Abstract：
:Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway. In breast cancer and several other types of cancer, increased PHGDH expression is associated with patient mortality. Early studies focused on the role of PHGDH in promoting cell proliferation in the small percentage of breast cancers with PHGDH gene amplification. However, recent studies have revealed a critical role for PHGDH and downstream enzymes of the serine synthesis pathway and one carbon metabolism in NADPH production and the maintenance of redox homeostasis, which are required for enrichment of breast cancer stem cells in response to hypoxia or chemotherapy. These results provide a mechanism for PHGDH overexpression in breast cancers in which PHGDH is not amplified and have implications for improving the response of triple-negative breast cancers to cytotoxic chemotherapy. Cancer Res; 76(22); 6458-62. ©2016 AACR.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Samanta D,Semenza GLdoi
10.1158/0008-5472.CAN-16-1730subject
Has Abstractpub_date
2016-11-15 00:00:00pages
6458-6462issue
22eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-16-1730journal_volume
76pub_type
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