Abstract：
:We have investigated the antiproliferative and cytotoxic effects of selected enediynes against three Kaposi's sarcoma (KS) cell lines. The enediynes tested were found to be very potent in inhibiting the growth of KS cells. Treatment with concentrations of 10(-10) M or less were capable of producing 50% inhibition of growth. Furthermore, treatment of KS cells with enediynes induced apoptosis in up to 80% of the cells. This unique class of antitumor agents has therapeutic potential for the treatment of KS.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Corbeil J,Richman DD,Wrasidlo W,Nicolaou KC,Looney DJsubject
Has Abstractpub_date
1994-08-15 00:00:00pages
4270-3issue
16eissn
0008-5472issn
1538-7445journal_volume
54pub_type
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