Haem, not protein or inorganic iron, is responsible for endogenous intestinal N-nitrosation arising from red meat.

abstract：:A phosphorylation site was introduced into chimeric monoclonal antibody B72.3 (MAb-chB72.3) by site-specific mutation of the coding sequence. The phosphorylation site for the cAMP-dependent protein kinase was positioned at the carboxyl terminus of the heavy-chain constant region of MAb-chB72.3. The resultant modified ...

journal_title：Cancer research

authors： Lin L,Daugherty B,Schlom J,Pestka S

更新日期：1996-09-15 00:00:00

abstract：:In order to further understand the role of the host organ in tumor progression, we have transplanted into nude mice histologically intact human colon cancer tissue on the serosal layers of the stomach (heterotopic site) and the serosal layers of the colon (orthotopic site). Xenograft lines Co-3, which is well differen...

journal_title：Cancer research

authors： Togo S,Shimada H,Kubota T,Moossa AR,Hoffman RM

更新日期：1995-02-01 00:00:00

abstract：:The reactivities of two anti-bladder cancer monoclonal antibodies, AN43 and BB369, were characterized. AN43 and BB369 reacted with a majority (greater than 50%) of bladder cancer tissue sections tested by immunoperoxidase staining. When tested against a panel of 27 normal human tissues, AN43 and BB369 reacted only wit...

journal_title：Cancer research

authors： Liebert M,Wedemeyer GA,Stein JA,Washington RW Jr,Flint A,Ren LQ,Grossman HB

更新日期：1989-12-01 00:00:00

abstract：:Southern blot-hybridization analysis of DNAs from human tumors demonstrated amplification of the epidermal growth factor (EGF) receptor gene in 10 of 12 squamous cell carcinoma cell lines tested and in none of 18 tumor cell lines of nonsquamous cell carcinomas. The degree of amplification in the squamous cells varied ...

journal_title：Cancer research

authors： Yamamoto T,Kamata N,Kawano H,Shimizu S,Kuroki T,Toyoshima K,Rikimaru K,Nomura N,Ishizaki R,Pastan I

更新日期：1986-01-01 00:00:00

abstract：:Small-molecule inhibitors of PARP1/2, such as olaparib, have been proposed to serve as a synthetic lethal therapy for cancers that harbor BRCA1 or BRCA2 mutations. Indeed, in clinical trials, PARP1/2 inhibitors elicit sustained antitumor responses in patients with germline BRCA gene mutations. In hypothesizing that ad...

journal_title：Cancer research

authors： Bajrami I,Frankum JR,Konde A,Miller RE,Rehman FL,Brough R,Campbell J,Sims D,Rafiq R,Hooper S,Chen L,Kozarewa I,Assiotis I,Fenwick K,Natrajan R,Lord CJ,Ashworth A

更新日期：2014-01-01 00:00:00

abstract：:Cancer-associated retinopathy (CAR) is an ocular manifestation of a paraneoplastic syndrome whereby immunological reactions to retinal antigens aberrantly expressed in tumor cells lead to the degeneration of retinal photoreceptor cells. In our previous study (H. Ohguro et al., Invest. Ophthalmol. Vis. Sci., 40: 82-89,...

journal_title：Cancer research

authors： Maeda A,Ohguro H,Maeda T,Wada I,Sato N,Kuroki Y,Nakagawa T

更新日期：2000-04-01 00:00:00

abstract：:MicroRNAs are noncoding RNAs that inhibit the expression of their targets in a sequence-specific manner and play crucial roles during oncogenesis. Here we show that microRNA-7 (miR-7) inhibits p21-activated kinase 1 (Pak1) expression, a widely up-regulated signaling kinase in multiple human cancers, by targeting the 3...

journal_title：Cancer research

authors： Reddy SD,Ohshiro K,Rayala SK,Kumar R

更新日期：2008-10-15 00:00:00

abstract：:Data are presented indicating marked antineoplastic activity for cis-dichlorodiammineplatinum(II) in MOPC 104E myeloma. One-eighteenth of the dose that produced 100% cures can be combined with noncurative, low doses of cyclophosphamide and 1,3-bis(2-chloroethyl)-1-nitrosourea to produce antineoplastic activity of the ...

journal_title：Cancer research

authors： Ghanta VK,Jones MT,Woodard DA,Durant JR,Hiramoto RN

更新日期：1977-03-01 00:00:00

abstract：:Using whole viable human colon carcinoma HT29 cells as immunogen, we produced a monoclonal antibody (mAb) termed 69-6-5. The antibody was functionally selected on its anti-cell-spreading activity. By immunoprecipitation of surface radiolabeled cell lysates from HT29-D4 cells (an HT29 cell clone), mAb 69-6-5 recognized...

journal_title：Cancer research

authors： Lehmann M,Rabenandrasana C,Tamura R,Lissitzky JC,Quaranta V,Pichon J,Marvaldi J

更新日期：1994-04-15 00:00:00

abstract：:A series of nitrofuran-based compounds were identified as inhibitors of estrogen signaling in a cell-based, high-throughput screen of a diverse library of small molecules. These highly related compounds were subsequently found to inhibit topoisomerase II in vitro at concentrations similar to that required for the inhi...

journal_title：Cancer research

authors： Polycarpou-Schwarz M,Müller K,Denger S,Riddell A,Lewis J,Gannon F,Reid G

更新日期：2007-05-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an aggressive clinical course, whereas others having an indolent behavior. We conducted an integrative and multidisciplinary analysis of 177 MCL to determine whether the immunogenetic features of the clonotypic B-cell receptors (BcR) ma...

journal_title：Cancer research

authors： Navarro A,Clot G,Royo C,Jares P,Hadzidimitriou A,Agathangelidis A,Bikos V,Darzentas N,Papadaki T,Salaverria I,Pinyol M,Puig X,Palomero J,Vegliante MC,Amador V,Martinez-Trillos A,Stefancikova L,Wiestner A,Wilson W,Po

更新日期：2012-10-15 00:00:00

abstract：:Several reports have suggested that a decrease or absence of adenosine deaminase complexing protein (ADCP) is consistently associated with cancer. However, in other studies, decreased as well as increased ADCP levels were found. In the present study, we investigated ADCP levels in 37 colorectal adenocarcinomas and cor...

journal_title：Cancer research

authors： ten Kate J,Wijnen JT,van der Goes RG,Quadt R,Griffioen G,Bosman FT,Khan PM

更新日期：1984-10-01 00:00:00

abstract：:Recent characterization of abnormal phosphatidylcholine metabolism in tumor cells by nuclear magnetic resonance (NMR) has identified novel fingerprints of tumor progression that are potentially useful as clinical diagnostic indicators. In the present study, we analyzed the concentrations of phosphatidylcholine metabol...

journal_title：Cancer research

authors： Iorio E,Mezzanzanica D,Alberti P,Spadaro F,Ramoni C,D'Ascenzo S,Millimaggi D,Pavan A,Dolo V,Canevari S,Podo F

更新日期：2005-10-15 00:00:00

abstract：:Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (...

journal_title：Cancer research

authors： Hecht SS,el-Bayoumy K,Rivenson A,Amin S

更新日期：1994-01-01 00:00:00

abstract：:3,3',5-Triiodo-L-thyronine (200 microgram/100 g) is shown to be a potent liver parenchymal cell mitogen in the rat, and thyroidectomy is seen to severely inhibit hepatocyte proliferation in regenerating rat liver. Taken together, these observations point to a crucial role for the iodothyronine in liver cell hyperplasi...

journal_title：Cancer research

authors： Short J,Klein K,Kibert L,Ove P

更新日期：1980-07-01 00:00:00

abstract：:Loss of serine or threonine phosphorylation sites from exon 3 of beta-catenin has been identified in approximately half of colorectal tumors which lack adenomatous polyposis coli (APC) mutations, but the overall contribution of beta-catenin mutations to sporadic colorectal tumorigenesis is unclear. We therefore used P...

journal_title：Cancer research

authors： Samowitz WS,Powers MD,Spirio LN,Nollet F,van Roy F,Slattery ML

更新日期：1999-04-01 00:00:00

abstract：:L-Histidinol, an analogue of the amino acid L-histidine, has been reported to be able to increase the specificity of 5-fluorouracil (FUra), through both protection of normal tissues at risk and potentiation of leukemic cell killing. It is postulated that this occurs through prevention of the entry of normal cells into...

journal_title：Cancer research

authors： Edelstein MB,Heilbrun LK

更新日期：1988-03-15 00:00:00

abstract：:Forestomach papillomas and skin papillomas were induced very efficiently by a single dose administration of the chemical carcinogen methylnitrosourea (MNU) in transgenic mice (rasH2 line) carrying human hybrid c-Ha-ras genes, which encode the prototype p21 gene product. The incidence of forestomach papillomas was dose...

journal_title：Cancer research

authors： Ando K,Saitoh A,Hino O,Takahashi R,Kimura M,Katsuki M

更新日期：1992-02-15 00:00:00

abstract：:Genetic changes found in human osteogenic sarcoma cells, including loss of the p53 and Rb tumor suppressor elements and overexpression of the cyclin G1 (CYCG1) proto-oncogene, suggest the potential of gene transfer as a treatment for metastatic disease. In this study, we examined the effects of antisense cyclin G1, in...

journal_title：Cancer research

authors： Skotzko M,Wu L,Anderson WF,Gordon EM,Hall FL

更新日期：1995-12-01 00:00:00

abstract：:After many years of productive study on the signaling networks, posttranslational regulatory control of effector molecules remains an intensely investigated and continuously evolving field of research to connect signaling with phenotypic changes. In recent years, there have been intriguing results on the interaction o...

journal_title：Cancer research

authors： Kumar R,Hung MC

更新日期：2005-04-01 00:00:00

abstract：:Tbx3 encodes a transcriptional repressor that is important for diverse patterning events during development, and Tbx3 mutation in humans causes the ulnar-mammary syndrome. Here, we describe the identification of Tbx3 in array-based search for genes downstream Wnt/beta-catenin that are implicated in liver tumorigenesis...

journal_title：Cancer research

authors： Renard CA,Labalette C,Armengol C,Cougot D,Wei Y,Cairo S,Pineau P,Neuveut C,de Reyniès A,Dejean A,Perret C,Buendia MA

更新日期：2007-02-01 00:00:00

abstract：:Clinical efficacy of PD-1/PD-L1 targeting relies upon the reactivation of tumor-specific but functionally impaired PD-1+ T cells present before therapy. Thus, analyzing early-stage primary tumors may reveal the presence of T cells that are not yet functionally impaired. In this study, we report that activated (HLA-DR+...

journal_title：Cancer research

authors： Tassi E,Grazia G,Vegetti C,Bersani I,Bertolini G,Molla A,Baldassari P,Andriani F,Roz L,Sozzi G,Pastorino U,Mortarini R,Anichini A

更新日期：2017-02-15 00:00:00

abstract：:The promotion of crude shark cartilage extracts as a cure for cancer has contributed to at least two significant negative outcomes: a dramatic decline in shark populations and a diversion of patients from effective cancer treatments. An alleged lack of cancer in sharks constitutes a key justification for its use. Here...

journal_title：Cancer research

authors： Ostrander GK,Cheng KC,Wolf JC,Wolfe MJ

更新日期：2004-12-01 00:00:00

abstract：:Biologically active phorbol ester derivatives displace [3H]phorbol-12, 13-dibutyrate from thioglycollate-elicited mouse peritoneal macrophages in a time-, temperature-, and concentration-dependent manner. Scatchard analysis revealed an apparent Kd of 54.1 nM and 8.0 X 10(5) sites/cell, indicating that these macrophage...

journal_title：Cancer research

authors： Sturm RJ,Smith BM,Lane RW,Laskin DL,Harris LS,Carchman RA

更新日期：1983-10-01 00:00:00

abstract：:Advocates bring unique and important viewpoints to the cancer research process, ensuring that scientific and medical advances are patient-centered and relevant. In this article, we discuss the benefits of engaging advocates in cancer research and underscore ways in which both the scientific and patient communities can...

journal_title：Cancer research

authors： Salamone JM,Lucas W,Brundage SB,Holloway JN,Stahl SM,Carbine NE,London M,Greenwood N,Goyes R,Chisholm DC,Price E,Carlin R,Winarsky S,Baker KB,Maues J,Shajahan-Haq AN

更新日期：2018-10-15 00:00:00

abstract：:High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiologic factor in prostate cancer (CaP) occurrence, recurrence, and progression. Androgen induces ROS production in the prostate by a yet unknown mechanism. Here, to the best of our knowledge, we report for the first ti...

journal_title：Cancer research

authors： Basu HS,Thompson TA,Church DR,Clower CC,Mehraein-Ghomi F,Amlong CA,Martin CT,Woster PM,Lindstrom MJ,Wilding G

更新日期：2009-10-01 00:00:00

abstract：:N4G3, a cell line that overexpresses translation initiation factor eIF4G, one of the components of eIF4F, was made by stable transfection of the human eIF4G cDNA into NIH3T3 cells. The cells expressed 80-100 times greater levels of eIF4G mRNA than did NIH3T3 cells. N4G3 cells formed transformed foci on a monolayer of ...

journal_title：Cancer research

authors： Fukuchi-Shimogori T,Ishii I,Kashiwagi K,Mashiba H,Ekimoto H,Igarashi K

更新日期：1997-11-15 00:00:00

abstract：:DNA mismatch repair (MMR) plays a key role in the cytotoxic response of human cells to methylating agents, however, the cascade of events leading to cell cycle arrest and cell death has yet to be characterized. We studied the role of MMR in the transcriptional response to DNA methylation damage in two human cellular m...

journal_title：Cancer research

authors： di Pietro M,Marra G,Cejka P,Stojic L,Menigatti M,Cattaruzza MS,Jiricny J

更新日期：2003-12-01 00:00:00

abstract：:Human embryonic lung fibroblasts (F-136-35-56) capable of growing in medium containing DL-homocysteine instead of L-methionine and human acute lymphoblastic leukemia cells (CCRF-HSB-2) with absolute methionine requirement exhibited dose-dependent growth inhibition when semipurified L-methionine-degrading enzyme (L-met...

journal_title：Cancer research

authors： Kreis W,Baker A,Ryan V,Bertasso A

更新日期：1980-03-01 00:00:00

abstract：:Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy ove...

journal_title：Cancer research

authors： Allen GW,Saba C,Armstrong EA,Huang SM,Benavente S,Ludwig DL,Hicklin DJ,Harari PM

更新日期：2007-02-01 00:00:00