LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer.

abstract：:Although targeting the Ras/Raf/MEK pathway remains a promising anticancer strategy, mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitors in clinical development are likely to be limited in their ability to produce durable clinical responses due to the emergence of acquired drug...

journal_title：Cancer research

authors： Wang H,Daouti S,Li WH,Wen Y,Rizzo C,Higgins B,Packman K,Rosen N,Boylan JF,Heimbrook D,Niu H

更新日期：2011-08-15 00:00:00

abstract：:The human nm23 gene, a candidate metastatic suppressor gene, consists of two genes, nm23-H1 and nm23-H2. The potential mutation in the nm23-H1 gene was examined in colorectal cancer using a reverse transcription polymerase chain reaction amplification followed by DNA sequencing analysis. Genomic alterations in the nm2...

journal_title：Cancer research

authors： Wang L,Patel U,Ghosh L,Chen HC,Banerjee S

更新日期：1993-02-15 00:00:00

abstract：:The protein composition of breast secretions from 99 premenopausal women with benign or malignant breast diseases and from 70 control women without breast pathologies has been studied by using polyacrylamide gel electrophoresis. These fluids have been classified into two types according to their major polypeptide comp...

journal_title：Cancer research

authors： Sánchez LM,Vizoso F,Díez-Itza I,López-Otín C

更新日期：1992-01-01 00:00:00

abstract：:It is known that Wnt-1 signaling inhibits apoptosis by activating beta-catenin/tcf-mediated transcription. Here, we show that blocking Wnt-1 signaling in beta-catenin-deficient mesothelioma cell lines H28 and MS-1 induces apoptotic cell death. Both Wnt-1 small interfering RNA (siRNA) and Dishevelled siRNA induced sign...

journal_title：Cancer research

authors： You L,He B,Uematsu K,Xu Z,Mazieres J,Lee A,McCormick F,Jablons DM

更新日期：2004-05-15 00:00:00

abstract：:Activities of the adenine purine nucleotide cycle enzymes, i.e., adenylosuccinate (SAMP) synthetase, SAMP lyase, and adenosine 5'-monophosphate deaminse, were determined in hepatic tissue of rats fed and/or given injections of 3'-methyl-4-dimethylaminoazobenzene, 4'-methyl-4-dimethylaminoazobenzene, thioacetamide, eth...

journal_title：Cancer research

authors： Smith LD,Emerson RL,Nixon LK

更新日期：1979-06-01 00:00:00

abstract：:Human tumor cells containing ras oncogenes display enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine (Ara-C) and other deoxycytidine analogues (H-M. Koo, et al., Cancer Res., 56: 5211-5216, 1996). Human tumor cell lines with or without a ras oncogene as well as a pair of isogenic cell lines with one containing...

journal_title：Cancer research

authors： Koo HM,McWilliams MJ,Alvord WG,Vande Woude GF

更新日期：1999-12-15 00:00:00

abstract：:Brca2 is an important tumor suppressor associated with susceptibility to breast cancer. Although increasing evidence indicates that the primary function of Brca2 is to facilitate the repair of DNA damage via the homologous recombination pathway, how Brca2 prevents breast cancer is largely unknown. To study the role of...

journal_title：Cancer research

authors： Cheung AM,Elia A,Tsao MS,Done S,Wagner KU,Hennighausen L,Hakem R,Mak TW

更新日期：2004-03-15 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:The pharmacokinetics of vinblastine in humans was examined using a radioimmunoassay specific for both the Vinca alkaloids and aromatic ring [3H]vinblastine. The data were consistent with a three-compartment open model system with the following values, alpha phase: t1/2=3.90+/-1.46 min; Vc=16.8+/-7.1 liters. beta phase...

journal_title：Cancer research

authors： Owellen RJ,Hartke CA,Hains FO

更新日期：1977-08-01 00:00:00

abstract：:Peroxisome proliferators (PPs) act as nongenotoxic tumor promoters in rodents. Their hepatocarcinogenicity requires the presence of the PP-activated receptor alpha (PPARalpha); however, the exact role played by this transcription factor in the liver, more precisely in liver cell growth and differentiation, is not know...

journal_title：Cancer research

authors： Kaplanski C,Pauley CJ,Griffiths TG,Kawabata TT,Ledwith BJ

更新日期：2000-02-01 00:00:00

abstract：:Increased sialylation and branching of asparagine-linked oligosaccharides have recently been associated with both neoplastic transformation and the metastatic phenotype. Swainsonine, an inhibitor of Golgi alpha-mannosidase II blocks the synthesis of sialylated tri- and tetraantennary asparagine-linked oligosaccharides...

journal_title：Cancer research

authors： Dennis JW

更新日期：1986-10-01 00:00:00

abstract：:Gene amplification is an important mechanism of increased gene expression in a number of human solid tumors. We have recently identified and cloned sequences from a novel DNA amplification unit in malignant fibrous histiocytoma. The amplified sequences are derived from chromosome 12q13-14 and encode a gene designated ...

journal_title：Cancer research

authors： Smith SH,Weiss SW,Jankowski SA,Coccia MA,Meltzer PS

更新日期：1992-07-01 00:00:00

abstract：:The localization of biliary glycoprotein (BGP) and its mRNA in normal colonic mucosa was studied by immunohistochemistry and in situ hybridization. BGP mRNA was confined to columnar epithelial cells and expressed abundantly in the superficial mature cells and at low levels in differentiating cells in the upper crypts....

journal_title：Cancer research

authors： Frängsmyr L,Baranov V,Prall F,Yeung MM,Wagener C,Hammarström S

更新日期：1995-07-15 00:00:00

abstract：:The fibroblast growth factors (FGF) play diverse roles in development, wound healing, and angiogenesis. The intracellular signal transduction pathways, which mediate these pleiotropic activities, remain incompletely understood. We show here that the proangiogenic factors FGF2 and FGF8b can activate signal transducers ...

journal_title：Cancer research

authors： Yang X,Qiao D,Meyer K,Friedl A

更新日期：2009-02-15 00:00:00

abstract：:Aberrant FLT3 expression and/or mutation plays a significant role in leukemogenesis. This has prompted the development of selective small molecule tyrosine kinase inhibitors against FLT3. However, like most tyrosine kinase inhibitors, those against FLT3 are not completely specific and at the doses required to complete...

journal_title：Cancer research

authors： Piloto O,Levis M,Huso D,Li Y,Li H,Wang MN,Bassi R,Balderes P,Ludwig DL,Witte L,Zhu Z,Hicklin DJ,Small D

更新日期：2005-02-15 00:00:00

abstract：:Sodium saccharin and sodium ascorbate are known to promote urinary bladder carcinogenesis in rats following initiation with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or N-butyl-N-(4-hydroxybutyl) nitrosamine. Sodium salts of other organic acids have also been shown to be bladder tumor promoters. In addition...

journal_title：Cancer research

authors： Cohen SM,Ellwein LB,Okamura T,Masui T,Johansson SL,Smith RA,Wehner JM,Khachab M,Chappel CI,Schoenig GP

更新日期：1991-04-01 00:00:00

abstract：:Pancreatic cancer is a disease with limited therapeutic options. Resistance to chemotherapies poses a significant clinical challenge for patients with pancreatic cancer and contributes to a high rate of recurrence. Oncogenic KRAS, a critical driver of pancreatic cancer, promotes metabolic reprogramming and upregulates...

journal_title：Cancer research

authors： Mukhopadhyay S,Goswami D,Adiseshaiah PP,Burgan W,Yi M,Guerin TM,Kozlov SV,Nissley DV,McCormick F

更新日期：2020-04-15 00:00:00

abstract：:We have identified RGS17 as a commonly induced gene in lung and prostate tumors. Through microarray and gene expression analysis, we show that expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Through knockdown and overexpression of RGS17 in tumor cells, we show that ...

journal_title：Cancer research

authors： James MA,Lu Y,Liu Y,Vikis HG,You M

更新日期：2009-03-01 00:00:00

abstract：:The growth inhibitory effects of combinations of antifolates on hepatoma cells in culture have been examined. In these studies methotrexate or the lipophilic inhibitors of dihydrofolate reductase were used with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolate (PDDF). Under certain conditions partial ...

journal_title：Cancer research

authors： Galivan J,Nimec Z,Rhee M

更新日期：1987-10-15 00:00:00

abstract：:The cross-linked dimer of bovine pancreatic RNase (M.W. 28,000) is significantly more effective than the monomer in inhibiting tumor development in mice when administered i.p. 1 day after inoculation with sarcoma 180J ascites cells. Animals bearing solid tumors were not affected. In AKR/J mice with advanced leukemia, ...

journal_title：Cancer research

authors： Tarnowski GS,Kassel RL,Mountain IM,Blackburn P,Wilson G,Wang D

更新日期：1976-11-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) functions primarily as an inhibitory neurotransmitter in the mature central nervous system, and GABA/GABA receptors are also present in nonneural tissues, including cancer, but their precise function in nonneuronal or cancerous cells has thus far been poorly defined. Through the genome-w...

journal_title：Cancer research

authors： Takehara A,Hosokawa M,Eguchi H,Ohigashi H,Ishikawa O,Nakamura Y,Nakagawa H

更新日期：2007-10-15 00:00:00

abstract：:"Self" melanocyte differentiation antigens are potential targets for specific melanoma immunotherapy. Vaccination against murine tyrosinase-related protein (TRP)-1/gp75 was shown recently to cause melanoma rejection, which was accompanied by autoimmune skin depigmentation (vitiligo). To further explore the linkage bet...

journal_title：Cancer research

authors： Bronte V,Apolloni E,Ronca R,Zamboni P,Overwijk WW,Surman DR,Restifo NP,Zanovello P

更新日期：2000-01-15 00:00:00

abstract：:Steroid and xenobiotic receptor (SXR) or human pregnane X receptor (hPXR) has been shown to play an important role in the regulation of genes related to xenobiotic detoxification, such as cytochrome P450 3A4 and multidrug resistance gene 1. Cytochrome P450 enzymes, conjugation enzymes, and transporters are all conside...

journal_title：Cancer research

authors： Miki Y,Suzuki T,Kitada K,Yabuki N,Shibuya R,Moriya T,Ishida T,Ohuchi N,Blumberg B,Sasano H

更新日期：2006-01-01 00:00:00

abstract：:Whole-genome sequencing studies have recently identified a quarter of cases of the rare childhood brainstem tumor diffuse intrinsic pontine glioma to harbor somatic mutations in ACVR1. This gene encodes the type I bone morphogenic protein receptor ALK2, with the residues affected identical to those that, when mutated ...

journal_title：Cancer research

authors： Taylor KR,Vinci M,Bullock AN,Jones C

更新日期：2014-09-01 00:00:00

abstract：:The olfactory marker protein (OMP) is a M(r) 19,000 polypeptide originally considered a selective marker for differentiated olfactory receptor neurons. In an attempt to induce neoplastic proliferation in the olfactory cells, we made mice transgenic for the simian virus 40 large T-antigen gene linked to the OMP gene pr...

journal_title：Cancer research

authors： Servenius B,Vernachio J,Price J,Andersson LC,Peterson PA

更新日期：1994-10-01 00:00:00

abstract：:Successful antiestrogen treatment in patients with tamoxifen-responsive breast tumors is often followed by an outgrowth of tumors cells that are antiestrogen resistant, implying that estrogen-dependent tumors can become estrogen-independent. In an effect to mimic this progression, we have transfected fibroblast growth...

journal_title：Cancer research

authors： McLeskey SW,Kurebayashi J,Honig SF,Zwiebel J,Lippman ME,Dickson RB,Kern FG

更新日期：1993-05-01 00:00:00

abstract：:Previous experiments have suggested that some mutant forms of p53 are able to inactivate the endogenous wild-type p53 protein in a dominant-negative fashion. However, it remains unknown whether tumors with such dominant-negative (transdominant) p53 mutants have a biological significance that is different from that of ...

journal_title：Cancer research

authors： Marutani M,Tonoki H,Tada M,Takahashi M,Kashiwazaki H,Hida Y,Hamada J,Asaka M,Moriuchi T

更新日期：1999-10-01 00:00:00

abstract：:Ras signaling originates from transient nanoscale compartmentalized regions of the plasma membrane composed of specific proteins and lipids. The highly specific lipid composition of these nanodomains, termed nanoclusters, facilitates effector recruitment and therefore influences signal transduction. This suggests that...

journal_title：Cancer research

authors： Fuentes NR,Mlih M,Barhoumi R,Fan YY,Hardin P,Steele TJ,Behmer S,Prior IA,Karpac J,Chapkin RS

更新日期：2018-07-15 00:00:00

abstract：:Here, we report the molecular regulation of interleukin (IL)-8 expression in human melanoma cells. The inflammatory cytokines IL-1beta and tumor necrosis factor-alpha (TNF-alpha) up-regulated IL-8 expression, in a time- and concentration-dependent manner, in three metastatic melanoma variants, SBC-2 (nonmetastatic), A...

journal_title：Cancer research

authors： Singh RK,Varney ML

更新日期：1998-04-01 00:00:00

abstract：:This report describes and presents some preliminary results from a prospective clinical investigation to determine the ablative effect of thiotepa (N,N',N''-triethylene phosphoramide) on superficial low-stage bladder cancer and the effectiveness of this agent in the prevention of recurrent or new tumors. In the small ...

journal_title：Cancer research

authors：

更新日期：1977-08-01 00:00:00