Abstract：
:To examine genetic instability during carcinogenesis, we screened 171 carcinomas of the breast, liver, proximal colon, stomach, pancreas, uterine cervix, and ovary for replication error at four microsatellite marker loci on chromosome 2, 3, and 17. A significantly high incidence of genetic instability was observed in pancreatic (6 of 9 tumors) and gastric cancers (22 of 57 cases). In other types of carcinoma, the incidence of replication error-positive cases was relatively low (3-16%). Among gastric carcinomas, significantly more replication error-positive cases were observed in the poorly differentiated types (16 of 25 cases) than in well differentiated types (3 of 18) (P = 0.0023 by Fisher's exact test). Our results suggested that genetic instability is likely to play an important role in development of pancreatic and gastric cancers, particularly poorly differentiated adenocarcinomas.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Han HJ,Yanagisawa A,Kato Y,Park JG,Nakamura Ysubject
Has Abstractpub_date
1993-11-01 00:00:00pages
5087-9issue
21eissn
0008-5472issn
1538-7445journal_volume
53pub_type
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