Conversion of 5'-deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine to methionine in cultured human leukemic cells.

abstract：:miR-31 inhibits breast cancer metastasis via the pleiotropic suppression of a cohort of prometastatic target genes that include integrin alpha(5) (ITGA5), radixin (RDX), and RhoA. We previously showed that the concomitant overexpression of ITGA5, RDX, and RhoA was capable of overriding the antimetastatic effects of ec...

journal_title：Cancer research

authors： Valastyan S,Chang A,Benaich N,Reinhardt F,Weinberg RA

更新日期：2010-06-15 00:00:00

abstract：:Exposure of tumor cells to cytotoxic agents simultaneously activates a variety of intracellular signaling pathways. Some of these pathways involve enzymes from the protein kinase C (PKC) family of serine/threonine kinases. This family includes isoenzymes that negatively influence cell death, whereas other demonstrate ...

journal_title：Cancer research

authors： Filomenko R,Poirson-Bichat F,Billerey C,Belon JP,Garrido C,Solary E,Bettaieb A

更新日期：2002-03-15 00:00:00

abstract：:Lymphomas are rarely, if ever, found to be in excess following exposure to ionizing radiation. Hodgkin's disease has never been linked to radiation, and the evidence for non-Hodgkin's lymphoma (NHL) is very weak. Low doses of radiation from diagnostic X-ray procedures or from occupational exposures do not appear to ca...

journal_title：Cancer research

authors： Boice JD Jr

更新日期：1992-10-01 00:00:00

abstract：:We have advanced the view that estrogens activate the estrogen receptor (ER) alpha complex differently. A group of planar (estradiol, genistein, and coumestrol) and nonplanar (methoxychlor and its mono- and didemethylated phenolic metabolites) environmental estrogens, which are all full estrogens in MCF-7 breast cance...

journal_title：Cancer research

authors： Bentrem D,Fox JE,Pearce ST,Liu H,Pappas S,Kupfer D,Zapf JW,Jordan VC

更新日期：2003-11-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a malignancy of stem cells with an unlimited capacity for self-renewal. MUC1 is a secreted, oncogenic mucin that is expressed aberrantly in AML blasts, but its potential uses to target AML stem cells have not been explored. Here, we report that MUC1 is highly expressed on AML CD34(+)/li...

journal_title：Cancer research

authors： Stroopinsky D,Rosenblatt J,Ito K,Mills H,Yin L,Rajabi H,Vasir B,Kufe T,Luptakova K,Arnason J,Nardella C,Levine JD,Joyce RM,Galinsky I,Reiter Y,Stone RM,Pandolfi PP,Kufe D,Avigan D

更新日期：2013-09-01 00:00:00

abstract：:Oncogenic BRAF alleles are both necessary and sufficient for cellular transformation, suggesting that chemical inhibition of the activated mutant protein kinase may reverse the tumor phenotype. Here, we report the characterization of SB-590885, a novel triarylimidazole that selectively inhibits Raf kinases with more p...

journal_title：Cancer research

authors： King AJ,Patrick DR,Batorsky RS,Ho ML,Do HT,Zhang SY,Kumar R,Rusnak DW,Takle AK,Wilson DM,Hugger E,Wang L,Karreth F,Lougheed JC,Lee J,Chau D,Stout TJ,May EW,Rominger CM,Schaber MD,Luo L,Lakdawala AS,Adams JL,

更新日期：2006-12-01 00:00:00

abstract：:The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with breast cancer. We report that HER-2 is a new substrate for caspase-8 and that tumor necrosis factor alpha (TNF-alpha) stimulation leads to an early caspase-8-dependent HER-2 cleavage in MC...

journal_title：Cancer research

authors： Benoit V,Chariot A,Delacroix L,Deregowski V,Jacobs N,Merville MP,Bours V

更新日期：2004-04-15 00:00:00

abstract：:The pharmacokinetics of vinblastine in humans was examined using a radioimmunoassay specific for both the Vinca alkaloids and aromatic ring [3H]vinblastine. The data were consistent with a three-compartment open model system with the following values, alpha phase: t1/2=3.90+/-1.46 min; Vc=16.8+/-7.1 liters. beta phase...

journal_title：Cancer research

authors： Owellen RJ,Hartke CA,Hains FO

更新日期：1977-08-01 00:00:00

abstract：:Angiostatin4.5 (AS4.5) is a naturally occurring human angiostatin isoform, consisting of plasminogen kringles 1-4 plus 85% of kringle 5 (amino acids Lys78 to Arg529). Prior studies indicate that plasminogen is converted to AS4.5 in a two-step reaction. First, plasminogen is activated to plasmin. Then plasmin undergoes...

journal_title：Cancer research

authors： Wang H,Schultz R,Hong J,Cundiff DL,Jiang K,Soff GA

更新日期：2004-01-01 00:00:00

abstract：:Activation of activator protein 1 (AP-1) and nuclear factor kappaB (NFkappaB)-dependent transcription is required for tumor promotion in cell culture models and transgenic mice. Dominant-negative c-Jun (TAM67) blocks AP-1 activation by dimerizing with Jun or Fos family proteins and blocks NFkappaB activation by intera...

journal_title：Cancer research

authors： Matthews CP,Birkholz AM,Baker AR,Perella CM,Beck GR Jr,Young MR,Colburn NH

更新日期：2007-03-15 00:00:00

abstract：:Motility related protein-1 (MRP-1) is a transmembrane glycoprotein that is identical to the CD9 antigen. In previous studies, we showed that various types of cultured tumor cells transfected with MRP-1/CD9 cDNA have low motility and diminished metastatic potential to the lung. More recently we used immunohistochemical...

journal_title：Cancer research

authors： Higashiyama M,Taki T,Ieki Y,Adachi M,Huang CL,Koh T,Kodama K,Doi O,Miyake M

更新日期：1995-12-15 00:00:00

abstract：:Local chemotherapy with biodegradable polymers prolongs survival with minimal morbidity in patients with intracranial high-grade gliomas. However, use of local chemotherapy for metastatic brain tumors has not been defined. We studied the safety and the efficacy of locally delivered chemotherapy with and without concur...

journal_title：Cancer research

authors： Ewend MG,Williams JA,Tabassi K,Tyler BM,Babel KM,Anderson RC,Pinn ML,Brat DJ,Brem H

更新日期：1996-11-15 00:00:00

abstract：:Glioblastomas display cellular hierarchies with self-renewing tumor-initiating cells (TIC), also known as cancer stem cells, at the apex. Although the TIC hypothesis remains controversial and the functional assays to define the TIC phenotype are evolving, we and others have shown that TICs may contribute to therapeuti...

journal_title：Cancer research

authors： Kim Y,Wu Q,Hamerlik P,Hitomi M,Sloan AE,Barnett GH,Weil RJ,Leahy P,Hjelmeland AB,Rich JN

更新日期：2013-08-01 00:00:00

abstract：:We have found that the synthetic compound CC-5079 potently inhibits cancer cell growth in vitro and in vivo by a novel combination of molecular mechanisms. CC-5079 inhibits proliferation of cancer cell lines from various organs and tissues at nanomolar concentrations. Its IC(50) value ranges from 4.1 to 50 nmol/L. The...

journal_title：Cancer research

authors： Zhang LH,Wu L,Raymon HK,Chen RS,Corral L,Shirley MA,Narla RK,Gamez J,Muller GW,Stirling DI,Bartlett JB,Schafer PH,Payvandi F

更新日期：2006-01-15 00:00:00

abstract：:Surgical resection followed by radiation therapy is the mainstay of treatment for glioblastoma multiforme (GBM), the most aggressive of the malignant gliomas. The poor clinical response of GBM and the intrinsic radiation resistance of this tumor type have prompted clinical investigations seeking to define the role of ...

journal_title：Cancer research

authors： Yount GL,Haas-Kogan DA,Levine KS,Aldape KD,Israel MA

更新日期：1998-09-01 00:00:00

abstract：:Promoter methylation of the mismatch repair gene plays a key role in sporadic microsatellite instability (MSI) colorectal cancers. However, promoter methylation often occurs in proximal colon cancers, and molecular phenotypes underlying MSI cancers in distal colon have not been fully clarified. Our goal was to clarify...

journal_title：Cancer research

authors： Watanabe T,Kobunai T,Toda E,Yamamoto Y,Kanazawa T,Kazama Y,Tanaka J,Tanaka T,Konishi T,Okayama Y,Sugimoto Y,Oka T,Sasaki S,Muto T,Nagawa H

更新日期：2006-10-15 00:00:00

abstract：:Autophagy is frequently activated in radioresistant cancer cells where it provides a cell survival strategy. The mTOR inhibitor rapamycin activates autophagy but paradoxically it also enhances radiosensitivity. In this study, we investigated the mechanisms of these opposing actions in radiation-resistant glioma or par...

journal_title：Cancer research

authors： Nam HY,Han MW,Chang HW,Lee YS,Lee M,Lee HJ,Lee BW,Lee HJ,Lee KE,Jung MK,Jeon H,Choi SH,Park NH,Kim SY,Kim SW

更新日期：2013-07-15 00:00:00

abstract：:Hypoxia-inducible factor (HIF)-1, a heterodimeric transcription factor composed of HIF-1alpha and HIF-1beta subunits coordinates pathophysiologic responses toward decreased oxygen availability. It is now appreciated that enhanced protein translation of HIF-1alpha under normoxia accounts for an alternative regulatory c...

journal_title：Cancer research

authors： Zhou J,Callapina M,Goodall GJ,Brüne B

更新日期：2004-12-15 00:00:00

abstract：:Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate carcinoma. We used cDNA microarrays containing 1500 cDNAs to profile transcripts regulated by androgens in prostate can...

journal_title：Cancer research

authors： Lin B,Ferguson C,White JT,Wang S,Vessella R,True LD,Hood L,Nelson PS

更新日期：1999-09-01 00:00:00

abstract：:Mitomycin C (MC) is a naturally occurring anticancer agent which has been shown to be more cytotoxic to hypoxic tumor cells than to their aerobic counterparts. The mechanism of action of this agent is thought to involve biological reductive activation, to a species that alkylates DNA. A comparison of the cytotoxicity ...

journal_title：Cancer research

authors： Pritsos CA,Sartorelli AC

更新日期：1986-07-01 00:00:00

abstract：:Migration from the primary tumor is a crucial step in the metastatic cascade. Cells with various degrees of adhesion and motility migrate and are launched into the bloodstream as single circulating tumor cells (CTC) or multicellular CTC clusters. The frequency and size distributions of these clusters have been recentl...

journal_title：Cancer research

authors： Bocci F,Kumar Jolly M,Onuchic JN

更新日期：2019-11-01 00:00:00

abstract：:Molecular markers of pancreatic neoplasia could aid in the evaluation of visible pancreatic lesions and indicate neoplasia invisible to imaging. We evaluated methylation-specific PCR (MSP) assays that detect aberrantly methylated DNA for their use as markers of pancreatic neoplasia. Methylation analysis was done on pa...

journal_title：Cancer research

authors： Matsubayashi H,Canto M,Sato N,Klein A,Abe T,Yamashita K,Yeo CJ,Kalloo A,Hruban R,Goggins M

更新日期：2006-01-15 00:00:00

abstract：:We analyzed the immunohistochemical expression of three epitopes of the tumor-associated glycoprotein 72 (TAG-72) in whole cross-sections of primary colorectal carcinomas and in regional lymph node metastases using monoclonal antibodies (MAbs) B72.3, CC-49, and CC-83, which recognize distinct carbohydrate antigenic de...

journal_title：Cancer research

authors： Muraro R,Frati L,Bei R,Ficari F,Valli C,French D,Mammarella S,Caramia F,Fegiz G,Mariani-Costantini R

更新日期：1991-10-01 00:00:00

abstract：:Whereas transcriptional silencing of genes due to epigenetic mechanisms is one of the most important alterations in acute lymphoblastic leukemia (ALL), some recent studies indicate that DNA methylation contributes to down-regulation of miRNAs during tumorigenesis. To explore the epigenetic alterations of miRNAs in ALL...

journal_title：Cancer research

authors： Agirre X,Vilas-Zornoza A,Jiménez-Velasco A,Martin-Subero JI,Cordeu L,Gárate L,San José-Eneriz E,Abizanda G,Rodríguez-Otero P,Fortes P,Rifón J,Bandrés E,Calasanz MJ,Martín V,Heiniger A,Torres A,Siebert R,Román-Gomez J,

更新日期：2009-05-15 00:00:00

abstract：:The mechanism by which gonadotropin-releasing hormone (GnRH) agonists and antagonists inhibit tumor cell growth and proliferation is controversial. Direct mediation of the antitumor effects through the high-affinity GnRH receptors has been questioned because of the low level of expression of receptors on the tumor cel...

journal_title：Cancer research

authors： Kakar SS

更新日期：1998-10-15 00:00:00

abstract：:We previously reported that thymidine kinase (TK) activity in a spontaneously TK-deficient (TK-) mouse tumor cell line (called L61-M) could be partially restored by brief exposure of the cells in vitro to the DNA-hypomethylating agent 5-azacytidine. We now show that similar results can be obtained by exposing L61-M ce...

journal_title：Cancer research

authors： Liteplo RG,Alvarez E,Frost P,Kerbel RS

更新日期：1985-11-01 00:00:00

abstract：:Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer. As a result, profiling tumor pTyr levels may reveal therapeutic insights critical to combating disease. Existing discovery and targeted mass spectrometry-based methods used to monitor pTyr networks invol...

journal_title：Cancer research

authors： Stopfer LE,Flower CT,Gajadhar AS,Patel B,Gallien S,Lopez-Ferrer D,White FM

更新日期：2021-01-28 00:00:00

abstract：:Picroliv, an iridoid glycoside derived from the plant Picrorhiza kurroa, is used traditionally to treat fever, asthma, hepatitis, and other inflammatory conditions. However, the exact mechanism of its therapeutic action is still unknown. Because nuclear factor-kappaB (NF-kappaB) activation plays a major role in inflam...

journal_title：Cancer research

authors： Anand P,Kunnumakkara AB,Harikumar KB,Ahn KS,Badmaev V,Aggarwal BB

更新日期：2008-11-01 00:00:00

abstract：:The formation of 7-(2-hydroxyethyl)guanine (7-HEG) in DNA of target and nontarget tissues was investigated in male B6C3F1 mice (20/group) and F344 rats (10/group) exposed to 0, 3, 10, 33, 100, or 300 (rats only) ppm ethylene oxide (ETO) by inhalation for 6 h/day for 4 weeks (5 days/week) and mice exposed to 100 ppm ET...

journal_title：Cancer research

authors： Walker VE,Fennell TR,Upton PB,Skopek TR,Prevost V,Shuker DE,Swenberg JA

更新日期：1992-08-15 00:00:00

abstract：:The relationship between adenosine deaminase (ADA) and a human membrane thymus leukemia (HTL) antigen-detected by an antithymocyte serum was explored. A freeze-thaw extract of the T-cell-derived cell line, MOLT 4, was applied to an immunoabsorbant column of a rabbit antiserum to calf ADA. The bound MOLT 4 ADA was elut...

journal_title：Cancer research

authors： Dowell BL,Segars JH,Metzgar RS

更新日期：1981-01-01 00:00:00