in their mature counterparts. These observations imply that PRL-3 may be involved in the early development of the circulatory system. Because PRL-3 mRNA had been reported to be consistently elevated in m...

journal_title：Cancer research

authors： Guo K,Li J,Wang H,Osato M,Tang JP,Quah SY,Gan BQ,Zeng Q

更新日期：2006-10-01 00:00:00

abstract：:Male Wistar rats were given 50 mug of aflatoxin B1 twice a week for 4 weeks, and thereafter 75 mug twice a week for 10 weeks. Their livers were investigated histologically and histochemically for glycogen, RNA, fat, alkaline and acid phosphatases, adenosine triphosphatase, 5'-nucleotidase, glucose-6-phosphatase, gluco...

journal_title：Cancer research

authors： Kalengayi MM,Desmet VJ

更新日期：1975-10-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) gamma is an important signaling molecule in cells of mesenchymal origin, inducing differentiation and regulating cell proliferation in several cell types such as vascular smooth muscle cells. Leiomyomas arise from smooth muscle cells of the uterine myometrium with an i...

journal_title：Cancer research

authors： Houston KD,Copland JA,Broaddus RR,Gottardis MM,Fischer SM,Walker CL

更新日期：2003-03-15 00:00:00

abstract：:Treatment of rats with either intermittent bolus i.v. injections or continuous i.v. infusions of the same sublethal daily dose of tumor necrosis factor (TNF) results in decreased food intake and decreased nitrogen balance compared to saline-treated control rats. After 4 days of treatment, rats treated with intermitten...

journal_title：Cancer research

authors： Darling G,Fraker DL,Jensen JC,Gorschboth CM,Norton JA

更新日期：1990-07-01 00:00:00

abstract：:Antiangiogenic therapy is efficacious in metastatic renal cell carcinoma (mRCC). However, the ability of antiangiogenic drugs to delay tumor progression and extend survival is limited, due to either innate or acquired drug resistance. Furthermore, there are currently no validated biomarkers that predict which mRCC pat...

journal_title：Cancer research

authors： Robinson SP,Boult JKR,Vasudev NS,Reynolds AR

更新日期：2017-08-01 00:00:00

abstract：:Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells across the bone marrow endothelium (BMEC) remains a poorly understood step in metastasis. Prostate cancer cells roll on E-selectin(+) BMEC through E-selectin ligand-binding interactions under shear flow, and prostate cancer cells ex...

journal_title：Cancer research

authors： Barthel SR,Hays DL,Yazawa EM,Opperman M,Walley KC,Nimrichter L,Burdick MM,Gillard BM,Moser MT,Pantel K,Foster BA,Pienta KJ,Dimitroff CJ

更新日期：2013-01-15 00:00:00

abstract：:8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H) -one (mitozolomide) demonstrates curative action against a range of murine tumor model systems. At single doses of between 20 and 40 mg/kg, the latter of which approximates the 10% lethal dose value in mice, the compound elicited cures against the L121...

journal_title：Cancer research

authors： Hickman JA,Stevens MF,Gibson NW,Langdon SP,Fizames C,Lavelle F,Atassi G,Lunt E,Tilson RM

更新日期：1985-07-01 00:00:00

abstract：:The high uptake and prolonged renal retention of monoclonal antibody fragments that are conjugated with radiometal chelates precludes their routine clinical use due to high background counts, which may hinder detection of nearby lesions and/or cause renal radiotoxicity. We report on the potential use of Lys as a pharm...

journal_title：Cancer research

authors： DePalatis LR,Frazier KA,Cheng RC,Kotite NJ

更新日期：1995-11-15 00:00:00

abstract：:Transforming growth factor betas (TGF-beta) play a dual role in carcinogenesis, functioning as tumor suppressors early in the process, and then switching to act as prometastatic factors in late-stage disease. We have previously shown that high molecular weight TGF-beta antagonists can suppress metastasis without the p...

journal_title：Cancer research

authors： Nam JS,Suchar AM,Kang MJ,Stuelten CH,Tang B,Michalowska AM,Fisher LW,Fedarko NS,Jain A,Pinkas J,Lonning S,Wakefield LM

更新日期：2006-06-15 00:00:00

abstract：:Both activating and inactivating mutations in protein tyrosine phosphatase Ptpn11 (encoding Shp2) are associated with tumorigenesis. However, the underlying mechanisms remain unclear. Here, we show that Shp2 plays an important role in mitosis, dysregulation of which results in chromosome instability and cancer predisp...

journal_title：Cancer research

authors： Liu X,Zheng H,Qu CK

更新日期：2012-10-15 00:00:00

abstract：:Sixteen clones (RASK-1 to -16) of murine monoclonal antibodies were raised against ras Mr 21,000 protein (p21). The p21 produced by Escherichia coli with inserted v-Ki-ras genes was used as immunogen. RASK-1 was found to be specific for Ki-ras p21, whereas RASK-2 to -16 reacted with the p21s of Ki-, N-, and Ha-ras gen...

journal_title：Cancer research

authors： Yoshida K,Hamatani K,Koide H,Ikeda H,Nakamura N,Akiyama M,Tsuchiyama H,Nakayama E,Shiku H

更新日期：1988-10-01 00:00:00

abstract：:Two subclones of L1210 murine leukemia (L1210-46.1 and L1210-56.3) were isolated in the absence of selective agents. Subclone 56.3 appeared to be more sensitive than was subclone 46.1 to treatment with dexamethasone, 1-beta-D-arabinofuranosyl cytosine, vincristine, and X-irradiation. No differences between the parent ...

journal_title：Cancer research

authors： Brouwer M,Smets LA,Jongsma AP

更新日期：1983-06-01 00:00:00

abstract：:Gemcitabine is currently the best treatment available for pancreatic cancer, but the disease develops resistance to the drug over time. Agents that can either enhance the effects of gemcitabine or overcome chemoresistance to the drug are needed for the treatment of pancreatic cancer. Curcumin, a component of turmeric ...

journal_title：Cancer research

authors： Kunnumakkara AB,Guha S,Krishnan S,Diagaradjane P,Gelovani J,Aggarwal BB

更新日期：2007-04-15 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive and incurable subtype of B-cell non-Hodgkin lymphomas. Although patients often respond initially to first-line treatment with chemotherapy plus monoclonal antibodies, relapse and decreased response to further lines of treatment eventually occurs. Harnessing the immune system...

journal_title：Cancer research

authors： Cheng F,Wang H,Horna P,Wang Z,Shah B,Sahakian E,Woan KV,Villagra A,Pinilla-Ibarz J,Sebti S,Smith M,Tao J,Sotomayor EM

更新日期：2012-09-01 00:00:00

abstract：:Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell-inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment. Here we demonstrate functional...

journal_title：Cancer research

authors： Davis RJ,Moore EC,Clavijo PE,Friedman J,Cash H,Chen Z,Silvin C,Van Waes C,Allen C

更新日期：2017-05-15 00:00:00

abstract：:Activity increase of the cytosolic isozyme of thymidine kinase (TK) in resected specimens of lung tumor patients would be a useful marker for tumor malignancy and prognosis. In 24 resected cases of malignant lung tumors, the whole enzyme extracts of the tumorous part of the specimens showed that the activities of TK, ...

journal_title：Cancer research

authors： Yusa T,Yamaguchi Y,Ohwada H,Hayashi Y,Kuroiwa N,Morita T,Asanagi M,Moriyama Y,Fujimura S

更新日期：1988-09-01 00:00:00