Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis.

abstract：:The purpose of this paper is to report the extant observations at the Ellis Fischel State Cancer Hospital-Cancer Research Center and in the literature on the gross rates of growth of human mammary cancer as measured for primary cancers in the breast by mammography and for metastatic cancer in the skin and lymph nodes ...

journal_title：Cancer research

authors： Spratt JS Jr,Kaltenbach ML,Spratt JA

更新日期：1977-01-01 00:00:00

abstract：:Crude tissue or tumor extracts either do not contain sufficient inosine 5'-monophosphate dehydrogenase (IMPD) activity to be measured spectrophotometrically, or interfering enzyme activities prevent the use of a more sensitive radiochemical assay. A modified assay system which incorporates alpha, beta-methylene adenos...

journal_title：Cancer research

authors： Proffitt RT,Pathak VK,Villacorte DG,Presant CA

更新日期：1983-04-01 00:00:00

abstract：:An immunogenic tumor and a nonimmunogenic tumor were used in C57BL/Ka and CBA/Rij mice, respectively, in a study in which lymph node morphology was quantitatively measured. Lymph nodes were cut in semiseries, and a morphometrical analysis was done on the paracortical and cortical areas as major parts of the active lym...

journal_title：Cancer research

authors： van de Velde CJ,Meyer CJ,Cornellsse CJ,van der Velde EA,van Putten LM,Swaveling A

更新日期：1978-03-01 00:00:00

abstract：:Chinese hamster V-79 cells were treated with high cytotoxic or low noncytotoxic concentrations of the highly carcinogenic and mutagenic (-)-(1R,2S,3S,4R)-3,4-dihydroxy-1, 2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene [(-)-B[c]PhDE; fjord-region diol epoxide] or its biologically less active (+)-(1S,2R,3R,4S) enantiome...

journal_title：Cancer research

authors： Wei SJ,Chang RL,Cui XX,Merkler KA,Wong CQ,Yagi H,Jerina DM,Conney AH

更新日期：1996-08-15 00:00:00

abstract：:Cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF) are significantly associated with tumor growth and metastasis. Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)). This cyclop...

journal_title：Cancer research

authors： Grau R,Iñiguez MA,Fresno M

更新日期：2004-08-01 00:00:00

abstract：:Rodent biliary glycoprotein (Bgp), also known as C-CAM, has recently been shown to function as a tumor suppressor in colon, prostate, and bladder cancers. This glycoprotein is a member of the carcinoembryonic antigen family and is one of the only proteins in this family to encode either a long (71-73 amino acids) or s...

journal_title：Cancer research

authors： Turbide C,Kunath T,Daniels E,Beauchemin N

更新日期：1997-07-01 00:00:00

abstract：:Deregulation of translation initiation factors contributes to many pathogenic conditions, including cancer. Here, we report the definition of a novel regulatory pathway for translational initiation with possible therapeutic import in cancer. Specifically, we found that casein kinase 1ε (CK1ε) is highly expressed in br...

journal_title：Cancer research

authors： Shin S,Wolgamott L,Roux PP,Yoon SO

更新日期：2014-01-01 00:00:00

abstract：:The induction, accumulation, and persistence of sister chromatid exchanges (SCEs) and high SCE frequency cells (HFCs) was measured in peripheral blood lymphocytes of women with breast cancer before chemotherapy and on multiple occasions during and after therapy. Chemotherapy consisted of i.v. infusion of cyclophospham...

journal_title：Cancer research

authors： Tucker JD,Wyrobek AJ,Ashworth LK,Christensen ML,Burton GV,Carrano AV,Everson RB

更新日期：1990-08-15 00:00:00

abstract：:Risk assessment of dioxins is currently based on induction of liver tumors in rats. The toxicity of dioxins is characterized by large sensitivity differences among animal species and even strains of the same species, which complicates the risk assessment. The significance of these differences in dioxin-induced carcino...

journal_title：Cancer research

authors： Viluksela M,Bager Y,Tuomisto JT,Scheu G,Unkila M,Pohjanvirta R,Flodström S,Kosma VM,Mäki-Paakkanen J,Vartiainen T,Klimm C,Schramm KW,Wärngård L,Tuomisto J

更新日期：2000-12-15 00:00:00

abstract：:Rapid or accelerated tumor cell repopulation after significant tumor cell killing induced by various cytotoxic agents often compromises the expected therapeutic benefit of such tumor responses. Here, we discuss the concept that tumor cell repopulation after certain cytotoxic therapies, using vascular disrupting agents...

journal_title：Cancer research

authors： Shaked Y,Kerbel RS

更新日期：2007-08-01 00:00:00

abstract：:Meningiomas constitute the second most common central nervous system tumor, and yet relatively little is known about the molecular events that are important for the pathogenesis and malignant progression of these tumors. We have used serial analysis of gene expression to compare the transcriptomes of nonneoplastic men...

journal_title：Cancer research

authors： Cuevas IC,Slocum AL,Jun P,Costello JF,Bollen AW,Riggins GJ,McDermott MW,Lal A

更新日期：2005-06-15 00:00:00

abstract：:A new type of monoclonal antibody (mAb)-based, highly specific phototherapy (photoimmunotherapy; PIT) that uses a near infrared (NIR) phthalocyanine dye, IRDye700DX (IR700) conjugated with a mAb, has recently been described. NIR light exposure leads to immediate, target-selective necrotic cell death in vitro. Detectin...

journal_title：Cancer research

authors： Nakajima T,Sano K,Mitsunaga M,Choyke PL,Kobayashi H

更新日期：2012-09-15 00:00:00

abstract：:The regulators of mitochondrial cell death in cancer have remained elusive, hampering the development of new therapies. Here, we showed that protein isoforms of mitochondrial fission factor (MFF1 and MFF2), a molecule that controls mitochondrial size and shape, that is, mitochondrial dynamics, were overexpressed in pa...

journal_title：Cancer research

authors： Seo JH,Chae YC,Kossenkov AV,Lee YG,Tang HY,Agarwal E,Gabrilovich DI,Languino LR,Speicher DW,Shastrula PK,Storaci AM,Ferrero S,Gaudioso G,Caroli M,Tosi D,Giroda M,Vaira V,Rebecca VW,Herlyn M,Xiao M,Fingerman D,Ma

更新日期：2019-12-15 00:00:00

abstract：:MEK inhibition is of interest in cancer drug development, but clinical activity in metastatic colorectal cancer (mCRC) has been limited. Preclinical studies demonstrated Wnt pathway overexpression in KRAS-mutant cell lines resistant to the MEK inhibitor, selumetinib. The combination of selumetinib and cyclosporin A, a...

journal_title：Cancer research

authors： Krishnamurthy A,Dasari A,Noonan AM,Mehnert JM,Lockhart AC,Leong S,Capasso A,Stein MN,Sanoff HK,Lee JJ,Hansen A,Malhotra U,Rippke S,Gustafson DL,Pitts TM,Ellison K,Davis SL,Messersmith WA,Eckhardt SG,Lieu CH

更新日期：2018-09-15 00:00:00

abstract：:The cyclin dependent kinase (CDK) inhibitors p15, p16, p21, and p27 are frequently deleted, silenced, or downregulated in many malignancies. Inactivation of CDK inhibitors predisposes mice to tumor development, showing that these genes function as tumor suppressors. Here, we describe high-throughput murine leukemia vi...

journal_title：Cancer research

authors： Kool J,Uren AG,Martins CP,Sie D,de Ridder J,Turner G,van Uitert M,Matentzoglu K,Lagcher W,Krimpenfort P,Gadiot J,Pritchard C,Lenz J,Lund AH,Jonkers J,Rogers J,Adams DJ,Wessels L,Berns A,van Lohuizen M

更新日期：2010-01-15 00:00:00

abstract：:FoxP3 is a member of the forkhead family of transcription factors critically involved in the development and function of CD25(+) regulatory T cells (Treg). Until recently, FoxP3 expression was thought to be restricted to the T-cell lineage. However, using immunohistochemistry and flow cytometric analysis of human mela...

journal_title：Cancer research

authors： Ebert LM,Tan BS,Browning J,Svobodova S,Russell SE,Kirkpatrick N,Gedye C,Moss D,Ng SP,MacGregor D,Davis ID,Cebon J,Chen W

更新日期：2008-04-15 00:00:00

abstract：:The microenvironment of rapidly growing tumors is associated with increased energy demand and diminished vascular supply, resulting in focal areas of prominent hypoxia. A number of hypoxia-responsive genes have been associated with growing tumors, and here we demonstrate that the multidrug resistance (MDR1) gene produ...

journal_title：Cancer research

authors： Comerford KM,Wallace TJ,Karhausen J,Louis NA,Montalto MC,Colgan SP

更新日期：2002-06-15 00:00:00

abstract：:Although chemoresistance remains a primary challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), exploiting oxidative stress might offer novel therapeutic clues. Here we explored the potential of targeting cystine/glutamate exchanger (SLC7A11/xCT), which contributes to the maintenance of intracellular...

journal_title：Cancer research

authors： Daher B,Parks SK,Durivault J,Cormerais Y,Baidarjad H,Tambutte E,Pouysségur J,Vučetić M

更新日期：2019-08-01 00:00:00

abstract：:The bcl-2 family of genes code for proteins that contain anti-apoptotic or pro-apoptotic activity. The human bfl-1 gene contains an open reading frame for a 175-amino acid Bcl-2 family protein. Among the various Bcl-2 family members, the Bfl-1 protein shares the highest homology with the mouse A1 protein. These two pr...

journal_title：Cancer research

authors： D'Sa-Eipper C,Subramanian T,Chinnadurai G

更新日期：1996-09-01 00:00:00

abstract：:The fibroblast growth factors (FGF) play diverse roles in development, wound healing, and angiogenesis. The intracellular signal transduction pathways, which mediate these pleiotropic activities, remain incompletely understood. We show here that the proangiogenic factors FGF2 and FGF8b can activate signal transducers ...

journal_title：Cancer research

authors： Yang X,Qiao D,Meyer K,Friedl A

更新日期：2009-02-15 00:00:00

abstract：:Triple-negative breast cancers (TNBC), which include the basal-like and claudin-low disease subtypes, are aggressive malignancies for which effective therapeutic targets are lacking. NF-κB activation has an established role in breast malignancy, and it is higher in TNBC than other breast cancer subtypes. On this basis...

journal_title：Cancer research

authors： Ito-Kureha T,Koshikawa N,Yamamoto M,Semba K,Yamaguchi N,Yamamoto T,Seiki M,Inoue J

更新日期：2015-01-01 00:00:00

abstract：:The antitumor effects of methotrexate with 5-fluorouracil against the Sarcoma 180 mouse tumor model were found to be schedule dependent. Pretreatment of tumor-bearing animals with methotrexate significantly enhanced the antitumor activity of the combination relative to simultaneous treatment or to those with methotrex...

journal_title：Cancer research

authors： Bertino JR,Sawicki WL,Lindquist CA,Gupta VS

更新日期：1977-01-01 00:00:00

abstract：:The radiation response of autochthonous tumors induced by s.c. injection of 3-methylcholanthrene in ICR/JCL mice was studied. The tumors were mostly fibrosarcomas and grew with an average volume-doubling time of 2.6 days, independently of the time tumor appearance or dose of the chemical used. The tumors were locally ...

journal_title：Cancer research

authors： Tanooka H,Hoshino H,Tanaka K,Nagase M

更新日期：1980-07-01 00:00:00

abstract：:Our recent studies have shown that the FoxM1B transcription factor is overexpressed in human glioma tissues and that the level of its expression correlates directly with glioma grade. However, whether FoxM1B plays a role in the early development of glioma (i.e., in transformation) is unknown. In this study, we found t...

journal_title：Cancer research

authors： Dai B,Pieper RO,Li D,Wei P,Liu M,Woo SY,Aldape KD,Sawaya R,Xie K,Huang S

更新日期：2010-04-01 00:00:00

abstract：:The presence of immunosuppressive macrophages that become activated in the tumor microenvironment constitutes a major factor responsible for tumor growth and malignancy. In line with this knowledge, we report here that macrophage proliferation is a significant feature of advanced stages of cancer. Moreover, we have fo...

journal_title：Cancer research

authors： Giurisato E,Lonardi S,Telfer B,Lussoso S,Risa-Ebrí B,Zhang J,Russo I,Wang J,Santucci A,Finegan KG,Gray NS,Vermi W,Tournier C

更新日期：2020-08-15 00:00:00

abstract：:Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with can...

journal_title：Cancer research

authors： Siolas D,Hannon GJ

更新日期：2013-09-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) with 11q23 translocations is usually associated with MLL gene rearrangement, but little is known about its leukemogenesis. We analyzed the gene expression profiles of pediatric ALL samples according to their translocations. Using oligonucleotide microarray analysis, we identified dis...

journal_title：Cancer research

authors： Tsutsumi S,Taketani T,Nishimura K,Ge X,Taki T,Sugita K,Ishii E,Hanada R,Ohki M,Aburatani H,Hayashi Y

更新日期：2003-08-15 00:00:00

abstract：:We have developed a model system which can be utilized for characterizing both the molecular basis of natural killer (NK):tumor interactions and the consequences of these interactions on tumor growth in vivo. This model system consists of several tumor lines which were derived from the murine lymphoma ASL1w under cond...

journal_title：Cancer research

authors： Smithson G,Wolcott RM,Chervenak R

更新日期：1992-08-01 00:00:00

abstract：:Defects in a developmental signaling pathway involving mammalian homologues of the Drosophila segment polarity gene, patched (ptc) and its ligand, sonic hedgehog (shh), contribute to tumor formation in several tissues. Recently, a subset of medulloblastoma, the most common malignant brain tumor in children, was found ...

journal_title：Cancer research

authors： Wetmore C,Eberhart DE,Curran T

更新日期：2000-04-15 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. However, clinical trials targeting the VEGF pathway are often ineffective, suggesting that other factors/pathways are also important in tumor angiogenesis. We have previously shown that the Notch ligand Delta-like 4 (DLL4) is up-regu...

journal_title：Cancer research

authors： Li JL,Sainson RC,Shi W,Leek R,Harrington LS,Preusser M,Biswas S,Turley H,Heikamp E,Hainfellner JA,Harris AL

更新日期：2007-12-01 00:00:00