Radiation and non-Hodgkin's lymphoma.

abstract：:Prostate tumor cells, which characteristically metastasize to bone, initiate binding interactions with bone marrow endothelium under blood flow conditions through binding interactions with E-selectin. We hypothesized that E-selectin ligands on prostate tumor cells are directly associated with bone-metastatic potential...

journal_title：Cancer research

authors： Dimitroff CJ,Descheny L,Trujillo N,Kim R,Nguyen V,Huang W,Pienta KJ,Kutok JL,Rubin MA

更新日期：2005-07-01 00:00:00

abstract：:Mutations in the human adenomatous polyposis (APC) gene are causative for familial adenomatous polyposis (FAP), a rare condition in which numerous colonic polyps arise during puberty and, if left untreated, lead to colon cancer. The APC gene is a tumor suppressor that has been termed the "gatekeeper gene" for colon ca...

journal_title：Cancer research

authors： Oshima M,Murai N,Kargman S,Arguello M,Luk P,Kwong E,Taketo MM,Evans JF

更新日期：2001-02-15 00:00:00

abstract：:ErbB-2 (HER-2/neu) is a transforming oncogene expressed by a substantial fraction of breast cancers, and monoclonal antibody therapy directed toward this antigen is an established treatment modality. However, not all tumors respond, and with a monoclonal antibody directed to a single epitope, there is always the risk ...

journal_title：Cancer research

authors： Park JM,Terabe M,Steel JC,Forni G,Sakai Y,Morris JC,Berzofsky JA

更新日期：2008-03-15 00:00:00

abstract：:Two monoclonal antibodies, OC 125 and OC 133, bind to distinct determinants on the surface of human epithelial ovarian carcinoma cell lines. OC 125 and OC 133 recognize determinants on molecules with molecular weights greater than 200,000 and 80,000, respectively. When binding to four different cell lines was compared...

journal_title：Cancer research

authors： Masuho Y,Zalutsky M,Knapp RC,Bast RC Jr

更新日期：1984-07-01 00:00:00

abstract：:Melanoma is a disease characterized by lesions that activate ERK. Although 70% of cutaneous melanomas harbor activating mutations in the BRAF and NRAS genes, the alterations that drive tumor progression in the remaining 30% are largely undefined. Vemurafenib, a selective inhibitor of RAF kinases, has clinical utility ...

journal_title：Cancer research

authors： Nissan MH,Pratilas CA,Jones AM,Ramirez R,Won H,Liu C,Tiwari S,Kong L,Hanrahan AJ,Yao Z,Merghoub T,Ribas A,Chapman PB,Yaeger R,Taylor BS,Schultz N,Berger MF,Rosen N,Solit DB

更新日期：2014-04-15 00:00:00

abstract：:In this study, we have exploited the power of insertional mutagenesis to elucidate tumor progression pathways in mice carrying two oncogenes (MYC/Runx2) that collaborate to drive early lymphoma development. Neonatal infection of these mice with Moloney murine leukemia virus resulted in accelerated tumor onset with ass...

journal_title：Cancer research

authors： Stewart M,Mackay N,Hanlon L,Blyth K,Scobie L,Cameron E,Neil JC

更新日期：2007-06-01 00:00:00

abstract：:Transformation with ras oncogenes results in increased radiation sur vival in many but not all cells. In addition, prenyltransferase inhibitors which inhibit ras proteins by blocking posttranslational modification radiosensitize cells with oncogenic ras. These findings suggest that oncogenic ras contributes to intrins...

journal_title：Cancer research

authors： Bernhard EJ,Stanbridge EJ,Gupta S,Gupta AK,Soto D,Bakanauskas VJ,Cerniglia GJ,Muschel RJ,McKenna WG

更新日期：2000-12-01 00:00:00

abstract：:Although common in hematologic and mesenchymal malignancies, recurrent gene fusions have not been well characterized in epithelial carcinomas. Recently, using a novel bioinformatic approach, we identified recurrent gene fusions between TMPRSS2 and the ETS family members ERG or ETV1 in the majority of prostate cancers....

journal_title：Cancer research

authors： Tomlins SA,Mehra R,Rhodes DR,Smith LR,Roulston D,Helgeson BE,Cao X,Wei JT,Rubin MA,Shah RB,Chinnaiyan AM

更新日期：2006-04-01 00:00:00

abstract：:Prostate cancer is the most commonly diagnosed noncutaneous neoplasm and second most common cause of cancer-related mortality in western men. To investigate the mechanisms of prostate cancer development and progression, we did expression profiling of human prostate cancer and benign tissues. We show that the SOX4 is o...

journal_title：Cancer research

authors： Liu P,Ramachandran S,Ali Seyed M,Scharer CD,Laycock N,Dalton WB,Williams H,Karanam S,Datta MW,Jaye DL,Moreno CS

更新日期：2006-04-15 00:00:00

abstract：:Angiogenesis inhibitor TNP-470, 6-O-(N-chloroacetyl-carbamoyl)-fumagillol, semisynthetic analogue of fumagillin, has strong inhibitory activities against in vivo tumor growth and metastasis in a wide variety of tumors. However, it is still unknown whether this agent inhibits bone metastasis. We examined the effects of...

journal_title：Cancer research

authors： Sasaki A,Alcalde RE,Nishiyama A,Lim DD,Mese H,Akedo H,Matsumura T

更新日期：1998-02-01 00:00:00

abstract：:The pattern of protein phosphorylation induced by phorbol-12-myristate-13-acetate (PMA) was analyzed by two-dimensional gel electrophoresis in human HL-60 leukemia cells, which are susceptible to induction of cell differentiation by PMA, and in cells from an HL-60 cell variant designated R-94 that are resistant to suc...

journal_title：Cancer research

authors： Anderson NL,Gemmell MA,Coussens PM,Murao S,Huberman E

更新日期：1985-10-01 00:00:00

abstract：:Deletion of the chromosome 5q [del(5q)] is one of the most common cytogenetic abnormalities observed in patients with de novo myelodysplastic syndromes (MDS) and therapy-related MDS or acute myeloid leukemia (t-MDS/tAML). Emerging evidence indicates that activation of the Wnt/β-catenin pathway contributes to the devel...

journal_title：Cancer research

authors： Li L,Sheng Y,Li W,Hu C,Mittal N,Tohyama K,Seba A,Zhao YY,Ozer H,Zhu T,Qian Z

更新日期：2017-08-01 00:00:00

abstract：:To elucidate the role of tumor vascularization on the localization of adoptively transferred, interleukin 2-activated natural killer (A-NK) cells, pulmonary B16 melanoma metastases were analyzed with respect to location, morphological appearance, origin and density of microvessels, and infiltration by A-NK cells. The ...

journal_title：Cancer research

authors： Nannmark U,Johansson BR,Bryant JL,Unger ML,Hokland ME,Goldfarb RH,Basse PH

更新日期：1995-10-15 00:00:00

abstract：:Two characteristics of immune responses to weakly immunogenic plasma cell tumors were demonstrated in this study. (a) Elevated lymphoproliferative responses following in vivo inoculation of sublethal doses of plasma cell tumors were detected by a mixed lymphocyte-tumor interaction (MLTI) assay. Specificity of elevated...

journal_title：Cancer research

authors： Boyer PJ,Fahey JL

更新日期：1976-04-01 00:00:00

abstract：:Plasmids may have unique advantages as a gene delivery system. However, a major obstacle is the low in vivo transduction efficiency. In this study, an electroporation-based gene transduction approach was taken to study the effect of interleukin (IL)-2 or IL-12 gene transduction on the growth of experimental murine tum...

journal_title：Cancer research

authors： Lohr F,Lo DY,Zaharoff DA,Hu K,Zhang X,Li Y,Zhao Y,Dewhirst MW,Yuan F,Li CY

更新日期：2001-04-15 00:00:00

abstract：:Initial studies have identified TSP50 as a human testes-specific gene that is demethylated in breast cancer. In this study, we will present new data related to the TSP50 gene. We have found that the TSP50 gene product shares a similar enzymatic structure with many serine proteases. However, the most critical catalytic...

journal_title：Cancer research

authors： Shan J,Yuan L,Xiao Q,Chiorazzi N,Budman D,Teichberg S,Xu HP

更新日期：2002-01-01 00:00:00

abstract：:Although radiotherapy (RT) decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer (TNBC) have increased risk of local recurrence following breast-conserving therapy. The relationship between RT and local recurrence is unknown. Here, we tested the hypothesis tha...

journal_title：Cancer research

authors： Rafat M,Aguilera TA,Vilalta M,Bronsart LL,Soto LA,von Eyben R,Golla MA,Ahrari Y,Melemenidis S,Afghahi A,Jenkins MJ,Kurian AW,Horst KC,Giaccia AJ,Graves EE

更新日期：2018-08-01 00:00:00

abstract：:We have shown that a mutant derivative of Chinese hamster ovary CHO-K1 cells, ADR-5, which shows hypersensitivity to topoisomerase II (topo II)-inhibitory drugs, is cross-sensitive to the site-selective cyclic AMP analogue 8-chloro-cyclic AMP. We tested the hypothesis that overexpression of the type I alpha regulatory...

journal_title：Cancer research

authors： North PS,Davies SL,Ciardiello F,Damiano V,Bianco C,Pepe S,Bianco AR,Harris AL,Hickson ID,Tortora G

更新日期：1994-08-01 00:00:00

abstract：:To examine genetic instability during carcinogenesis, we screened 171 carcinomas of the breast, liver, proximal colon, stomach, pancreas, uterine cervix, and ovary for replication error at four microsatellite marker loci on chromosome 2, 3, and 17. A significantly high incidence of genetic instability was observed in ...

journal_title：Cancer research

authors： Han HJ,Yanagisawa A,Kato Y,Park JG,Nakamura Y

更新日期：1993-11-01 00:00:00

abstract：:As previously reported for natural killer (NK) cells of normal individuals, prior incubation of peripheral blood lymphocytes from cancer patients with human normal serum or monomeric immunoglobulin G reduced their subsequent capacity to kill K562 target cells in a 4-h 51Cr release assay. The NK activity of such treate...

journal_title：Cancer research

authors： Pislarasu M,Oproiu A,Taranu D,Herberman RB,Sulica A

更新日期：1988-05-01 00:00:00

abstract：:Mortality or incidence rates of ten major neoplasms in migrants from several countries, their respective countries of origin, their American-born offspring, and United States whites were compared. Rates in succeeding generations of Americans increased most rapidly for colon cancer and most slowly for breast cancer, wi...

journal_title：Cancer research

authors： Thomas DB,Karagas MR

更新日期：1987-11-01 00:00:00

abstract：:Growth factors play an important role in regulating neural stem cell proliferation and differentiation. This study shows that platelet-derived growth factor (PDGF) induces a partial differentiation of neural stem/progenitor cells (NSPCs) in the absence of other mitogens in vitro. NSPCs thus acquire an immature morphol...

journal_title：Cancer research

authors： Erlandsson A,Brännvall K,Gustafsdottir S,Westermark B,Forsberg-Nilsson K

更新日期：2006-08-15 00:00:00

abstract：:Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems, but SA immunogenicity and interference by endogenous biotin may complicate clinical translation of this approach. In this study, we engineered a bispecific fusio...

journal_title：Cancer research

authors： Green DJ,Frayo SL,Lin Y,Hamlin DK,Fisher DR,Frost SH,Kenoyer AL,Hylarides MD,Gopal AK,Gooley TA,Orozco JJ,Till BG,O'Steen S,Orcutt KD,Wilbur DS,Wittrup KD,Press OW

更新日期：2016-11-15 00:00:00

abstract：:In the absence of excision repair, doxorubicin caused a striking (41-fold) increase in the frequency of large deletion mutations extending from the lac operator (lacO) into the lac repressor gene (lacI) of Escherichia coli. In contrast, there was only a 2-fold increase in the frequency of small deletions despite a 3-f...

journal_title：Cancer research

authors： Anderson RD,Veigl ML,Baxter J,Sedwick WD

更新日期：1991-08-01 00:00:00

abstract：:The NCI Genomic Data Commons (GDC) was launched in 2016 and makes available over 4 petabytes (PB) of cancer genomic and associated clinical data to the research community. This dataset continues to grow and currently includes over 14,500 patients. The GDC is an example of a biomedical data commons, which collocates bi...

journal_title：Cancer research

authors： Wilson S,Fitzsimons M,Ferguson M,Heath A,Jensen M,Miller J,Murphy MW,Porter J,Sahni H,Staudt L,Tang Y,Wang Z,Yu C,Zhang J,Ferretti V,Grossman RL,GDC Project.

更新日期：2017-11-01 00:00:00

abstract：:The steroid hormone 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] has potential to be used as an antitumor agent, but its clinical application is restricted by the strong calcemic activity. Therefore, new vitamin D3 analogues are developed with increased growth inhibitory and reduced calcemic activity. In the present study,...

journal_title：Cancer research

authors： Vink-van Wijngaarden T,Pols HA,Buurman CJ,van den Bemd GJ,Dorssers LC,Birkenhäger JC,van Leeuwen JP

更新日期：1994-11-01 00:00:00

abstract：:Angiostatin, a proteolytic fragment of plasminogen, is a potent angiogenesis inhibitor able to suppress tumor growth and metastasis through inhibition of endothelial cell proliferation and migration. Previously, we showed that angiostatin binds and inhibits F(1)F(o) ATP synthase on the endothelial cell surface and tha...

journal_title：Cancer research

authors： Chi SL,Pizzo SV

更新日期：2006-01-15 00:00:00

abstract：:The anticancer oxazaphosphorine prodrugs cyclophosphamide and ifosfamide are activated in human liver by a 4-hydroxylation reaction catalyzed by multiple cytochrome P450 (CYP) enzymes. In the present study, we used a cultured human hepatocyte model to identify possible inducers of the CYP-catalyzed activation of these...

journal_title：Cancer research

authors： Chang TK,Yu L,Maurel P,Waxman DJ

更新日期：1997-05-15 00:00:00

abstract：:Caveolin-1 (CAV1) is the main structural component of caveolae, which are plasma membrane invaginations that participate in vesicular trafficking and signal transduction events. Although evidence describing the function of CAV1 in several cancer types has recently accumulated, its role in melanoma tumor formation and ...

journal_title：Cancer research

authors： Trimmer C,Whitaker-Menezes D,Bonuccelli G,Milliman JN,Daumer KM,Aplin AE,Pestell RG,Sotgia F,Lisanti MP,Capozza F

更新日期：2010-10-01 00:00:00

abstract：:The Notch ligand Dll4 has a recognized role during both physiologic and tumor angiogenesis, as it contributes to regulate Notch activity in endothelial cells (EC). The effects of Dll4 on Notch signaling in tumor cells expressing Notch receptors remain, however, largely unknown. Here, we report that escape of human T-c...

journal_title：Cancer research

authors： Indraccolo S,Minuzzo S,Masiero M,Pusceddu I,Persano L,Moserle L,Reboldi A,Favaro E,Mecarozzi M,Di Mario G,Screpanti I,Ponzoni M,Doglioni C,Amadori A

更新日期：2009-02-15 00:00:00