Coexpression of cytokeratins characteristic for myoepithelial and luminal cell lineages in rat 13762NF mammary adenocarcinoma tumors and their spontaneous metastases.

abstract：:A founder allele in the CHEK2 gene (1100delC) has been associated with an elevated risk of breast cancer. This allele is responsible for the majority of CHEK2-associated breast cancers in women from northern European countries; however, within Europe, it seems to be rare in countries that are close to the Mediterranea...

journal_title：Cancer research

authors： Zhang S,Phelan CM,Zhang P,Rousseau F,Ghadirian P,Robidoux A,Foulkes W,Hamel N,McCready D,Trudeau M,Lynch H,Horsman D,De Matsuda ML,Aziz Z,Gomes M,Costa MM,Liede A,Poll A,Sun P,Narod SA

更新日期：2008-04-01 00:00:00

abstract：:Osteosarcoma is the most frequent primary bone tumor that develops mainly in the young, the median age of diagnosis being 18 years. Despite improvement in osteosarcoma treatment, survival rate is only 30% at 5 years for patients with pulmonary metastases at diagnosis. This warrants exploration of new therapeutic optio...

journal_title：Cancer research

authors： Lamoureux F,Richard P,Wittrant Y,Battaglia S,Pilet P,Trichet V,Blanchard F,Gouin F,Pitard B,Heymann D,Redini F

更新日期：2007-08-01 00:00:00

abstract：:The in vivo efficacy of the antitumor, immunosuppressive antibiotic mycophenolic acid is known to be limited by its rapid conversion to the biologically inactive 7-0-glucuronide, catalyzed by UDP-glucuronosyl transferase activity, which is widely distributed among normal tissues, including intestinal epithelium. We ha...

journal_title：Cancer research

authors： Franklin TJ,Jacobs V,Jones G,Plé P,Bruneau P

更新日期：1996-03-01 00:00:00

abstract：:We have studied the cellular expression of NB/70K, a glycoprotein proposed to be human ovarian tumor associated described previously. Analysis of cells bearing this antigen in malignant ascites shows expression in tumor cells of gynecological origin (ovarian, endometrial) and to a limited degree in breast cancer cells...

journal_title：Cancer research

authors： Bizzari JP,Mackillop WJ,Buick RN

更新日期：1983-02-01 00:00:00

abstract：:Increased levels of DNA fragments have frequently been found in the blood plasma of cancer patients. Published data suggest that only a fraction of the DNA in blood plasma is derived from cancer cells. However, it is not known how much of the circulating DNA is from cancer or from noncancer cells. By quantitative meth...

journal_title：Cancer research

authors： Jahr S,Hentze H,Englisch S,Hardt D,Fackelmayer FO,Hesch RD,Knippers R

更新日期：2001-02-15 00:00:00

abstract：:Although regulatory T cells (Tregs) have been detected in clinically apparent and experimentally induced tumors, the significance of their presence is obscured because past studies examined late-stage tumors that had formed in immunocompetent hosts and thus had evolved mechanisms to escape immunologic recognition and/...

journal_title：Cancer research

authors： Bui JD,Uppaluri R,Hsieh CS,Schreiber RD

更新日期：2006-07-15 00:00:00

abstract：:Copper, zinc, and iron were quantitated in the serum and lymphoid cells of the peripheral blood of healthy children and children with acute lymphocytic leukemia. Copper and iron concentrations in serum and cells were significantly higher and zinc concentration in the cells significantly lower in leukemic patients than...

journal_title：Cancer research

authors： Carpentieri U,Myers J,Thorpe L,Daeschner CW 3rd,Haggard ME

更新日期：1986-02-01 00:00:00

abstract：:Physical activity is defined as bodily movement due to skeletal muscle contraction that results in quantifiable energy expenditure. Both epidemiological and laboratory data indicate that the level of physical activity in which an individual engages may affect cancer risk. Exercise is distinguished from other types of ...

journal_title：Cancer research

authors： Thompson HJ

更新日期：1994-04-01 00:00:00

abstract：:Sunitinib is an antiangiogenic therapy given as a first-line treatment for renal cell carcinoma (RCC). While treatment improves progression-free survival, most patients relapse. We hypothesized that patient relapse can stem from the development of a lymphatic network driven by the production of the main growth factor ...

journal_title：Cancer research

authors： Dufies M,Giuliano S,Ambrosetti D,Claren A,Ndiaye PD,Mastri M,Moghrabi W,Cooley LS,Ettaiche M,Chamorey E,Parola J,Vial V,Lupu-Plesu M,Bernhard JC,Ravaud A,Borchiellini D,Ferrero JM,Bikfalvi A,Ebos JM,Khabar KS,Grép

更新日期：2017-03-01 00:00:00

abstract：:We cloned mouse ING1 homologue (mINGh), an A1/Bfl-1-interacting protein, from mouse mammary glands using a yeast two-hybrid assay and unexpectedly found four splicing variants of mINGh by reverse transcription-PCR assay and sequence analysis. The alternative splicing variants were mINGh-S, mINGh-M, mINGh-L, and mINGh-...

journal_title：Cancer research

authors： Ha S,Lee S,Chung M,Choi Y

更新日期：2002-03-01 00:00:00

abstract：:Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) are rare genodermatoses transmitted as recessive and autosomal traits that result in reduced capacity to repair UV-induced DNA lesions. Although XP, but not TTD, patients are prone to basal and squamous cell carcinomas, to date no comparative studies of the XP a...

journal_title：Cancer research

authors： Otto AI,Riou L,Marionnet C,Mori T,Sarasin A,Magnaldo T

更新日期：1999-03-15 00:00:00

abstract：:Microsomal epoxide hydrolase (mEH) is involved in the metabolism of tobacco-derived carcinogens. Polymorphisms in exons 3 and 4 of the EPHX gene have been reported to be associated with variations in mEH activity. We examined whether the predicted mEH activity modified the lung cancer risk among 150 cases and 172 cont...

journal_title：Cancer research

authors： Benhamou S,Reinikainen M,Bouchardy C,Dayer P,Hirvonen A

更新日期：1998-12-01 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum, CDDP) is one of the most used drugs for osteosarcoma chemotherapy. By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CDDP resistance was mainly associated with the increase of both the int...

journal_title：Cancer research

authors： Pasello M,Michelacci F,Scionti I,Hattinger CM,Zuntini M,Caccuri AM,Scotlandi K,Picci P,Serra M

更新日期：2008-08-15 00:00:00

abstract：:Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb) trastuzumab. In a prospective, randomized phase III clinical trial ev...

journal_title：Cancer research

authors： Turcotte M,Allard D,Mittal D,Bareche Y,Buisseret L,José V,Pommey S,Delisle V,Loi S,Joensuu H,Kellokumpu-Lehtinen PL,Sotiriou C,Smyth MJ,Stagg J

更新日期：2017-10-15 00:00:00

abstract：:Phosphate ore mining and processing operations are associated with dusty conditions and potential exposure to gamma radiation and radon daughter products. Although most current measurements are within Occupational Safety and Health Administration (OSHA) guidelines, no measurements exist for the era preceding modern st...

journal_title：Cancer research

authors： Block G,Matanoski GM,Seltser R,Mitchell T

更新日期：1988-12-15 00:00:00

abstract：:Adriamycin, amsacrine, and etoposide produce protein-associated DNA breaks in numerous cell types. However, in vitro exposure to Adriamycin (0.1-50.0 micrograms/ml) resulted in no detectable DNA cleavage in lymphocytes from patients with B-cell chronic lymphocytic leukemia (CLL) or in either B- or T-lymphocytes from n...

journal_title：Cancer research

authors： Potmesil M,Hsiang YH,Liu LF,Bank B,Grossberg H,Kirschenbaum S,Forlenza TJ,Penziner A,Kanganis D

更新日期：1988-06-15 00:00:00

abstract：:Brca2 is an important tumor suppressor associated with susceptibility to breast cancer. Although increasing evidence indicates that the primary function of Brca2 is to facilitate the repair of DNA damage via the homologous recombination pathway, how Brca2 prevents breast cancer is largely unknown. To study the role of...

journal_title：Cancer research

authors： Cheung AM,Elia A,Tsao MS,Done S,Wagner KU,Hennighausen L,Hakem R,Mak TW

更新日期：2004-03-15 00:00:00

abstract：:A monoclonal antibody, CSTO-1, has been produced against a stomach adenocarcinoma-associated antigen. The antibody is cytotoxic to stomach, colon, and lung adenocarcinoma lines but is completely noncytotoxic to normal blood elements and leukemic cell lines. The monoclonal antibody reacts with tumor cell membranes in e...

journal_title：Cancer research

authors： Togashi H,Terasaki PI,Chia D,Kukes G,Mugishima H,Kasai K,Suyama N,Fukushima K,Hirota M

更新日期：1984-09-01 00:00:00

abstract：:Down-regulation of gelsolin, an actin-binding protein, is frequently found in several types of transformed cells and tumors. The present study demonstrates that gelsolin protein and RNA were absent or markedly reduced in human breast cancer cell lines relative to "normal" mortal human mammary epithelial cells and beni...

journal_title：Cancer research

authors： Asch HL,Head K,Dong Y,Natoli F,Winston JS,Connolly JL,Asch BB

更新日期：1996-11-01 00:00:00

abstract：:BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer; however, the functional consequences of BAG-1 expression and its mechanism of action in breast cancer cells have not been stu...

journal_title：Cancer research

authors： Townsend PA,Cutress RI,Sharp A,Brimmell M,Packham G

更新日期：2003-07-15 00:00:00

abstract：:Frequent loss of heterozygosity (LOH) on the long arm of chromosome 5 (5q) has been reported in many types of human malignancies, including gastric carcinoma. One of the targets of 5q-LOH in colorectal carcinoma is certainly the adenomatous polyposis coli (APC) gene on 5q21. However, other evidence has suggested the p...

journal_title：Cancer research

authors： Tamura G,Ogasawara S,Nishizuka S,Sakata K,Maesawa C,Suzuki Y,Terashima M,Saito K,Satodate R

更新日期：1996-02-01 00:00:00

abstract：:Procarbazine, a chemotherapeutic hydrazine, is thought to be metabolized to an alkylating species similar to methyl carbonium ion by multistep reactions involving cytochrome P-450, monoamine oxidase, and cytosolic enzymes. The DNA-damaging and cytotoxic potential of procarbazine and its metabolites in murine L1210 leu...

journal_title：Cancer research

authors： Erikson JM,Tweedie DJ,Ducore JM,Prough RA

更新日期：1989-01-01 00:00:00

abstract：:Tissue survival responses to ionizing radiation are nonlinear with dose, rather yielding tissue-specific descending curves that impede straightforward analysis of biologic effects. Apoptotic cell death often occurs at low doses, while at clinically relevant intermediate doses, double-strand break misrepair yields mito...

journal_title：Cancer research

authors： Martin ML,Adileh M,Hsu KS,Hua G,Lee SG,Li C,Fuller JD,Rotolo JA,Bodo S,Klingler S,Haimovitz-Friedman A,Deasy JO,Fuks Z,Paty PB,Kolesnick RN

更新日期：2020-03-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors are known to exert antimetastatic and antiangiogenic activity in vitro and in vivo. RECK is a membrane-anchored glycoprotein that negatively regulates matrix metalloproteinases (MMPs) and inhibits tumor metastasis and angiogenesis. In this study, we test the possibility that HDAC ...

journal_title：Cancer research

authors： Liu LT,Chang HC,Chiang LC,Hung WC

更新日期：2003-06-15 00:00:00

abstract：:Human papillomaviruses (HPV), especially genotypes 16 and 18, are probable effectors of human urogenital malignancies. Although the male urethra is a proposed reservoir of HPV transmission, the association between HPV and squamous cell carcinoma (SCC) of the male urethra has not been studied. The highly sensitive tech...

journal_title：Cancer research

authors： Wiener JS,Liu ET,Walther PJ

更新日期：1992-09-15 00:00:00

abstract：:We have advanced the view that estrogens activate the estrogen receptor (ER) alpha complex differently. A group of planar (estradiol, genistein, and coumestrol) and nonplanar (methoxychlor and its mono- and didemethylated phenolic metabolites) environmental estrogens, which are all full estrogens in MCF-7 breast cance...

journal_title：Cancer research

authors： Bentrem D,Fox JE,Pearce ST,Liu H,Pappas S,Kupfer D,Zapf JW,Jordan VC

更新日期：2003-11-01 00:00:00

abstract：:Radioimmunotherapy (RAIT) using a humanized murine monoclonal antibody, chimeric L6 (ChL6), has produced objective tumor reduction in 50% of chemotherapy-refractory patients with metastatic breast cancer in our prior studies. Because myelosuppression limited dose escalation, we evaluated the ability of granulocyte col...

journal_title：Cancer research

authors： Richman CM,DeNardo SJ,O'Grady LF,DeNardo GL

更新日期：1995-12-01 00:00:00

abstract：:Recently, we have shown that the p53 tumor suppressor gene product can inhibit expression of the bcl-2 gene. In this report, we explored the molecular basis for p53-mediated down-regulation of bcl-2 gene expression using a cotransfection approach involving p53 expression plasmids and chloramphenicol acetyltransferase ...

journal_title：Cancer research

authors： Miyashita T,Harigai M,Hanada M,Reed JC

更新日期：1994-06-15 00:00:00

abstract：:Copper plays an essential role in promoting angiogenesis. Tumors that become angiogenic acquire the ability to enter a phase of rapid growth and exhibit increased metastatic potential, the major cause of morbidity in cancer patients. We report that copper deficiency induced by tetrathiomolybdate (TM) significantly imp...

journal_title：Cancer research

authors： Pan Q,Kleer CG,van Golen KL,Irani J,Bottema KM,Bias C,De Carvalho M,Mesri EA,Robins DM,Dick RD,Brewer GJ,Merajver SD

更新日期：2002-09-01 00:00:00

abstract：:Stromal cell-derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 are implicated in the pathogenesis and prognosis of acute myelogenous leukemia (AML). Cellular microparticles, submicron vesicles shed from the plasma membrane of various cells, are also associated with human pathology. In the present study, we invest...

journal_title：Cancer research

authors： Kalinkovich A,Tavor S,Avigdor A,Kahn J,Brill A,Petit I,Goichberg P,Tesio M,Netzer N,Naparstek E,Hardan I,Nagler A,Resnick I,Tsimanis A,Lapidot T

更新日期：2006-11-15 00:00:00