Sunitinib Stimulates Expression of VEGFC by Tumor Cells and Promotes Lymphangiogenesis in Clear Cell Renal Cell Carcinomas.

abstract：:Although immunotherapy based on the adoptive transfer of tumor-specific T lymphocytes has been shown to result in dramatic clinical responses in some patients, the relatively low levels of engraftment and persistence of the adoptively transferred cells may limit these responses in many patients. In an attempt to devel...

journal_title：Cancer research

authors： Charo J,Finkelstein SE,Grewal N,Restifo NP,Robbins PF,Rosenberg SA

更新日期：2005-03-01 00:00:00

abstract：:The differential display technique was used to identify mRNAs differentially expressed in human melanoma cell lines with different metastatic capacity. We report the isolation of nine different clones, of which four were uniquely expressed in the highly metastatic human melanoma cell line MV3, whereas the other five c...

journal_title：Cancer research

authors： van Groningen JJ,Bloemers HP,Swart GW

更新日期：1995-12-15 00:00:00

abstract：:Our objectives were to test whether polymorphic variation in the (CAG)n repeat of the androgen receptor (AR) gene affects penetrance of germ-line BRCA mutations for ovarian cancer or age of diagnosis for ovarian cancer. Using a case-series study design, 179 consecutive Ashkenazi Jewish ovarian cancer patients were gen...

journal_title：Cancer research

authors： Levine DA,Boyd J

更新日期：2001-02-01 00:00:00

abstract：:Partial regression in cutaneous malignant melanoma has been reported by a number of observers, albeit not all, to be associated with a relatively poor prognosis; in contrast, a keratoacanthoma, which eventually regresses, does not metastasize. The Hammond effect could explain the possibly poor prognosis of the thin re...

journal_title：Cancer research

authors： Prehn RT

更新日期：1996-03-01 00:00:00

abstract：:Anti-inflammatory drugs and antibiotics alter the risk of breast cancer in women, but roles for bacteria and inflammation in breast malignancies are poorly understood. A recent study in mice suggests that intestinal bacteria can trigger mammary carcinoma. The mechanisms involved in this effect suggest that dysregulate...

journal_title：Cancer research

authors： Rao VP,Poutahidis T,Fox JG,Erdman SE

更新日期：2007-02-01 00:00:00

abstract：:A murine monoclonal antibody 14.18 specifically recognizes disialoganglioside GD2, the major ganglioside expressed on the surface of human neuroblastoma cells. This monoclonal antibody (Mab) is of immunoglobulin G3 isotype, has an affinity constant (KA) of 3.5 X 10(8) M-1, and reacts preferentially with tumor cells an...

journal_title：Cancer research

authors： Mujoo K,Cheresh DA,Yang HM,Reisfeld RA

更新日期：1987-02-15 00:00:00

abstract：:Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos...

journal_title：Cancer research

authors： Nakase K,Ishimaru F,Avitahl N,Dansako H,Matsuo K,Fujii K,Sezaki N,Nakayama H,Yano T,Fukuda S,Imajoh K,Takeuchi M,Miyata A,Hara M,Yasukawa M,Takahashi I,Taguchi H,Matsue K,Nakao S,Niho Y,Takenaka K,Shinagawa K,

更新日期：2000-08-01 00:00:00

abstract：:Bloom syndrome is an autosomal recessive disorder whose characteristics include an increased risk for many types of cancers. In contrast to the homozygous mutations of Bloom syndrome, heterozygous carriers of BLM mutations may be at increased risk for developing colorectal cancer. We have screened 2,333 Jewish individ...

journal_title：Cancer research

authors： Cleary SP,Zhang W,Di Nicola N,Aronson M,Aube J,Steinman A,Haddad R,Redston M,Gallinger S,Narod SA,Gryfe R

更新日期：2003-04-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with poor outcomes with current therapies. Gemcitabine is the primary adjuvant drug used clinically, but its effectiveness is limited. In this study, our objective was to use a rationale-driven approach to identify novel biomarkers for outcome in patient...

journal_title：Cancer research

authors： Colbert LE,Petrova AV,Fisher SB,Pantazides BG,Madden MZ,Hardy CW,Warren MD,Pan Y,Nagaraju GP,Liu EA,Saka B,Hall WA,Shelton JW,Gandhi K,Pauly R,Kowalski J,Kooby DA,El-Rayes BF,Staley CA 3rd,Adsay NV,Curran WJ Jr,

更新日期：2014-05-15 00:00:00

abstract：:K-ras gene mutations have been reported as early events in colorectal tumorigenesis, but their role in tumor initiation and development is still unclear. To analyze and compare K-ras mutational patterns between colorectal tissues at different stages of tumor progression in individual patients, 65 colorectal tissue sam...

journal_title：Cancer research

authors： Zhu D,Keohavong P,Finkelstein SD,Swalsky P,Bakker A,Weissfeld J,Srivastava S,Whiteside TL

更新日期：1997-06-15 00:00:00

abstract：:Epithelial ovarian cancer comprises three major histological subtypes (serous, mucinous, and endometrioid), and it is becoming clear that the developmental pathways for these subtypes are fundamentally different. In particular, endometrioid ovarian cancers probably arise by the malignant transformation of ectopic endo...

journal_title：Cancer research

authors： Obata K,Morland SJ,Watson RH,Hitchcock A,Chenevix-Trench G,Thomas EJ,Campbell IG

更新日期：1998-05-15 00:00:00

abstract：:The potential of transforming growth factor-alpha (TGF-alpha) to function as an autocrine growth factor was evaluated in numerous ovarian carcinoma cell lines. All 17 lines which were examined expressed the epidermal growth factor receptor and 16 cell lines, in addition, concomitantly secreted TGF-alpha. Radioimmunoas...

journal_title：Cancer research

authors： Stromberg K,Collins TJ 4th,Gordon AW,Jackson CL,Johnson GR

更新日期：1992-01-15 00:00:00

abstract：:Pyrazine diazohydroxide (PZDH) is a novel antineoplastic agent that appears to form DNA adducts via the reactive pyrazine diazonium ion and produces substantial antitumor activity in preclinical models. We conducted a phase I trial to determine the maximally tolerated dose of PZDH that could be administered as a 5-min...

journal_title：Cancer research

authors： Vogelzang NJ,Mick R,Janisch L,Berezin F,Schilsky RL,Ratain MJ

更新日期：1994-01-01 00:00:00

abstract：:Morphine is used to treat pain in several medical conditions including cancer. Here we show that morphine, in a concentration typical of that observed in patients' blood, stimulates human microvascular endothelial cell proliferation and angiogenesis in vitro and in vivo. It does so by activating mitogen-activated prot...

journal_title：Cancer research

authors： Gupta K,Kshirsagar S,Chang L,Schwartz R,Law PY,Yee D,Hebbel RP

更新日期：2002-08-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers largely due to disseminated disease at the time of presentation. Here, we investigated the role and mechanism of action of the metastasis-associated protein anterior gradient 2 (AGR2) in the pathogenesis of pancreatic cancer. AGR2 was induc...

journal_title：Cancer research

authors： Dumartin L,Whiteman HJ,Weeks ME,Hariharan D,Dmitrovic B,Iacobuzio-Donahue CA,Brentnall TA,Bronner MP,Feakins RM,Timms JF,Brennan C,Lemoine NR,Crnogorac-Jurcevic T

更新日期：2011-11-15 00:00:00

abstract：:The effects of four anti-GM2 monoclonal antibodies (DMAb-1, DMAb-2, DMAb-3, and DMAb-5) were studied on spheroid cultures from a human glioma cell line (D-54 MG) that is known to express high levels of GM2. The spheroids developed central necrosis 48 h after antibody exposures at concentrations greater than 6 microgra...

journal_title：Cancer research

authors： Bjerkvig R,Engebraaten O,Laerum OD,Fredman P,Svennerholm L,Vrionis FD,Wikstrand CJ,Bigner DD

更新日期：1991-09-01 00:00:00

abstract：:Patient-derived xenografts (PDX) are tumor-in-mouse models for cancer. PDX collections, such as the NCI PDXNet, are powerful resources for preclinical therapeutic testing. However, variations in experimental and analysis procedures have limited interpretability. To determine the robustness of PDX studies, the PDXNet t...

journal_title：Cancer research

authors： Evrard YA,Srivastava A,Randjelovic J,Doroshow JH,Dean DA 2nd,Morris JS,Chuang JH,NCI PDXNet Consortium.

更新日期：2020-06-01 00:00:00

abstract：:Retinoic acid (RA) is a master epigenetic regulator that plays a pivotal role in both breast morphogenesis and development. Here, we show for the first time that RA, via the RA receptor alpha (RARalpha), epigenetically regulates in a concerted fashion the transcription of two RA-responsive genes, the RA receptor beta2...

journal_title：Cancer research

authors： Bistulfi G,Pozzi S,Ren M,Rossetti S,Sacchi N

更新日期：2006-11-01 00:00:00

abstract：:Intentional bacterial infections can produce efficacious antitumor responses in mice, rats, dogs, and humans. However, low overall success rates and intense side effects prevent such approaches from being employed clinically. In this work, we titered bacteria and/or the proinflammatory cytokine TNFα in a set of establ...

journal_title：Cancer research

authors： Hatzikirou H,López Alfonso JC,Leschner S,Weiss S,Meyer-Hermann M

更新日期：2017-04-01 00:00:00

abstract：:The forkhead transcription factor Foxp3 is highly expressed in CD4+CD25+ regulatory T cells (Treg) and was recently identified as a key player in mediating their inhibitory functions. Here, we describe for the first time the expression and function of Foxp3 in pancreatic ductal adenocarcinoma cells and tumors. Foxp3 e...

journal_title：Cancer research

authors： Hinz S,Pagerols-Raluy L,Oberg HH,Ammerpohl O,Grüssel S,Sipos B,Grützmann R,Pilarsky C,Ungefroren H,Saeger HD,Klöppel G,Kabelitz D,Kalthoff H

更新日期：2007-09-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) cells have constitutively high expression of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX) 2. These NSCLC cells also have increased prostaglandin expression (PGE2). Many lung cancers also express 12-lipoxygenase RNA and 12-lipoxygenase protein and biosynthesize 12(S)-hy...

journal_title：Cancer research

authors： Soriano AF,Helfrich B,Chan DC,Heasley LE,Bunn PA Jr,Chou TC

更新日期：1999-12-15 00:00:00

abstract：:The presence of a valine (V) versus a phenylanaline (F) at position 158 of Fc gamma RIIIa/CD16a improves the affinity for IgG and is associated with higher therapeutic response to rituximab. Increased CD16 expression on natural killer (NK) cells from donors with the VV or VF versus FF genotype has recently been report...

journal_title：Cancer research

authors： Congy-Jolivet N,Bolzec A,Ternant D,Ohresser M,Watier H,Thibault G

更新日期：2008-02-15 00:00:00

abstract：:Promotional properties of a high-fat diet in intestinal cancer were studied by feeding a 30% beef fat diet to 8 groups of rats (25 rats/group) for time periods varying from 1 to 21 weeks after 8 weekly s.c. injections of azoxymethane (AOM) (8 mg/ kg). Two other groups were fed the high-fat diet, one for 8 weeks prior ...

journal_title：Cancer research

authors： Bull AW,Soullier BK,Wilson PS,Hayden MT,Nigro ND

更新日期：1979-12-01 00:00:00

abstract：:The implementation of a number of chemical carcinogen screening programs has been accompanied by the observation that some screens might have high false-positive error rates. With designs presently used at the National Cancer Institute and historical spontaneous tumor rates based upon control animals in previous exper...

journal_title：Cancer research

authors： Fears TR,Tarone RE,Chu KC

更新日期：1977-07-01 00:00:00

abstract：:Infiltrating macrophages are a key component of inflammation during tumorigenesis, but the direct evidence of such linkage remains unclear. We report here that persistent coculturing of immortalized prostate epithelial cells with macrophages, without adding any carcinogens, induces prostate tumorigenesis and that indu...

journal_title：Cancer research

authors： Fang LY,Izumi K,Lai KP,Liang L,Li L,Miyamoto H,Lin WJ,Chang C

更新日期：2013-09-15 00:00:00

abstract：:The capacity of lymph nodes to eradicate cancer is a controversial issue. The purpose of this study was to determine the interplay between tumor growth and host resistance at early stages of lymph node metastasis. A metastasis model was made in the rat mesenteric lymph node, and migration of cancer cells was visualize...

journal_title：Cancer research

authors： Nagata H,Arai T,Soejima Y,Suzuki H,Ishii H,Hibi T

更新日期：2004-11-15 00:00:00

abstract：:Two human B-cell lines carrying a 14;18 chromosome translocation [t(14;18)(q32;q21)], designated FL-218 and FL-318, were established from effusion cells of two Japanese patients manifesting the transformed histology of follicular lymphoma. The FL-218 and FL-318 cell lines were composed of cells in the hyperdiploid ran...

journal_title：Cancer research

authors： Amakawa R,Fukuhara S,Ohno H,Tanabe S,Horii M,Matsuyama F,Kato I,Kakita T,Nagauchi O

更新日期：1990-04-15 00:00:00

abstract：:The critical region on human chromosome 3p21.3 harboring a putative lung cancer tumor suppressor gene (TSG) was previously defined by allelotyping and recently refined by overlapping homozygous deletions. We report the construction of a 700-kb (cosmid and one P1 phage) clone contig covering the deletion overlap and it...

journal_title：Cancer research

authors： Wei MH,Latif F,Bader S,Kashuba V,Chen JY,Duh FM,Sekido Y,Lee CC,Geil L,Kuzmin I,Zabarovsky E,Klein G,Zbar B,Minna JD,Lerman MI

更新日期：1996-04-01 00:00:00

abstract：:Metastasis-suppressing gene product CD82 and its analogue CD9 are considered to suppress the malignancy of various human cancers, although the rationale for this effect is unknown. The present study addresses phenotypic changes in Chinese hamster ovary mutant cell line ldlD deficient in UDP-Glc 4-epimerase and express...

journal_title：Cancer research

authors： Ono M,Handa K,Withers DA,Hakomori S

更新日期：1999-05-15 00:00:00

abstract：:Vigorous activity after diagnosis was recently reported to be inversely associated with prostate cancer-specific mortality. However, men with metastatic disease may decrease their activity due to their disease; thus, a causal interpretation is uncertain. We therefore prospectively examined vigorous activity and brisk ...

journal_title：Cancer research

authors： Richman EL,Kenfield SA,Stampfer MJ,Paciorek A,Carroll PR,Chan JM

更新日期：2011-06-01 00:00:00