Abstract:
:The ability to engineer specific mutations in mice has proven essential to advancing our understanding of the molecular basis of cancer. Chromosomal rearrangements, a common and clinically relevant class of cancer-causing mutations, have however remained difficult to faithfully recapitulate in vivo The development of genetic tools for in vivo somatic genome editing has recently overcome this limitation and led to the generation of more sophisticated and accurate preclinical models of human cancers. Here, we review the potential applications of these new technologies to the study of tumor biology and discuss their advantages over more conventional strategies, their limitations, and the remaining challenges. Cancer Res; 76(17); 4918-23. ©2016 AACR.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Maddalo D,Ventura Adoi
10.1158/0008-5472.CAN-16-0726subject
Has Abstractpub_date
2016-09-01 00:00:00pages
4918-23issue
17eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-16-0726journal_volume
76pub_type
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