Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia.

abstract：:Inhibitors of 5alpha-reductase (SRD5A) that lower intraprostatic levels of dihydrotestosterone (DHT) reduce the overall incidence of prostate cancer (PCa), but there is significant variation in chemopreventive activity between individual men. In seeking molecular alterations that might underlie this variation, we comp...

journal_title：Cancer research

authors： Mostaghel EA,Geng L,Holcomb I,Coleman IM,Lucas J,True LD,Nelson PS

更新日期：2010-02-15 00:00:00

abstract：:The thymidylate synthase inhibitor 5-fluorouracil (5-FU) continues to play a pivotal role in the treatment of cancer. A downstream event of thymidylate synthase inhibition involves the induction of a self-defeating base excision repair process. With the depletion of TTP pools, there is also an increase in dUMP. Metabo...

journal_title：Cancer research

authors： Fischer JA,Muller-Weeks S,Caradonna SJ

更新日期：2006-09-01 00:00:00

abstract：:In the immediately preceding paper, we demonstrated that the microvasculature supplying peritoneal lining tissues of mice bearing either of two transplantable ascites carcinomas was hyperpermeable to circulating macromolecules. Solid tumors have been shown to exhibit similar levels of microvascular hyperpermeability, ...

journal_title：Cancer research

authors： Nagy JA,Meyers MS,Masse EM,Herzberg KT,Dvorak HF

更新日期：1995-01-15 00:00:00

abstract：:Overexpression of cyclin D1 is believed to endow mammary epithelial cells (MEC) with a proliferative advantage by virtue of its contribution to pRB inactivation. Accordingly, abrogation of the kinase-dependent function of cyclin D1 is sufficient to render mice resistant to breast cancer initiated by ErbB2. Here, we re...

journal_title：Cancer research

authors： Brown NE,Jeselsohn R,Bihani T,Hu MG,Foltopoulou P,Kuperwasser C,Hinds PW

更新日期：2012-12-15 00:00:00

abstract：:The p53-regulated gene product p21WAF1/CIP1 is the prototype of a family of small proteins that negatively regulate the cell cycle. To learn more about p21WAF1/CIP1 regulation in vivo, monoclonal antibodies were developed for immunohistochemistry. These revealed that p21WAF1/CIP1 expression followed radiation-induced ...

journal_title：Cancer research

authors： el-Deiry WS,Tokino T,Waldman T,Oliner JD,Velculescu VE,Burrell M,Hill DE,Healy E,Rees JL,Hamilton SR

更新日期：1995-07-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution and contributes to therapeutic resistance. Here, we demonstrate that PDA tumor cell-derived proinflammatory cytokine IL1β is essential for the esta...

journal_title：Cancer research

authors： Das S,Shapiro B,Vucic EA,Vogt S,Bar-Sagi D

更新日期：2020-03-01 00:00:00

abstract：:The tumorigenicity of dexamethasone-treated tissue-cultured mammary tumor cells was compared to that of untreated mammary tumor cells. The dexamethasone-induced cells progressed faster in normal syngeneic animals than did untreated mammary tumor cells. The fact that the growth rate differential was also observed in at...

journal_title：Cancer research

authors： Gillette RW,Wunderlich DA

更新日期：1978-10-01 00:00:00

abstract：:The Bcl-2 homologue Bak is a potent inducer of apoptosis. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the entire coding region of the bak gene (exons 2-6) in 24 primary gastric cancers (6 early-stage and 18 advanced-stage cancers) and 20 primary colorectal cancers (6 ear...

journal_title：Cancer research

authors： Kondo S,Shinomura Y,Miyazaki Y,Kiyohara T,Tsutsui S,Kitamura S,Nagasawa Y,Nakahara M,Kanayama S,Matsuzawa Y

更新日期：2000-08-15 00:00:00

abstract：:Inoculation of the Soehner-Dmochowski isolate of the Moloney strain of murine sarcoma virus (MSV), designated MSV-SD, consistently leads to the development of bone tumors in the susceptible New Zealand black (NB) rats. Two separate cell cultures have been established from 2 individual MSV-SD-induced NB rat bone tumors...

journal_title：Cancer research

authors： Chan JC,East JL,Dmochowski L

更新日期：1975-09-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine with a broad range of physiologic and pathologic functions. Because in cancer, IL-6 contributes to a microenvironment that promotes tumor cell survival, angiogenesis, and inflammation, understanding the mechanism responsible for its production is important. In neuroblasto...

journal_title：Cancer research

authors： Silverman AM,Nakata R,Shimada H,Sposto R,DeClerck YA

更新日期：2012-05-01 00:00:00

abstract：:We studied the effect of the anticancer drug taxol on the cytotoxic mechanism of major histocompatibility complex nonrestricted lymphocytes and their activation with interleukin 2. Unseparated lymphocytes or highly enriched natural killer or T-cells were treated with 0.2-10 micrograms/ml of taxol for various times and...

journal_title：Cancer research

authors： Chuang LT,Lotzová E,Heath J,Cook KR,Munkarah A,Morris M,Wharton JT

更新日期：1994-03-01 00:00:00

abstract：:The possible alteration of transformation-related antigens in cells that revert to a normal phenotype but that continue to retain the viral genome, has been investigated in [3H]glucosamine-labeled extracts of rat cells exhibiting a reversible temperature-dependent restriction in the expression of transformation and in...

journal_title：Cancer research

authors： Rieber M,Bacalao J,Rieber M

更新日期：1977-04-01 00:00:00

abstract：:Protein kinase C (PKC) has been implicated in enhancing cellular sensitivity to cis-diamminedichloroplatinum(II) (CP). We have synthesized a series of novel analogues of lyngbyatoxin A (7-linalylindolactam V), a natural tumor promoter and a potent activator of PKC, and investigated the effects of these synthetic compo...

journal_title：Cancer research

authors： Basu A,Kozikowski AP,Sato K,Lazo JS

更新日期：1991-05-15 00:00:00

abstract：:Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B), and its effector FKBP-rapamycin-associated protein (FRAP) occurs via autocrine stimulation or inactivation of the tumor suppressor PTEN in many cancers. Here we demonstrate that in human pro...

journal_title：Cancer research

authors： Zhong H,Chiles K,Feldser D,Laughner E,Hanrahan C,Georgescu MM,Simons JW,Semenza GL

更新日期：2000-03-15 00:00:00

abstract：:Primary rat tracheal epithelial cells can be transformed in vitro by N-methyl-N'-nitro-N-nitrosoguanidine. The earliest recognizable morphological transformant is the enhanced growth variant (EGV), characterized by enhanced proliferative capacity. Transformed EGV colonies can progress to give rise to immortal cell lin...

journal_title：Cancer research

authors： Endo S,Nettesheim P,Oshimura M,Walker C

更新日期：1990-02-01 00:00:00

abstract：:The inactivation of p53 functions enhances the efficiency and decreases the latency of producing induced pluripotent stem cells (iPSC) in culture. The formation of iPSCs in culture starts with a rapid set of cell divisions followed by an epigenetic reprogramming of the DNA and chromatin. The mechanisms by which the p5...

journal_title：Cancer research

authors： Yi L,Lu C,Hu W,Sun Y,Levine AJ

更新日期：2012-11-01 00:00:00

abstract：:Human polynucleotide phosphorylase (hPNPase(old-35)) is a type I IFN-inducible 3',5' exoribonuclease that mediates mRNA degradation. In melanoma cells, slow and sustained overexpression of hPNPase(old-35) induces G(1) cell cycle arrest ultimately culminating in apoptosis, whereas rapid overexpression of hPNPase(old-35...

journal_title：Cancer research

authors： Sarkar D,Park ES,Barber GN,Fisher PB

更新日期：2007-09-01 00:00:00

abstract：:The nucleus has been shown to be a site for the inositol lipid cycle that can be affected by treatment of quiescent cells with growth factors such as insulin-like growth factor I (IGF-I). Indeed, the exposure of Swiss 3T3 cells to IGF-I results in a rapid and transient increase in nuclear phospholipase C (PLC) beta1 a...

journal_title：Cancer research

authors： Manzoli L,Billi AM,Rubbini S,Bavelloni A,Faenza I,Gilmour RS,Rhee SG,Cocco L

更新日期：1997-06-01 00:00:00

abstract：:The gadd45 gene, a growth arrest and DNA damage (gadd)-induced gene, is transcriptionally activated by UV irradiation through two distinct pathways. One requires the sequence-specific binding of the p53 tumor suppressor protein to a responsive element within the third intron of the gadd45 gene, and the other is p53-in...

journal_title：Cancer research

authors： Takahashi S,Saito S,Ohtani N,Sakai T

更新日期：2001-02-01 00:00:00

abstract：:One of the major limitations of tumor-specific vaccination is the generation of antigen-loss variants that are able to escape the immune response elicited by a monoantigenic peptide epitope. Here, we report the identification of a new HLA-B*3701-restricted epitope shared by four different members of the MAGE family. P...

journal_title：Cancer research

authors： Tanzarella S,Russo V,Lionello I,Dalerba P,Rigatti D,Bordignon C,Traversari C

更新日期：1999-06-01 00:00:00

abstract：:Variant cell lines that are sensitive to density-dependent inhibition of growth have been isolated from three of four SV40-transformed human fibroblast cell lines. Variants were isolated by plating the transformed cells at low density, by treating them with 5-fluorodeoxyuridine, or by growing them on glutaraldehyde-fi...

journal_title：Cancer research

authors： Rosenberg N,Schaeffer WI,Diamond L

更新日期：1975-08-01 00:00:00

abstract：:Cancer patients and tumor-bearing animals excrete high levels of modified purines and pyrimidines some of which, e.g., N2,N2-dimethylguanosine, can originate only from transfer RNA (tRNA). Until recently, it could not be ascertained whether the high level of excretion of such compounds is due to cell death or specific...

journal_title：Cancer research

authors： Borek E,Baliga BS,Gehrke CW,Kuo CW,Belman S,Troll W,Waalkes TP

更新日期：1977-09-01 00:00:00

abstract：:DNA methylation aberrations have been implicated in acquired resistance to platinum drugs in ovarian cancer. In this study, we elucidated an epigenetic signature associated with platinum drug resensitization that may offer utility in predicting the outcomes of patients who are coadministered a DNA methyltransferase in...

journal_title：Cancer research

authors： Fang F,Cardenas H,Huang H,Jiang G,Perkins SM,Zhang C,Keer HN,Liu Y,Nephew KP,Matei D

更新日期：2018-02-01 00:00:00

abstract：:The potential of transforming growth factor-alpha (TGF-alpha) to function as an autocrine growth factor was evaluated in numerous ovarian carcinoma cell lines. All 17 lines which were examined expressed the epidermal growth factor receptor and 16 cell lines, in addition, concomitantly secreted TGF-alpha. Radioimmunoas...

journal_title：Cancer research

authors： Stromberg K,Collins TJ 4th,Gordon AW,Jackson CL,Johnson GR

更新日期：1992-01-15 00:00:00

abstract：:Xeroderma pigmentosum (XP) is a sun-sensitive, cancer-prone genetic disorder characterized by a defect in nucleotide excision repair. The human nucleotide excision repair and transcription gene ERCC2 is able to restore survival to normal levels after exposure to UV light in XP complementation group D cells. No enhance...

journal_title：Cancer research

authors： Takayama K,Salazar EP,Lehmann A,Stefanini M,Thompson LH,Weber CA

更新日期：1995-12-01 00:00:00

abstract：:Tumor hypoxia is associated clinically with therapeutic resistance and poor patient outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth. In this study, we investigated the hypothesis that impeding the reuptake of bicarbonate produced extrace...

journal_title：Cancer research

authors： McIntyre A,Hulikova A,Ledaki I,Snell C,Singleton D,Steers G,Seden P,Jones D,Bridges E,Wigfield S,Li JL,Russell A,Swietach P,Harris AL

更新日期：2016-07-01 00:00:00

abstract：:The molecular hallmark of Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL) is the expression of 1 of 2 alternate forms of the aberrant BCR-ABL protein-p210BCR-ABL or p190BCR-ABL. The presence of BCR-ABL message provides a target for analyzing the lineage derivation of this disease. We, therefore, st...

journal_title：Cancer research

authors： Estrov Z,Talpaz M,Kantarjian HM,Zipf TF,McClain KL,Kurzrock R

更新日期：1993-07-15 00:00:00

abstract：:The proto-oncogene MET is aberrantly activated via overexpression or mutation in numerous cancers, making it a prime anticancer molecular target. However, the clinical success of MET-directed tyrosine kinase inhibitors (TKI) has been limited due, in part, to mutations in the MET kinase domain that confer therapeutic r...

journal_title：Cancer research

authors： Miyajima N,Tsutsumi S,Sourbier C,Beebe K,Mollapour M,Rivas C,Yoshida S,Trepel JB,Huang Y,Tatokoro M,Shinohara N,Nonomura K,Neckers L

更新日期：2013-12-01 00:00:00

abstract：:Analysis of human fibrosarcoma cells exposed to radiolabeled monoclonal antibody 19-24, which recognizes sarcoma-associated antigen p102, revealed that over 54% of the cell surface-bound radioactivity was internalized. No modulation of cell surface p102 antigen by monoclonal antibody 19-24 was observed in human fibros...

journal_title：Cancer research

authors： Stastny JJ,Das Gupta TK

更新日期：1993-12-01 00:00:00

abstract：:Microarray gene expression profiling is a powerful tool for generating molecular cancer classifications. However, elucidating biological insights from these large data sets has been challenging. Previously, we identified a gene expression-based classification of primary uveal melanomas that accurately predicts metasta...

journal_title：Cancer research

authors： Onken MD,Ehlers JP,Worley LA,Makita J,Yokota Y,Harbour JW

更新日期：2006-05-01 00:00:00