Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties.

abstract：:Ras associated with diabetes (Rad) is a Ras-related GTPase that promotes cell growth by accelerating cell cycle transitions. Rad knockdown induced cell cycle arrest and premature senescence without additional cellular stress in multiple cancer cell lines, indicating that Rad expression might be critical for the cell c...

journal_title：Cancer research

authors： Lee I,Yeom SY,Lee SJ,Kang WK,Park C

更新日期：2010-06-01 00:00:00

abstract：:The in vitro antiproliferative effect of highly purified recombinant human gamma-interferon was studied with special reference to specific binding to tumor cells of interferon (IFN) labeled with 125I. Recombinant human gamma-interferon markedly suppressed the growth of 6 of 10 human epidermal tumor cell lines tested; ...

journal_title：Cancer research

authors： Nagao S,Sato K,Osada Y

更新日期：1986-07-01 00:00:00

abstract：:Ascorbate free radical stimulates the growth of human promyelocytic leukemia cells (HL-60) in the presence of a limited amount of serum (1%) when added to the cells under conditions where it is impermeable. Maximum growth stimulation occurs at concentrations from 5 x 10(-9) to 2 x 10(-8) M. Ascorbate mimicks the stimu...

journal_title：Cancer research

authors： Alcaín FJ,Burón MI,Rodríguez-Aguilera JC,Villalba JM,Navas P

更新日期：1990-09-15 00:00:00

abstract：:Regulators of differentiated cell fate can offer targets for managing cancer development and progression. Here, we identify Runx2 as a new regulator of epithelial cell fate in mammary gland development and breast cancer. Runx2 is expressed in the epithelium of pregnant mice in a strict temporally and hormonally regula...

journal_title：Cancer research

authors： Owens TW,Rogers RL,Best S,Ledger A,Mooney AM,Ferguson A,Shore P,Swarbrick A,Ormandy CJ,Simpson PT,Carroll JS,Visvader J,Naylor MJ

更新日期：2014-09-15 00:00:00

abstract：:Interleukin 2 (IL-2) is a secreted glycoprotein which acts as an activation and proliferative signal for lymphocytes expressing membrane-bound glycoprotein IL-2 receptors. We have recently established that swainsonine (SW), an inhibitor of mannosidase II during N-linked glycoprotein processing, augmented mitogen-induc...

journal_title：Cancer research

authors： Bowlin TL,McKown BJ,Kang MS,Sunkara PS

更新日期：1989-08-01 00:00:00

abstract：:The issue of resistance to targeted drug therapy is of pressing concern, as it constitutes a major barrier to progress in managing cancer. One important aspect is the role of stochasticity in determining the nature of the patient response. We examine two particular experiments. The first measured the maximal response ...

journal_title：Cancer research

authors： Kessler DA,Austin RH,Levine H

更新日期：2014-09-01 00:00:00

abstract：:Increased levels of DNA fragments have frequently been found in the blood plasma of cancer patients. Published data suggest that only a fraction of the DNA in blood plasma is derived from cancer cells. However, it is not known how much of the circulating DNA is from cancer or from noncancer cells. By quantitative meth...

journal_title：Cancer research

authors： Jahr S,Hentze H,Englisch S,Hardt D,Fackelmayer FO,Hesch RD,Knippers R

更新日期：2001-02-15 00:00:00

abstract：:Nile blue derivatives have been shown to be potentially effective photosensitizers for photodynamic therapy of malignant tumors. Results of a previous study suggested that the high accumulation of these dyes in cells may be the result of dye aggregation, partition in membrane lipids, and/or sequestration in subcellula...

journal_title：Cancer research

authors： Lin CW,Shulok JR,Kirley SD,Cincotta L,Foley JW

更新日期：1991-05-15 00:00:00

abstract：:Human lymphoblastoid cell lines from normal individuals and from patients with ataxia telangiectasia were either proficient or deficient in their ability to repair the mutagenic DNA adduct O6-methylguanine that is induced by methylating carcinogens. There was no relationship between the capacity to repair O6-methylgua...

journal_title：Cancer research

authors： Shiloh Y,Becker Y

更新日期：1981-12-01 00:00:00

abstract：:Protein kinase C delta (PKCdelta), a Ca(2+)-independent, phospholipid-dependent serine/threonine kinase, is among the novel PKCs (delta, epsilon, and eta) expressed in mouse epidermis. We reported that FVB/N transgenic mice that overexpress ( approximately 8-fold) PKCdelta protein in basal epidermal cells and cells of...

journal_title：Cancer research

authors： Aziz MH,Wheeler DL,Bhamb B,Verma AK

更新日期：2006-01-15 00:00:00

abstract：:A 16,500 molecular weight fraction of maleic vinyl ether (MVE-2) induced tumoristatic and tumoricidal activity in peritoneal macrophages of BALB/c and C57BL/6 mice following i.p. administration. Growth of B16 melanoma cells in vitro was inhibited up to 85% by MVE-2-activated, but not resident, peritoneal macrophages. ...

journal_title：Cancer research

authors： Loveless SE,Munson AE

更新日期：1981-10-01 00:00:00

abstract：:Combining microtubule-targeting antimitotic drugs with targeted apoptosis potentiators is a promising new chemotherapeutic strategy to treat cancer. In this study, we investigate the cellular mechanism by which navitoclax (previously called ABT-263), a Bcl-2 family inhibitor, potentiates apoptosis triggered by paclita...

journal_title：Cancer research

authors： Shi J,Zhou Y,Huang HC,Mitchison TJ

更新日期：2011-07-01 00:00:00

abstract：:Carcinogenic heterocyclic amines are activated by N-acetyltransferase (NAT) enzymes, encoded by NAT1 and NAT2, to genotoxic compounds that can form DNA adducts in the colon epithelium. We have examined the relation of polymorphisms in the genes coding for both enzymes to risk of colorectal cancer and the gene-environm...

journal_title：Cancer research

authors： Chen J,Stampfer MJ,Hough HL,Garcia-Closas M,Willett WC,Hennekens CH,Kelsey KT,Hunter DJ

更新日期：1998-08-01 00:00:00

abstract：:The ability of cancer cells to evade apoptosis is dictated by a shift in the balance between proapoptotic and antiapoptotic gene expression programs. Monocyte chemotactic protein-induced protein 1 (MCPIP1) is a zinc-finger RNA binding protein with important roles in mediating inflammatory responses. Overexpression of ...

journal_title：Cancer research

authors： Lu W,Ning H,Gu L,Peng H,Wang Q,Hou R,Fu M,Hoft DF,Liu J

更新日期：2016-03-15 00:00:00

abstract：:ABL 364 is a murine monoclonal IgG3 antibody directed against the Lewis Y carbohydrate antigen (Le(y)) expressed on the surface of many epithelial cell tumors. The antibody mediates cytotoxicity via activation of human complement or human effector cells, and has been evaluated in several clinical trials including two ...

journal_title：Cancer research

authors： Co MS,Baker J,Bednarik K,Janzek E,Neruda W,Mayer P,Plot R,Stumper B,Vasquez M,Queen C,Loibner H

更新日期：1996-03-01 00:00:00

abstract：:We have found that the synthetic compound CC-5079 potently inhibits cancer cell growth in vitro and in vivo by a novel combination of molecular mechanisms. CC-5079 inhibits proliferation of cancer cell lines from various organs and tissues at nanomolar concentrations. Its IC(50) value ranges from 4.1 to 50 nmol/L. The...

journal_title：Cancer research

authors： Zhang LH,Wu L,Raymon HK,Chen RS,Corral L,Shirley MA,Narla RK,Gamez J,Muller GW,Stirling DI,Bartlett JB,Schafer PH,Payvandi F

更新日期：2006-01-15 00:00:00

abstract：:Peripheral blood myeloblasts from five patients with acute myeloblastic leukemia and peripheral remission leukocytes from two of these patients were radiolabeled by the lactoperoxidase-catalyzed surface radioiodination technique and incubated in a nutrient medium at 37 degrees. Radioactive materials shed from viable c...

journal_title：Cancer research

authors： Taub RN,Roncari DA,Baker MA

更新日期：1978-12-01 00:00:00

abstract：:Several in vitro cell systems were exposed to hematoporphyrin derivative (HPD): established lines of rat kangaroo epithelial kidney; normal mouse embryonic fibroblasts; and differentiated neonatal rat myocardial cells. The uptake of HPD (25 to 100 micrograms/ml) by individual cells occurred rapidly over a 2-hr period ...

journal_title：Cancer research

authors： Berns MW,Dahlman A,Johnson FM,Burns R,Sperling D,Guiltinan M,Siemens A,Walter R,Wright W,Hammer-Wilson M,Wile A

更新日期：1982-06-01 00:00:00

abstract：:Mean plasma hypoxanthine (Hyp) concentrations determined by high-pressure liquid chromatography were 0.56 microM (range, 0.2 to 1.9 microM) in 16 normal subjects, 0.68 microM (range, 0.1 to 1.1 microM) in 10 untreated acute leukemic subjects, and 0.89 microM (range, 0.3 to 2.6 microM) in 14 solid tumor patients. Despi...

journal_title：Cancer research

authors： Wung WE,Howell SB

更新日期：1984-07-01 00:00:00

abstract：:The migration of three human prostate tumor epithelial cell lines (TSU-pr1, PC-3, DU-145) in response to secreted protein from a human prostate stromal cell line was investigated by using the modified blind-well Boyden chamber assay. Migrated cells were quantified by spectrophotometrically measuring the concentration ...

journal_title：Cancer research

authors： Djakiew D,Pflug BR,Delsite R,Onoda M,Lynch JH,Arand G,Thompson EW

更新日期：1993-03-15 00:00:00

abstract：:Metastasis-suppressing gene product CD82 and its analogue CD9 are considered to suppress the malignancy of various human cancers, although the rationale for this effect is unknown. The present study addresses phenotypic changes in Chinese hamster ovary mutant cell line ldlD deficient in UDP-Glc 4-epimerase and express...

journal_title：Cancer research

authors： Ono M,Handa K,Withers DA,Hakomori S

更新日期：1999-05-15 00:00:00

abstract：:Uptake of actinomycin D (AD) was characterized in Ehrlich ascites tumor cells in vitro. The time course of uptake consists of an initial component that represents a unidirectional flux of AD into the cells, following which the net uptake rate falls to achieve a velocity that is constant over a 45-min interval of obser...

journal_title：Cancer research

authors： Bowen D,Goldman ID

更新日期：1975-11-01 00:00:00

abstract：:Tumorigenesis can arise from inappropriate activation of developmental genes in mature tissues. Here, we show that the developmental regulator Six1 is overexpressed in ovarian carcinoma cell lines (OCC) compared with normal ovarian surface epithelium. As observed in other cancers, Six1 overexpression in OCC leads to i...

journal_title：Cancer research

authors： Behbakht K,Qamar L,Aldridge CS,Coletta RD,Davidson SA,Thorburn A,Ford HL

更新日期：2007-04-01 00:00:00

abstract：:Degradation and invasion of basement membrane by tumor cells involves the cooperative hydrolysis of proteoglycans, collagens, and glycoproteins mediated by a number of enzymes including proteases, collagenases, and glycosidases. In order to study these processes in vitro, a tissue culture system was developed in which...

journal_title：Cancer research

authors： Woynarowska B,Wikiel H,Bernacki RJ

更新日期：1989-10-15 00:00:00

abstract：:Antiestrogen resistance is frequently observed in patients after longterm treatment with tamoxifen, a nonsteroidal antiestrogen widely used for endocrine therapy of breast cancer. In vitro studies in resistant cells showed that the expression of natural estrogen-responsive genes is frequently altered. Using MVLN cells...

journal_title：Cancer research

authors： Badia E,Duchesne MJ,Semlali A,Fuentes M,Giamarchi C,Richard-Foy H,Nicolas JC,Pons M

更新日期：2000-08-01 00:00:00

abstract：:Chemotherapy, radiation, and growth inhibitory drugs preferentially eliminate actively growing cancer cells. Cancer recurrence is currently thought to be due to nondividing cancer stem/progenitor cells that are resistant to these therapies. Different therapeutic approaches need to be considered for the elimination of ...

journal_title：Cancer research

authors： Engelmann K,Shen H,Finn OJ

更新日期：2008-04-01 00:00:00

abstract：:Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer with poor prognosis. As transient and stable modifications to chromatin have emerged as critical mechanisms in oncogenic signaling, efforts to target epigenetic modifiers as a therapeutic strategy have accelerated in recent years. To identify chromatin...

journal_title：Cancer research

authors： Bhat AV,Palanichamy Kala M,Rao VK,Pignata L,Lim HJ,Suriyamurthy S,Chang KT,Lee VK,Guccione E,Taneja R

更新日期：2019-05-01 00:00:00

abstract：:Osimertinib, a mutant-specific third-generation EGFR tyrosine kinase inhibitor, is emerging as the preferred first-line therapy for EGFR-mutant lung cancer, yet resistance inevitably develops in patients. We modeled acquired resistance to osimertinib in transgenic mouse models of EGFRL858R -induced lung adenocarcinoma...

journal_title：Cancer research

authors： Starrett JH,Guernet AA,Cuomo ME,Poels KE,van Alderwerelt van Rosenburgh IK,Nagelberg A,Farnsworth D,Price KS,Khan H,Ashtekar KD,Gaefele M,Ayeni D,Stewart TF,Kuhlmann A,Kaech SM,Unni AM,Homer R,Lockwood WW,Michor F,G

更新日期：2020-05-15 00:00:00

abstract：:Loss of expression of the apoptosis protease activator protein-1 (APAF-1) in human melanoma is thought to promote resistance to programmed cell death by preventing caspase-9 activation. However, the role of the APAF-1-dependent pathway in apoptosis activated by cellular stress and/or DNA damage has been recently quest...

journal_title：Cancer research

authors： Zanon M,Piris A,Bersani I,Vegetti C,Molla A,Scarito A,Anichini A

更新日期：2004-10-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) is characterized by a pathogenic vasculature that drives aggressive local invasion. Recent work suggests that GBM cells recruit bone marrow-derived progenitor cells (BMDC) to facilitate recurrence after radiotherapy, but how this may be achieved is unclear. In this study, we established t...

journal_title：Cancer research

authors： Burrell K,Singh S,Jalali S,Hill RP,Zadeh G

更新日期：2014-07-15 00:00:00