Abstract:
:Although common in hematologic and mesenchymal malignancies, recurrent gene fusions have not been well characterized in epithelial carcinomas. Recently, using a novel bioinformatic approach, we identified recurrent gene fusions between TMPRSS2 and the ETS family members ERG or ETV1 in the majority of prostate cancers. Here, we interrogated the expression of all ETS family members in prostate cancer profiling studies and identified marked overexpression of ETV4 in 2 of 98 cases. In one such case, we confirmed the overexpression of ETV4 using quantitative PCR, and by rapid amplification of cDNA ends, quantitative PCR, and fluorescence in situ hybridization, we show that the TMPRSS2 (21q22) and ETV4 (17q21) loci are fused in this case. This result defines a third molecular subtype of prostate cancer and supports the hypothesis that dysregulation of ETS family members through fusions with TMRPSS2 may be an initiating event in prostate cancer development.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Tomlins SA,Mehra R,Rhodes DR,Smith LR,Roulston D,Helgeson BE,Cao X,Wei JT,Rubin MA,Shah RB,Chinnaiyan AMdoi
10.1158/0008-5472.CAN-06-0168subject
Has Abstractpub_date
2006-04-01 00:00:00pages
3396-400issue
7eissn
0008-5472issn
1538-7445pii
66/7/3396journal_volume
66pub_type
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