Overexpression of the RI alpha subunit of protein kinase A confers hypersensitivity to topoisomerase II inhibitors and 8-chloro-cyclic adenosine 3'5'-monophosphate in Chinese hamster ovary cells.

abstract：:Tumor-specific immune tolerance limits the effectiveness of cancer vaccines. In addition, tumor vaccines alone have a limited potential for the treatment of measurable tumor burdens. This highlights the importance of identifying more potent cancer vaccine strategies for clinical testing. We tested immune-modulating do...

journal_title：Cancer research

authors： Machiels JP,Reilly RT,Emens LA,Ercolini AM,Lei RY,Weintraub D,Okoye FI,Jaffee EM

更新日期：2001-05-01 00:00:00

abstract：:We and others have reported previously that adults with glioma are 1.5- to 4-fold less likely than controls to report a variety of allergic conditions. The consistent nature of this relationship calls for a biological explanation so that preventative or therapeutic modalities can be explored. We enrolled 403 newly dia...

journal_title：Cancer research

authors： Wiemels JL,Wiencke JK,Patoka J,Moghadassi M,Chew T,McMillan A,Miike R,Barger G,Wrensch M

更新日期：2004-11-15 00:00:00

abstract：:The SK3 channel, a potassium channel, was recently shown to control cancer cell migration, a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel was markedly associated with bone metastasis. The SK3 channel was shown to control constitutive Ca(2+) entry and cancer cell migration t...

journal_title：Cancer research

authors： Chantôme A,Potier-Cartereau M,Clarysse L,Fromont G,Marionneau-Lambot S,Guéguinou M,Pagès JC,Collin C,Oullier T,Girault A,Arbion F,Haelters JP,Jaffrès PA,Pinault M,Besson P,Joulin V,Bougnoux P,Vandier C

更新日期：2013-08-01 00:00:00

abstract：:[D-Arg1,D-Trp5,7,9,Leu11]Substance P (SP) was identified out of a panel of novel SP analogues as the most potent inhibitor of small cell lung cancer (SCLC) cell growth. This analogue inhibited proliferation of H-510 and H-69 SCLC cells in liquid culture and in semisolid media (IC50, 5 microM). Colony formation stimula...

journal_title：Cancer research

authors： Seckl MJ,Higgins T,Widmer F,Rozengurt E

更新日期：1997-01-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) is a glycoprotein metabolized primarily by the liver. Subcellular fractions of rat liver were examined for CEA binding activity. Hepatocyte plasma membrane and microsome fractions bound CEA, and this binding shared the calcium requirement, neuraminidase sensitivity, and carbohydrate spec...

journal_title：Cancer research

authors： Byrn RA,Medrek P,Thomas P,Jeanloz RW,Zamcheck N

更新日期：1985-07-01 00:00:00

abstract：:Serum galactosyltransferase isoenzyme II (GT-II) was assayed in 409 coded serum samples obtained from the National Cancer Institute Tumor Serum Bank using a monoclonal antibody-based immunoassay. The serum panel consisted of samples from patients with confirmed, metastatic ovarian, breast, stomach, esophageal, pancrea...

journal_title：Cancer research

authors： Uemura M,Winant RC,Brandt AE

更新日期：1988-09-15 00:00:00

abstract：:Tumor hypoxia is associated with resistance to antiangiogenic therapy and poor prognosis. The Siah E3 ubiquitin ligases regulate the hypoxic response pathway by modulating the turnover of the master proangiogenic transcription factor hypoxia-inducible factor-1α (Hif-1α). In this study, we show that genetic deficiency ...

journal_title：Cancer research

authors： Wong CS,Sceneay J,House CM,Halse HM,Liu MC,George J,Hunnam TC,Parker BS,Haviv I,Ronai Z,Cullinane C,Bowtell DD,Möller A

更新日期：2012-04-01 00:00:00

abstract：:The human nm23 gene, a candidate metastatic suppressor gene, consists of two genes, nm23-H1 and nm23-H2. The potential mutation in the nm23-H1 gene was examined in colorectal cancer using a reverse transcription polymerase chain reaction amplification followed by DNA sequencing analysis. Genomic alterations in the nm2...

journal_title：Cancer research

authors： Wang L,Patel U,Ghosh L,Chen HC,Banerjee S

更新日期：1993-02-15 00:00:00

abstract：:The influence of methotrexate (MTX), dibutyryl cyclic AMP, and actinomycin D on production of human chorionic gonadotropin (HCG) in normal first trimester human placental organ cultures was compared. Actinomycin D (10(-8) to 10(-6) M) elevated HCG production by as much as 3.5-fold in normal placenta, and a 2-fold incr...

journal_title：Cancer research

authors： Huot RI,Nardone RM,Stromberg K

更新日期：1987-01-15 00:00:00

abstract：:Unlike the growth factor dependence of normal cells, cancer cells can maintain growth factor-independent glycolysis and survival through expression of oncogenic kinases, such as BCR-Abl. Although targeted kinase inhibition can promote cancer cell death, therapeutic resistance develops frequently, and further mechanist...

journal_title：Cancer research

authors： Mason EF,Zhao Y,Goraksha-Hicks P,Coloff JL,Gannon H,Jones SN,Rathmell JC

更新日期：2010-10-15 00:00:00

abstract：:Eleven patients with advanced breast cancer and four with astrocytoma were treated with plasma perfused over columns containing staphylococcal Protein A (SPA). Doses of 5 to 20 mg of SPA were bound to collodion charcoal particles, and this treatment resulted in partial remissions in one patient with astrocytoma and in...

journal_title：Cancer research

authors： Bertram JH,Grunberg SM,Shulman I,Apuzzo ML,Boquiren D,Kunkel L,Hengst JC,Nelson J,Waugh WJ,Plotkin D

更新日期：1985-09-01 00:00:00

abstract：:Apoptosis is a mode of cell death that is carefully regulated based on cellular and environmental signals. The ability to modulate the individual cellular machinery and thereby to promote apoptosis is an important strategy in cancer therapy. It has previously been shown that overexpression of the transcription factor ...

journal_title：Cancer research

authors： Hunt KK,Deng J,Liu TJ,Wilson-Heiner M,Swisher SG,Clayman G,Hung MC

更新日期：1997-11-01 00:00:00

abstract：:Extramedullary myelopoiesis occurs commonly in tumor-bearing animals and is known to lead to accumulation of peripheral myeloid-derived suppressor cells (MDSC), which play an important role in immune escape. However, the cellular and molecular mechanisms by which tumors induce extramedullary myelopoiesis are poorly un...

journal_title：Cancer research

authors： Kim EK,Jeon I,Seo H,Park YJ,Song B,Lee KA,Jang Y,Chung Y,Kang CY

更新日期：2014-11-15 00:00:00

abstract：:The cadherin family of transmembrane glycoproteins plays a critical role in cell-to-cell adhesion and cadherin dysregulation is strongly associated with cancer metastasis and progression. In this study, we report a novel interaction between protein kinase D1 [PKD1; formerly known as protein kinase C mu (PKCmu)] and E-...

journal_title：Cancer research

authors： Jaggi M,Rao PS,Smith DJ,Wheelock MJ,Johnson KR,Hemstreet GP,Balaji KC

更新日期：2005-01-15 00:00:00

abstract：:A series of mouse mammary tumor subpopulation lines were compared for growth properties and sensitivity to chemotherapeutic drugs when grown as boluses in a collagen gel matrix versus in monolayer culture. Although the cell lines exhibited characteristic rates of bolus expansion in collagen, this growth was not parall...

journal_title：Cancer research

authors： Miller BE,Miller FR,Heppner GH

更新日期：1985-09-01 00:00:00

abstract：:We have previously reported the development of a recombinant vaccinia virus vaccine expressing the human carcinoembryonic antigen (CEA) gene, designated rV(NYC)-CEA. This construct has been shown to elicit specific anti-CEA immune responses and an antitumor effect in a murine tumor model. In the studies reported here,...

journal_title：Cancer research

authors： Kantor J,Irvine K,Abrams S,Snoy P,Olsen R,Greiner J,Kaufman H,Eggensperger D,Schlom J

更新日期：1992-12-15 00:00:00

abstract：:Elimination of both alleles of the gene that encodes the cyclin kinase inhibitor p21(WAF1/cip1) increases the frequency and size of intestinal tumors in Apc1638+/- mice that inherit a mutant allele of the Apc gene, and intermediate effects are seen if a single p21 allele is inactivated. The increased tumor formation i...

journal_title：Cancer research

authors： Yang WC,Mathew J,Velcich A,Edelmann W,Kucherlapati R,Lipkin M,Yang K,Augenlicht LH

更新日期：2001-01-15 00:00:00

abstract：:The addition of B-cell lymphoma 2 (Bcl-2) antisense to dacarbazine in the treatment of metastatic melanoma demonstrates improved response rates and progression-free survival when compared with dacarbazine alone. Studies on small cohorts of melanoma patients have shown variability in Bcl-2 expression (60%-96% positive)...

journal_title：Cancer research

authors： Divito KA,Berger AJ,Camp RL,Dolled-Filhart M,Rimm DL,Kluger HM

更新日期：2004-12-01 00:00:00

abstract：:We investigated the effect of iododeoxyuridine (IdUrd) exposure on cis-diamminedichloroplatinum (CDDP) cytotoxicity in the human bladder cancer cell line 647V. Following a 48-h incubation with 2-20 microM IdUrd, a 1-h exposure to 0-120 microM CDDP produced a dose-dependent increase in CDDP cytotoxicity as measured by ...

journal_title：Cancer research

authors： Chi KH,Kunugi KA,Kinsella TJ

更新日期：1994-05-15 00:00:00

abstract：:Tubulysins are highly toxic tubulin-targeting agents with a narrow therapeutic window that are interesting for application in antibody-drug conjugates (ADC). For full control over drug-antibody ratio (DAR) and the effect thereof on pharmacokinetics and tumor targeting, a dual-labeling approach was developed, wherein t...

journal_title：Cancer research

authors： Cohen R,Vugts DJ,Visser GW,Stigter-van Walsum M,Bolijn M,Spiga M,Lazzari P,Shankar S,Sani M,Zanda M,van Dongen GA

更新日期：2014-10-15 00:00:00

abstract：:Inactivation of the p53 tumor suppressor gene is a common finding in human cancer. In most cases, inactivation is due to a point mutation in the gene, but rearrangement of the p53 gene is sometimes observed. We analyzed the inactivation of p53 in the human pancreas cancer cell line Hs766T, which harbors a structural a...

journal_title：Cancer research

authors： Slebos RJ,Resnick MA,Taylor JA

更新日期：1998-12-01 00:00:00

abstract：:The semaphorins and their receptors, the neuropilins and the plexins, are constituents of a complex regulatory system that controls axonal guidance. Moreover, many types of tumor cells express various members of semaphorins and receptors, but the biological activities within tumor mass and the signal transduction mech...

journal_title：Cancer research

authors： Catalano A,Lazzarini R,Di Nuzzo S,Orciari S,Procopio A

更新日期：2009-02-15 00:00:00

abstract：:A single i.p. injection of butylated hydroxytoluene (BHT) 6 h before a single urethan injection had varying effects on lung tumorigenesis in mice of different strains and ages. Strains exhibiting both high (A/J, SWR/J) and low (BALB/cByJ, 129/J, C57BL/6J) susceptibility to urethan tumorigenesis were tested in this stu...

journal_title：Cancer research

authors： Malkinson AM,Thaete LG

更新日期：1986-04-01 00:00:00

abstract：:Alterations in expression of or responsiveness to transforming growth factor beta (TGF-beta) are frequently found in human and animal epithelial cancers and are though to be important for loss of growth control in the neoplastic cell. We show here that keratinocyte cell lines from mice with a targeted deletion of the ...

journal_title：Cancer research

authors： Glick AB,Weinberg WC,Wu IH,Quan W,Yuspa SH

更新日期：1996-08-15 00:00:00

abstract：:The anticarcinogenic activities of retinoic acid (RA) are believed to be mediated by the nuclear RA receptor (RAR) and by the RA-binding protein cellular RA-binding protein-II (CRABP-II). In MCF-7 mammary carcinoma cells, growth inhibition by RA entails an early cell cycle arrest followed by induction of apoptosis. He...

journal_title：Cancer research

authors： Donato LJ,Suh JH,Noy N

更新日期：2007-01-15 00:00:00

abstract：:Shedding of tumor cell gangliosides may contribute to tumor cell escape from host immune destruction. Thus, it would be of interest to block the shedding of these immunosuppressive molecules. To this end, we studied a ceramide analogue, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP). D-PDMP is a pot...

journal_title：Cancer research

authors： Li R,Ladisch S

更新日期：1996-10-15 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. However, clinical trials targeting the VEGF pathway are often ineffective, suggesting that other factors/pathways are also important in tumor angiogenesis. We have previously shown that the Notch ligand Delta-like 4 (DLL4) is up-regu...

journal_title：Cancer research

authors： Li JL,Sainson RC,Shi W,Leek R,Harrington LS,Preusser M,Biswas S,Turley H,Heikamp E,Hainfellner JA,Harris AL

更新日期：2007-12-01 00:00:00

abstract：:Resistance to antineoplastic drugs is a major problem in the clinical management of cancer. Previous studies have demonstrated that the cytotoxicity of certain anticancer drugs is increased by lowering the glutathione (GSH) levels with buthionine sulfoximine (BSO), a specific inhibitor of gamma-glutamylcysteine synthe...

journal_title：Cancer research

authors： Dusre L,Mimnaugh EG,Myers CE,Sinha BK

更新日期：1989-02-01 00:00:00

abstract：:Hypoxia is considered to be a major cause of tumor radioresistance. Reoxygenation of previously hypoxic areas after a priming dose of radiation is associated with an increase in tumor radiosensitivity. In a study of a hypoxic mammary carcinoma, 31P nuclear magnetic resonance spectra showed statistically significant in...

journal_title：Cancer research

authors： Koutcher JA,Alfieri AA,Devitt ML,Rhee JG,Kornblith AB,Mahmood U,Merchant TE,Cowburn D

更新日期：1992-09-01 00:00:00

abstract：:Human B-cell lymphomas are frequently associated with specific genetic changes caused by chromosomal translocations that activate proto-oncogenes. For lymphomas of mice expressing murine leukemia virus, mutagenic proviral insertions are thought to play a similar role. Here we report studies designed to determine wheth...

journal_title：Cancer research

authors： Shin MS,Fredrickson TN,Hartley JW,Suzuki T,Akagi K,Morse HC 3rd

更新日期：2004-07-01 00:00:00