Serial sacrifice study of pathogenesis of 210Po-induced lung tumors in Syrian golden hamsters.

Abstract:

:The pathogenesis of 210Po-induced tumors in the peripheral lung of Syrian golden hamsters has been studied in a serial sacrifice experiment utilizing both plastic (glycol methacrylate) and routine paraffin embedding procedures for lung sections. A rapid progression from hyperplasia of bronchiolar-type cells that appear in the alveolar region to malignant tumors was documented. Tumors began appearing as early as 15 weeks after the first intratracheal instillation of 210Po.

journal_name

Cancer Res

journal_title

Cancer research

authors

Kennedy AR,McGundy RB,Little JB

subject

Has Abstract

pub_date

1978-04-01 00:00:00

pages

1127-35

issue

4

eissn

0008-5472

issn

1538-7445

journal_volume

38

pub_type

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