当前位置： SCI文献检索 > CANCER RESEARCH期刊下所有文献 > The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models.

The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models.

Abstract：

:The proto-oncogene MET is aberrantly activated via overexpression or mutation in numerous cancers, making it a prime anticancer molecular target. However, the clinical success of MET-directed tyrosine kinase inhibitors (TKI) has been limited due, in part, to mutations in the MET kinase domain that confer therapeutic resistance. Circumventing this problem remains a key challenge to improving durable responses in patients receiving MET-targeted therapy. MET is an HSP90-dependent kinase, and in this report we show that HSP90 preferentially interacts with and stabilizes activated MET, regardless of whether the activation is ligand-dependent or is a consequence of kinase domain mutation. In contrast, many MET-TKI show a preference for the inactive form of the kinase, and activating mutations in MET can confer resistance. Combining the HSP90 inhibitor ganetespib with the MET-TKI crizotinib achieves synergistic inhibition of MET, its downstream signaling pathways, and tumor growth in both TKI-sensitive and -resistant MET-driven tumor models. These data suggest that inclusion of an HSP90 inhibitor can partially restore TKI sensitivity to previously resistant MET mutants, and they provide the foundation for clinical evaluation of this therapeutic combination in patients with MET-driven cancers.

journal_name

Cancer Res

journal_title

Cancer research

authors

Miyajima N,Tsutsumi S,Sourbier C,Beebe K,Mollapour M,Rivas C,Yoshida S,Trepel JB,Huang Y,Tatokoro M,Shinohara N,Nonomura K,Neckers L

doi

10.1158/0008-5472.CAN-13-1156

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

7022-33

issue

23

eissn

0008-5472

issn

1538-7445

pii

0008-5472.CAN-13-1156

journal_volume

73

pub_type

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