Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.

abstract：:We have developed a new strain of rats (resistant rat) which exhibit resistance against the carcinogenic action of several carcinogenic compounds. In the present study, we compared the ability of resistant rat liver to activate 3'-methyl-4-dimethylaminoazobenzene and 2-acetylaminofluorene to highly reactive metabolite...

journal_title：Cancer research

authors： Yano M,Higashi T,Kano S,Tateishi N,Kido Y,Mori T,Higashi K,Sakamoto Y

更新日期：1989-10-01 00:00:00

abstract：:The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the ectonucleotidase CD39, which generates AMP from ATP, but do not express the AMPase CD73. In contrast, CD73 defined a subset of effect...

journal_title：Cancer research

authors： Gourdin N,Bossennec M,Rodriguez C,Vigano S,Machon C,Jandus C,Bauché D,Faget J,Durand I,Chopin N,Tredan O,Marie JC,Dubois B,Guitton J,Romero P,Caux C,Ménétrier-Caux C

更新日期：2018-07-01 00:00:00

abstract：:While colony formation assays provide sensitive indices of tumor cell proliferation and growth inhibition imposed by many chemotherapeutic agents, drugs which require metabolic activation lack activity in such assays. In the present study, we have utilized freshly isolated rat hepatocytes for the activation of drugs w...

journal_title：Cancer research

authors： Alley MC,Powis G,Appel PL,Kooistra KL,Lieber MM

更新日期：1984-02-01 00:00:00

abstract：:Members of cutaneous melanoma (CM) families with dysplastic nevi (DN) are at high risk of developing CM. Using a shuttle vector plasmid, pSP189, cell lines from three patients with CM plus DN were previously found to have elevated post-UV plasmid mutability. To investigate familial occurrence of this cellular phenotyp...

journal_title：Cancer research

authors： Moriwaki SI,Tarone RE,Tucker MA,Goldstein AM,Kraemer KH

更新日期：1997-10-15 00:00:00

abstract：:The rTSbeta protein has been hypothesized to synthesize signaling molecules that can down-regulate thymidylate synthase. These molecules share biological and chemical properties with acyl-homoserine lactones (AHL), suggesting some AHLs might act as rTS signaling mimics and down-regulate thymidylate synthase. We have d...

journal_title：Cancer research

authors： Dolnick R,Wu Q,Angelino NJ,Stephanie LV,Chow KC,Sufrin JR,Dolnick BJ

更新日期：2005-07-01 00:00:00

abstract：:We review and compare statistical methods for the analysis of in vivo tumor growth experiments. The methods most commonly used are deficient in that they have either low power or misleading type I error rates. We propose a set of multivariate statistical modeling methods that correct these problems, illustrating their...

journal_title：Cancer research

authors： Heitjan DF,Manni A,Santen RJ

更新日期：1993-12-15 00:00:00

abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are lysophospholipid mediators of diverse cellular processes important for cancer progression. S1P is produced by two sphingosine kinases, SphK1 and SphK2. Expression of SphK1 is elevated in many cancers. Here, we report that LPA markedly enhanced SphK1 mRN...

journal_title：Cancer research

authors： Shida D,Fang X,Kordula T,Takabe K,Lépine S,Alvarez SE,Milstien S,Spiegel S

更新日期：2008-08-15 00:00:00

abstract：:Thirty-six wild-caught woodchucks (Marmota monax) were characterized according to sex, weight, trapping locality, liver pathology, and serum or hepatic markers of woodchuck hepatitis virus. Liver subcellular fractions were assayed for microsomal cytochromes P-450, aryl hydrocarbon hydroxylase, glutathione, cytosolic e...

journal_title：Cancer research

authors： De Flora S,Camoirano A,Romano M,Astengo M,Cesarone CF,Millman I

更新日期：1987-08-01 00:00:00

abstract：:In vivo experiments performed with NIH (nu/nu, bg/bg, xid/xid) triple immunodeficient (TD) mice revealed the striking ability of i.v. injected B16-F1 and B16-F10 murine melanoma cells to colonize not only the lungs but also the liver of TD mice. Subsequently, B16 melanoma cell cultures, which express very low levels o...

journal_title：Cancer research

authors： Calorini L,Marozzi A,Byers HR,Waneck GL,Lee KW,Isselbacher KJ,Gattoni-Celli S

更新日期：1992-07-15 00:00:00

abstract：:The basal layer of the epidermis and hair follicles is composed of actively cycling, transit-amplifying cells and quiescent cells including stem cells. To determine which population is the target of carcinogenic chemicals, we treated CD-1 female mice topically with 5-fluorouracil (5-FU), an agent known to kill cycling...

journal_title：Cancer research

authors： Morris RJ,Coulter K,Tryson K,Steinberg SR

更新日期：1997-08-15 00:00:00

abstract：:This report describes the application of a new approach, the universal response surface approach, to the quantitative assessment of drug interaction, i.e., the determination of synergism, antagonism, additivity, potentiation, inhibition, and coalitive action. The specific drug combination and experimental growth syste...

journal_title：Cancer research

authors： Greco WR,Park HS,Rustum YM

更新日期：1990-09-01 00:00:00

abstract：:Nitromidazole and nitrofuran derivatives comprise a large family of compounds, some of which have been shown to be hypoxic cell specific radiosensitizers in vivo and in vitro. The effects of metronidazole (2-methyl-5-nitroimidazole-1-ethanol) and nitrofurazone (5-nitro-2-furaldehyde semicarbazone) were studied on cell...

journal_title：Cancer research

authors： Mohindra JK,Rauth AM

更新日期：1976-03-01 00:00:00

abstract：:The cytochrome P-450 in hepatic microsomes prepared from rats pretreated with hematoporphyrin derivative was shown to be rapidly destroyed in the presence of long-wave ultraviolet light. The photocatalytic destruction of the heme-protein was dependent on both the dose of ultraviolet light and of hematoporphyrin deriva...

journal_title：Cancer research

authors： Das M,Dixit R,Mukhtar H,Bickers DR

更新日期：1985-02-01 00:00:00

abstract：:The simian polyoma virus SV40 has been detected in specific human tumors including non-Hodgkin's lymphomas, although a causative role for the virus has not been convincingly demonstrated. Aberrant methylation of CpG islands in promoter regions is a frequent method of silencing tumor suppressor genes (TSGs) in cancers ...

journal_title：Cancer research

authors： Shivapurkar N,Takahashi T,Reddy J,Zheng Y,Stastny V,Collins R,Toyooka S,Suzuki M,Parikh G,Asplund S,Kroft SH,Timmons C,McKenna RW,Feng Z,Gazdar AF

更新日期：2004-06-01 00:00:00

abstract：:This study identifies ataxia-telangiectasia mutated (ATM) as a further component of the complex signaling network of radiation-induced DNA damage in nontargeted bystander cells downstream of ataxia-telangiectasia and Rad3-related (ATR) and provides a rationale for molecular targeted modulation of these effects. In dir...

journal_title：Cancer research

authors： Burdak-Rothkamm S,Rothkamm K,Prise KM

更新日期：2008-09-01 00:00:00

abstract：:The in vitro cytotoxicities of the four drugs most frequently used for intravesical chemotherapy (Adriamycin, epodyl, mitomycin C, Thiotepa) and epirubicin were compared using monolayers and multicellular tumor spheroids of the human bladder cancer cell line, MGH-U1. Adriamycin and epirubicin were most cytotoxic again...

journal_title：Cancer research

authors： Knuchel R,Hofstadter F,Jenkins WE,Masters JR

更新日期：1989-03-15 00:00:00

abstract：:The possibility that the female sex steroid progesterone plays a role in meningioma proliferation has been suggested by a number of investigators; and it had been shown that many meningiomas have high affinity progesterone binding sites. The aim of this study was to examine the expression of progesterone receptor mRNA...

journal_title：Cancer research

authors： Carroll RS,Glowacka D,Dashner K,Black PM

更新日期：1993-03-15 00:00:00

abstract：:CC-1065, a novel antibiotic produced by Streptomyces zelensis, was active against several experimental tumors in vivo and a broad spectrum of human tumor cells in vitro. This report describes its biological and biochemical effects of L1210 leukemia cells. CC-1065 is one of the most cytotoxic agents known. The concentr...

journal_title：Cancer research

authors： Li LH,Swenson DH,Schpok SL,Kuentzel SL,Dayton BD,Krueger WC

更新日期：1982-03-01 00:00:00

abstract：:The detection of tumor suppressor gene promoter methylation in sputum-derived exfoliated cells predicts early lung cancer. Here, we identified genetic determinants for this epigenetic process and examined their biologic effects on gene regulation. A two-stage approach involving discovery and replication was used to as...

journal_title：Cancer research

authors： Leng S,Stidley CA,Liu Y,Edlund CK,Willink RP,Han Y,Landi MT,Thun M,Picchi MA,Bruse SE,Crowell RE,Van Den Berg D,Caporaso NE,Amos CI,Siegfried JM,Tesfaigzi Y,Gilliland FD,Belinsky SA

更新日期：2012-02-01 00:00:00

abstract：:Down-regulation of gelsolin, an actin-binding protein, is frequently found in several types of transformed cells and tumors. The present study demonstrates that gelsolin protein and RNA were absent or markedly reduced in human breast cancer cell lines relative to "normal" mortal human mammary epithelial cells and beni...

journal_title：Cancer research

authors： Asch HL,Head K,Dong Y,Natoli F,Winston JS,Connolly JL,Asch BB

更新日期：1996-11-01 00:00:00

abstract：:To investigate the mechanism of action of the antineoplastic drug estramustine, we compared its effects on human prostate cancer cells with those of vinblastine. At their respective concentrations that result in 50% inhibition of clonogenic growth, both drugs caused an accumulation of cells blocked at mitosis and simi...

journal_title：Cancer research

authors： Dahllöf B,Billström A,Cabral F,Hartley-Asp B

更新日期：1993-10-01 00:00:00

abstract：:Although chrysotile asbestos is a proven human carcinogen, several studies have concluded that these fibers are not mutagenic to cultured mammalian cells. We show here, on the other hand, that when tested using the AL cell system that detects both intragenic and multilocus mutations, chrysotile is indeed mutagenic and...

journal_title：Cancer research

authors： Hei TK,Piao CQ,He ZY,Vannais D,Waldren CA

更新日期：1992-11-15 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis of transformed and cancer cells but not of most normal cells. Recent studies have revealed an unforeseen toxicity of TRAIL toward normal human hepatocytes, thereby bringing into question the safety of systemic administrati...

journal_title：Cancer research

authors： Ozoren N,Kim K,Burns TF,Dicker DT,Moscioni AD,El-Deiry WS

更新日期：2000-11-15 00:00:00

abstract：:Antitumor type I T-cell responses involving IFN-γ production are critical to control cancer, but the efficacy of this response is limited by a variety of immunosuppressive mechanisms that promote tumoral immune escape. One critical mechanism involves the accumulation of FOXP3(+) T regulatory cells (Treg), a class of s...

journal_title：Cancer research

authors： Redjimi N,Raffin C,Raimbaud I,Pignon P,Matsuzaki J,Odunsi K,Valmori D,Ayyoub M

更新日期：2012-09-01 00:00:00

abstract：:Human cutaneous fatty acid-binding protein (C-FABP) gene is capable of inducing the metastatic phenotype when overexpressed in nonmetastatic rat Rama 37 cells. However, the mechanism of how it induces metastasis is not clear. Northern and slot blot analyses revealed that expression of the endogenous vascular endotheli...

journal_title：Cancer research

authors： Jing C,Beesley C,Foster CS,Chen H,Rudland PS,West DC,Fujii H,Smith PH,Ke Y

更新日期：2001-06-01 00:00:00

abstract：:Epithelial cell lines derived from rat tracheal implants 2 and 9 months after a 4-week exposure to 200 micrograms dimethylbenz(a)anthracene-beeswax pellets, and previously assayed for growth in soft agarose and tumorigenicity, were tested at the same time of subculture for cytochalasin B-induced multinucleation to det...

journal_title：Cancer research

authors： Marchok AC,Martin DH

更新日期：1987-07-01 00:00:00

abstract：:The nonspecific accumulation of radioactivity in bone marrow, liver, and spleen in patients with melanoma injected with radiolabeled whole IgG of anti-high molecular weight-melanoma associated antigen (HMW-MAA) monoclonal antibody (mAb) hampers the application of immunoscintigraphy to visualize melanoma lesions. This ...

journal_title：Cancer research

authors： Temponi M,Gold AM,Ferrone S

更新日期：1992-05-01 00:00:00

abstract：:Akt activation has been implicated broadly in tumorigenesis, but the basis for its dysregulation in cancer cells is incompletely understood. In this study, we sought to clarify a regulatory role for the Akt-binding carboxy-terminal modulator protein (CTMP), which has been controversial. In evaluating CTMP expression i...

journal_title：Cancer research

authors： Liu YP,Liao WC,Ger LP,Chen JC,Hsu TI,Lee YC,Chang HT,Chen YC,Jan YH,Lee KH,Zeng YH,Hsiao M,Lu PJ

更新日期：2013-10-15 00:00:00

abstract：:Local irradiation of tumors of rats bearing 3924A hepatomas resulted in more than a doubling of the putrescine levvel and nearly a doubling of spermidine concentration in the serum within 12 hr. Within 24 hr, the putrescine concentration had increased four-fold in the serum, along with a continued increase in the sper...

journal_title：Cancer research

authors： Russell DH,Looney WB,Kovacs CJ,Hopkins HA,Dattilo JW,Morris HP

更新日期：1976-02-01 00:00:00

abstract：:8-Chloroadenosine 3',5'-monophosphate has been reported to inhibit growth of various mammalian cell lines at micromolar concentrations. We have used Chinese hamster ovary cell lines with mutated cyclic AMP-dependent protein kinase or altered cyclic nucleotide metabolism to show that a metabolite, 8-chloroadenosine, is...

journal_title：Cancer research

authors： Van Lookeren Campagne MM,Villalba Díaz F,Jastorff B,Kessin RH

更新日期：1991-03-15 00:00:00