Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis.

abstract：:N-Nitrosodibutylamine and its omega-hydroxylated metabolite N-nitrosobutyl(4-hydroxybutyl)amine (NB4HBA) induce tumors in the urine bladder of different animal species through their common urinary metabolite N-nitrosobutyl(3-carboxypropyl)amine (NB3CPA), resulting from the oxidation of the alcoholic group of NB4HBA to...

journal_title：Cancer research

authors： Bonfanti M,Magagnotti C,Bonati M,Fanelli R,Airoldi L

更新日期：1988-07-01 00:00:00

abstract：:Dietary factors can modify metabolic events involved in the initiation, promotion, or progression of tumors. To determine whether a high-sucrose diet has any effect on the development of enzyme-altered foci during the promotion step of chemical hepatocarcinogenesis in rats, 1-day-old Sprague-Dawley rats were given a s...

journal_title：Cancer research

authors： Hei TK,Sudilovsky O

更新日期：1985-06-01 00:00:00

abstract：:Cell proliferation in 211 primary non-small cell lung carcinomas was assessed by using an immunostaining of proliferating cell nuclear antigen (PCNA) and a silver staining of argyrophilic nucleolar organizer region (Ag-NOR). More than 5% PCNA positive cells was designated PCNA(+), and less than 5% was PCNA(-). A mean ...

journal_title：Cancer research

authors： Ishida T,Kaneko S,Akazawa K,Tateishi M,Sugio K,Sugimachi K

更新日期：1993-10-15 00:00:00

abstract：:The i.p. inoculation of C3H mice with 5 times 10-6 cells of a transplantable ovarian carcinoma invariably evokes accumulation of large amounts of ascitic fluid. Histological and pharmacotherapeutic studies indicate that obstruction to peritoneal lymphatic drainage is a key factor in the formation of carcinomatous asci...

journal_title：Cancer research

authors： Feldman GB

更新日期：1975-02-01 00:00:00

abstract：:Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy ove...

journal_title：Cancer research

authors： Allen GW,Saba C,Armstrong EA,Huang SM,Benavente S,Ludwig DL,Hicklin DJ,Harari PM

更新日期：2007-02-01 00:00:00

abstract：:The effect of the AC33 tumor on protein synthesis in Lewis-Wistar rats was investigated under four different dietary regimens. The four diets used were: (a) 1.25 g amino acids plus 12.5 g glucose per day, (b) 1.25 g amino acids, (c) 1.25 g glucose per day, and (d) 12.5 g glucose per day. The rats were maintained on th...

journal_title：Cancer research

authors： Stein TP,Oram-Smith JC,Leskiw MJ,Wallace HW,Miller EE

更新日期：1976-11-01 00:00:00

abstract：:The concentration of potassium (K+) and sodium (Na+) was measured in breast cyst fluid (BCF) from 611 cysts greater than 3 ml aspirated in 520 women with gross cystic disease of the breast. These women were enrolled, from 1983 on, in a cohort study aimed at assessing the relationship between cyst type, as defined by t...

journal_title：Cancer research

authors： Naldoni C,Costantini M,Dogliotti L,Bruzzi P,Bucchi L,Buzzi G,Torta M,Angeli A

更新日期：1992-04-01 00:00:00

abstract：:Cell differentiation within stem cell lineages can check proliferative potential, but nodal pathways that can limit tumor growth are obscure. Here, we report that lung cancer cell populations generate phenotypic and oncogenic plasticity via a switch between differentiation programs controlled by SOX2 and SOX9, thus al...

journal_title：Cancer research

authors： Lin SC,Chou YT,Jiang SS,Chang JL,Chung CH,Kao YR,Chang IS,Wu CW

更新日期：2016-12-01 00:00:00

abstract：:Bone marrow biopsy specimens from patients with myeloma were cultured in either 1 of 2 thin-film culture systems, a controlled environment steady state system or a rocker tube configuration of the system, for periods up to 42 days. Both functional and morphological characteristics of the myeloma cells were well-mainta...

journal_title：Cancer research

authors： Gailani S,McLimans WF,Mundy GR,Nussbaum A,Roholt O,Zeigel R

更新日期：1976-04-01 00:00:00

abstract：:A clone of a human gastric carcinoma cell line was used to determine whether cells which had survived a treatment with Melphalan would express altered survival responses when treated again with this agent 1 week or more later. Cells were treated for 1 h each week with 2 micrograms/ml (99% lethal dose). After the first...

journal_title：Cancer research

authors： Barranco SC,Townsend CM Jr,Weintraub B,Beasley EG,MacLean KK,Shaeffer J,Liu NH,Schellenberg K

更新日期：1990-06-15 00:00:00

abstract：:A number of studies in bacteria have indicated that deoxythymidine 5'-triphosphate may be a repressor or corepressor of ribonucleotide reductase. For determination of whether a similar regulating mechanism exists in mammalian cells, HeLa cells and partially hepatectomized rats were treated with either methotrexate, 5-...

journal_title：Cancer research

authors： Elford HL,Bonner EL,Kerr BH,Hanna SD,Smulson M

更新日期：1977-12-01 00:00:00

abstract：:Knockout and expression studies suggest that estrogen receptor beta (ERbeta) plays a prominent role in ovarian function and pathology. Moreover, ovarian cancers are characterized by high morbidity and low responsiveness to anti-estrogens. Here we demonstrate, using quantitative PCR to measure ERalpha and ERbeta levels...

journal_title：Cancer research

authors： Bardin A,Hoffmann P,Boulle N,Katsaros D,Vignon F,Pujol P,Lazennec G

更新日期：2004-08-15 00:00:00

abstract：:Specific inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) have been developed that efficiently inhibit the oncogenic RAF-MEK-ERK pathway. We used a systems-based approach to identify breast cancer subtypes particularly susceptible to MEK inhibitors and to understa...

journal_title：Cancer research

authors： Mirzoeva OK,Das D,Heiser LM,Bhattacharya S,Siwak D,Gendelman R,Bayani N,Wang NJ,Neve RM,Guan Y,Hu Z,Knight Z,Feiler HS,Gascard P,Parvin B,Spellman PT,Shokat KM,Wyrobek AJ,Bissell MJ,McCormick F,Kuo WL,Mills GB,

更新日期：2009-01-15 00:00:00

abstract：:ARID1A, encoding a subunit of the SWI/SNF complex, is the most frequently mutated epigenetic regulator in human cancers and is mutated in more than 50% of ovarian clear cell carcinomas (OCCC), a disease that currently has no effective therapy. Inhibition of histone deacetylase 6 (HDAC6) suppresses the growth of ARID1A...

journal_title：Cancer research

authors： Fukumoto T,Fatkhutdinov N,Zundell JA,Tcyganov EN,Nacarelli T,Karakashev S,Wu S,Liu Q,Gabrilovich DI,Zhang R

更新日期：2019-11-01 00:00:00

abstract：:12-O-Tetradecanoylphorbol-13-acetate (TPA) is an effective comitogen in phytohemagglutinin-treated bovine lymphocytes. Concurrent addition of 10(-8) M TPA gives a greater than 6-fold increase in DNA synthesis over cultures treated with the lectin alone. The delayed addition of phorbol ester, relative to the start of t...

journal_title：Cancer research

authors： Kensler TW,Mueller GC

更新日期：1978-03-01 00:00:00

abstract：:Single-chain antigen-binding proteins, or sFvs, represent potentially unique molecules for targeted delivery of drugs, toxins, or radionuclides to a tumor site. In previous studies (Cancer Res., 51:6363-6371, 1991) using a human colon carcinoma xenograft model, it was demonstrated that the sFv has an extremely rapid p...

journal_title：Cancer research

authors： Yokota T,Milenic DE,Whitlow M,Schlom J

更新日期：1992-06-15 00:00:00

abstract：:Targeting dendritic cells in vivo by transcutaneous peptide immunization (TCI) represents an efficient immunization strategy to induce tumor-specific CTL because it reflects the physiologic conditions occurring during pathogen infection. Here we show that including a Th1 peptide in TCI can activate preexisting memory ...

journal_title：Cancer research

authors： Hosoi A,Takeda Y,Furuichi Y,Kurachi M,Kimura K,Maekawa R,Takatsu K,Kakimi K

更新日期：2008-05-15 00:00:00

abstract：:Infiltrating macrophages are a key component of inflammation during tumorigenesis, but the direct evidence of such linkage remains unclear. We report here that persistent coculturing of immortalized prostate epithelial cells with macrophages, without adding any carcinogens, induces prostate tumorigenesis and that indu...

journal_title：Cancer research

authors： Fang LY,Izumi K,Lai KP,Liang L,Li L,Miyamoto H,Lin WJ,Chang C

更新日期：2013-09-15 00:00:00

abstract：:Recent studies have revealed that procaspase-8 has an important function in cell adhesion and motility. Src phosphorylation controls this function by preventing the conversion of procaspase-8, which is an adhesion/migration factor, to mature caspase-8, which is an apoptosis-inducing factor. This provides a mechanism t...

journal_title：Cancer research

authors： Frisch SM

更新日期：2008-06-15 00:00:00

abstract：:Monocytes and dendritic cells are key players in the immune response. Because dendritic cells drive the tumor host defense, it is important that monocytes and dendritic cells survive cytotoxic tumor therapy. Although most of the anticancer drugs target DNA, the DNA repair capacity of monocytes and dendritic cells has ...

journal_title：Cancer research

authors： Briegert M,Kaina B

更新日期：2007-01-01 00:00:00

abstract：:Receptor protein-tyrosine kinases (RPTKs) are tightly regulated during normal cellular processes including cell growth, differentiation, and metabolism. Recently, a RPTK-like molecule named novel oncogene with kinase-domain (NOK) has been cloned and characterized. Overexpression of NOK caused severe cellular transform...

journal_title：Cancer research

authors： Chen Y,Li YH,Chen XP,Gong LM,Zhang SP,Chang ZJ,Zhang XF,Fu XY,Liu L

更新日期：2005-12-01 00:00:00

abstract：:Analysis of leukemic cell phenotypes using cell surface antigens and various enzymes indicates that acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease consisting of four major subclasses with additional subsets existing within these subclasses. These different types of ALL appear to reflect seq...

journal_title：Cancer research

authors： Greaves MF

更新日期：1981-11-01 00:00:00

abstract：:A unique electrophoretic form of lactate dehydrogenase (LDH-Z), formerly observed in a choriocarcinoma cell line (JEG-3) and first-trimester placenta, has been shown to be the same as that produced in hydatidiform mole and term placenta. We have also observed LDH-Z in second-trimester placenta, choriocarcinoma metasta...

journal_title：Cancer research

authors： Siciliano MJ,Bordelon-Riser ME,Freedman RS,Kohler PO

更新日期：1980-02-01 00:00:00

abstract：:In this paper, we describe the role of chemokine receptor CXCR4 activation by its natural ligand, the chemokine stromal cell-derived factor (SDF-1) (CXCL12), in glioblastoma cell growth in vitro. We show that both CXC chemokine receptor 4 (CXCR4) and SDF-1 mRNA are expressed in several human glioblastoma multiforme tu...

journal_title：Cancer research

authors： Barbero S,Bonavia R,Bajetto A,Porcile C,Pirani P,Ravetti JL,Zona GL,Spaziante R,Florio T,Schettini G

更新日期：2003-04-15 00:00:00

abstract：:Von Hippel-Lindau (VHL) tumor suppressor protein is expressed in neurons of the central nervous system and plays an important role during the neuronal differentiation of central nervous system progenitor cells. To elucidate the neuronal differentiating potential of VHL protein in neuroblastoma cells, we overexpressed ...

journal_title：Cancer research

authors： Murata H,Tajima N,Nagashima Y,Yao M,Baba M,Goto M,Kawamoto S,Yamamoto I,Okuda K,Kanno H

更新日期：2002-12-01 00:00:00

abstract：:Although targeting the Ras/Raf/MEK pathway remains a promising anticancer strategy, mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitors in clinical development are likely to be limited in their ability to produce durable clinical responses due to the emergence of acquired drug...

journal_title：Cancer research

authors： Wang H,Daouti S,Li WH,Wen Y,Rizzo C,Higgins B,Packman K,Rosen N,Boylan JF,Heimbrook D,Niu H

更新日期：2011-08-15 00:00:00

abstract：:Galectin-3, a beta-galactoside binding protein, plays a significant role in cell to extracellular matrix interactions. Despite its extracellular expression, the precise physiological mechanisms that trigger its release from the intracellular milieu have not been characterized. The present analyses were, therefore, don...

journal_title：Cancer research

authors： Zhu WQ,Ochieng J

更新日期：2001-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with poor outcomes with current therapies. Gemcitabine is the primary adjuvant drug used clinically, but its effectiveness is limited. In this study, our objective was to use a rationale-driven approach to identify novel biomarkers for outcome in patient...

journal_title：Cancer research

authors： Colbert LE,Petrova AV,Fisher SB,Pantazides BG,Madden MZ,Hardy CW,Warren MD,Pan Y,Nagaraju GP,Liu EA,Saka B,Hall WA,Shelton JW,Gandhi K,Pauly R,Kowalski J,Kooby DA,El-Rayes BF,Staley CA 3rd,Adsay NV,Curran WJ Jr,

更新日期：2014-05-15 00:00:00

abstract：:Arsenite-induced mitotic abnormalities result in mitotic death in several cancer cell lines. However, how arsenite induces these effects is not known. We have previously shown that arsenite induces mitotic arrest, mitotic abnormalities, and mitotic death in CGL-2 cells. To further delineate the mechanism of action of ...

journal_title：Cancer research

authors： Yih LH,Tseng YY,Wu YC,Lee TC

更新日期：2006-02-15 00:00:00

abstract：:Resistance to anticancer therapeutics greatly affects the phenotypic and functional properties of tumor cells, but how chemoresistance contributes to the tumorigenic activities of cancer stem-like cells remains unclear. In this study, we found that a characteristic of cancer stem-like cells from chemoresistant tumors ...

journal_title：Cancer research

authors： Yamashina T,Baghdadi M,Yoneda A,Kinoshita I,Suzu S,Dosaka-Akita H,Jinushi M

更新日期：2014-05-15 00:00:00