Abstract：
:Immunity to infectious agents involves a coordinated response of innate and adaptive immune cells working in concert, with many feed-forward and regulatory interactions between both arms of the immune system. In contrast, many therapeutic strategies to augment immunity against tumors have focused predominantly on stimulation of adaptive immunity. However, a growing appreciation of the potential contributions of innate immune effectors to antitumor immunity, especially in the context of combination immunotherapy, is leading to novel strategies to elicit a more integrated immune response against cancer. Here we review antitumor activities of innate immune cells, mechanisms of their synergy with adaptive immune responses against tumors, and discuss recent studies highlighting the potential of combination therapies recruiting both innate and adaptive immune effectors to eradicate established tumors. Cancer Res; 77(19); 5215-21. ©2017 AACR.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Moynihan KD,Irvine DJdoi
10.1158/0008-5472.CAN-17-1340subject
Has Abstractpub_date
2017-10-01 00:00:00pages
5215-5221issue
19eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-17-1340journal_volume
77pub_type
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