Detection of precancerous cervical lesions is differential by human papillomavirus type.

abstract：:ADAMs (a disintegrin and metalloproteinase) have important roles in development and diseases such as cancer. Previously, an ADAM15 splice variant (ADAM15B), which contains an inserted cytoplasmic Src-binding site, was linked to clinical aggressiveness in breast cancer, yet little was known about how this splice varian...

journal_title：Cancer research

authors： Maretzky T,Le Gall SM,Worpenberg-Pietruk S,Eder J,Overall CM,Huang XY,Poghosyan Z,Edwards DR,Blobel CP

更新日期：2009-06-01 00:00:00

abstract：:Vitamin E succinate (VES), a derivative of the fat-soluble vitamin D-alpha-tocopherol (vitamin E), inhibited growth and induced apoptotic cell death of estrogen receptor-negative human breast cancer cells. VES-induced apoptosis in MDA-MB-231 and SKBR-3 cells occurred through a Fas pathway. Total protein levels of the ...

journal_title：Cancer research

authors： Turley JM,Fu T,Ruscetti FW,Mikovits JA,Bertolette DC 3rd,Birchenall-Roberts MC

更新日期：1997-03-01 00:00:00

abstract：:miR-31 inhibits breast cancer metastasis via the pleiotropic suppression of a cohort of prometastatic target genes that include integrin alpha(5) (ITGA5), radixin (RDX), and RhoA. We previously showed that the concomitant overexpression of ITGA5, RDX, and RhoA was capable of overriding the antimetastatic effects of ec...

journal_title：Cancer research

authors： Valastyan S,Chang A,Benaich N,Reinhardt F,Weinberg RA

更新日期：2010-06-15 00:00:00

abstract：:Potentiation of the EBV-specific CTL response by immunization with CTL epitopes has been proposed as a logical approach for immune-targeting nasopharyngeal carcinoma (NPC) cells in vivo. This approach will undoubtedly be influenced by the ability of these malignant cells to endogenously process and present target epit...

journal_title：Cancer research

authors： Khanna R,Busson P,Burrows SR,Raffoux C,Moss DJ,Nicholls JM,Cooper L

更新日期：1998-01-15 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:Human breast cancer (HBC) cell growth suppression by okadaic acid (OA) was previously found to involve elevated expression of oncogenes c-myc and c-fos and apoptosis. Since, c-Myc influences diverse pathways of cell growth, we hypothesized that elevated levels of c-Myc are involved in HBC growth suppression. Here, we ...

journal_title：Cancer research

authors： Zhang L,Wali A,Ramana CV,Rishi AK

更新日期：2007-11-01 00:00:00

abstract：:Most cancer-associated single-nucleotide polymorphisms (SNP) identified using genome-wide association studies are located outside of protein-coding regions, and their significance and mode of action have been a source of continuing debate. One proposed mechanism of action of the SNPs is that they would affect the acti...

journal_title：Cancer research

authors： Sur I,Tuupanen S,Whitington T,Aaltonen LA,Taipale J

更新日期：2013-07-15 00:00:00

abstract：:Fresh surgical explants of human carcinomas were implanted as first transplant generation xenografts under the kidney capsule of mice. Immunocompetent and immune-deficient mice were compared for their ability to support the persistence and growth of these xenografts. Consistent growth of tumor xenografts could not be ...

journal_title：Cancer research

authors： Bennett JA,Pilon VA,MacDowell RT

更新日期：1985-10-01 00:00:00

abstract：:The chemokine receptor CXCR4 plays a central role in organ-specific homing and tumor spreading and is induced by hypoxia. B lymphocytes are exposed to low oxygen tensions during their development, but the influence of hypoxia on their physiology is poorly understood. Here, we show that hypoxia is associated with up-re...

journal_title：Cancer research

authors： Piovan E,Tosello V,Indraccolo S,Masiero M,Persano L,Esposito G,Zamarchi R,Ponzoni M,Chieco-Bianchi L,Dalla-Favera R,Amadori A

更新日期：2007-09-15 00:00:00

abstract：:Malignant and uninvolved human breast tissues were maintained in organ culture for 3 to 6 days. Under these conditions, the three-dimensional glandular architecture is maintained with the least disruption of tissue integrity. The biosynthesis and release of glycoproteins were studied by using the incorporation of [14C...

journal_title：Cancer research

authors： Gendler SJ,Dermer GB,Silverman LM,Tökés ZA

更新日期：1982-11-01 00:00:00

abstract：:Regulation of tyrosine aminotransferase gene expression was studied in an adult rat hepatocyte line (RALA255-10G) which is temperature sensitive for the maintenance of the differentiated liver phenotype. Glucocorticoid hormones such as cortisol were necessary for expression of the aminotransferase gene. In the absence...

journal_title：Cancer research

authors： Chou JY,Yeoh GC

更新日期：1987-10-15 00:00:00

abstract：:While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic T lymphocytes (CTL). Because CD4(+) T cells improve CTL respon...

journal_title：Cancer research

authors： Ahrends T,Bąbała N,Xiao Y,Yagita H,van Eenennaam H,Borst J

更新日期：2016-05-15 00:00:00

abstract：:Taxol is a novel antitumor agent with demonstrated efficacy against ovarian, breast, and non-small cell lung cancers in Phase II clinical trials, but which has been shown not to cross the blood-brain barrier. To adapt taxol as a therapy for brain tumors, we have incorporated it into a biodegradable polyanhydride matri...

journal_title：Cancer research

authors： Walter KA,Cahan MA,Gur A,Tyler B,Hilton J,Colvin OM,Burger PC,Domb A,Brem H

更新日期：1994-04-15 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is activated to DNA alkylating species via two different alpha-hydroxylation pathways. Methylene hydroxylation leads to DNA methylation, whereas methyl hydroxylation yields DNA pyridyloxobutylation. We have developed a high-pressure liquid chromatography assay utili...

journal_title：Cancer research

authors： Peterson LA,Mathew R,Hecht SS

更新日期：1991-10-15 00:00:00

abstract：:The s.c.-propagated murine glioma, GL-26, was established in tissue culture. The tissue culture line, with a doubling time of 36 hr, was used as the common source for all tumor cells. Suspensions of the tumor cells were transplanted intracerebrally in mice to produce an anaplastic ependymoblastoma. In vitro 51-Cr cyto...

journal_title：Cancer research

authors： Albright L,Madigan JC,Gaston MR,Houchens DP

更新日期：1975-03-01 00:00:00

abstract：:Sporadic prostate carcinoma is the most common male cancer in the Western world, yet many of the major genetic events involved in the progression of this often fatal cancer remain to be elucidated. Numerous cytogenetic and allelotype studies have reported frequent loss of heterozygosity on chromosomal arm 10q in spora...

journal_title：Cancer research

authors： Cairns P,Okami K,Halachmi S,Halachmi N,Esteller M,Herman JG,Jen J,Isaacs WB,Bova GS,Sidransky D

更新日期：1997-11-15 00:00:00

abstract：:A single cancer cell contains large numbers of genetic alterations that in combination create the malignant phenotype. However, whether amplified and mutated genes form functional and physical interaction networks that could explain the selection for cells with combined alterations is unknown. To investigate this issu...

journal_title：Cancer research

authors： Nikolsky Y,Sviridov E,Yao J,Dosymbekov D,Ustyansky V,Kaznacheev V,Dezso Z,Mulvey L,Macconaill LE,Winckler W,Serebryiskaya T,Nikolskaya T,Polyak K

更新日期：2008-11-15 00:00:00

abstract：:Alterations in the expression of the epidermal growth factor (EGF) receptor ErbB family are frequently encountered in a number of human cancers. Two of these receptors, ErbB3 and ErbB4, are known to bind a family of related proteins termed heregulins (HRGs) or neu differentiation factors. In biologically relevant syst...

journal_title：Cancer research

authors： Lewis GD,Lofgren JA,McMurtrey AE,Nuijens A,Fendly BM,Bauer KD,Sliwkowski MX

更新日期：1996-03-15 00:00:00

abstract：:Carcinomas of the exocrine pancreas are poorly understood and have a poor prognosis because of their highly malignant nature. Using two human pancreatic cancer cell lines, AsPc-1 and Capan-2, we have investigated avenues that might be useful in targeting the delivery of antineoplastic agents to such cancers. Qualitati...

journal_title：Cancer research

authors： Gonzalez DE,Covitz KM,Sadée W,Mrsny RJ

更新日期：1998-02-01 00:00:00

abstract：:Increasing the expression of c-FMS (colony-stimulating factor 1 receptor) by introduction of a transgene reduced the concentration of retinoic acid or 1,25-dihydroxy vitamin D3 needed to cause myeloid or monocytic cell differentiation and hypophosphorylation of the retinoblastoma tumor suppressor protein (RB) typicall...

journal_title：Cancer research

authors： Yen A,Sturgill R,Varvayanis S

更新日期：1997-05-15 00:00:00

abstract：:Members of cutaneous melanoma (CM) families with dysplastic nevi (DN) are at high risk of developing CM. Using a shuttle vector plasmid, pSP189, cell lines from three patients with CM plus DN were previously found to have elevated post-UV plasmid mutability. To investigate familial occurrence of this cellular phenotyp...

journal_title：Cancer research

authors： Moriwaki SI,Tarone RE,Tucker MA,Goldstein AM,Kraemer KH

更新日期：1997-10-15 00:00:00

abstract：:Identification of the molecular mechanism of action (MoA) of bioactive compounds is a crucial step for drug development but remains a challenging task despite recent advances in technology. In this study, we applied multidimensional proteomics, sensitivity correlation analysis, and transcriptomics to identify a common...

journal_title：Cancer research

authors： Peuget S,Zhu J,Sanz G,Singh M,Gaetani M,Chen X,Shi Y,Saei AA,Visnes T,Lindström MS,Rihani A,Moyano-Galceran L,Carlson JW,Hjerpe E,Joneborg U,Lehti K,Hartman J,Helleday T,Zubarev R,Selivanova G

更新日期：2020-04-01 00:00:00

abstract：:Combined cytogenetic and biochemical approaches were used to investigate the contributions of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) in the maintenance of genomic stability in nonirradiated and irradiated primary mouse embryo fibroblasts (MEF). We show that telomere dysfunction contributes on...

journal_title：Cancer research

authors： Martín M,Genescà A,Latre L,Jaco I,Taccioli GE,Egozcue J,Blasco MA,Iliakis G,Tusell L

更新日期：2005-11-15 00:00:00

abstract：:PE-35 mouse monoclonal antibody (MoAb) (IgG1) detecting an epithelial antigen with a molecular weight of 35,000 was characterized serologically. Immunoperoxidase staining and double immunoenzymatic staining showed that PE-35 antigen is predominantly on nonlymphoid cells in the medulla of thymus. By immunoelectron micr...

journal_title：Cancer research

authors： Takahashi T,Ueda R,Nishida K,Namikawa R,Fukami H,Matsuyama M,Masaoka A,Imaizumi M,Takahashi T

更新日期：1988-04-01 00:00:00

abstract：:: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilizat...

journal_title：Cancer research

authors： La T,Liu GZ,Farrelly M,Cole N,Feng YC,Zhang YY,Sherwin SK,Yari H,Tabatabaee H,Yan XG,Guo ST,Liu T,Thorne RF,Jin L,Zhang XD

更新日期：2018-12-01 00:00:00

abstract：:Combining microtubule-targeting antimitotic drugs with targeted apoptosis potentiators is a promising new chemotherapeutic strategy to treat cancer. In this study, we investigate the cellular mechanism by which navitoclax (previously called ABT-263), a Bcl-2 family inhibitor, potentiates apoptosis triggered by paclita...

journal_title：Cancer research

authors： Shi J,Zhou Y,Huang HC,Mitchison TJ

更新日期：2011-07-01 00:00:00

abstract：:SMYD3 methyltransferase is nearly undetectable in normal human tissues but highly expressed in several cancers, including breast cancer, although its contributions to pathogenesis in this setting are unclear. Here we report that histone H2A.Z.1 is a substrate of SMYD3 that supports malignancy. SMYD3-mediated dimethyla...

journal_title：Cancer research

authors： Tsai CH,Chen YJ,Yu CJ,Tzeng SR,Wu IC,Kuo WH,Lin MC,Chan NL,Wu KJ,Teng SC

更新日期：2016-10-15 00:00:00

abstract：:The mechanism(s) by which high-linear energy transfer a particles, like those emitted by inhaled radon and radon daughters, cause lung cancer has not been elucidated. Conceivably, DNA damage that is induced by a particles may be mediated by the metabolic generation of reactive oxygen species (ROS), in addition to dire...

journal_title：Cancer research

authors： Narayanan PK,Goodwin EH,Lehnert BE

更新日期：1997-09-15 00:00:00

abstract：:Breast cancer-initiating cells have been recently identified in breast carcinoma as CD44+/CD24(-/low) cells, which exclusively retain tumorigenic activity and display stem cell-like properties. However, at present, direct evidence that breast cancer-initiating cells can be propagated in vitro is still lacking. We repo...

journal_title：Cancer research

authors： Ponti D,Costa A,Zaffaroni N,Pratesi G,Petrangolini G,Coradini D,Pilotti S,Pierotti MA,Daidone MG

更新日期：2005-07-01 00:00:00

abstract：:DNA polymerase beta is a nuclear protein essential to DNA repair in mammalian cells. A high frequency of mutations in this gene has been reported in colorectal cancers. To clarify the tumorigenesis steps of human prostate cancers in the molecular basis, we examined the entire coding region of the human DNA polymerase ...

journal_title：Cancer research

authors： Dobashi Y,Shuin T,Tsuruga H,Uemura H,Torigoe S,Kubota Y

更新日期：1994-06-01 00:00:00