Enhancement of 5-fluorouracil sensitivity by an rTS signaling mimic in H630 colon cancer cells.

abstract：:Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all three markers (triple negative or basal-like). While targeted therapies for ER+/PR+ and HER2+ tumors have revolutionized...

journal_title：Cancer research

authors： McCleland ML,Adler AS,Shang Y,Hunsaker T,Truong T,Peterson D,Torres E,Li L,Haley B,Stephan JP,Belvin M,Hatzivassiliou G,Blackwood EM,Corson L,Evangelista M,Zha J,Firestein R

更新日期：2012-11-15 00:00:00

abstract：:HsRec2/Rad51B is a 350-amino acid protein with a molecular mass of 38,300 Da that appears to be involved in cell cycle regulation and UV-induced apoptosis. The mouse and human genes were isolated based on their homology to a recombinational repair gene from Ustilago maydis and contain functional domains to hRAD51 and ...

journal_title：Cancer research

authors： Havre PA,Rice MC,Noe M,Kmiec EB

更新日期：1998-10-15 00:00:00

abstract：:Medulloblastoma is the most common malignant pediatric brain tumor and is one of the leading causes of cancer-related mortality in children. Treatment failure mainly occurs in children harboring metastatic tumors, which typically carry an isochromosome 17 or gain of 17q, a common hallmark of intermediate and high-risk...

journal_title：Cancer research

authors： Traenka C,Remke M,Korshunov A,Bender S,Hielscher T,Northcott PA,Witt H,Ryzhova M,Felsberg J,Benner A,Riester S,Scheurlen W,Grunewald TG,von Deimling A,Kulozik AE,Reifenberger G,Taylor MD,Lichter P,Butt E,Pfister SM

更新日期：2010-10-15 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) that arises in immune-deficient patients is an aggressive B-cell neoplasm that is universally associated with the EBV. Patients with EBV(+) PCNSL face a particularly poor prognosis with median survival times of 2-12 months despite aggressive management with radiation the...

journal_title：Cancer research

authors： Roychowdhury S,Peng R,Baiocchi RA,Bhatt D,Vourganti S,Grecula J,Gupta N,Eisenbeis CF,Nuovo GJ,Yang W,Schmalbrock P,Ferketich A,Moeschberger M,Porcu P,Barth RF,Caligiuri MA

更新日期：2003-03-01 00:00:00

abstract：:The mouse breast cancer cell lines 4T1, 4T07, and 67NR are highly tumorigenic but vary in metastatic potential: 4T1 widely disseminates, resulting in secondary tumors in the lung, liver, bone, and brain; 4T07 spreads to the lung and liver but is unable to establish metastatic nodules; 67NR is unable to metastasize. Th...

journal_title：Cancer research

authors： Manka D,Spicer Z,Millhorn DE

更新日期：2005-12-15 00:00:00

abstract：:We developed a novel approach for conducting multisample, multigene, ultradeep bisulfite sequencing analysis of DNA methylation patterns in clinical samples. A massively parallel sequencing-by-synthesis method (454 sequencing) was used to directly sequence >100 bisulfite PCR products in a single sequencing run without...

journal_title：Cancer research

authors： Taylor KH,Kramer RS,Davis JW,Guo J,Duff DJ,Xu D,Caldwell CW,Shi H

更新日期：2007-09-15 00:00:00

abstract：:All mammalian cells express 3 closely related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogenesis when they are mutationally activated at codon 12, 13, or 61. Although there is a high degree of similarity among the isoforms, K-Ras mutations are far more frequently observed in cancer, and each isofor...

journal_title：Cancer research

authors： Prior IA,Lewis PD,Mattos C

更新日期：2012-05-15 00:00:00

abstract：:The tumorigenicity of dexamethasone-treated tissue-cultured mammary tumor cells was compared to that of untreated mammary tumor cells. The dexamethasone-induced cells progressed faster in normal syngeneic animals than did untreated mammary tumor cells. The fact that the growth rate differential was also observed in at...

journal_title：Cancer research

authors： Gillette RW,Wunderlich DA

更新日期：1978-10-01 00:00:00

abstract：:It has been hypothesized that rapidly dividing tumor cells can outpace adoptively transferred antitumor lymphocytes when tumors are large. However, this hypothesis is at odds with clinical observations indicating that bulky tumors can be destroyed by small numbers of adoptively transferred antitumor T cells. We sought...

journal_title：Cancer research

authors： Hwang LN,Yu Z,Palmer DC,Restifo NP

更新日期：2006-01-15 00:00:00

abstract：:Several responses of 10T 1/2 cells and of cells from strains transformed by X-irradiation or by methylcholanthrene exposure were examined. Malignant potential, as determined by the ability of the cells to initiate tumors in syngeneic hosts, either normal or rendered immunodeficient, varied by a factor of 10(6). The gr...

journal_title：Cancer research

authors： Hahn GM

更新日期：1980-10-01 00:00:00

abstract：:The interaction of Adriamycin and pivaloyloxymethyl butyrate (AN-9) was investigated in IMR-32 neuroblastoma and MCF-7 breast adenocarcinoma cells. Adriamycin is a widely used anticancer drug, whereas AN-9 is an anticancer agent presently undergoing Phase II clinical trials. The anticancer activity of AN-9 has been at...

journal_title：Cancer research

authors： Cutts SM,Rephaeli A,Nudelman A,Hmelnitsky I,Phillips DR

更新日期：2001-11-15 00:00:00

abstract：:Aberrant activation of Wnt signaling plays an important role in hepatocarcinogenesis. In addition to direct effects on tumor cells, Wnt signaling might be involved in the organization of tumor microenvironment. In this study, we have explored whether Wnt signaling blockade by exogenous expression of Wnt antagonists co...

journal_title：Cancer research

authors： Hu J,Dong A,Fernandez-Ruiz V,Shan J,Kawa M,Martínez-Ansó E,Prieto J,Qian C

更新日期：2009-09-01 00:00:00

abstract：:In the present study, we examined the role of prolactin and glucocorticoids in regulating bcl-x transcription in mammary epithelial cells. We report that dexamethasone, but not prolactin, induced native bcl-x gene expression in a dose-dependent manner in HC11 cells and enhanced serum-starved HC11 cell survival. This e...

journal_title：Cancer research

authors： Schorr K,Furth PA

更新日期：2000-11-01 00:00:00

abstract：:Identification and reversal of treatment resistance mechanisms of clinically refractory tumor cells is critical for successful cancer therapy. Here we show that ATP-binding cassette member B5 (ABCB5) identifies therapy-refractory tumor cells in colorectal cancer patients following fluorouracil (5-FU)-based chemoradiat...

journal_title：Cancer research

authors： Wilson BJ,Schatton T,Zhan Q,Gasser M,Ma J,Saab KR,Schanche R,Waaga-Gasser AM,Gold JS,Huang Q,Murphy GF,Frank MH,Frank NY

更新日期：2011-08-01 00:00:00

abstract：:Data are presented in support of the hypothesis that malignant tumors, containing abnormally permeable, degenerating cells, can be selectively detected using monoclonal antibodies to intracellular antigens. Biodistribution, imaging, and autoradiographic studies were performed in nude mice transplanted with four differ...

journal_title：Cancer research

authors： Epstein AL,Chen FM,Taylor CR

更新日期：1988-10-15 00:00:00

abstract：:Tumors are complex tissues composed of transformed epithelial cells as well as cancer-activated fibroblasts (CAF) that facilitate epithelial tumor cell invasion. We show here that CAFs and other mesenchymal cells rely much more on glutamine than epithelial tumor cells; consequently, they are more sensitive to inhibiti...

journal_title：Cancer research

authors： Mestre-Farrera A,Bruch-Oms M,Peña R,Rodríguez-Morató J,Alba-Castellón L,Comerma L,Quintela-Fandino M,Duñach M,Baulida J,Pozo ÓJ,García de Herreros A

更新日期：2021-01-15 00:00:00

abstract：:Despite the initial efficacy of androgen deprivation therapy, most patients with advanced prostate cancer eventually progress to hormone-refractory prostate cancer, for which there is no curative therapy. Previous studies from our laboratory and others have shown the antiproliferative and proapoptotic effects of 3,3'-...

journal_title：Cancer research

authors： Bhuiyan MM,Li Y,Banerjee S,Ahmed F,Wang Z,Ali S,Sarkar FH

更新日期：2006-10-15 00:00:00

abstract：:We present a light scattering study using angle-resolved low coherence interferometry (a/LCI) to assess nuclear morphology and subcellular structure within MCF-7 cells at several time points after treatment with chemotherapeutic agents. Although the nuclear diameter and eccentricity are not observed to change, the lig...

journal_title：Cancer research

authors： Chalut KJ,Ostrander JH,Giacomelli MG,Wax A

更新日期：2009-02-01 00:00:00

abstract：:The Adenomatous polyposis coli (Apc) gene is mutated in up to 80% of sporadic colorectal cancers. After Apc loss, there is deregulation of the Wnt signaling pathway and transactivation of T-cell factor/leukemia enhancing factor target genes such as C-Myc. This review focuses on recent data highlighting the importance ...

journal_title：Cancer research

authors： Wilkins JA,Sansom OJ

更新日期：2008-07-01 00:00:00

abstract：:Animal models of human prostate cancer are very limited in number but are of obvious importance to develop. Dr. Morris Pollard (M. Pollard, J. Natl. Cancer Inst., 51: 1235-1241, 1973) has reported that Lobund-Wistar rats develop spontaneous metastatic prostatic cancer when they become old (approximately 25% incidence ...

journal_title：Cancer research

authors： Pugh TD,Chang C,Uemura H,Weindruch R

更新日期：1994-11-15 00:00:00

abstract：:Insulin-like growth factor I action has been implicated in the pathogenesis of many different malignancies, including breast cancer. Insulin-like growth factor I receptors (IGF-IRs) are overexpressed in virtually all breast cancer cell lines, in which they are believed to enhance growth and inhibit apoptosis. In this ...

journal_title：Cancer research

authors： Resnik JL,Reichart DB,Huey K,Webster NJ,Seely BL

更新日期：1998-03-15 00:00:00

abstract：:N-Demethylated metabolites of the antineoplastic agent hexamethylmelamine were synthesized, and their toxicities and antitumor activities were determined in vivo. Determinations of the lethal dose for 10% of the male C57BL X DBA/2 F1 (hereafter called BD2F1) mice showed hexamethylmelamine toxicity to be decreased by N...

journal_title：Cancer research

authors： Lake LM,Grunden EE,Johnson BM

更新日期：1975-10-01 00:00:00

abstract：:Many tumors contain extensive regions of hypoxia. Because hypoxic cells are markedly more resistant to killing by radiation, repeated attempts have been made to improve the oxygenation of tumors to enhance radiotherapy. We have studied the oxygenation of tumor xenografts in nude mice after treatment with the farnesylt...

journal_title：Cancer research

authors： Cohen-Jonathan E,Evans SM,Koch CJ,Muschel RJ,McKenna WG,Wu J,Bernhard EJ

更新日期：2001-03-01 00:00:00

abstract：:Cancer research has long been hampered by the limitations of the current model systems. Both cultured cells and mouse xenografts grow in an environment highly dissimilar to that of their originating tumor, frequently resulting in promising treatments that are ultimately clinically ineffective. The development of highl...

journal_title：Cancer research

authors： Morton JJ,Bird G,Refaeli Y,Jimeno A

更新日期：2016-11-01 00:00:00

abstract：:The multistage process of cancer formation is driven by the progressive acquisition of somatic mutations. Replication stress creates genomic instability in mammals. Using a well-defined multistep leukemia model driven by Spi-1/PU.1 overexpression in the mouse and Spi-1/PU.1-overexpressing human leukemic cells, we inve...

journal_title：Cancer research

authors： Rimmelé P,Komatsu J,Hupé P,Roulin C,Barillot E,Dutreix M,Conseiller E,Bensimon A,Moreau-Gachelin F,Guillouf C

更新日期：2010-09-01 00:00:00

abstract：:Although neoplasia is caused by clonal proliferation of cells, the resulting tumors are frequently heterogeneous, being composed of both neoplastic and reactive cells. Therefore, identification of tumors as neoplastic processes is frequently obscured. We studied cutaneous angiofibroma, which is a tumor of unknown etio...

journal_title：Cancer research

authors： Vortmeyer AO,Böni R,Pack SD,Darling TN,Zhuang Z

更新日期：1999-01-15 00:00:00

abstract：:A widely held tenet of present day oncology is that tumor cells treated with anticancer agents die from apoptosis, and that cells resistant to apoptosis are resistant to cancer treatment. We suggest, in this review, that this tenet may need to be reexamined for human tumors of nonhematological origin, for two principa...

journal_title：Cancer research

authors： Brown JM,Wouters BG

更新日期：1999-04-01 00:00:00

abstract：:The soybean-derived Bowman Birk inhibitor (BBI) has been shown to inhibit carcinogenesis in both in vitro and in vivo model systems. In the present study, we have utilized a BBI affinity column to determine whether cellular enzymes, present in C3H/10T1/2 cells, specifically interact with this inhibitor. Using this tec...

journal_title：Cancer research

authors： Billings PC,St Clair W,Owen AJ,Kennedy AR

更新日期：1988-04-01 00:00:00

abstract：:Alkaline phosphatase was monitored in 17 mice with s.c.-implanted tumors to relate the total circulating alkaline phosphatase to the total number of tumor cells in each mouse. There was a semilogarithmic relationship between the alkaline phosphatase units and the number of tumor cells. A time-independent standard plot...

journal_title：Cancer research

authors： Hiramoto RN,Ghanta VK,Soong SJ,Hurst DC

更新日期：1977-02-01 00:00:00

abstract：:Although mutated forms of ras are not associated with the majority of breast cancers (<5%), there is considerable experimental evidence that hyperactive Ras can promote breast cancer growth and development. Therefore, we determined whether Ras and Ras-responsive signaling pathways were activated persistently in nine w...

journal_title：Cancer research

authors： Eckert LB,Repasky GA,Ulkü AS,McFall A,Zhou H,Sartor CI,Der CJ

更新日期：2004-07-01 00:00:00