Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance.

abstract：:Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has been associated with increased growth, metastasis, and angiogenesis of some tumors. Because myeloma tumor cells express high levels of the syndecan-1 heparan sulfate proteoglycan and because these tumors grow as highly...

journal_title：Cancer research

authors： Kelly T,Miao HQ,Yang Y,Navarro E,Kussie P,Huang Y,MacLeod V,Casciano J,Joseph L,Zhan F,Zangari M,Barlogie B,Shaughnessy J,Sanderson RD

更新日期：2003-12-15 00:00:00

abstract：:The alpha(v)beta(3) integrin is expressed on proliferating endothelial cells such as those present in growing tumors, as well as on tumor cells of various origin. Tumor-induced angiogenesis can be blocked in vivo by antagonizing the alpha(v)beta(3) integrin with small peptides containing the Arg-Gly-Asp (RGD) amino ac...

journal_title：Cancer research

authors： Janssen ML,Oyen WJ,Dijkgraaf I,Massuger LF,Frielink C,Edwards DS,Rajopadhye M,Boonstra H,Corstens FH,Boerman OC

更新日期：2002-11-01 00:00:00

abstract：:The lymphocytes from some Fanconi's anemia patients appeared to be more radiosensitive than normal as measured by the number of X-ray-(or bleomycin-) induced chromosome aberrations seen following G2 treatment. Fibroblasts from the same patients, however, all showed the same degree of colony survival as normals followi...

journal_title：Cancer research

authors： Duckworth-Rysiecki G,Taylor AM

更新日期：1985-01-01 00:00:00

abstract：:When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and ulceration of the nearby stomach and intestines before achieving tum...

journal_title：Cancer research

authors： Fujimoto TN,Colbert LE,Huang Y,Molkentine JM,Deorukhkar A,Baseler L,de la Cruz Bonilla M,Yu M,Lin D,Gupta S,Cabeceiras PK,Kingsley CV,Tailor RC,Sawakuchi GO,Koay EJ,Piwnica-Worms H,Maitra A,Taniguchi CM

更新日期：2019-05-01 00:00:00

abstract：:We analyzed the gene expression profiles of clinical lung carcinomas using a cDNA microarray containing 27,648 genes or expressed sequence tags, and identified CDCA5 (cell division cycle associated 5) to be upregulated in the majority of lung cancers. Tumor tissue microarray analysis of 262 non-small cell lung cancer ...

journal_title：Cancer research

authors： Nguyen MH,Koinuma J,Ueda K,Ito T,Tsuchiya E,Nakamura Y,Daigo Y

更新日期：2010-07-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is characterized by a pathogenic vasculature that drives aggressive local invasion. Recent work suggests that GBM cells recruit bone marrow-derived progenitor cells (BMDC) to facilitate recurrence after radiotherapy, but how this may be achieved is unclear. In this study, we established t...

journal_title：Cancer research

authors： Burrell K,Singh S,Jalali S,Hill RP,Zadeh G

更新日期：2014-07-15 00:00:00

abstract：:To better understand the events occurring during immunotherapy of liver metastases with effector cells, we have developed a clinically relevant animal model in which both effector-tumor cell interactions and survival can be evaluated. A cell line of human gastric carcinoma (HR) metastatic to the liver has been establi...

journal_title：Cancer research

authors： Yasumura S,Lin WC,Hirabayashi H,Vujanovic NL,Herberman RB,Whiteside TL

更新日期：1994-07-15 00:00:00

abstract：:The ability of polyribosomes, obtained from several bacterial species, to suppress the development of cutaneous SaD2 fibrosarcomas in DBA/2 mice were evaluated. Suppression of tumor appearance depended upon the tumor load at the time of treatment, dose of polyribosomes, and species source of polyribosomes, with Serrat...

journal_title：Cancer research

authors： Urban RW,Edwards BS,Segal W

更新日期：1980-05-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to radiotherapy, chemotherapy, or a combination of these modalities, and surgery remains the only curative intervention for localized disease. Although cancer-associated fibroblasts (CAF) are abundant in PDAC tumors, the effects of radiotherapy on CAFs and th...

journal_title：Cancer research

authors： Pereira PMR,Edwards KJ,Mandleywala K,Carter LM,Escorcia FE,Campesato LF,Cornejo M,Abma L,Mohsen AA,Iacobuzio-Donahue CA,Merghoub T,Lewis JS

更新日期：2020-04-15 00:00:00

abstract：:The effect of rhodium(II) acetate, propionate, and methoxyacetate on the activity of 17 enzymes was evaluated. The enzymes were preincubated with the rhodium(II) complexes in order to detect irreversible inhibition. All enzymes that have essential sulfhydryl groups in or near their active site were found to be irrever...

journal_title：Cancer research

authors： Howard RA,Spring TG,Bear JL

更新日期：1976-12-01 00:00:00

abstract：:Leucine-rich repeat-containing 3B (LRRC3B) is an evolutionarily highly conserved leucine-rich repeat-containing protein, but its biological significance is unknown. Using restriction landmark genomic scanning and pyrosequencing, we found that the promoter region of LRRC3B was aberrantly methylated in gastric cancer. G...

journal_title：Cancer research

authors： Kim M,Kim JH,Jang HR,Kim HM,Lee CW,Noh SM,Song KS,Cho JS,Jeong HY,Hahn Y,Yeom YI,Yoo HS,Kim YS

更新日期：2008-09-01 00:00:00

abstract：:Quantitative optical cytochemistry permits the determination of many different parameters in whole cells or parts of cells. Total amounts of DNA, RNA, and protein and/or the amounts of these substances in nucleus or nucleolus are examples. Techniques in this field have contributed considerably to the development of ou...

journal_title：Cancer research

authors： Caspersson TO

更新日期：1979-07-01 00:00:00

abstract：:Ubiquitination and ubiquitin-like posttranslational modifications (PTM) regulate activity and stability of oncoproteins and tumor suppressors. This implicates PTMs as antineoplastic targets. One way to alter PTMs is to inhibit activity of deubiquitinases (DUB) that remove ubiquitin or ubiquitin-like proteins from subs...

journal_title：Cancer research

authors： Mustachio LM,Lu Y,Kawakami M,Roszik J,Freemantle SJ,Liu X,Dmitrovsky E

更新日期：2018-02-01 00:00:00

abstract：:Chloroethylnitrosoureas induce reactive O6-guanine adducts in DNA that can form either interstrand cross-links or a covalent complex with the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). To test our hypothesis that these end-products are formed from the common precursor, 1-O6-ethanoguanine, we com...

journal_title：Cancer research

authors： Gonzaga PE,Potter PM,Niu TQ,Yu D,Ludlum DB,Rafferty JA,Margison GP,Brent TP

更新日期：1992-11-01 00:00:00

abstract：:It has been proposed that cellular retinoic acid binding protein is essential for retinoid-induced differentiation of embryonal carcinoma line PCC4.aza1R. To assess the generality of this proposal, we have tested for the presence of cellular retinoic acid binding protein activities in several other embryonal carcinoma...

journal_title：Cancer research

authors： Matthaei KI,McCue PA,Sherman MI

更新日期：1983-06-01 00:00:00

abstract：:Neuroblastoma arises from the embryonal neural crest secondary to a block in differentiation. Long-term patient survival correlates inversely with the extent of differentiation, and treatment with retinoic acid or other prodifferentiation agents improves survival modestly. In this study, we show the histone chaperone ...

journal_title：Cancer research

authors： Barbieri E,De Preter K,Capasso M,Chen Z,Hsu DM,Tonini GP,Lefever S,Hicks J,Versteeg R,Pession A,Speleman F,Kim ES,Shohet JM

更新日期：2014-02-01 00:00:00

abstract：:Although it is widely accepted that tumor suppressor genes play an important role in the genesis and progression of human cancer, little is known about genetic events that accumulate during multistage lung carcinogenesis. Thus, to determine a subset of tumor suppressor genes that are involved in the genesis and progre...

journal_title：Cancer research

authors： Shiseki M,Kohno T,Nishikawa R,Sameshima Y,Mizoguchi H,Yokota J

更新日期：1994-11-01 00:00:00

abstract：:The glutathione transferase P (GST-P) gene is known for its specific expression during chemical hepatocarcinogenesis of the rat and is used as a tumor marker for hepatocellular carcinoma. We have shown recently that the upstream 2.9-kb region of the GST-P gene is sufficient for conferring tumor-specific expression of ...

journal_title：Cancer research

authors： Suzuki T,Imagawa M,Hirabayashi M,Yuki A,Hisatake K,Nomura K,Kitagawa T,Muramatsu M

更新日期：1995-06-15 00:00:00

abstract：:The multistage process of cancer formation is driven by the progressive acquisition of somatic mutations. Replication stress creates genomic instability in mammals. Using a well-defined multistep leukemia model driven by Spi-1/PU.1 overexpression in the mouse and Spi-1/PU.1-overexpressing human leukemic cells, we inve...

journal_title：Cancer research

authors： Rimmelé P,Komatsu J,Hupé P,Roulin C,Barillot E,Dutreix M,Conseiller E,Bensimon A,Moreau-Gachelin F,Guillouf C

更新日期：2010-09-01 00:00:00

abstract：:Replicating adenoviruses (Ads) are designed to replicate in and destroy cancer cells, generating viral progeny that spread within the tumor. To address the importance of the primary cellular receptor for Ads, the coxsackievirus and Ad receptor (CAR), in permitting intratumoral spread of a replicating Ad, we have used ...

journal_title：Cancer research

authors： Douglas JT,Kim M,Sumerel LA,Carey DE,Curiel DT

更新日期：2001-02-01 00:00:00

abstract：:We report that tumor necrosis factor (TNF) alpha induced a strong antitumor immune reaction when it was produced in arteries leading to tumors by gene transfer in vivo. We used a mouse model carrying a sarcoma-180 tumor in the right footpad and injected the fusogenic liposomes encapsulating the human TNF-alpha gene in...

journal_title：Cancer research

authors： Mizuguchi H,Nakagawa T,Toyosawa S,Nakanishi M,Imazu S,Nakanishi T,Tsutsumi Y,Nakagawa S,Hayakawa T,Ijuhin N,Mayumi T

更新日期：1998-12-15 00:00:00

abstract：:Retinoic acid (RA) is a potent in vitro inhibitor of cell proliferation in various malignant cell lines. The exact mechanisms of its actions, however, are not fully understood. To further elucidate the nature of this inhibition, we investigated the effects of RA in an estrogen receptor-negative human breast cancer cel...

journal_title：Cancer research

authors： Gucev ZS,Oh Y,Kelley KM,Rosenfeld RG

更新日期：1996-04-01 00:00:00

abstract：:Recent in vitro studies of the epidermal growth factor receptor (EGFR) family have revealed complex signaling interactions involving the production of ligand-mediated heterodimers synergistic for the transformation of cells in vitro. In a series of 70 patients with childhood medulloblastoma, we have used immunohistoch...

journal_title：Cancer research

authors： Gilbertson RJ,Perry RH,Kelly PJ,Pearson AD,Lunec J

更新日期：1997-08-01 00:00:00

abstract：:The role of the insulin-like growth factor I receptor (IGF-IR) in programmed cell death has been investigated in vivo in a biodiffusion chamber, where the extent of cell death could be determined quantitatively. We found that a decrease in the number of IGF-IRs causes massive apoptosis in vivo in several transplantabl...

journal_title：Cancer research

authors： Resnicoff M,Abraham D,Yutanawiboonchai W,Rotman HL,Kajstura J,Rubin R,Zoltick P,Baserga R

更新日期：1995-06-01 00:00:00

abstract：:The interleukin (IL)-13 receptor alpha2 (IL-13Ralpha2) chain is a primary binding and internalization subunit for a Th2-derived immune regulatory cytokine, IL-13. Although extremely high levels of IL-13Ralpha2 chain are expressed on a variety of human tumor cells and specimens, its precise role in tumor immunology has...

journal_title：Cancer research

authors： Kawakami K,Terabe M,Kawakami M,Berzofsky JA,Puri RK

更新日期：2006-04-15 00:00:00

abstract：:Purines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor mic...

journal_title：Cancer research

authors： Di Virgilio F

更新日期：2012-11-01 00:00:00

abstract：:Androgen receptors (ARs) belong to the family of hormone receptors that are ligand-dependent transcription factors. Endocrine therapy provides effective treatment for prostate cancer until mutations arise that alter the ligand responsiveness of AR. In this study, structural models were developed for the functional dom...

journal_title：Cancer research

authors： McDonald S,Brive L,Agus DB,Scher HI,Ely KR

更新日期：2000-05-01 00:00:00

abstract：:A subline of H35 hepatoma cells has been developed which exhibits 80-fold resistance to 5,10-dideazatetrahydrofolate, an antifolate which inhibits glycinamideribonucleotide transformylase. The cells are cross-resistant to methotrexate, an inhibitor of dihydrofolate reductase and 10-propargyl-5,8-dideazafolate and its ...

journal_title：Cancer research

authors： Rhee MS,Wang Y,Nair MG,Galivan J

更新日期：1993-05-15 00:00:00

abstract：:Functional studies using freshly isolated tumor-infiltrating B lymphocytes(TIB) are difficult to perform and interpret. Here we document a novel function of TIB using fresh human lung cancer tissues engrafted in SCID mice; they are at activated state and produce tumor-specific antibodies in tumor microenvironment: (a)...

journal_title：Cancer research

authors： Yasuda M,Takenoyama M,Obata Y,Sugaya M,So T,Hanagiri T,Sugio K,Yasumoto K

更新日期：2002-03-15 00:00:00

abstract：:GPRC5A is a G-protein-coupled receptor expressed in lung tissue but repressed in most human lung cancers. Studies in Gprc5a(-/-) mice have established its role as a tumor-suppressor function in this setting, but the basis for its role has been obscure. Here, we report that GPRC5A functions as a negative modulator of E...

journal_title：Cancer research

authors： Zhong S,Yin H,Liao Y,Yao F,Li Q,Zhang J,Jiao H,Zhao Y,Xu D,Liu S,Song H,Gao Y,Liu J,Ma L,Pang Z,Yang R,Ding C,Sun B,Lin X,Ye X,Guo W,Han B,Zhou BP,Chin YE,Deng J

更新日期：2015-05-01 00:00:00