Inhibitory effect of green tea on the growth of established skin papillomas in mice.

abstract：:Twenty-seven patients with advanced cancer were entered in a phase I study of bolus i.v. 5-fluorouracil at a dose of 370 mg/m2/day for 5 days combined with a continuous i.v. infusion of (6S)-folinic acid for 5.5 days, starting 24 h in advance of the first 5-fluorouracil dose. The dose of (6S)-folinic acid was escalate...

journal_title：Cancer research

authors： Newman EM,Akman SA,Harrison JS,Leong LA,Margolin KA,Morgan RJ,Raschko JW,Somlo G,Ahn CW,Doroshow JH

更新日期：1992-05-01 00:00:00

abstract：:Tumorigenesis can arise from inappropriate activation of developmental genes in mature tissues. Here, we show that the developmental regulator Six1 is overexpressed in ovarian carcinoma cell lines (OCC) compared with normal ovarian surface epithelium. As observed in other cancers, Six1 overexpression in OCC leads to i...

journal_title：Cancer research

authors： Behbakht K,Qamar L,Aldridge CS,Coletta RD,Davidson SA,Thorburn A,Ford HL

更新日期：2007-04-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. However, clinical trials targeting the VEGF pathway are often ineffective, suggesting that other factors/pathways are also important in tumor angiogenesis. We have previously shown that the Notch ligand Delta-like 4 (DLL4) is up-regu...

journal_title：Cancer research

authors： Li JL,Sainson RC,Shi W,Leek R,Harrington LS,Preusser M,Biswas S,Turley H,Heikamp E,Hainfellner JA,Harris AL

更新日期：2007-12-01 00:00:00

abstract：:Epidemiological and animal model studies indicate that increased calorie intake increases the risk for colon cancer development. Previous studies in animal models restricted the calorie intake severely, and none of these studies have investigated a dose-response effect of different levels of calorie restriction on col...

journal_title：Cancer research

authors： Kumar SP,Roy SJ,Tokumo K,Reddy BS

更新日期：1990-09-15 00:00:00

abstract：:The role of natural killer group 2, member D receptor (NKG2D)-expressing natural killer (NK) cells in tumor immunosurveillance is now well established. Nevertheless, tumor progression occurs despite tumor immunosurveillance, leading to cancer persistence in immunocompetent hosts. STAT3 plays a pivotal role both in onc...

journal_title：Cancer research

authors： Bedel R,Thiery-Vuillemin A,Grandclement C,Balland J,Remy-Martin JP,Kantelip B,Pallandre JR,Pivot X,Ferrand C,Tiberghien P,Borg C

更新日期：2011-03-01 00:00:00

abstract：:Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "bacterial" ancestry, these antibiotics also target mitochondrial ...

journal_title：Cancer research

authors： Chatzispyrou IA,Held NM,Mouchiroud L,Auwerx J,Houtkooper RH

更新日期：2015-11-01 00:00:00

abstract：:The signaling pathways that mediate the development of pancreatic ductal adenocarcinoma (PDAC) downstream of mutant Kras remain incompletely understood. Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer. Phosphorylation of rpS6 was increased in pancreatic acinar cells ...

journal_title：Cancer research

authors： Khalaileh A,Dreazen A,Khatib A,Apel R,Swisa A,Kidess-Bassir N,Maitra A,Meyuhas O,Dor Y,Zamir G

更新日期：2013-03-15 00:00:00

abstract：:Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly understood. Here we show that intratumoral copper levels influence PD-L1 exp...

journal_title：Cancer research

authors： Voli F,Valli E,Lerra L,Kimpton K,Saletta F,Giorgi FM,Mercatelli D,Rouaen JRC,Shen S,Murray JE,Ahmed-Cox A,Cirillo G,Mayoh C,Beavis PA,Haber M,Trapani JA,Kavallaris M,Vittorio O

更新日期：2020-10-01 00:00:00

abstract：:Xeroderma pigmentosum variant (XPV) patients with mutations in the DNA polymerase eta (pol eta) gene are hypersensitive to sunlight and have greatly increased susceptibility to sunlight-induced skin cancer. Consistent with the ability of Pol eta to efficiently bypass UV light-induced cyclobutane pyrimidine dimers, XPV...

journal_title：Cancer research

authors： Lin Q,Clark AB,McCulloch SD,Yuan T,Bronson RT,Kunkel TA,Kucherlapati R

更新日期：2006-01-01 00:00:00

abstract：:Sequential morphological changes occurring after brief carcinogen exposures of heterotopic tracheal transplants in rats were semiquantitatively studied. Tracheas were exposed to 7,12-dimethylbenz(a)anthracene for 1, 2, or 4 weeks, during which time means of 138, 152, and 160 microgram 7,12-dimethylbenz(a)anthracene, r...

journal_title：Cancer research

authors： Topping DC,Griesemer RA,Nettesheim P

更新日期：1979-12-01 00:00:00

abstract：:The oxidation of the bladder carcinogen 2-naphthylamine (2-NA) by prostaglandin H synthase (PHS) in vitro was examined. Oxygen uptake studies of 2-NA oxidation in the presence of glutathione, as well as extensive product analysis data, are consistent with a one-electron mechanism of 2-NA oxidation by PHS. The formatio...

journal_title：Cancer research

authors： Boyd JA,Eling TE

更新日期：1987-08-01 00:00:00

abstract：:The growth inhibitory effects of combinations of antifolates on hepatoma cells in culture have been examined. In these studies methotrexate or the lipophilic inhibitors of dihydrofolate reductase were used with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolate (PDDF). Under certain conditions partial ...

journal_title：Cancer research

authors： Galivan J,Nimec Z,Rhee M

更新日期：1987-10-15 00:00:00

abstract：:Three widely studied cell lines were used to examine the nature of the G1 arrest induced in human tumor cells by ionizing radiation and its relation to p53 status. Cell lines MCF-7 and RKO express wild-type p53, whereas HT29 expresses mutant p53. Exponentially growing cells were irradiated with 6 Gy, and the progressi...

journal_title：Cancer research

authors： Nagasawa H,Li CY,Maki CG,Imrich AC,Little JB

更新日期：1995-05-01 00:00:00

abstract：:The human nm23 gene, a candidate metastatic suppressor gene, consists of two genes, nm23-H1 and nm23-H2. The potential mutation in the nm23-H1 gene was examined in colorectal cancer using a reverse transcription polymerase chain reaction amplification followed by DNA sequencing analysis. Genomic alterations in the nm2...

journal_title：Cancer research

authors： Wang L,Patel U,Ghosh L,Chen HC,Banerjee S

更新日期：1993-02-15 00:00:00

abstract：:Emerging knowledge on how the dysregulated function of signaling networks contributes to the malignant growth of squamous cell carcinoma of the head and neck (HNSCC) can now be exploited to identify novel mechanism-based anticancer treatments. In this regard, we have observed that persistent activation of the serine/t...

journal_title：Cancer research

authors： Amornphimoltham P,Patel V,Sodhi A,Nikitakis NG,Sauk JJ,Sausville EA,Molinolo AA,Gutkind JS

更新日期：2005-11-01 00:00:00

abstract：:Drug sensitivity assays were performed using a variation of a colorimetric [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)] assay on V79, CHO-AuxB1, CHRC5, NCI-H460, and NCI-H249 cell lines following optimization of experimental conditions for each cell line. Results from this assay were compared w...

journal_title：Cancer research

authors： Carmichael J,DeGraff WG,Gazdar AF,Minna JD,Mitchell JB

更新日期：1987-02-15 00:00:00

abstract：:Optimal delivery of chemotherapy intensity is dependent on host- and tumor-specific characteristics. In this article, the chemotherapy late intensity schedule is revised to account for tumor growth instability, where a small tumor cell fraction emerges that exhibits a higher proliferation rate than the parent strain. ...

journal_title：Cancer research

authors： Castorina P,Carcò D,Guiot C,Deisboeck TS

更新日期：2009-11-01 00:00:00

abstract：:Occurrence of estrone, estradiol, and testosterone glucuronyltranferase activities was tested in a well-differentiated hepatoma, Reuber H35. Transferase activities for estrone and estradiol were found in the hepatoma. The Michaelis-Menten kinetics of these two microsomal glucuronyltransferase activities were similar i...

journal_title：Cancer research

authors： Gessner T

更新日期：1977-07-01 00:00:00

abstract：:Human erythrocytes have been used as a model for evaluating the chemical carcinogen-plasma membrane interaction. The carcinogenic aromatic amines 2-acetylaminofluorene, dimethylaminoazobenzene, and 3'-methyldimethylaminoazobene stabilize erythrocytes against lysis in hypotonic solution. In general, the stabilization p...

journal_title：Cancer research

authors： Litman GW,Litman RT,Henry CJ

更新日期：1976-02-01 00:00:00

abstract：:Heat shock protein 70 (HSP70) inhibits apoptosis and thereby increases the survival of cells exposed to a wide range of lethal stimuli. HSP70 has also been shown to increase the tumorigenicity of cancer cells in rodent models. The protective function of this chaperone involves interaction and neutralization of the cas...

journal_title：Cancer research

authors： Schmitt E,Parcellier A,Gurbuxani S,Cande C,Hammann A,Morales MC,Hunt CR,Dix DJ,Kroemer RT,Giordanetto F,Jäättelä M,Penninger JM,Pance A,Kroemer G,Garrido C

更新日期：2003-12-01 00:00:00

abstract：:Although epithelial cell adhesion molecule (EpCAM) has previously been shown to promote tumor progression, the underlying mechanisms remain largely unknown. Here, we report that the EGF-like domain I within the extracellular domain of EpCAM (EpEX) binds EGFR, activating both AKT and MAPK signaling to inhibit forkhead ...

journal_title：Cancer research

authors： Chen HN,Liang KH,Lai JK,Lan CH,Liao MY,Hung SH,Chuang YT,Chen KC,Tsuei WW,Wu HC

更新日期：2020-11-15 00:00:00

abstract：:ADAMs (a disintegrin and metalloproteinase) have important roles in development and diseases such as cancer. Previously, an ADAM15 splice variant (ADAM15B), which contains an inserted cytoplasmic Src-binding site, was linked to clinical aggressiveness in breast cancer, yet little was known about how this splice varian...

journal_title：Cancer research

authors： Maretzky T,Le Gall SM,Worpenberg-Pietruk S,Eder J,Overall CM,Huang XY,Poghosyan Z,Edwards DR,Blobel CP

更新日期：2009-06-01 00:00:00

abstract：:The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate inhibitors of CBP/p300 are of clinical value. We developed a specific and potent acetyl-lysine competitive protein-protein interaction i...

journal_title：Cancer research

authors： Picaud S,Fedorov O,Thanasopoulou A,Leonards K,Jones K,Meier J,Olzscha H,Monteiro O,Martin S,Philpott M,Tumber A,Filippakopoulos P,Yapp C,Wells C,Che KH,Bannister A,Robson S,Kumar U,Parr N,Lee K,Lugo D,Jeffrey P

更新日期：2015-12-01 00:00:00

abstract：:The carcinogenicities for rats and mice of N-methyl-4-aminoazobenzene (MAB) and its hepatic microsomal metabolite N-hydroxy-N-methyl-4-aminoazobenzene (N-hydroxy-MAB) were compared under several conditions. N-Ethyl-4-aminoazobenzene, 4-aminoazobenzene, and their N-hydroxy derivatives were also included in some of the ...

journal_title：Cancer research

authors： Miller EC,Kadlubar FF,Miller JA,Pitot HC,Drinkwater NR

更新日期：1979-09-01 00:00:00

abstract：:Virtually all patients with chronic myelogenous leukemia (CML) express an aberrant protein (p210 Bcr-Abl) that contains NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl. In a yeast two-hybrid screen, we have identified TSG101 as a binding partner for Bcr. Because TSG101 is a subunit of the mam...

journal_title：Cancer research

authors： Olabisi OO,Mahon GM,Kostenko EV,Liu Z,Ozer HL,Whitehead IP

更新日期：2006-06-15 00:00:00

abstract：:There is evidence from experimental work that hypoxia induces apoptosis in apoptosis-sensitive neoplastic cells and that this apoptotic sensitivity is lost during malignant progression. Oxygenation profiles and apoptotic indices in human squamous cell cancer of the uterine cervix have been determined, and a subgroup o...

journal_title：Cancer research

authors： Höckel M,Schlenger K,Höckel S,Vaupel P

更新日期：1999-09-15 00:00:00

abstract：:Chemotherapy with 4'-O-tetrahydropyranyladriamycin (THP-ADM), a new derivative of Adriamycin, was equally or more effective against several experimental mouse tumors than it was with Adriamycin (ADM). When mice with P388 leukemia were given i.p. injections of THP-ADM or ADM daily for 9 consecutive days, the maximum in...

journal_title：Cancer research

authors： Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

更新日期：1982-04-01 00:00:00

abstract：:Previously, we have shown that metastasis-associated protein 1 (MTA1) overexpression in transgenic mice was accompanied by high incidence of spontaneous B-cell lymphomas including diffuse large B-cell lymphomas (DLBCL). To understand the molecular basis of lymphoma in MTA1-transgenic (MTA1-TG) mice, we wished to ident...

journal_title：Cancer research

authors： Balasenthil S,Gururaj AE,Talukder AH,Bagheri-Yarmand R,Arrington T,Haas BJ,Braisted JC,Kim I,Lee NH,Kumar R

更新日期：2007-08-01 00:00:00

abstract：:1-Nitropyrene (1-NP) originating from such sources as diesel exhaust emissions and coal combustion fly ash has been detected in the environment. 1-NP, in addition to being both a bacterial and mammalian mutagen, is carcinogenic in rats. The purpose of this study was to quantitate 1-NP metabolism and macromolecular cov...

journal_title：Cancer research

authors： Bond JA,Mauderly JL

更新日期：1984-09-01 00:00:00

abstract：:Although androgen ablation therapy is effective in treating primary prostate cancers, a significant number of patients develop incurable castration-resistant disease. Recent studies have suggested a potential synergy between vaccination and androgen ablation, yet the enhanced T-cell function is transient. Using a defi...

journal_title：Cancer research

authors： Tang S,Moore ML,Grayson JM,Dubey P

更新日期：2012-04-15 00:00:00