Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures.

abstract：:We have demonstrated previously that there is a marked decrease in the level of labeled fucose incorporated into an amino acid fucoside, i.e., fucosyl-N-acetylglucosaminylasparagine (FL4c) in SV40-transformed human embryonic lung cells (SV40-WI-38) as compared to WI-38 cells (Morton, P.A., Klinger, M. M., and Steiner,...

journal_title：Cancer research

authors： Steiner SM,Morton PA

更新日期：1984-10-01 00:00:00

abstract：:The effects of combined administration of cimetidine and tetragastrin on gastric acid secretion, the labeling index of the gastric mucosa, and the incidence of gastric adenocarcinomas induced by N-methyl-N'-nitro-N-nitrosoguanidine were investigated in inbred Wistar rats. Prolonged administration of tetragastrin in de...

journal_title：Cancer research

authors： Tatsuta M,Iishi H,Yamamura H,Baba M,Yamamoto R,Taniguchi H

更新日期：1988-03-15 00:00:00

abstract：:Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers formed the Text Information Extraction System (TIES) Cancer...

journal_title：Cancer research

authors： Jacobson RS,Becich MJ,Bollag RJ,Chavan G,Corrigan J,Dhir R,Feldman MD,Gaudioso C,Legowski E,Maihle NJ,Mitchell K,Murphy M,Sakthivel M,Tseytlin E,Weaver J

更新日期：2015-12-15 00:00:00

abstract：:We have identified RGS17 as a commonly induced gene in lung and prostate tumors. Through microarray and gene expression analysis, we show that expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Through knockdown and overexpression of RGS17 in tumor cells, we show that ...

journal_title：Cancer research

authors： James MA,Lu Y,Liu Y,Vikis HG,You M

更新日期：2009-03-01 00:00:00

abstract：:Two human breast carcinoma cell lines, EP and MW, were established in culture from malignant pleural effusions. In addition to producing tumors in antithymocyte serum-immunosuppressed mice, both cell lines showed epithelial characteristics and anchorage-independent growth in soft agar. EP and MW differed in morphology...

journal_title：Cancer research

authors： Chu MY,Hagerty MG,Wiemann MC,Tibbetts LM,Sato S,Cummings FJ,Bogaars HA,Leduc EH,Calabresi P

更新日期：1985-03-01 00:00:00

abstract：:The influence of gangliosides on tumor growth and frequency of metastasis in vivo as well as on growth and motility of neoplastic cells in vitro was tested utilizing human and rodent cell populations. In mice receiving injections of a ganglioside mixture twice daily the tumor volume, the number of spontaneous metastas...

journal_title：Cancer research

authors： Alessandri G,Filippeschi S,Sinibaldi P,Mornet F,Passera P,Spreafico F,Cappa PM,Gullino PM

更新日期：1987-08-15 00:00:00

abstract：:Correlation was greater than 90% between feline leukemia virus (FeLV), group-specific antigen (GSA) in leukocytes, and viral infectivity (VI) in serum or plasma from 132 cats infected with either the Rickard strain of FeLV, the Snyder-Theilen strain of feline sarcoma virus, or field strains of FeLV. Detection of GSA i...

journal_title：Cancer research

authors： Hoover EA,Olsen RG,Mathes LE,Schaller JP

更新日期：1977-10-01 00:00:00

abstract：:Mutations that alter normal splice patterns and genomic rearrangements are common causes of hereditary diseases including hereditary nonpolyposis colorectal cancer. However, abnormal transcripts can be difficult to detect and interpret because splicing patterns are often heterogeneous even in normal cells. Standard te...

journal_title：Cancer research

authors： Nakagawa H,Yan H,Lockman J,Hampel H,Kinzler KW,Vogelstein B,De La Chapelle A

更新日期：2002-08-15 00:00:00

abstract：:Metronomic chemotherapy refers to the close, regular administration of comparatively low doses of cytotoxic drugs, with minimal or no drug-free breaks, over prolonged periods. It is thought to have an antiangiogenic basis. However, whereas surprisingly durable and potent tumor responses have been observed in a number ...

journal_title：Cancer research

authors： Shaked Y,Emmenegger U,Francia G,Chen L,Lee CR,Man S,Paraghamian A,Ben-David Y,Kerbel RS

更新日期：2005-08-15 00:00:00

abstract：:The clinical effects and pharmacokinetics of high-dose uridine were determined in seven patients with advanced-stage cancer and in one healthy volunteer. Uridine was also examined for its effect on 5-fluorouracil toxicity in two patients. Uridine was administered as a 1-hr i.v. infusion at doses of 1 to 12 g/sq m. Pla...

journal_title：Cancer research

authors： Leyva A,van Groeningen CJ,Kraal I,Gall H,Peters GJ,Lankelma J,Pinedo HM

更新日期：1984-12-01 00:00:00

abstract：:Oncogene activation and loss of tumor suppressor function changes the metabolic activity of cancer cells to drive unrestricted proliferation. Moreover, cancer cells adapt their metabolism to sustain growth and survival when access to oxygen and nutrients is restricted, such as in poorly vascularized tumor areas. We sh...

journal_title：Cancer research

authors： Kaymak I,Maier CR,Schmitz W,Campbell AD,Dankworth B,Ade CP,Walz S,Paauwe M,Kalogirou C,Marouf H,Rosenfeldt MT,Gay DM,McGregor GH,Sansom OJ,Schulze A

更新日期：2020-01-15 00:00:00

abstract：:The cyanomorpholino derivative of doxorubicin (MRA-CN) is a DNA intercalator and alkylator that is a highly potent cytotoxin, non-cross-resistant in multidrug-resistant cells, and noncardiotoxic in comparison with doxorubicin. To further examine mechanisms of action and resistance to MRA-CN, a cell line resistant to M...

journal_title：Cancer research

authors： Lau DH,Lewis AD,Ehsan MN,Sikic BI

更新日期：1991-10-01 00:00:00

abstract：:The rat pancreatic carcinoma cell line AR4-2J was screened for growth-associated genes linked to the mitogenic effect of the novel gut brain hormone, pituitary adenylate cyclase activating polypeptide (PACAP). Using the mRNA differential display technique, we identified and sequenced an unknown rat gene, PACAP-respons...

journal_title：Cancer research

authors： Schäfer H,Trauzold A,Siegel EG,Fölsch UR,Schmidt WE

更新日期：1996-06-01 00:00:00

abstract：:Electron paramagnetic resonance imaging (EPRI) enables noninvasive spatial mapping of free radical metabolism and has recently been shown to provide in vivo physiologic information regarding alterations in the redox state of tumors and neoplastic tissues. With the use of nitroxide spin probes, it has been shown that c...

journal_title：Cancer research

authors： Mikuni T,He G,Petryakov S,Fallouh MM,Deng Y,Ishihara R,Kuppusamy P,Tatsuta M,Zweier JL

更新日期：2004-09-15 00:00:00

abstract：:The association between the consumption of onions and leeks (vegetables belonging to the Allium genus), garlic supplements, and the risk of lung carcinoma was investigated in a large-scale prospective cohort study on diet and cancer in the Netherlands. The Netherlands Cohort Study was started in 1986 among 120,852 men...

journal_title：Cancer research

authors： Dorant E,van den Brandt PA,Goldbohm RA

更新日期：1994-12-01 00:00:00

abstract：:The biological activity of two novel 14-epi-analogues of 1,25(OH)2D3, 19-nor-14-epi-23-yne-1,25(OH)2D3 (TX 522) and 19-nor-14,20-bisepi-23-yne-1,25(OH)2D3 (TX 527), is described. Both analogues were at least 10 times more potent than 1,25(OH)2D3 in inhibiting in vitro cell proliferation and had much lower in vivo calc...

journal_title：Cancer research

authors： Verlinden L,Verstuyf A,Van Camp M,Marcelis S,Sabbe K,Zhao XY,De Clercq P,Vandewalle M,Bouillon R

更新日期：2000-05-15 00:00:00

abstract：:A balanced lipid metabolism is crucial for all cells. Disturbance of this homeostasis by nonphysiological intracellular accumulation of fatty acids can result in apoptosis. This was proven in animal studies and was correlated to some human diseases, like lipotoxic cardiomyopathy. Some metabolic mechanisms of lipo-apop...

journal_title：Cancer research

authors： Pohle T,Brändlein S,Ruoff N,Müller-Hermelink HK,Vollmers HP

更新日期：2004-06-01 00:00:00

abstract：:Many N-nitroso compounds (NOC) are carcinogens. In this controlled study of 21 healthy male volunteers, levels of NOC on a high (420 grams) red meat diet were significantly greater (P = 0.001) than on a low (60 grams) meat diet but not significantly greater when an equivalent amount of vegetable protein was fed. An 8-...

journal_title：Cancer research

authors： Cross AJ,Pollock JR,Bingham SA

更新日期：2003-05-15 00:00:00

abstract：:Human erythrocytes have been used as a model for evaluating the chemical carcinogen-plasma membrane interaction. The carcinogenic aromatic amines 2-acetylaminofluorene, dimethylaminoazobenzene, and 3'-methyldimethylaminoazobene stabilize erythrocytes against lysis in hypotonic solution. In general, the stabilization p...

journal_title：Cancer research

authors： Litman GW,Litman RT,Henry CJ

更新日期：1976-02-01 00:00:00

abstract：:A series of mouse mammary tumor subpopulation lines were compared for growth properties and sensitivity to chemotherapeutic drugs when grown as boluses in a collagen gel matrix versus in monolayer culture. Although the cell lines exhibited characteristic rates of bolus expansion in collagen, this growth was not parall...

journal_title：Cancer research

authors： Miller BE,Miller FR,Heppner GH

更新日期：1985-09-01 00:00:00

abstract：:The presence of a quinone group in the structure of a series of model compounds was shown to produce cell kill by a mechanism involving free radicals and active oxygen species. Furthermore, the ability of the compound to bind to DNA appeared to enhance its cytocidal activity. The same model compounds were used to inve...

journal_title：Cancer research

authors： Begleiter A,Blair GW

更新日期：1984-01-01 00:00:00

abstract：:In an attempt to identify phytochemicals contributing to the well-documented preventive effect of plant-based diets on cancer incidence and mortality, we have previously shown that certain flavonoids inhibit in vitro angiogenesis. Here, we show that the flavonoid luteolin inhibited tumor growth and angiogenesis in a m...

journal_title：Cancer research

authors： Bagli E,Stefaniotou M,Morbidelli L,Ziche M,Psillas K,Murphy C,Fotsis T

更新日期：2004-11-01 00:00:00

abstract：:Many tumor types have p53 and/or RB mutations, and it is unclear what role the mutations of these tumor suppressor genes have on the efficacy of chemotherapeutic agents. The effect of p53 and RB inactivation on sensitivity to chemotherapeutic drugs was examined using a model system in which p53 or RB was inactivated i...

journal_title：Cancer research

authors： Hawkins DS,Demers GW,Galloway DA

更新日期：1996-02-15 00:00:00

abstract：:The possible alteration of transformation-related antigens in cells that revert to a normal phenotype but that continue to retain the viral genome, has been investigated in [3H]glucosamine-labeled extracts of rat cells exhibiting a reversible temperature-dependent restriction in the expression of transformation and in...

journal_title：Cancer research

authors： Rieber M,Bacalao J,Rieber M

更新日期：1977-04-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with breast cancer progression and metastasis. Here, we report that ectopic overexpression of SOX4 in immortalized human mammary epithelial cells is sufficient for acquisition of mesenchymal traits, enhanced cell migration, and inv...

journal_title：Cancer research

authors： Zhang J,Liang Q,Lei Y,Yao M,Li L,Gao X,Feng J,Zhang Y,Gao H,Liu DX,Lu J,Huang B

更新日期：2012-09-01 00:00:00

abstract：:Herpesvirus saimiri (HVS) was propagated in vero cells for 3 passages at 39 degrees and cloned 3 times at 34 degrees. This virus was inoculated into cotton-topped marmoset and squirrel monkeys; all inoculated monkeys became infected as HVS was reisolated after their circulating lymphocytes were cultured with vero cell...

journal_title：Cancer research

authors： Falk L,Wright J,Deinhardt F,Wolfe L,Schaffer P,Benyesh-Melnick M

更新日期：1976-02-01 00:00:00

abstract：:Fusarium moniliforme (FM) is a major fungal pathogen of corn and is involved with stalk rot disease. FM is widely spread throughout the world, including the United States. Most strains of FM produce several mycotoxins, the most prominent of which is called fumonisin. Recent epidemiological studies indicated that inges...

journal_title：Cancer research

authors： Huang C,Dickman M,Henderson G,Jones C

更新日期：1995-04-15 00:00:00

abstract：:Removal of T-lymphocytes from marrow inoculum with monoclonal antibody plus complement permitted establishment of long-lived allogeneic chimeras between C57BL/6 and AKR/J mice. Development of leukemia was prevented for 15 mo. Protection from leukemia occurred with both young (4 wk) and older (4 mo) recipients. AKR mic...

journal_title：Cancer research

authors： Wustrow TP,Good RA

更新日期：1985-12-01 00:00:00

abstract：:Hypoxia in solid tumors is associated with treatment resistance and increased metastatic potential. Although hypoxia has been reported in pancreatic cancer patients, there is little direct evidence that this contributes to their overall poor prognosis. To address this, we examined the associations between hypoxia and ...

journal_title：Cancer research

authors： Chang Q,Jurisica I,Do T,Hedley DW

更新日期：2011-04-15 00:00:00

abstract：:In vivo 31P nuclear magnetic resonance spectroscopy was used to examine the bioenergetics of the rat 9L gliosarcoma during untreated growth and in response to chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Tumor growth was associated with a decline in the phosphocreatine and nucleoside triphosphate resonances...

journal_title：Cancer research

authors： Steen RG,Tamargo RJ,McGovern KA,Rajan SS,Brem H,Wehrle JP,Glickson JD

更新日期：1988-02-01 00:00:00