Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer.

abstract：:Although aberrant microRNA (miRNA) is expressed in different types of human cancer tissues, its pathophysiologic role and the relevance of tumorigenesis and metastasis are still largely unknown. Here, we defined miRNAs involved in cancer metastasis (metastamirs) using an established mouse model for peritoneal dissemin...

journal_title：Cancer research

authors： Takei Y,Takigahira M,Mihara K,Tarumi Y,Yanagihara K

更新日期：2011-02-15 00:00:00

abstract：:Cloned lines of Adriamycin (ADR)-sensitive and -resistant P388 leukemia have been established from single cell cultures. A marker chromosome M1 was found in all cells in the heterogeneous resistant P388/ADR parental line as well as in the cloned resistant lines P388/ADR/3 and P388/ADR/7; a different marker chromosome ...

journal_title：Cancer research

authors： Goldenberg GJ,Wang H,Blair GW

更新日期：1986-06-01 00:00:00

abstract：:Tumors of varying malignant potential arise from the complex epithelial lining of the nephron. Although the molecular characteristics of renal clear cell carcinomas, which arise from the proximal tubule, have been studied, little is known about tumors that develop from other parts of the renal tubular system. To eluci...

journal_title：Cancer research

authors： Polascik TJ,Cairns P,Epstein JI,Fuzesi L,Ro JY,Marshall FF,Sidransky D,Schoenberg M

更新日期：1996-04-15 00:00:00

abstract：:Nickel is a toxic, mutagenic, and carcinogenic metal of significant occupational and environmental concern. Although several cellular targets of nickel have been identified, considerable evidence suggests that it can act indirectly upon DNA by inducing the formation of oxidized purines or pyrimidines that constitute p...

journal_title：Cancer research

authors： Higinbotham KG,Rice JM,Diwan BA,Kasprzak KS,Reed CD,Perantoni AO

更新日期：1992-09-01 00:00:00

abstract：:Despite the impressive results obtained in animal models, the clinical use of tumor necrosis factor-alpha (TNF) as an anticancer drug is limited by severe toxicity. We have shown previously that targeted delivery of TNF to aminopeptidase N (CD13), a marker of angiogenic vessels, improved the therapeutic index of this ...

journal_title：Cancer research

authors： Curnis F,Gasparri A,Sacchi A,Longhi R,Corti A

更新日期：2004-01-15 00:00:00

abstract：:Pathologic conditions associated with hyperinsulinemia, such as obesity, metabolic syndrome, and diabetes, seem to increase the risk of breast cancer. Here, we studied molecular mechanisms by which insulin activates the expression of leptin, an obesity hormone that has been shown to promote breast cancer progression i...

journal_title：Cancer research

authors： Bartella V,Cascio S,Fiorio E,Auriemma A,Russo A,Surmacz E

更新日期：2008-06-15 00:00:00

abstract：:Inherent and acquired therapeutic resistance in breast cancer remains a major clinical challenge. In human breast cancer samples, overexpression of the oncogenic transcription factor FoxM1 has been suggested to be a marker of poor prognosis. In this study, we report that FoxM1 overexpression confers resistance to the ...

journal_title：Cancer research

authors： Carr JR,Park HJ,Wang Z,Kiefer MM,Raychaudhuri P

更新日期：2010-06-15 00:00:00

abstract：:The RNA-binding protein PNO1 is critical for ribosome biogenesis, but its potential role in cancer remains unknown. In this study, online data mining, cDNA, and tissue microarrays indicated that PNO1 expression was higher in colorectal cancer tissue than in noncancerous tissue, and its overexpression was associated wi...

journal_title：Cancer research

authors： Shen A,Chen Y,Liu L,Huang Y,Chen H,Qi F,Lin J,Shen Z,Wu X,Wu M,Li Q,Qiu L,Yu N,Sferra TJ,Peng J

更新日期：2019-05-01 00:00:00

abstract：:Osteoprotegerin (OPG), a novel, secreted tumor necrosis factor receptor family member that inhibits osteoclast formation and activity was examined for its activity in a syngeneic tumor model of humoral hypercalcemia of malignancy. Normal mice bearing Colon-26 tumors develop increases in both parathyroid hormone-relate...

journal_title：Cancer research

authors： Capparelli C,Kostenuik PJ,Morony S,Starnes C,Weimann B,Van G,Scully S,Qi M,Lacey DL,Dunstan CR

更新日期：2000-02-15 00:00:00

abstract：:Somatostatin receptors (SSTR) are highly expressed in well-differentiated neuroendocrine tumors (NET). Octreotide, an SSTR agonist, has been used to suppress the production of vasoactive hormones and relieve symptoms of hormone hypersecretion with functional NETs. In a clinical trial, an empiric dose of octreotide tre...

journal_title：Cancer research

authors： Heidari P,Wehrenberg-Klee E,Habibollahi P,Yokell D,Kulke M,Mahmood U

更新日期：2013-12-01 00:00:00

abstract：:Mitochondria were isolated from lymphoblasts grown for 5 days in cell culture. Measurement of mitochondrial respiratory activity revealed poor response to adenosine 5'-diphosphate with reduced nicotinamide adenine dinucleotide-linked substrates but well-coupled active respiration with succinate as substrate. These mit...

journal_title：Cancer research

authors： Carpentieri U,Sordahl LA

更新日期：1975-12-01 00:00:00

abstract：:The conversion of transforming growth factor beta (TGF-beta) from a tumor suppressor to a tumor promoter occurs frequently during mammary tumorigenesis, yet the molecular mechanisms underlying this phenomenon remain undefined. We show herein that TGF-beta repressed nuclear factor-kappaB (NF-kappaB) activity in normal ...

journal_title：Cancer research

authors： Neil JR,Schiemann WP

更新日期：2008-03-01 00:00:00

abstract：:Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all three markers (triple negative or basal-like). While targeted therapies for ER+/PR+ and HER2+ tumors have revolutionized...

journal_title：Cancer research

authors： McCleland ML,Adler AS,Shang Y,Hunsaker T,Truong T,Peterson D,Torres E,Li L,Haley B,Stephan JP,Belvin M,Hatzivassiliou G,Blackwood EM,Corson L,Evangelista M,Zha J,Firestein R

更新日期：2012-11-15 00:00:00

abstract：:The human papillomavirus type 16 (HPV-16), the type most often associated with cervical cancer, immortalizes primary keratinocytes and inhibits serum/calcium-stimulated differentiation in culture. In this study, we have used a model of keratinocyte immortalization based upon HPV-16 to analyze perturbation of function ...

journal_title：Cancer research

authors： Wilding J,Vousden KH,Soutter WP,McCrea PD,Del Buono R,Pignatelli M

更新日期：1996-11-15 00:00:00

abstract：:The efficacy of novel cancer therapeutics has been hampered by the ability to deliver these agents to the tumor at effective concentrations. Liposomes have been used as a method to overcome some delivery issues and, in combination with hyperthermia, have been shown to increase drug delivery to tumors. Particle size ha...

journal_title：Cancer research

authors： Kong G,Braun RD,Dewhirst MW

更新日期：2000-08-15 00:00:00

abstract：:Lymphoid cell subpopulations infiltrating into autografts of methylcholanthrene-induced sarcomas in rats immunized with autologous tumor cells were identified in terms of immunohistochemical and cytofluorographic techniques using various monoclonal antibodies raised against different classes of rat lymphohemopoietic c...

journal_title：Cancer research

authors： Ishii Y,Matsuura A,Takami T,Uede T,Ibayashi Y,Uede T,Imamura M,Kikuchi K,Kikuchi Y

更新日期：1984-09-01 00:00:00

abstract：:Membrane type-1 matrix metalloproteinase (MT1-MMP) is a promising drug target in malignancy. The structure of MT1-MMP includes the hemopexin domain (PEX) that is distinct from and additional to the catalytic domain. Current MMP inhibitors target the conserved active site in the catalytic domain and, as a result, repre...

journal_title：Cancer research

authors： Remacle AG,Golubkov VS,Shiryaev SA,Dahl R,Stebbins JL,Chernov AV,Cheltsov AV,Pellecchia M,Strongin AY

更新日期：2012-05-01 00:00:00

abstract：:Experiments were performed to determine if differences in porphyrin photosensitivity could be observed for cells with varying efficiency in DNA damage repair, as well as for cells which make up components of the vasculature. Photofrin II is undergoing current clinical evaluation for photodynamic therapy of solid tumor...

journal_title：Cancer research

authors： Gomer CJ,Rucker N,Murphree AL

更新日期：1988-08-15 00:00:00

abstract：:The present studies were designed to examine the influence of dietary selenite supplementation on the initiation phase of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis and to correlate selenite-induced changes in the binding of DMBA metabolites to rat mammary cell DNA with the ultimate tumor inc...

journal_title：Cancer research

authors： Liu JZ,Gilbert K,Parker HM,Haschek WM,Milner JA

更新日期：1991-09-01 00:00:00

abstract：:A malignant hamster melanoma cell line HM-1 derived from the heterogenous malignant hamster melanoma MM1 contains a specific, high affinity binding protein for estrogens. Partial purification of the binding protein with ammonium sulfate (40% saturation) increased mean binding content (3.1 +/- 1.2 (SD) fmol/mg protein)...

journal_title：Cancer research

authors： Schleicher RL,Hitselberger MH,Beattie CW

更新日期：1987-01-15 00:00:00

abstract：:Galectin-3 (Gal-3), a pleiotropic carbohydrate-binding protein, is a selective binding partner of activated K-Ras-GTP. Because both proteins are antiapoptotic and associated with cancer progression, we questioned the possible functional role of Gal-3 in K-Ras activation. We found that overexpression of Gal-3 in human ...

journal_title：Cancer research

authors： Shalom-Feuerstein R,Cooks T,Raz A,Kloog Y

更新日期：2005-08-15 00:00:00

abstract：:The incidence of skin cancer is on the rise, with over 1 million new cases yearly. Although it is known that squamous cell cancers (SCC) are caused by UV light, the mechanism(s) involved remains poorly understood. In vitro studies with epithelial cells or reports examining malignant skin lesions suggest that loss of E...

journal_title：Cancer research

authors： Brouxhon S,Kyrkanides S,O'Banion MK,Johnson R,Pearce DA,Centola GM,Miller JN,McGrath KH,Erdle B,Scott G,Schneider S,VanBuskirk J,Pentland AP

更新日期：2007-08-15 00:00:00

abstract：:We performed parallel array comparative genomic hybridization and array expression analysis of the 12p11-p12 amplicon in human testicular seminomas and an ovarian carcinoma cell line using an expressed sequence tags (ESTs) array spotted with 8254 ESTs. The data were normalized using a robust statistical modeling and t...

journal_title：Cancer research

authors： Bourdon V,Naef F,Rao PH,Reuter V,Mok SC,Bosl GJ,Koul S,Murty VV,Kucherlapati RS,Chaganti RS

更新日期：2002-11-01 00:00:00

abstract：:It has been proposed that cross talk between integrin and growth factor receptor signaling such as ErbB2 (HER2) is required for activation of downstream effectors and ErbB2-mediated mammary tumorigenesis. Here we show that transforming growth factor beta (TGF-beta) induced focal adhesion kinase (FAK)-dependent cluster...

journal_title：Cancer research

authors： Wang SE,Xiang B,Zent R,Quaranta V,Pozzi A,Arteaga CL

更新日期：2009-01-15 00:00:00

abstract：:Ether phospholipids are analogues of the naturally occurring 2-lyso-phosphatidylcholine that have been reported to have in vitro/in vivo antitumor activity. Their antiproliferative effect has been found against a variety of animal and human tumor cell lines. We have characterized the cytostatic activity of two ether p...

journal_title：Cancer research

authors： Principe P,Sidoti C,Braquet P

更新日期：1992-05-01 00:00:00

abstract：:Colony-stimulating factor-1 (CSF-1) and its receptor (CSF-1R) have been implicated in the pathogenesis and progression of various types of cancer, including breast cancer. This is based on high levels of circulating CSF-1 in patient sera with aggressive disease and increased CSF-1R staining in the tumor tissues. Howev...

journal_title：Cancer research

authors： Patsialou A,Wyckoff J,Wang Y,Goswami S,Stanley ER,Condeelis JS

更新日期：2009-12-15 00:00:00

abstract：:Cellular senescence is a potent tumor-suppressive program that prevents neoplastic events. Paradoxically, senescent cells develop an inflammatory secretome, termed the senescence-associated secretory phenotype, which is implicated in age-related pathologies including cancer. Here, we report that senescent cells active...

journal_title：Cancer research

authors： Han L,Long Q,Li S,Xu Q,Zhang B,Dou X,Qian M,Jiramongkol Y,Guo J,Cao L,Chin YE,Lam EW,Jiang J,Sun Y

更新日期：2020-08-15 00:00:00

abstract：:SR31747A is a sigma ligand with potent antiproliferative activity against tumor cells and for which three binding proteins have been identified to date: (a) SRBP-1 (also called sigma 1); (b) HIS; and (c) sigma 2. In this study, we characterized an additional SR31747A binding site, i.e., SRBP-2 (SR31747A-binding protei...

journal_title：Cancer research

authors： Vidal H,Mondesert G,Galiègue S,Carrière D,Dupuy PH,Carayon P,Combes T,Bribes E,Simony-Lafontaine J,Kramar A,Loison G,Casellas P

更新日期：2003-08-15 00:00:00

abstract：:We have investigated the ability of several drugs commonly used in the treatment of human cancer to induce bcl2 phosphorylation and cell death in human cell lines derived from acute leukemia, lymphoma, breast cancer, and prostate cancer. The results of this analysis indicate that drugs affecting the integrity of micro...

journal_title：Cancer research

authors： Haldar S,Basu A,Croce CM

更新日期：1997-01-15 00:00:00

abstract：:Male Wistar rats were given 50 mug of aflatoxin B1 twice a week for 4 weeks, and thereafter 75 mug twice a week for 10 weeks. Their livers were investigated histologically and histochemically for glycogen, RNA, fat, alkaline and acid phosphatases, adenosine triphosphatase, 5'-nucleotidase, glucose-6-phosphatase, gluco...

journal_title：Cancer research

authors： Kalengayi MM,Desmet VJ

更新日期：1975-10-01 00:00:00