Abstract：
:Transplabtable Zajdela rat ascites hepatoma cells, previously considered "nonproducers," synthesize detectable amounts of intracellular alpha-fetoprotein (AFP) and fibrinogen, but fail to secret or release these serum proteins. Evidence for defective secretory mechanisms for serum proteins in these hepatoma cells (a) explains the failure to detect AFP in either the serum or ascitic fluid of rats bearing this hepatoma, (b) indicates that some hepatoma cells should be classified as "nonsecretors," rather than nonproducers of AFP, and (c) suggests that failure to detect AFP in some human and animal hepatomas in vivo and in vitro may also reflect failure of secretion rather than failure of intracellular synthesis.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Sarcione EJ,Smalley JRsubject
Has Abstractpub_date
1976-09-01 00:00:00pages
3203-6issue
9 pt.1eissn
0008-5472issn
1538-7445journal_volume
36pub_type
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