Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers.

abstract：:It has been hypothesized that rapidly dividing tumor cells can outpace adoptively transferred antitumor lymphocytes when tumors are large. However, this hypothesis is at odds with clinical observations indicating that bulky tumors can be destroyed by small numbers of adoptively transferred antitumor T cells. We sought...

journal_title：Cancer research

authors： Hwang LN,Yu Z,Palmer DC,Restifo NP

更新日期：2006-01-15 00:00:00

abstract：:The interaction of hypoxia-inducible factor 1alpha and the CH1 domain of the transcriptional coactivator p300/CBP is necessary for the expression of hypoxia responsive genes and tumor angiogenesis. The transcription factor CITED2 binds p300/CBP at the CH1 domain and functions as a negative regulator of hypoxia signali...

journal_title：Cancer research

authors： Fox SB,Bragança J,Turley H,Campo L,Han C,Gatter KC,Bhattacharya S,Harris AL

更新日期：2004-09-01 00:00:00

abstract：:Fractalkine is a CX3C-type chemokine that induces chemotaxis of monocytes and cytotoxic T cells. Using the differential display method for examining gene expression in p53-defective cells transfected by adenovirus containing wild-type p53, we observed that fractalkine was induced by ectopic expression of p53. An elect...

journal_title：Cancer research

authors： Shiraishi K,Fukuda S,Mori T,Matsuda K,Yamaguchi T,Tanikawa C,Ogawa M,Nakamura Y,Arakawa H

更新日期：2000-07-15 00:00:00

abstract：:Identification of factors that mediate visceral and bone metastatic spread and subsequent bone remodeling events is highly relevant to successful therapeutic intervention in advanced human prostate cancer. TBX2, a T-box family transcription factor that negatively regulates cell-cycle inhibitor p21, plays critical role...

journal_title：Cancer research

authors： Nandana S,Tripathi M,Duan P,Chu CY,Mishra R,Liu C,Jin R,Yamashita H,Zayzafoon M,Bhowmick NA,Zhau HE,Matusik RJ,Chung LW

更新日期：2017-03-15 00:00:00

abstract：:The Lewis lung carcinoma is a transplantable metastatic tumor of the C57BL mouse strain. When cells derived from this tumor are inoculated onto the chorioallantoic membrane (CAM) of 9- to 11-day-old chick embryos, large tumors are produced. Although most of these tumors contain mouse cells, they can no longer be trans...

journal_title：Cancer research

authors： Belin D,Ossowski L

更新日期：1983-07-01 00:00:00

abstract：:Unscheduled DNA synthesis (UDS) indicated by melphalan was studied in freshly collected tumor cells from human melanoma metastases. Comparative studies were done on human bone marrow blast cells. Significant levels of UDS comparable with those in myeloblasts were found in only two of eight melanoma cell populations. T...

journal_title：Cancer research

authors： Lewensohn R,Ringborg U,Hansson J

更新日期：1982-01-01 00:00:00

abstract：:A genome-wide computational screen was performed to identify tumor-associated alternative RNA splicing isoforms. A BLAST algorithm was used to compare 11,014 genes from RefSeq with 3,471,822 human expressed sequence tag sequences. The screen identified 26,258 alternative splicing isoforms of which 845 were significant...

journal_title：Cancer research

authors： Wang Z,Lo HS,Yang H,Gere S,Hu Y,Buetow KH,Lee MP

更新日期：2003-02-01 00:00:00

abstract：:We examined the effect of rate of temperature rise on the thermosensitivity of a murine lymphoblastic leukemia. L1210 cells suspended in RPMI 1630 medium:5% fetal bovine serum at pH 7.4 were heated from 37 degrees C-42 degrees C, or 44 degrees C over variable times (immediately, 30, 60, 120, 180 min) in a circulating ...

journal_title：Cancer research

authors： Burns CP,Lambert BJ,Haugstad BN,Guffy MM

更新日期：1986-04-01 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) is constitutively activated in many types of cancers and has been implicated in gene expression important for angiogenesis, tumor growth, progression, and metastasis. Here, we show that the NF-kappaB activator, IkappaB kinase-alpha (IKKalpha), but not IKKbeta,...

journal_title：Cancer research

authors： DeBusk LM,Massion PP,Lin PC

更新日期：2008-12-15 00:00:00

abstract：:Two principal virus-directed antigens have been identified on the surface of oncornavirus-infected chick embryo cells. One is identical with the major virus type-specific envelope antigen, which is a glycoprotein with a molecular weight of 85,000. The 2nd antigen (tumor-specific cell surface antigen) is specific for t...

journal_title：Cancer research

authors： Bauer H,Kurth R,Rohrschneider L,Gelderblom H

更新日期：1976-02-01 00:00:00

abstract：:The purpose of this study was to evaluate the efficacy of treatment with recombinant interleukin-2 (rIL-2) and lymphokine-activated killer cells in patients with advanced bladder cancer and to study the induced changes in the distribution of leukocyte subsets in blood and tumor. Nine patients with metastatic transitio...

journal_title：Cancer research

authors： Hermann GG,Geertsen PF,von der Maase H,Steven K,Andersen C,Hald T,Zeuthen J

更新日期：1992-02-01 00:00:00

abstract：:Three Burkitt's lymphoma cell lines were studied for their response to cis-diamminedichloroplatinum(II) (cis-DDP) and L-phenylalanine mustard (L-PAM) with the objective of relating cytotoxicity to DNA cross-linking in human cells. Cytotoxicity was measured by cell proliferation and colony formation assays. DNA interst...

journal_title：Cancer research

authors： Ducore JM,Erickson LC,Zwelling LA,Laurent G,Kohn KW

更新日期：1982-03-01 00:00:00

abstract：:Two aminoanthraquinone analogs 1,4-bis(2-[(2-hydroxyethyl)amino]ethylamino)-9,10-anthracenedione (HAQ) and 1,4-dihydroxy-5,8-bis(2-[(2-hydroxyethyl)amino]ethylamino]-9,10-anthracenedione (DHAQ) have been shown to possess similar therapeutic activities against experimental tumors but different toxicities to the animal...

journal_title：Cancer research

authors： Au WW,Butler MA,Matney TS,Loo TL

更新日期：1981-02-01 00:00:00

abstract：:Cell systems as different as normal human blood lymphocytes and frog auricles release spontaneously a nucleoprotein complex in their culture medium. This release seems to be an active mechanism that is unrelated to cell death. The presence of RNA in this complex is demonstrated. The amount of extracellular RNA is regu...

journal_title：Cancer research

authors： Stroun M,Anker P,Beljanski M,Henri J,Lederrey C,Ojha M,Maurice PA

更新日期：1978-10-01 00:00:00

abstract：:[3H]Pregn-4-ene-3,20-dione ([3H]progesterone)-receptor complexes from human mammary carcinoma were found to be stabilized in the presence of glycerol. The dissociation rate constant was lowered and the equilibrium dissociation constant was decreased (KD=3 nM in the absence of glycerol and 1.1 nM in the presence of 30%...

journal_title：Cancer research

authors： Pichon MF,Milgrom E

更新日期：1977-02-01 00:00:00

abstract：:Topotecan (SK&F 104864, hycamptamine, NSC 609699) is believed to exert its cytotoxic effects through inhibition of topoisomerase I, the activity of which recovers rapidly on removal of the drug in vitro. In vivo studies show that the activity of topotecan is schedule dependent, favoring repeated doses. Early human stu...

journal_title：Cancer research

authors： Haas NB,LaCreta FP,Walczak J,Hudes GR,Brennan JM,Ozols RF,O'Dwyer PJ

更新日期：1994-03-01 00:00:00

abstract：:Three widely studied cell lines were used to examine the nature of the G1 arrest induced in human tumor cells by ionizing radiation and its relation to p53 status. Cell lines MCF-7 and RKO express wild-type p53, whereas HT29 expresses mutant p53. Exponentially growing cells were irradiated with 6 Gy, and the progressi...

journal_title：Cancer research

authors： Nagasawa H,Li CY,Maki CG,Imrich AC,Little JB

更新日期：1995-05-01 00:00:00

abstract：:In vitro responsiveness of endometrial adenocarcinoma to progestins was evaluated histologically by incubation of tissue fragments in medium containing 10(-6) M medroxyprogesterone acetate. In a series of 19 experiments, formation of sub- and supranuclear vacuoles, which reflects accumulation of glycogen in response t...

journal_title：Cancer research

authors： Holinka CF,Deligdisch L,Gurpide E

更新日期：1984-01-01 00:00:00

abstract：:Angiogenesis is essential for the growth of solid tumors. We have observed previously that the vascular endothelial cells of astrocytic brain tumors express human telomerase reverse transcriptase (hTERT) mRNA, suggesting a role for telomerase in the angiogenesis of these neoplasms. Here, we used an in vitro model to d...

journal_title：Cancer research

authors： Falchetti ML,Pierconti F,Casalbore P,Maggiano N,Levi A,Larocca LM,Pallini R

更新日期：2003-07-01 00:00:00

abstract：:The human checkpoint kinase 2 (Chk2) plays a central role in regulation of the cellular response to DNA damage, resulting in cell cycle arrest, DNA repair, or apoptosis depending on severity of DNA damage and the cellular context. Chk2 inhibitors are being developed as sensitizers for chemotherapeutic agents. In contr...

journal_title：Cancer research

authors： Chen CR,Wang W,Rogoff HA,Li X,Mang W,Li CJ

更新日期：2005-07-15 00:00:00

abstract：:The effects of the anthracycline antiboties, daunomycin and adriamycin, on the DNA-directed activities of DNA polymerases from murine sarcoma virus, rat liver (high-molecular-weight species), Escherichia coli, and Micrococcus luteus were determined. Under all conditions tested, these compounds had greater inhibitory e...

journal_title：Cancer research

authors： Zunino F,Gambetta R,Di Marco A,Zaccara A,Luoni G

更新日期：1975-03-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer syndrome characterized by early age of onset colorectal cancer (mean 45 years) as well as endometrial, urinary tract, and upper gastrointestinal adenocarcinomas. The HNPCC phenotype has been shown to segregate with germline mutations in ...

journal_title：Cancer research

authors： Weber TK,Conlon W,Petrelli NJ,Rodriguez-Bigas M,Keitz B,Pazik J,Farrell C,O'Malley L,Oshalim M,Abdo M,Anderson G,Stoler D,Yandell D

更新日期：1997-09-01 00:00:00

abstract：:Oncogenic activation of the BRAF serine/threonine kinase has been associated with initiation and maintenance of melanoma tumors. As such, development of pharmacologic agents to target RAF proteins or their effector kinases is an area of intense investigation. Here we report the biological properties of GDC-0879, a hig...

journal_title：Cancer research

authors： Hoeflich KP,Herter S,Tien J,Wong L,Berry L,Chan J,O'Brien C,Modrusan Z,Seshagiri S,Lackner M,Stern H,Choo E,Murray L,Friedman LS,Belvin M

更新日期：2009-04-01 00:00:00

abstract：:We have recently identified a new gene, interleukin-17 receptor-like (IL-17RL), which is expressed in normal prostate and prostate cancer. This investigation is focused on the role of IL-17RL in prostate cancer. We found that IL-17RL was expressed at significantly higher levels in several androgen-independent prostate...

journal_title：Cancer research

authors： You Z,Shi XB,DuRaine G,Haudenschild D,Tepper CG,Lo SH,Gandour-Edwards R,de Vere White RW,Reddi AH

更新日期：2006-01-01 00:00:00

abstract：:The human papillomavirus (HPV) 16 E7 oncoprotein has been reported previously to stimulate DNA damage and to activate host cell DNA damage checkpoints. How HPV-16 E7 maintains proliferation despite activated DNA damage checkpoints is incompletely understood. Here, we provide evidence that cells expressing the HPV-16 E...

journal_title：Cancer research

authors： Spardy N,Covella K,Cha E,Hoskins EE,Wells SI,Duensing A,Duensing S

更新日期：2009-09-01 00:00:00

abstract：:In the present study, we investigated the effects of estrogens on the growth of the HL60 line in vitro and the presence of estrogen binding sites in the same cells. Cell proliferation was estimated by cell counts, [3H]thymidine incorporation, and determination of the percentage of cells in the S phase by flow cytometr...

journal_title：Cancer research

authors： Danel L,Cordier G,Revillard JP,Saez S

更新日期：1982-11-01 00:00:00

abstract：:High-risk human papilloma viruses are known to be associated with cervical cancers. We have reported previously that the high-risk human papillomavirus (HPV) E6 oncoprotein interacts with E6TP1, a novel Rap GTPase-activating protein (RapGAP). Similar to p53 tumor suppressor protein, the high-risk HPV E6 oncoproteins t...

journal_title：Cancer research

authors： Gao Q,Kumar A,Singh L,Huibregtse JM,Beaudenon S,Srinivasan S,Wazer DE,Band H,Band V

更新日期：2002-06-01 00:00:00

abstract：:Inflammation has increasingly been recognized as a critical component influencing tumor growth. Recent reports have revealed conflicting evidence for the role of Toll-like receptors (TLR) in modulating tumorigenesis. In our study, we implicate TLR3 in mediating immune surveillance with increased growth of implanted tr...

journal_title：Cancer research

authors： Chin AI,Miyahira AK,Covarrubias A,Teague J,Guo B,Dempsey PW,Cheng G

更新日期：2010-04-01 00:00:00

abstract：:Merbarone, a novel DNA topoisomerase II (topo II) inhibitor, differs from teniposide (VM-26) in that it inhibits topo II activities without stabilizing topo II-DNA covalent complexes. Thus, while the cellular effects of VM-26 are the consequences of inhibition of topo II catalytic activities and generation of topo II-...

journal_title：Cancer research

authors： Chen M,Beck WT

更新日期：1995-04-01 00:00:00

abstract：:Previous studies have favored a basic difference in the regulation of specialized protein production by cells derived from the usual tissue of origin (eutopic) and cancer cells derived from a tissue not normally producing the protein (ectopic). Thus N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate was believed to...

journal_title：Cancer research

authors： Rosen SW,Calvert I,Weintraub BD,Tseng JS,Rabson AS

更新日期：1980-11-01 00:00:00