Abstract：
:The Siah (seven in absentia homolog) family of RING-domain proteins are components of ubiquitin ligase complexes, targeting proteins for proteasomal degradation. Siah family members have been reported to function in Ras, estrogen, DNA-damage, and hypoxia response pathways. Although earlier reports implicated Siah proteins as tumor suppressors, recent studies in mouse models have shown that Siah inhibition impairs tumor growth and metastasis. Given their central role in oncogenic and angiogenic pathways, Siah proteins are attractive novel therapeutic targets in cancer.
journal_name
Cancer Resjournal_title
Cancer researchauthors
House CM,Möller A,Bowtell DDdoi
10.1158/0008-5472.CAN-09-1676subject
Has Abstractpub_date
2009-12-01 00:00:00pages
8835-8issue
23eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-09-1676journal_volume
69pub_type
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