Involvement of the lodothyronines in liver and hepatoma cell proliferation in the rat.

abstract：:Both clinical and experimental breast tumors often synthesize high levels of prostaglandins, most notably prostaglandin E2 (PGE2). We have reported previously that metastatic murine mammary tumor cells also express a high-affinity PGE2 receptor. We have now shown that the receptor plays a functional role in the metast...

journal_title：Cancer research

authors： Fulton AM,Zhang SZ,Chong YC

更新日期：1991-04-15 00:00:00

abstract：:A role of the epidermal growth factor receptor (EGFR) family has been suggested in colon cancer etiology, progression, and/or severity. Our recently identified pan-erbB inhibitor EGFR-related protein (ERRP) targets EGFRs by attenuating their activation and subsequent signaling leading to cellular growth inhibition. In...

journal_title：Cancer research

authors： Schmelz EM,Xu H,Sengupta R,Du J,Banerjee S,Sarkar FH,Rishi AK,Majumdar AP

更新日期：2007-06-01 00:00:00

abstract：:In order to study whether cell fusion would modify the DNA copy number of an amplified oncogene, somatic cell hybrids were made between the human neuroepithelioma cell line MCIXC and HeLaCOT human adenocarcinoma cells. MCIXC contains approximately 21 copies of the c-myc oncogene and HeLaCOT contains approximately 5 co...

journal_title：Cancer research

authors： Iman DS,Shay JW

更新日期：1989-08-15 00:00:00

abstract：:Intercellular communication was compared in early passage cultures of human mammary epithelial cells (HMEC) from normal and malignant breast tissues and immortalized nontumorigenic human breast cell lines (184A1 and 184B5). A clonogenic assay for the cell-mediated transfer of toxic metabolites of 6-thioguanine (TG) be...

journal_title：Cancer research

authors： Eldridge SR,Martens TW,Sattler CA,Gould MN

更新日期：1989-08-01 00:00:00

abstract：:The retroviral oncogene qin codes for a protein that belongs to the winged helix family of transcriptional regulators. The Qin protein is localized in the nucleus and binds to the same DNA consensus sequence as rat brain factor 1 (BF-1). Cellular Qin shows greater affinity to DNA than does viral Qin. Alone or fused to...

journal_title：Cancer research

authors： Li J,Chang HW,Lai E,Parker EJ,Vogt PK

更新日期：1995-12-01 00:00:00

abstract：:Caspase-8 is a proapoptotic protease that suppresses neuroblastoma metastasis by inducing programmed cell death. Paradoxically, caspase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can promote metastasis when apoptosis is compromised. Migration is enhanced by caspase-8 recru...

journal_title：Cancer research

authors： Barbero S,Mielgo A,Torres V,Teitz T,Shields DJ,Mikolon D,Bogyo M,Barilà D,Lahti JM,Schlaepfer D,Stupack DG

更新日期：2009-05-01 00:00:00

abstract：:Promoter methylation of the mismatch repair gene plays a key role in sporadic microsatellite instability (MSI) colorectal cancers. However, promoter methylation often occurs in proximal colon cancers, and molecular phenotypes underlying MSI cancers in distal colon have not been fully clarified. Our goal was to clarify...

journal_title：Cancer research

authors： Watanabe T,Kobunai T,Toda E,Yamamoto Y,Kanazawa T,Kazama Y,Tanaka J,Tanaka T,Konishi T,Okayama Y,Sugimoto Y,Oka T,Sasaki S,Muto T,Nagawa H

更新日期：2006-10-15 00:00:00

abstract：:Levels of epidermal growth factor receptor (EGF-R) and insulin-like growth factor receptor (IGF-R) in breast cancer tissue were evaluated. The binding of growth factors was compared to the content of estrogen receptors (ER) and progesterone receptors (PgR). EGF-R correlated negatively to the ER and PgR (Kendall correl...

journal_title：Cancer research

authors： Pekonen F,Partanen S,Mäkinen T,Rutanen EM

更新日期：1988-03-01 00:00:00

abstract：:GW572016 (Lapatinib) is a tyrosine kinase inhibitor in clinical development for cancer that is a potent dual inhibitor of epidermal growth factor receptor (EGFR, ErbB-1) and ErbB-2. We determined the crystal structure of EGFR bound to GW572016. The compound is bound to an inactive-like conformation of EGFR that is ver...

journal_title：Cancer research

authors： Wood ER,Truesdale AT,McDonald OB,Yuan D,Hassell A,Dickerson SH,Ellis B,Pennisi C,Horne E,Lackey K,Alligood KJ,Rusnak DW,Gilmer TM,Shewchuk L

更新日期：2004-09-15 00:00:00

abstract：:Stromal cell-derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 are implicated in the pathogenesis and prognosis of acute myelogenous leukemia (AML). Cellular microparticles, submicron vesicles shed from the plasma membrane of various cells, are also associated with human pathology. In the present study, we invest...

journal_title：Cancer research

authors： Kalinkovich A,Tavor S,Avigdor A,Kahn J,Brill A,Petit I,Goichberg P,Tesio M,Netzer N,Naparstek E,Hardan I,Nagler A,Resnick I,Tsimanis A,Lapidot T

更新日期：2006-11-15 00:00:00

abstract：:Capan 1, a human pancreatic cancer cell line, is routinely grown in 10% fetal calf serum (FCS). In order to characterize the factors needed for its proliferation, FCS was replaced by a synthetic serum (Ultroser G). For Capan 1 proliferation we found that Ultroser G was as efficient as FCS. A subfraction of Ultroser G ...

journal_title：Cancer research

authors： Clerc P,Bensaadi N,Pradel P,Estival A,Clemente F,Vaysse N

更新日期：1991-07-15 00:00:00

abstract：:In breast cancer bone metastasis, tumor cells stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone stimulate tumor growth. The alphavbeta3 integrin is an adhesion receptor expressed by breast cancer cells and osteoclasts. It is implicated in tumor cell invasion and...

journal_title：Cancer research

authors： Zhao Y,Bachelier R,Treilleux I,Pujuguet P,Peyruchaud O,Baron R,Clément-Lacroix P,Clézardin P

更新日期：2007-06-15 00:00:00

abstract：:Solid tumors often contain poorly vascularized necrotic regions. In order to determine how such regions are formed within tumors and to identify substances which affect their formation, we have transformed nontumorigenic BALB/c 3T3 cells with an activated Ha-ras oncogene. Cells that were derived from independent clone...

journal_title：Cancer research

authors： Peretz D,Kimel N,Fujii DK,Neufeld G

更新日期：1993-01-01 00:00:00

abstract：:Protein kinase Ciota (PKCiota) is an oncogene required for maintenance of the transformed phenotype of non-small cell lung cancer cells. However, the role of PKCiota in lung tumor development has not been investigated. To address this question, we established a mouse model in which oncogenic Kras(G12D) is activated by...

journal_title：Cancer research

authors： Regala RP,Davis RK,Kunz A,Khoor A,Leitges M,Fields AP

更新日期：2009-10-01 00:00:00

abstract：:Recently, we have reported that the toxicity of the membrane-active agent valinomycin (VM) can be reduced with maintenance and/or enhancement of its antitumor activity by incorporation in liposomes (S. S. Daoud and Juliano, Cancer Res., 46:5518-5525, 1986). Since the underlying defect(s) in multidrug resistance reside...

journal_title：Cancer research

authors： Daoud SS,Juliano RL

更新日期：1989-05-15 00:00:00

abstract：:The reactivities of two anti-bladder cancer monoclonal antibodies, AN43 and BB369, were characterized. AN43 and BB369 reacted with a majority (greater than 50%) of bladder cancer tissue sections tested by immunoperoxidase staining. When tested against a panel of 27 normal human tissues, AN43 and BB369 reacted only wit...

journal_title：Cancer research

authors： Liebert M,Wedemeyer GA,Stein JA,Washington RW Jr,Flint A,Ren LQ,Grossman HB

更新日期：1989-12-01 00:00:00

abstract：:Primary solid tumors were mechanically and/or enzymatically disassociated, and the resulting suspensions of single cells and small clumps of cells were seeded onto three different substrates, i.e., tissue culture plastic, rat smooth muscle cells (SMCs), and SMC-derived extracellular matrix. Tests of the relative effec...

journal_title：Cancer research

authors： Bogenmann E,Mark C,Isaacs H,Neustein HB,De Clerck YA,Laug WE,Jones PA

更新日期：1983-03-01 00:00:00

abstract：:Dilantin (phenytoin) is a commonly used antiepileptic agent that is known to decrease conductance of sodium and calcium ions and delay outward potassium currents. Separate from its antiseizure activity, dilantin interferes with microtubule protein polymerization. It induces metaphase arrest and potentiates the effects...

journal_title：Cancer research

authors： Lobert S,Ingram JW,Correia JJ

更新日期：1999-10-01 00:00:00

abstract：:Although chemokine and growth factor receptors are attractive and popular targets for cancer therapeutic intervention, structure-based targeting of the ligands themselves is generally not considered practical. New evidence indicates that a notable exception to this is macrophage migration inhibitory factor (MIF). MIF,...

journal_title：Cancer research

authors： Winner M,Meier J,Zierow S,Rendon BE,Crichlow GV,Riggs R,Bucala R,Leng L,Smith N,Lolis E,Trent JO,Mitchell RA

更新日期：2008-09-15 00:00:00

abstract：:The effects of 5-mercapto-2'-deoxyuridine (MUdr) on DNA synthesis in a primary murine spleen lymphocyte culture system stimulated by phytohemagglutinin (PHA) were studied. Inhibition of thymidine incorporation into acid insoluble nucleic acid material was 50% at 0.5 mM MUdR concentration, while inhibition of deoxyurid...

journal_title：Cancer research

authors： Bogyo D,Bardos TJ,Chmielewicz ZF

更新日期：1976-09-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (Stat3) is activated by cytokines and growth factors in lung cancers and regulates expression of genes implicated in cell growth, survival, and transformation. Previously, we found that mice with a deletion of the G protein-coupled receptor, family C, group 5, membe...

journal_title：Cancer research

authors： Chen Y,Deng J,Fujimoto J,Kadara H,Men T,Lotan D,Lotan R

更新日期：2010-11-01 00:00:00

abstract：:About two thirds of laryngeal cancers originate at the vocal cords. Early-stage detection of malignant vocal fold alterations, including a discrimination of premalignant lesions, represents a major challenge in laryngology as precancerous vocal fold lesions and small carcinomas are difficult to distinguish by means of...

journal_title：Cancer research

authors： Unger J,Lohscheller J,Reiter M,Eder K,Betz CS,Schuster M

更新日期：2015-01-01 00:00:00

abstract：:The expression of human leukocyte antigen (HLA) class I alleles was analyzed in 65 renal cell carcinomas using one-dimensional isoelectric focusing. Normal organ tissue and peripheral blood lymphocytes were used as controls. The patients were serologically typed using the standard microcytotoxicity test. Forty-two pat...

journal_title：Cancer research

authors： Luboldt HJ,Kubens BS,Rübben H,Grosse-Wilde H

更新日期：1996-02-15 00:00:00

abstract：:Recent expression profile analyses revealed that lung adenocarcinomas can be divided into several subgroups with diverse pathological features. Because cellular heterogeneity of tumors can confound these analyses, we used laser capture microdissection and microarray expression analysis to characterize the molecular pr...

journal_title：Cancer research

authors： Miura K,Bowman ED,Simon R,Peng AC,Robles AI,Jones RT,Katagiri T,He P,Mizukami H,Charboneau L,Kikuchi T,Liotta LA,Nakamura Y,Harris CC

更新日期：2002-06-01 00:00:00

abstract：:Receptor protein-tyrosine kinases (RPTKs) are tightly regulated during normal cellular processes including cell growth, differentiation, and metabolism. Recently, a RPTK-like molecule named novel oncogene with kinase-domain (NOK) has been cloned and characterized. Overexpression of NOK caused severe cellular transform...

journal_title：Cancer research

authors： Chen Y,Li YH,Chen XP,Gong LM,Zhang SP,Chang ZJ,Zhang XF,Fu XY,Liu L

更新日期：2005-12-01 00:00:00

abstract：:Hepatocellular carcinoma is the fifth most common cancer worldwide, and there is no effective therapy for unresectable disease. We have developed a targeted systemic therapy for hepatocellular carcinoma. The gene for a foreign enzyme is selectively expressed in the tumor cells and a nontoxic prodrug is then given, whi...

journal_title：Cancer research

authors： Schepelmann S,Hallenbeck P,Ogilvie LM,Hedley D,Friedlos F,Martin J,Scanlon I,Hay C,Hawkins LK,Marais R,Springer CJ

更新日期：2005-06-15 00:00:00

abstract：:One major rationale for using interleukin-2 and IFN-alpha in cancer immunotherapy is to activate tumor-specific T cells at the tumor site. To study the in situ T-cell response, we determined the T-cell receptor (TCR) repertoire in six melanoma metastases regressing after cytokine treatment obtained from five patients....

journal_title：Cancer research

authors： Willhauck M,Scheibenbogen C,Pawlita M,Möhler T,Thiel E,Keilholz U

更新日期：2003-07-01 00:00:00

abstract：:In cancer cell lines and rodent models, calcium and vitamin D favorably modulate cell proliferation, differentiation, and apoptosis in colonic epithelia. These effects may be modulated by local expression of the calcium receptor (CaR), the vitamin D receptor (VDR), and the P450 cytochromes, CYP27B1 and CYP24A1; howeve...

journal_title：Cancer research

authors： Ahearn TU,McCullough ML,Flanders WD,Long Q,Sidelnikov E,Fedirko V,Daniel CR,Rutherford RE,Shaukat A,Bostick RM

更新日期：2011-01-15 00:00:00

abstract：:Approximately 25% of breast cancers do not express the estrogen receptor-α (ERα) and consequently do not respond to endocrine therapy. In these tumors, ERα repression is often due to epigenetic modifications such as methylation and histone deacetylation. For this reason, we investigated the ability of the histone deac...

journal_title：Cancer research

authors： Sabnis GJ,Goloubeva O,Chumsri S,Nguyen N,Sukumar S,Brodie AM

更新日期：2011-03-01 00:00:00

abstract：:The expression of epidermal growth factor (EGF) receptor was examined immunohistochemically in a total of 122 gastric and 61 colonic carcinomas, out of which 16 gastric and 8 colonic carcinomas were also examined by 125I-labeled EGF binding analysis and Western blotting. The values of EGF binding were 12.68 +/- 1.98 (...

journal_title：Cancer research

authors： Yasui W,Sumiyoshi H,Hata J,Kameda T,Ochiai A,Ito H,Tahara E

更新日期：1988-01-01 00:00:00