当前位置： SCI文献检索 > CANCER RESEARCH期刊下所有文献 > Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers.

Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers.

Abstract：

:Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems, but SA immunogenicity and interference by endogenous biotin may complicate clinical translation of this approach. In this study, we engineered a bispecific fusion protein (FP) that evades the limitations imposed by this system. Briefly, one arm of the FP was an anti-human CD20 antibody (2H7), with the other arm of the FP an anti-chelated radiometal trap for a radiolabeled ligand (yttrium[Y]-DOTA) captured by a very high-affinity anti-Y-DOTA scFv antibody (C825). Head-to-head biodistribution experiments comparing SA-biotin and bispecific FP (2H7-Fc-C825) PRIT in murine subjects bearing human lymphoma xenografts demonstrated nearly identical tumor targeting by each modality at 24 hours. However, residual radioactivity in the blood and normal organs was consistently higher following administration of 1F5-SA compared with 2H7-Fc-C825. Consequently, tumor-to-normal tissue ratios of distribution were superior for 2H7-Fc-C825 (P < 0.0001). Therapy studies in subjects bearing either Ramos or Granta subcutaneous lymphomas demonstrated that 2H7-Fc-C825 PRIT is highly effective and significantly less myelosuppressive than 1F5-SA (P < 0.0001). All animals receiving optimal doses of 2H7-Fc-C825 followed by 90Y-DOTA were cured by 150 days, whereas the growth of tumors in control animals progressed rapidly with complete morbidity by 25 days. In addition to demonstrating reduced risk of immunogenicity and an absence of endogenous biotin interference, our findings offer a preclinical proof of concept for the preferred use of bispecific PRIT in future clinical trials, due to a slightly superior biodistribution profile, less myelosuppression, and superior efficacy. Cancer Res; 76(22); 6669-79. ©2016 AACR.

journal_name

Cancer Res

journal_title

Cancer research

authors

Green DJ,Frayo SL,Lin Y,Hamlin DK,Fisher DR,Frost SH,Kenoyer AL,Hylarides MD,Gopal AK,Gooley TA,Orozco JJ,Till BG,O'Steen S,Orcutt KD,Wilbur DS,Wittrup KD,Press OW

doi

10.1158/0008-5472.CAN-16-0571

subject

Has Abstract

pub_date

2016-11-15 00:00:00

pages

6669-6679

issue

22

eissn

0008-5472

issn

1538-7445

pii

0008-5472.CAN-16-0571

journal_volume

76

pub_type

杂志文章

相关文献

CANCER RESEARCH文献大全
  • DNA vaccines encoding full-length or truncated Neu induce protective immunity against Neu-expressing mammary tumors.

    abstract：:We generated DNA expression vectors encoding the full-length neu cDNA (designated pNeuN), the neu extracellular domain (pNeuE), or the neu extracellular and transmembrane domains (pNeuTM). The 293 cells transfected with pNeuN or pNeuTM expressed the neu extracellular domain on the surface membrane, whereas 293 cells t...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Chen Y,Hu D,Eling DJ,Robbins J,Kipps TJ

    更新日期：1998-05-01 00:00:00

  • Modification of myc gene amplification in human somatic cell hybrids.

    abstract：:In order to study whether cell fusion would modify the DNA copy number of an amplified oncogene, somatic cell hybrids were made between the human neuroepithelioma cell line MCIXC and HeLaCOT human adenocarcinoma cells. MCIXC contains approximately 21 copies of the c-myc oncogene and HeLaCOT contains approximately 5 co...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Iman DS,Shay JW

    更新日期：1989-08-15 00:00:00

  • Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells.

    abstract：:DNA methyltransferase 1 (DNMT1)-deficient mice are tumor-prone, and this has been proposed to result from the induction of genomic instability. To address whether loss of DNMT1, or the related protein DNMT3b, results in genomic instability in human cancer cells, we used a near-diploid human colorectal cancer cell line...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-05-1961

    authors： Karpf AR,Matsui S

    更新日期：2005-10-01 00:00:00

  • Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells.

    abstract：:Androgens via their receptor (AR) may play a role in prostate cancer etiology. This study focuses on the inhibitory effects of resveratrol on androgen action in the LNCaP prostate cancer cell line. We found that resveratrol represses different classes of androgen up-regulated genes at the protein or mRNA level includi...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Mitchell SH,Zhu W,Young CY

    更新日期：1999-12-01 00:00:00

  • Isolation of a complementary DNA encoding the catalytic subunit of protein kinase A and studies on the expression of this sequence in rat hepatomas and regenerating liver.

    abstract：:A complementary DNA (cDNA) clone (B4) encoding the catalytic subunit of a cAMP-dependent protein kinase (PKAc) was isolated from a lambda gt10 rat brain cDNA library, using a synthetic oligonucleotide probe whose sequence was based on the known amino acid sequence of a bovine cardiac PKAc. Sequence analysis of this cl...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Roth JS,Hsieh LL,Peraino C,Weinstein IB

    更新日期：1990-03-15 00:00:00

  • A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas.

    abstract：:We estimated associations between polymorphisms in the gene encoding microsomal epoxide hydrolase (mEH) among 464 cases diagnosed with first occurrence of colorectal adenoma and 510 matched controls. In an analysis controlling only for the matching variables, we found little or no association between adenoma and mEH g...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Cortessis V,Siegmund K,Chen Q,Zhou N,Diep A,Frankl H,Lee E,Zhu QS,Haile R,Levy D

    更新日期：2001-03-15 00:00:00

  • Live-cell imaging of invasion and intravasation in an artificial microvessel platform.

    abstract：:Methods to visualize metastasis exist, but additional tools to better define the biologic and physical processes underlying invasion and intravasation are still needed. One difficulty in studying metastasis stems from the complexity of the interface between the tumor microenvironment and the vascular system. Here, we ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-14-1042

    authors： Wong AD,Searson PC

    更新日期：2014-09-01 00:00:00

  • Mathematical modeling of tumor growth and metastatic spreading: validation in tumor-bearing mice.

    abstract：:Defining tumor stage at diagnosis is a pivotal point for clinical decisions about patient treatment strategies. In this respect, early detection of occult metastasis invisible to current imaging methods would have a major impact on best care and long-term survival. Mathematical models that describe metastatic spreadin...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-14-0721

    authors： Hartung N,Mollard S,Barbolosi D,Benabdallah A,Chapuisat G,Henry G,Giacometti S,Iliadis A,Ciccolini J,Faivre C,Hubert F

    更新日期：2014-11-15 00:00:00

  • Increased Expression of miR-23a Mediates a Loss of Expression in the RAF Kinase Inhibitor Protein RKIP.

    abstract：:RAF kinase inhibitor protein (RKIP) is a seminal regulator of intracellular signaling and exhibits both antimetastatic and antitumorigenic properties. Decreased expression of RKIP has been described in several human malignancies, including acute myelogenous leukemia (AML). As the mechanisms leading to RKIP loss in AML...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-15-3049

    authors： Hatzl S,Geiger O,Kuepper MK,Caraffini V,Seime T,Furlan T,Nussbaumer E,Wieser R,Pichler M,Scheideler M,Nowek K,Jongen-Lavrencic M,Quehenberger F,Wölfler A,Troppmair J,Sill H,Zebisch A

    更新日期：2016-06-15 00:00:00

  • Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism.

    abstract：:Loss of hSNF5 function is usually observed in malignant rhabdoid tumor (MRT), a highly aggressive pediatric neoplasm. Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A), p21(CIP1/WAF1), and cyclin D1 playing key roles in MRT cell growth control. However...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-09-1922

    authors： Kuwahara Y,Charboneau A,Knudsen ES,Weissman BE

    更新日期：2010-03-01 00:00:00

  • A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence.

    abstract：:: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilizat...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-18-1886

    authors： La T,Liu GZ,Farrelly M,Cole N,Feng YC,Zhang YY,Sherwin SK,Yari H,Tabatabaee H,Yan XG,Guo ST,Liu T,Thorne RF,Jin L,Zhang XD

    更新日期：2018-12-01 00:00:00

  • Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates.

    abstract：:Acquired resistance to cisplatin has been generated in vitro in two human ovarian carcinoma cell lines: 41M, established from a previously untreated patient; and CH1, from a patient previously treated with cisplatin and cis-diammine-1,1-cyclobutane dicarboxylatoplatinum(II) (carboplatin). In neither cell line with acq...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Kelland LR,Mistry P,Abel G,Loh SY,O'Neill CF,Murrer BA,Harrap KR

    更新日期：1992-07-15 00:00:00

  • NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes.

    abstract：:During the development of neoplasia, epithelial tissues undergo biochemical and structural changes that can manifest in tissue fluorescence. There have been several reports on different in vivo fluorescence characteristics between normal and precancerous (dysplastic) tissues. However, it has been difficult to identify...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Georgakoudi I,Jacobson BC,Müller MG,Sheets EE,Badizadegan K,Carr-Locke DL,Crum CP,Boone CW,Dasari RR,Van Dam J,Feld MS

    更新日期：2002-02-01 00:00:00

  • Major histocompatibility complex class I restricted cytotoxic T cells specific for natural melanoma peptides recognize unidentified shared melanoma antigen(s).

    abstract：:CTLs were generated in vitro from two healthy donors and one melanoma patient by stimulation of CD8+ T cells with autologous dendritic cells pulsed with natural melanoma peptides (NMPs), obtained by acid treatment of HLA-matched melanoma cells. CTLs showed MHC class I-restricted melanoma-specific cytolytic activity. I...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Imro MA,Manici S,Russo V,Consogno G,Bellone M,Rugarli C,Traversari C,Protti MP

    更新日期：1999-05-15 00:00:00

  • Reprogramming T lymphocytes for melanoma adoptive immunotherapy by T-cell receptor gene transfer with lentiviral vectors.

    abstract：:T-cell receptor (TCR) gene transfer for cancer immunotherapy is limited by the availability of large numbers of tumor-specific T cells. TCR alpha and beta chains were isolated from a highly lytic HLA-A2-restricted cytotoxic T lymphocyte (CTL) clone recognizing the melanoma-associated Melan-A/MART-1 antigen and inserte...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-09-0494

    authors： Bobisse S,Rondina M,Merlo A,Tisato V,Mandruzzato S,Amendola M,Naldini L,Willemsen RA,Debets R,Zanovello P,Rosato A

    更新日期：2009-12-15 00:00:00

  • Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets.

    abstract：:Despite their extensive clinical and pathologic heterogeneity, all malignant germ cell tumors (GCT) are thought to originate from primordial germ cells. However, no common biological abnormalities have been identified to date. We profiled 615 microRNAs (miRNA) in pediatric malignant GCTs, controls, and GCT cell lines ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-09-3301

    authors： Palmer RD,Murray MJ,Saini HK,van Dongen S,Abreu-Goodger C,Muralidhar B,Pett MR,Thornton CM,Nicholson JC,Enright AJ,Coleman N,Children's Cancer and Leukaemia Group.

    更新日期：2010-04-01 00:00:00

  • Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212.

    abstract：:Monoclonal antibodies (MAbs) 123C3 and 123A8 generated against a membrane preparation of a small cell lung carcinoma (SCLC) specimen recognize not only SCLC and bronchial carcinoids but also a significant portion of non-small cell lung carcinomas (non-SCLC) of various histological types. Together with 13 other monoclo...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Moolenaar CE,Muller EJ,Schol DJ,Figdor CG,Bock E,Bitter-Suermann D,Michalides RJ

    更新日期：1990-02-15 00:00:00

  • Cancer in first and second generation Americans.

    abstract：:Mortality or incidence rates of ten major neoplasms in migrants from several countries, their respective countries of origin, their American-born offspring, and United States whites were compared. Rates in succeeding generations of Americans increased most rapidly for colon cancer and most slowly for breast cancer, wi...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Thomas DB,Karagas MR

    更新日期：1987-11-01 00:00:00

  • The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55.

    abstract：:Failure of cytokinesis results in tetraploidy and can increase the genomic instability frequently observed in cancer. The peptidyl-prolyl isomerase Pin1, which is deregulated in many tumors, regulates several processes, including cell cycle progression. Here, we show a novel role for Pin1 in cytokinesis. Pin1 knockout...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-09-0825

    authors： van der Horst A,Khanna KK

    更新日期：2009-08-15 00:00:00

  • Relationship of a Mr 140 fibronectin receptor and other adhesion-related glycoproteins to tumor cell-cell interaction.

    abstract：:Primary melanocytes attach poorly to collagen type IV and laminin, in contrast to their firm attachment to collagen type I/III and fibronectin [Gilchrest et al., In vitro (Rockville), 21: 114-120, 1985]. We have now found that metastatic B16 melanoma cells attach well to collagen type IV, laminin, vitronectin, and fib...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Rieber M,Gross A,Rieber MS

    更新日期：1987-10-01 00:00:00

  • Selective protection against cis-diamminedichloroplatinum(II)-induced toxicity in kidney, gut, and bone marrow by diethyldithiocarbamate.

    abstract：:Diethyldithiocarbamate (DDTC) has been shown to inhibit nephrotoxicity induced by cis-platinum (DDP) without inhibition of tumor response in the rat. We report here that DDTC at doses of 25-300 mg/kg inhibits DDP-induced nephrotoxicity and bone marrow toxicity in C57BL/6 X DBA/2F1 (hereafter called B6D2F1) mice, F344 ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Bodenner DL,Dedon PC,Keng PC,Katz JC,Borch RF

    更新日期：1986-06-01 00:00:00

  • Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks.

    abstract：:The study of two major risk factors in the development of hepatocellular carcinoma, namely persistent hepatitis virus infection and exposure to dietary aflatoxins, has been hampered by lack of an experimental system. To this end we have used a Pekin duck model to examine the effect of congenital duck hepatitis B virus...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Cova L,Wild CP,Mehrotra R,Turusov V,Shirai T,Lambert V,Jacquet C,Tomatis L,Trépo C,Montesano R

    更新日期：1990-04-01 00:00:00

  • Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer.

    abstract：:Tumor development is angiogenesis dependent, and vascular endothelial growth factor (VEGF) is a key growth factor in this process. We demonstrate that high expression of VEGF mRNA in 55 superficial bladder cancers was associated with earlier recurrence (P = 0.001; hazard ratio, 3.09) and progression to a more invasive...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Crew JP,O'Brien T,Bradburn M,Fuggle S,Bicknell R,Cranston D,Harris AL

    更新日期：1997-12-01 00:00:00

  • Radioimmunotherapy for breast cancer using escalating fractionated doses of 131I-labeled chimeric L6 antibody with peripheral blood progenitor cell transfusions.

    abstract：:Radioimmunotherapy (RAIT) using a humanized murine monoclonal antibody, chimeric L6 (ChL6), has produced objective tumor reduction in 50% of chemotherapy-refractory patients with metastatic breast cancer in our prior studies. Because myelosuppression limited dose escalation, we evaluated the ability of granulocyte col...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Richman CM,DeNardo SJ,O'Grady LF,DeNardo GL

    更新日期：1995-12-01 00:00:00

  • Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.

    abstract：:The microenvironment of rapidly growing tumors is associated with increased energy demand and diminished vascular supply, resulting in focal areas of prominent hypoxia. A number of hypoxia-responsive genes have been associated with growing tumors, and here we demonstrate that the multidrug resistance (MDR1) gene produ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Comerford KM,Wallace TJ,Karhausen J,Louis NA,Montalto MC,Colgan SP

    更新日期：2002-06-15 00:00:00

  • Protection from procarbazine-induced damage of spermatogenesis in the rat by androgen.

    abstract：:Protection of spermatogenesis from cytotoxic drug-induced damage has been investigated in the rat. Complete germinal aplasia was observed at 8 and 11 weeks after four doses of procarbazine hydrochloride administered weekly (150 mg/kg, first dose; 100 mg/kg, 3 subsequent doses). Pretreatment of rats for 6 weeks plus co...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Delic JI,Bush C,Peckham MJ

    更新日期：1986-04-01 00:00:00

  • Differing patterns of human protooncogene expression in peripheral blood and bone marrow acute leukemia cells.

    abstract：:The levels of protooncogene RNA in matched bone marrow and peripheral blood cells obtained from patients with newly diagnosed acute myelogenous leukemia were compared. While the absolute amounts of c-myc RNA in the matched specimens are similar, the levels are not correlated. In contrast, while the levels of c-fos RNA...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Preisler HD,Sato H,Li YQ,Stein G,Stein J

    更新日期：1987-07-15 00:00:00

  • LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem-like Cells.

    abstract：:Cancer stem-like cells (CSC) in hepatocellular carcinoma (HCC) are thought to mediate therapeutic resistance and poor survival outcomes, but their intrinsic and extrinsic control is not well understood. In this study, we found that the chromatin modification factor LSD1 is highly expressed in HCC CSC where it decrease...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-17-1236

    authors： Liu C,Liu L,Chen X,Cheng J,Zhang H,Zhang C,Shan J,Shen J,Qian C

    更新日期：2018-02-15 00:00:00

  • Molecular cytogenetic mapping of the human melanoma antigen (MAGE) gene family to chromosome region Xq27-qter: implications for MAGE immunotherapy.

    abstract：:We have defined the chromosomal location of the human MAGE (melanoma antigen) gene family by polymerase chain reaction amplification of several segments of the MAGE genes from somatic cell hybrids containing well-defined groups of human chromosomes and hybrids containing human derivative chromosomes. The data show tha...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Oaks MK,Hanson JP Jr,O'Malley DP

    更新日期：1994-04-01 00:00:00

  • Induction of cell death by basic fibroblast growth factor in Ewing's sarcoma.

    abstract：:Ewing's sarcoma is thought to arise after developmental arrest of primitive neural cells during embryogenesis. Because basic fibroblast growth factor (bFGF) has a critical role in the regulation of cell survival, proliferation, and differentiation during embryogenesis, we have tested the hypothesis that bFGF and FGF r...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Sturla LM,Westwood G,Selby PJ,Lewis IJ,Burchill SA

    更新日期：2000-11-01 00:00:00