Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer.

abstract：:The chemokine receptor CXCR4 plays a central role in organ-specific homing and tumor spreading and is induced by hypoxia. B lymphocytes are exposed to low oxygen tensions during their development, but the influence of hypoxia on their physiology is poorly understood. Here, we show that hypoxia is associated with up-re...

journal_title：Cancer research

authors： Piovan E,Tosello V,Indraccolo S,Masiero M,Persano L,Esposito G,Zamarchi R,Ponzoni M,Chieco-Bianchi L,Dalla-Favera R,Amadori A

更新日期：2007-09-15 00:00:00

abstract：:The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of their high sequence homology. Here we analyze the separate contributions o...

journal_title：Cancer research

authors： Oxford G,Owens CR,Titus BJ,Foreman TL,Herlevsen MC,Smith SC,Theodorescu D

更新日期：2005-08-15 00:00:00

abstract：:Successful systemic gene therapy has been hindered by vector-related limitations, including toxicity and inefficient gene delivery to tumor cells after i.v. administration. To circumvent these problems, we developed a novel formulation between the polycation polyethyleneimine and DNA that mediates high-level tumor cel...

journal_title：Cancer research

authors： Sweeney P,Karashima T,Ishikura H,Wiehle S,Yamashita M,Benedict WF,Cristiano RJ,Dinney CP

更新日期：2003-07-15 00:00:00

abstract：:N-Nitrosodibutylamine and its omega-hydroxylated metabolite N-nitrosobutyl(4-hydroxybutyl)amine (NB4HBA) induce tumors in the urine bladder of different animal species through their common urinary metabolite N-nitrosobutyl(3-carboxypropyl)amine (NB3CPA), resulting from the oxidation of the alcoholic group of NB4HBA to...

journal_title：Cancer research

authors： Bonfanti M,Magagnotti C,Bonati M,Fanelli R,Airoldi L

更新日期：1988-07-01 00:00:00

abstract：:Irinotecan hydrochloride (CPT-11), an antitumor camptothecin derivative, causes severe forms of diarrhea clinically. We characterized CPT-11-induced diarrhea histologically and enzymologically and assessed the relationships between intestinal toxicity and the activity of the enzymes that play a key role in the major m...

journal_title：Cancer research

authors： Takasuna K,Hagiwara T,Hirohashi M,Kato M,Nomura M,Nagai E,Yokoi T,Kamataki T

更新日期：1996-08-15 00:00:00

abstract：:Methods to visualize metastasis exist, but additional tools to better define the biologic and physical processes underlying invasion and intravasation are still needed. One difficulty in studying metastasis stems from the complexity of the interface between the tumor microenvironment and the vascular system. Here, we ...

journal_title：Cancer research

authors： Wong AD,Searson PC

更新日期：2014-09-01 00:00:00

abstract：:Sequential morphological changes occurring after brief carcinogen exposures of heterotopic tracheal transplants in rats were semiquantitatively studied. Tracheas were exposed to 7,12-dimethylbenz(a)anthracene for 1, 2, or 4 weeks, during which time means of 138, 152, and 160 microgram 7,12-dimethylbenz(a)anthracene, r...

journal_title：Cancer research

authors： Topping DC,Griesemer RA,Nettesheim P

更新日期：1979-12-01 00:00:00

abstract：:PAX5 is a transcription factor essential for B-cell development. Recently, it has been found as a frequent target of aberrancies in childhood acute lymphoblastic leukemia (ALL; 30% of B cell ALL cases), showing monoallelic loss, point mutations, or chromosomal translocations. The role of these aberrancies is still poo...

journal_title：Cancer research

authors： Fazio G,Palmi C,Rolink A,Biondi A,Cazzaniga G

更新日期：2008-01-01 00:00:00

abstract：:The accumulated literature suggests that altering the immune capacities of animals or humans seldom has detectable effects on tumor incidence nor, it seems, does the growth of an untransplanted tumor, either spontaneous or induced, immunize the host against the growth of a subsequent implant of that tumor. These obser...

journal_title：Cancer research

authors： Prehn RT

更新日期：1994-02-15 00:00:00

abstract：:The telomere-telomerase hypothesis states that the vast majority of human tumors have a prolonged replicative life span throughout expressing telomerase, which compensates the cell division-associated loss of telomere DNA. The use of telomere length and telomerase expression as new biological markers in cancer patient...

journal_title：Cancer research

authors： Bechter OE,Eisterer W,Pall G,Hilbe W,Kühr T,Thaler J

更新日期：1998-11-01 00:00:00

abstract：:We investigated primary human lung cancers resected surgically or obtained at autopsy. Included were squamous cell carcinoma (SQC) (five cases), adenocarcinoma (ADC) (six cases), large cell carcinoma (LCC) (four cases), and small cell carcinoma (SCC) (two cases). The objective of the study was to search for the presen...

journal_title：Cancer research

authors： Shigematsu K,Kataoka Y,Kamio T,Kurihara M,Niwa M,Tsuchiyama H

更新日期：1990-04-15 00:00:00

abstract：:Upon MYC inactivation, tumors variously undergo proliferative arrest, cellular differentiation, and apoptosis and in some cases, apparently permanently revoking tumorigenesis. In liver tumor cells, we recently showed that MYC inactivation uncovers stem cell properties and triggers differentiation, but in this case, th...

journal_title：Cancer research

authors： Shachaf CM,Felsher DW

更新日期：2005-06-01 00:00:00

abstract：:The initiation and promotion of cancer is thought to result from a series of genetic mutations, some of which may be inherited. Our analysis of 337 lung cancer families suggested that, after allowing for an individual's pack-years of tobacco use, the pattern of disease was best explained by Mendelian codominant inheri...

journal_title：Cancer research

authors： Sellers TA,Potter JD,Bailey-Wilson JE,Rich SS,Rothschild H,Elston RC

更新日期：1992-05-01 00:00:00

abstract：:This study examined the association between 17p allelic loss and p53 gene mutation in a series of 16 esophageal adenocarcinomas arising on a background of Barrett's esophagus. Two highly polymorphic dinucleotide repeat polymorphisms mapping to 17p13 were analyzed to assess the frequency of 17p allelic loss in these tu...

journal_title：Cancer research

authors： Gleeson CM,Sloan JM,McGuigan JA,Ritchie AJ,Russell SE

更新日期：1995-08-01 00:00:00

abstract：:This study investigates the possible molecular basis leading to failure in a treatment that is composed of hypoxia and chemotherapy in a rat orthotopic hepatoma model. Hypoxia was induced by hepatic artery ligation, whereas chemotherapeutic effect was achieved by intraportal injection of cisplatin. High-dose sodium sa...

journal_title：Cancer research

authors： Yang ZF,Poon RT,To J,Ho DW,Fan ST

更新日期：2004-08-01 00:00:00

abstract：:Activin, a member of the transforming growth factor beta (TGFbeta) superfamily, regulates diverse processes, such as cellular growth and differentiation. There is increasing evidence that TGFbeta and its signaling effectors are key determinants of tumor cell behavior. Loss of sensitivity to TGFbeta-induced growth arre...

journal_title：Cancer research

authors： Razanajaona D,Joguet S,Ay AS,Treilleux I,Goddard-Léon S,Bartholin L,Rimokh R

更新日期：2007-08-01 00:00:00

abstract：:N-4-Hydroxyphenylretinamide (fenretinide or 4HPR), a derivative of retinoic acid, has been demonstrated to decrease the development of prostate cancer in a rat carcinogenesis model. This study was undertaken to determine if 4HPR is an effective agent for the treatment of established prostate cancer. In vitro, 4HPR was...

journal_title：Cancer research

authors： Pienta KJ,Nguyen NM,Lehr JE

更新日期：1993-01-15 00:00:00

abstract：:Pregnancy at early, but not late age, has a strong and life-long protective effect against breast cancer. The expected overall increase in breast cancer incidence demands the development of a pharmaceutical mimicry of early-age pregnancy-mediated protection. Recently, converging results from rodent models and women on...

journal_title：Cancer research

authors： Meier-Abt F,Bentires-Alj M,Rochlitz C

更新日期：2015-03-01 00:00:00

abstract：:Inflammation is a critical player in the development of both colitis-associated and sporadic colon cancers. Several studies suggest that the microbiota contribute to inflammation and tumorigenesis; however, studies to understand the role of the microbiota in colon tumor development in germ-free (GF) mice are limited. ...

journal_title：Cancer research

authors： Zhan Y,Chen PJ,Sadler WD,Wang F,Poe S,Núñez G,Eaton KA,Chen GY

更新日期：2013-12-15 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells, well equipped to initiate an immune response. Currently, tumor antigen-derived peptide loaded DCs are used in clinical vaccination in cancer patients. However, the optimal dose and route of administration of a DC vaccine still remain to be determined. Us...

journal_title：Cancer research

authors： Eggert AA,Schreurs MW,Boerman OC,Oyen WJ,de Boer AJ,Punt CJ,Figdor CG,Adema GJ

更新日期：1999-07-15 00:00:00

abstract：:DNA, isolated from two samples of human liver obtained from a suspected dimethylnitrosamine poisoning, contained 1363 to 1373 micromol of 7-methylguanine per mol of guanine and 273 to 317 micromol of O6-methylguanine per mol of guanine. Liver and kidney DNA obtained from unrelated cases contained no detectable methyla...

journal_title：Cancer research

authors： Herron DC,Shank RC

更新日期：1980-09-01 00:00:00

abstract：:Inflammatory stimuli clearly contribute to lung cancer development and progression, but the underlying pathogenic mechanisms are not fully understood. We found that the proinflammatory cytokine IL-1β is dramatically elevated in the serum of patients with non-small cell lung cancer (NSCLC). In vitro studies showed that...

journal_title：Cancer research

authors： Wang L,Zhang LF,Wu J,Xu SJ,Xu YY,Li D,Lou JT,Liu MF

更新日期：2014-09-01 00:00:00

abstract：:Monoclonal antibodies (mabs) have considerable potential for specific cancer treatment. However, due to the antigen heterogeneity and especially the low uptake in solid tumors, mabs have not been used successfully in most clinical trials to date. This study investigates the effects of a mab-cobra venom factor (CVF) co...

journal_title：Cancer research

authors： Juhl H,Sievers M,Baltzer K,Helmig F,Wolf H,Brenner W,Kalthoff H

更新日期：1995-12-01 00:00:00

abstract：:The association between the consumption of onions and leeks (vegetables belonging to the Allium genus), garlic supplements, and the risk of lung carcinoma was investigated in a large-scale prospective cohort study on diet and cancer in the Netherlands. The Netherlands Cohort Study was started in 1986 among 120,852 men...

journal_title：Cancer research

authors： Dorant E,van den Brandt PA,Goldbohm RA

更新日期：1994-12-01 00:00:00

abstract：:3q27 translocations affecting the BCL6 gene can involve not only immunoglobulin genes (IG) but also other as yet uncharacterized chromosomal loci as partners. Here, we describe cloning of the junctional area of a recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma of B-cell type and isolation of clones...

journal_title：Cancer research

authors： Akasaka T,Miura I,Takahashi N,Akasaka H,Yonetani N,Ohno H,Fukuhara S,Okuma M

更新日期：1997-01-01 00:00:00

abstract：:The study by Jaratlerdsiri and colleagues represents the first whole-genome sequencing study of prostate cancer from men in sub-Saharan Africa. Preliminary findings include a higher tumor mutation burden in these tumors compared with data from other available prostate cancer cohorts. Although larger studies are needed...

journal_title：Cancer research

authors： Huang FW

更新日期：2018-12-15 00:00:00

abstract：:The growth inhibitory effects of combinations of antifolates on hepatoma cells in culture have been examined. In these studies methotrexate or the lipophilic inhibitors of dihydrofolate reductase were used with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolate (PDDF). Under certain conditions partial ...

journal_title：Cancer research

authors： Galivan J,Nimec Z,Rhee M

更新日期：1987-10-15 00:00:00

abstract：:Cells that overexpress high-mobility group A1 (HMGA1) proteins exhibit deficient nucleotide excision repair (NER) after exposure to DNA-damaging agents, a condition ameliorated by artificially lowering intracellular levels of these nonhistone proteins. One possible mechanism for this NER inhibition is down-regulation ...

journal_title：Cancer research

authors： Adair JE,Maloney SC,Dement GA,Wertzler KJ,Smerdon MJ,Reeves R

更新日期：2007-07-01 00:00:00

abstract：:A malignant hamster melanoma cell line HM-1 derived from the heterogenous malignant hamster melanoma MM1 contains a specific, high affinity binding protein for estrogens. Partial purification of the binding protein with ammonium sulfate (40% saturation) increased mean binding content (3.1 +/- 1.2 (SD) fmol/mg protein)...

journal_title：Cancer research

authors： Schleicher RL,Hitselberger MH,Beattie CW

更新日期：1987-01-15 00:00:00

abstract：:In normal tissues, the steady-state level of CD44 mRNA is low, and the variety of alternatively spliced transcripts produced by this complex gene is limited. Conversely, increased and disorderly expression of this gene has been observed in a number of types of cancer. This study analyzed the order in which the CD44 va...

journal_title：Cancer research

authors： Goodison S,Yoshida K,Sugino T,Woodman A,Gorham H,Bolodeoku J,Kaufmann M,Tarin D

更新日期：1997-08-01 00:00:00