Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma.

abstract：:Extramedullary myelopoiesis occurs commonly in tumor-bearing animals and is known to lead to accumulation of peripheral myeloid-derived suppressor cells (MDSC), which play an important role in immune escape. However, the cellular and molecular mechanisms by which tumors induce extramedullary myelopoiesis are poorly un...

journal_title：Cancer research

authors： Kim EK,Jeon I,Seo H,Park YJ,Song B,Lee KA,Jang Y,Chung Y,Kang CY

更新日期：2014-11-15 00:00:00

abstract：:The calcium channel blocker verapamil has been shown to reverse multidrug resistance (T. Tsuruo et al., Cancer Res. 41: 1967-1972, 1981), but the mechanism of action of this agent has not been fully elucidated. A radioactive photoactive analogue of verapamil, N-[benzoyl-3,5-3H-(+/-)-5-[(3,4-dimethoxyphenetyl)methylami...

journal_title：Cancer research

authors： Yusa K,Tsuruo T

更新日期：1989-09-15 00:00:00

abstract：:Tumor-suppressors have commanded attention due to the selection for their inactivating mutations in human tumors. However, relatively little is understood about the inverse, namely, that tumors do not select for a large proportion of seemingly favorable mutations in tumor-suppressor genes. This could be explained by a...

journal_title：Cancer research

authors： Cunningham SC,Gallmeier E,Hucl T,Dezentje DA,Calhoun ES,Falco G,Abdelmohsen K,Gorospe M,Kern SE

更新日期：2006-06-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease that is characterized by a particularly marked resistance to chemotherapy. We previously showed an association between decreased expression of BNIP3 and chemoresistance in PDAC cell lines. To further explore the molecular basis of chemoresistance in PDAC...

journal_title：Cancer research

authors： Mahon PC,Baril P,Bhakta V,Chelala C,Caulee K,Harada T,Lemoine NR

更新日期：2007-07-15 00:00:00

abstract：:A transplantable bladder tumor (Chapman R-4909) of the rat, when first received in our laboratory, grew with a complex histopathology. The predominant component was transitional cell carcinoma, but there were foci of keratinization, including pearl formation, and foci of a less well-defined cystic appearance. We repor...

journal_title：Cancer research

authors： Toyoshima K,Abaza N,Leighton J

更新日期：1976-08-01 00:00:00

abstract：:Vinyl chloride (VC) induces angiosarcomas of the liver (ASL) and hepatocellular carcinomas (HCCs) in humans and rodents. We examined the presence of p53 gene mutations in ASL and HCC induced by VC in Sprague Dawley rats; 25 ASL and eight HCCs were analyzed for point mutations in exons 5-8, using PCR amplification, sin...

journal_title：Cancer research

authors： Barbin A,Froment O,Boivin S,Marion MJ,Belpoggi F,Maltoni C,Montesano R

更新日期：1997-05-01 00:00:00

abstract：:Pregnant C3HeB/FeJ mice were treated with ethylnitrosourea (ENU) on one of gestation Days 10, 13, or 15 to determine if ENU treatment at different stages of gestation would result in qualitative or quantitative differences in lung tumors induced in the offspring. Lung tumors were counted and measured 6 mo after treatm...

journal_title：Cancer research

authors： Branstetter DG,Stoner GD,Budd C,Conran PB,Goldblatt PJ

更新日期：1988-01-15 00:00:00

abstract：:There is little information on early molecular events in the development of N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis and of the effects of chemopreventive agents on these events. In this study, we identified genes in rat esophagus that were differentially expressed in response to short-te...

journal_title：Cancer research

authors： Reen RK,Dombkowski AA,Kresty LA,Cukovic D,Mele JM,Salagrama S,Nines R,Stoner GD

更新日期：2007-07-01 00:00:00

abstract：:Metabolic activation may be a key step in determining the tissue specificity of carcinogenic nitrosamines. In previous work, we characterized P450IIE1 (an acetone/ethanol-inducible form of cytochrome P-450) as the major enzyme for the metabolic activation of N-nitrosodimethylamine. In this work, we investigated the me...

journal_title：Cancer research

authors： Lee M,Ishizaki H,Brady JF,Yang CS

更新日期：1989-03-15 00:00:00

abstract：:Our recent study found that activation of signal transducer and activator of transcription 3 (Stat3) is up-regulated in human brain metastatic cells and contributes to brain metastasis of melanoma. However, the molecular mechanisms underlying this increased Stat3 activation and effect on brain metastasis are unknown. ...

journal_title：Cancer research

authors： Huang FJ,Steeg PS,Price JE,Chiu WT,Chou PC,Xie K,Sawaya R,Huang S

更新日期：2008-12-01 00:00:00

abstract：:Methylation-mediated silencing of G0-G1 switch gene 2 (G0S2) has been detected in a variety of solid tumors, whereas G0S2 induction is associated with remissions in patients with acute promyelocytic leukemia, implying that G0S2 may possess tumor suppressor activity. In this study, we clearly demonstrate that G0S2 oppo...

journal_title：Cancer research

authors： Yim CY,Sekula DJ,Hever-Jardine MP,Liu X,Warzecha JM,Tam J,Freemantle SJ,Dmitrovsky E,Spinella MJ

更新日期：2016-03-01 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation and class switch recombination of the immunoglobulin (IG) genes in B cells. It has recently been proposed that AID, as the newly identified DNA mutator in man, may be instrumental in initiation and progression of B-cell non-Hodgkin's ly...

journal_title：Cancer research

authors： Smit LA,Bende RJ,Aten J,Guikema JE,Aarts WM,van Noesel CJ

更新日期：2003-07-15 00:00:00

abstract：:Angiogenesis is a hallmark of cancer that promotes tumor progression and metastasis. However, antiangiogenic agents have limited efficacy in cancer therapy due to the development of resistance. In clear cell renal cell carcinoma (ccRCC), AXL expression is associated with antiangiogenic resistance and poor survival. He...

journal_title：Cancer research

authors： Xiao Y,Zhao H,Tian L,Nolley R,Diep AN,Ernst A,Fuh KC,Miao YR,von Eyben R,Leppert JT,Brooks JD,Peehl DM,Giaccia AJ,Rankin EB

更新日期：2019-11-15 00:00:00

abstract：:Cytochromes P-450IIB1 and P-450IIB2 were recently shown to be inducible in rat hepatocyte cultures maintained on a reconstituted extracellular tumor matrix (Matrigel) as indicated by increases in P-450IIB1 and -IIB2 mRNAs and immunoreactive proteins (J. Cell. Physiol., 134: 309-323, 1988). Here we show that treatment ...

journal_title：Cancer research

authors： Sinclair PR,Bement WJ,Haugen SA,Sinclair JF,Guzelian PS

更新日期：1990-09-01 00:00:00

abstract：:In this study, we identified 53 aberrantly hypermethylated DNA sequences in adult T-cell leukemia (ATL) cells using methylated CpG island amplification/representational difference analysis method. We also observed a proportionate increase in the methylation density of these regions with disease progression. Seven gene...

journal_title：Cancer research

authors： Yasunaga J,Taniguchi Y,Nosaka K,Yoshida M,Satou Y,Sakai T,Mitsuya H,Matsuoka M

更新日期：2004-09-01 00:00:00

abstract：:Retinoids are promising agents for cancer chemoprevention and therapy. Nuclear retinoic acid receptors (RARs; RARalpha, -beta, and -gamma) and retinoid X receptors (RXRs; RXRalpha, -beta, and -gamma) are thought to mediate most of retinoids' effects on cell growth and differentiation. Because the majority of human non...

journal_title：Cancer research

authors： Sun SY,Yue P,Dawson MI,Shroot B,Michel S,Lamph WW,Heyman RA,Teng M,Chandraratna RA,Shudo K,Hong WK,Lotan R

更新日期：1997-11-01 00:00:00

abstract：:alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)beta(3) and produced erosion pits on bone substrates, whereas this effect was not observed by cells f...

journal_title：Cancer research

authors： Tucci M,De Palma R,Lombardi L,Rodolico G,Berrino L,Dammacco F,Silvestris F

更新日期：2009-08-15 00:00:00

abstract：:Given the prevalence of Ras mutations in human cancer, it is critical to understand the effector pathways downstream of oncogenic Ras leading to transformation. To directly assess the requirement for Rac1 in K-ras-induced tumorigenesis, we employed a model of lung cancer in which an oncogenic allele of K-ras could be ...

journal_title：Cancer research

authors： Kissil JL,Walmsley MJ,Hanlon L,Haigis KM,Bender Kim CF,Sweet-Cordero A,Eckman MS,Tuveson DA,Capobianco AJ,Tybulewicz VL,Jacks T

更新日期：2007-09-01 00:00:00

abstract：:Clear cell renal carcinomas are most frequently characterized by loss of function of both copies of the von Hippel-Lindau (VHL) disease gene, suggesting that the VHL gene product plays an important role in regulating renal cell proliferation. To directly assess the function of the VHL gene product, we transfected the ...

journal_title：Cancer research

authors： Chen F,Kishida T,Duh FM,Renbaum P,Orcutt ML,Schmidt L,Zbar B

更新日期：1995-11-01 00:00:00

abstract：:The activity of an endonuclease(s) acting on double-stranded, ultraviolet-irradiated, and 2-acetylaminofluorene-bound DNA but not on double-stranded undamaged DNA triples within two hr after partial hepatectomy. Although the activity drops between four and six hr after operation, it remains above levels measured in li...

journal_title：Cancer research

authors： Van Lancker JL,Tomura T

更新日期：1981-06-01 00:00:00

abstract：:HsRec2/Rad51B is a 350-amino acid protein with a molecular mass of 38,300 Da that appears to be involved in cell cycle regulation and UV-induced apoptosis. The mouse and human genes were isolated based on their homology to a recombinational repair gene from Ustilago maydis and contain functional domains to hRAD51 and ...

journal_title：Cancer research

authors： Havre PA,Rice MC,Noe M,Kmiec EB

更新日期：1998-10-15 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) is an evolutionally conserved nuclear protein present in most eukaryotic species and catalyzes the formation of ADP-ribose polymers covalently attached to proteins. PARP is strongly activated by DNA single- or double-strand breaks and is thought to be involved in cellular responses t...

journal_title：Cancer research

authors： Kupper JH,Müller M,Bürkle A

更新日期：1996-06-15 00:00:00

abstract：:When human tumor xenotransplants into nude mice are used as experimental models, it is important to know whether their microvascular anatomy is rather host or tumor specific. Therefore a morphometric comparison of the vascular network in human squamous cell carcinomas and their xenotransplants was carried out. Biopsie...

journal_title：Cancer research

authors： Lauk S,Zietman A,Skates S,Fabian R,Suit HD

更新日期：1989-08-15 00:00:00

abstract：:Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species (ROS) to induce apoptosis or autophagy or ATP during times of nutrient stress. However, the contribution of proline metabolism to tumorigenesis in hypoxic microenvironments has not...

journal_title：Cancer research

authors： Liu W,Glunde K,Bhujwalla ZM,Raman V,Sharma A,Phang JM

更新日期：2012-07-15 00:00:00

abstract：:CD4+ T-cell responses against human tumor antigens are a potentially critical component of the antitumor immune response. Molecular methods have been devised for rapidly identifying MHC class II-restricted tumor antigens and elucidating the recognized epitopes. We describe here the identification of neo-poly(A) polyme...

journal_title：Cancer research

authors： Topalian SL,Gonzales MI,Ward Y,Wang X,Wang RF

更新日期：2002-10-01 00:00:00

abstract：:Tumor hypoxia induces the up-regulation of a gene program associated with angiogenesis, glycolysis, adaptation to pH, and apoptosis via the hypoxia-inducible transcription factors (Hifs) 1 and 2. Disruption of this pathway has been proposed as a cancer therapy. Here, we use short interfering RNAs to compare specific i...

journal_title：Cancer research

authors： Sowter HM,Raval RR,Moore JW,Ratcliffe PJ,Harris AL

更新日期：2003-10-01 00:00:00

abstract：:Tumor relapses remain a serious problem after allogeneic stem cell transplantation (alloSCT), despite the long-term persistence of minor histocompatibility antigen (MiHA)-specific memory CD8(+) T cells specific for the tumor. We hypothesized that these memory T cells may lose their function over time in transplanted p...

journal_title：Cancer research

authors： Norde WJ,Maas F,Hobo W,Korman A,Quigley M,Kester MG,Hebeda K,Falkenburg JH,Schaap N,de Witte TM,van der Voort R,Dolstra H

更新日期：2011-08-01 00:00:00

abstract：:Multiple transcriptional events take place when normal urothelium is transformed into tumor tissue. These can now be monitored simultaneously by the use of oligonucleotide arrays, and expression patterns of superficial and invasive tumors can be established. Single-cell suspensions were prepared from bladder biopsies ...

journal_title：Cancer research

authors： Thykjaer T,Workman C,Kruhøffer M,Demtröder K,Wolf H,Andersen LD,Frederiksen CM,Knudsen S,Orntoft TF

更新日期：2001-03-15 00:00:00

abstract：:5'-Deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine, which are metabolized to the methionine precursor, 5-methylthioribose-1-phosphate, by 5'-deoxy-5'-methylthioadenosine phosphorylase and purine nucleoside phosphorylase, respectively, can serve as sources of methionine for cultured HL-60 promyelocytic l...

journal_title：Cancer research

authors： Savarese TM,Ghoda LY,Dexter DL,Parks RE Jr

更新日期：1983-10-01 00:00:00

abstract：:Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant burden in developing countries. Here, we report the findings of whole-exome sequencing (WES) to dete...

journal_title：Cancer research

authors： Feber A,Worth DC,Chakravarthy A,de Winter P,Shah K,Arya M,Saqib M,Nigam R,Malone PR,Tan WS,Rodney S,Freeman A,Jameson C,Wilson GA,Powles T,Beck S,Fenton T,Sharp TV,Muneer A,Kelly JD

更新日期：2016-08-15 00:00:00